WO1990002728A3 - Derives de 6-oxo-9-fluor-prostaglandine, leur procede de production et leur utilisation pharmaceutique - Google Patents
Derives de 6-oxo-9-fluor-prostaglandine, leur procede de production et leur utilisation pharmaceutique Download PDFInfo
- Publication number
- WO1990002728A3 WO1990002728A3 PCT/DE1989/000588 DE8900588W WO9002728A3 WO 1990002728 A3 WO1990002728 A3 WO 1990002728A3 DE 8900588 W DE8900588 W DE 8900588W WO 9002728 A3 WO9002728 A3 WO 9002728A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- free
- hydrogen atom
- functionally modified
- fluor
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 2
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Des dérivés de 6-oxo-9-fluor-prostaglandine ont la formule (1), dans laquelle R1 représente les résidus COOR2 ou CONHSO¿2?R?2, où R2¿ est un groupe C¿5?-C6-cycloalkyle ou C6-C12-aryle ou un résidu hétérocyclique pentagonal ou hexagonal, ou lorsque R?1¿ est COOR2, R2 peut représenter un atome d'hydrogène ou un phénacyle libre ou substitué par 1-3 atomes d'halogène, A est un groupe CH=CH ou -C=C- à configuration en E, W est un groupe hydroxyméthylène libre ou fonctionnellement transformé ou un groupe (a) libre ou fonctionnellement transformé, alors que le groupe OH peut être situé en α ou en β, D est un groupe alkylène à chaîne droite ou ramifiée ayant entre 1 et 5 atomes de de carbone ou est une liaison directe, E est un groupe -C=C-, un groupe C¿2?-C4-alkényle, ou un groupe (b); R?3¿ est atome d'hydrogène, un groupe C¿2?-C4-alkenylène, un groupe C3-C10-cycloalkyle, un groupe C6-C12-aryle éventuellement substitué ou un groupe hétérocyclique pentagonal ou hexagonal, R?4¿ est atome d'hydrogène, un groupe méthyle ou un groupe hydroxyle libre ou fonctionnellement transformé, et lorsque R2 représente un atome d'hydrogène, ses sels avec des bases physiologiquement compatibles, des clathrates de cyclodextrine α, β ou η. L'invention concerne également les composés de formule (I) encapsulés dans des liposomes, leur procédé de production et leur utilisation pharmaceutique.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19883831222 DE3831222A1 (de) | 1988-09-09 | 1988-09-09 | 6-oxo-9-fluor-prostaglandin-derivate verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
| DEP3831222.0 | 1988-09-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1990002728A2 WO1990002728A2 (fr) | 1990-03-22 |
| WO1990002728A3 true WO1990002728A3 (fr) | 1990-07-26 |
Family
ID=6362926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/DE1989/000588 WO1990002728A2 (fr) | 1988-09-09 | 1989-09-10 | Derives de 6-oxo-9-fluor-prostaglandine, leur procede de production et leur utilisation pharmaceutique |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0434707A1 (fr) |
| DE (1) | DE3831222A1 (fr) |
| WO (1) | WO1990002728A2 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008959A1 (fr) * | 1992-10-20 | 1994-04-28 | Taisho Pharmaceutical Co., Ltd. | Derive de prostaglandine |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0069696A2 (fr) * | 1981-07-03 | 1983-01-12 | Schering Aktiengesellschaft | Dérivés prostaglandines-9-fluorés, leur préparation et application comme médicament |
| ZA881777B (en) * | 1987-03-13 | 1988-09-09 | Schering Aktiengesellschaft | 6-oxoprostaglandin-e derivatives.method for their manufacture and their use as pharmaceuticals |
-
1988
- 1988-09-09 DE DE19883831222 patent/DE3831222A1/de not_active Withdrawn
-
1989
- 1989-09-10 WO PCT/DE1989/000588 patent/WO1990002728A2/fr not_active Application Discontinuation
- 1989-09-10 EP EP19890909709 patent/EP0434707A1/fr not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0069696A2 (fr) * | 1981-07-03 | 1983-01-12 | Schering Aktiengesellschaft | Dérivés prostaglandines-9-fluorés, leur préparation et application comme médicament |
| ZA881777B (en) * | 1987-03-13 | 1988-09-09 | Schering Aktiengesellschaft | 6-oxoprostaglandin-e derivatives.method for their manufacture and their use as pharmaceuticals |
Non-Patent Citations (1)
| Title |
|---|
| Tele Systems, File Server, Databasis W.P.I.L. (Derwent), Nr. 88-271929 (39), siehe die Zusammenfassung & ZA 8801777 (Schering AG) 9. September 1988 & DE, A, 3708537 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1990002728A2 (fr) | 1990-03-22 |
| DE3831222A1 (de) | 1990-03-22 |
| EP0434707A1 (fr) | 1991-07-03 |
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