WO1990002119A1 - Derives de 1,2,3,4-tetrahydro-isoquinoline - Google Patents

Derives de 1,2,3,4-tetrahydro-isoquinoline Download PDF

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Publication number
WO1990002119A1
WO1990002119A1 PCT/JP1989/000825 JP8900825W WO9002119A1 WO 1990002119 A1 WO1990002119 A1 WO 1990002119A1 JP 8900825 W JP8900825 W JP 8900825W WO 9002119 A1 WO9002119 A1 WO 9002119A1
Authority
WO
WIPO (PCT)
Prior art keywords
group
phenyl
substituted
compound
methyl
Prior art date
Application number
PCT/JP1989/000825
Other languages
English (en)
Japanese (ja)
Inventor
Kiyofumi Ishikawa
Takashi Hayama
Takehiro Fukami
Ikuko Takahashi
Keiko Miura
Akira Okuyama
Original Assignee
Banyu Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharmaceutical Co., Ltd. filed Critical Banyu Pharmaceutical Co., Ltd.
Publication of WO1990002119A1 publication Critical patent/WO1990002119A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dérivés de 1,2,3,4-tétrahydro-isoquinoline représentés par la formule (I) et agents de potentialisation de l'effet antitumoral contenant ces composés en tant qu'ingrédients actifs. Dans la formule, R2 représente un groupe alkyle inférieur ou, lorsqu'il est combiné avec R1 ou R3, il représente un groupe méthylène, un élément parmi R1 ou R3 représente un groupe alkyle inférieur ou, lorsqu'il est combiné avec R2, il représente un groupe méthylène, et l'autre représente un groupe alcényle inférieur, un groupe alcényle inférieur-aryle substitué ou non substitué, un groupe alkyle inférieur-aryle substitué ou non substitué (à condition que l'on omette un groupe phényle non substitué), un groupe aryle substitué ou non substitué (à condition que l'on omette un groupe phényle non substitué), ou un groupe représenté par -(CH¿2?)m-A (où A représente un atome d'halogène, un groupe alkylsulfonyle inférieur, un groupe alkylthio inférieur-aryle substitué ou non substitué, un groupe alkylsulfinyle inférieur-aryle substitué ou non substitué, un groupe alkylsulfonyle inférieur-aryle substitué ou non substitué, un groupe arylthio substitué ou non substitué, un groupe arylsulfinyle substitué ou non substitué, un groupe arylsulfonyle substitué ou non substitué, un groupe alkyloxy substitué ou non substitué ou un groupe aryloxy substitué ou non substitué, un groupe N-benzyle-N(alkyle inférieur)amino, un groupe N,N-di(alkyle inférieur)amino, un groupe di(alkyloxy inférieur)phosphinoyle ou un groupe dibenzyloxyphosphinoyle, et m représente 2 ou 4), R?4¿ représente un groupe alkyle inférieur, Ar représente un groupe phényle éventuellement substitué par 1 à 3 groupes alkyloxy inférieur, et n représente 0, 1 ou 2.
PCT/JP1989/000825 1988-08-18 1989-08-15 Derives de 1,2,3,4-tetrahydro-isoquinoline WO1990002119A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20544588 1988-08-18
JP63/205445 1988-08-18

Publications (1)

Publication Number Publication Date
WO1990002119A1 true WO1990002119A1 (fr) 1990-03-08

Family

ID=16506999

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1989/000825 WO1990002119A1 (fr) 1988-08-18 1989-08-15 Derives de 1,2,3,4-tetrahydro-isoquinoline

Country Status (1)

Country Link
WO (1) WO1990002119A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0501693A1 (fr) * 1991-02-27 1992-09-02 Banyu Pharmaceutical Co., Ltd. Dérivés d'isoquinoleine
US5362736A (en) * 1991-02-27 1994-11-08 Banyu Pharmaceutical Co., Ltd. Isoquinoline derivatives
US5446164A (en) * 1993-02-25 1995-08-29 Banyu Pharmaceutical Co., Ltd. Process for preparing 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ol
WO2002051842A1 (fr) * 2000-12-23 2002-07-04 F. Hoffmann-La Roche Ag Derives de tetrahydropyridine, leur preparation et leur utilisation en tant qu'inhibiteurs de proliferation cellulaire
WO2003077874A2 (fr) * 2002-03-13 2003-09-25 The University Of Tennessee Research Foundation Composes tetrahydroisoquinoleine substitues, procedes de preparation et utilisation de ceux-ci
JP2007528877A (ja) * 2004-03-12 2007-10-18 アナリットコン エス アー Ｉｇｆ−１ｒ阻害剤としてのテトラヒドロイソキノリンおよびテトラヒドロベンゾアゼピン誘導体

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491665A (en) * 1979-10-19 1985-01-01 Burroughs Wellcome Co. Method of preparing isomers of bis isoquinolinium compounds

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Vol. 103, No. 9, see Abstract No. 71575X; & US,A,4491665 (Burroughs Wellcome Co.), 1 January 1985 (01.01.85). *
CHEMICAL ABSTRACTS, Vol. 61, No. 2, see Abstract Nos. 1829e, 1830c, YAKUGAKU ZASSHI, Vol. 84, No. 4, 329-33 (1964). *
CHEMICAL ABSTRACTS, Vol. 65, No. 5, see Abstract Nos. 7230b, 7230c; & JP,B,41 007 591 (Dainippon Pharmaceutical Co. Ltd.), 23 April 1966 (23.04.66). *
CHEMICAL ABSTRACTS, Vol. 74, No. 1, see Abstract No. 3491Z, YAKUGAKU ZASSHI, Vol. 90, No. 9, 1144-9 (1970). *
CHEMICAL ABSTRACTS, Vol. 81, No. 16, see Abstract No. 98555e, TETRAHEDRON, Vol. 30, No. 8, 931-4 (1974). *
CHEMICAL ABSTRACTS, Vol. 88, No. 17, see Abstract No. 121486p, HETEROCYCLES, Vol. 9, No. 1, 1-6 (1978). *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0501693A1 (fr) * 1991-02-27 1992-09-02 Banyu Pharmaceutical Co., Ltd. Dérivés d'isoquinoleine
US5362736A (en) * 1991-02-27 1994-11-08 Banyu Pharmaceutical Co., Ltd. Isoquinoline derivatives
US5446164A (en) * 1993-02-25 1995-08-29 Banyu Pharmaceutical Co., Ltd. Process for preparing 6,7-dialkoxy-3,4-dihydroisoquinolin-8-ol
US5498717A (en) * 1993-02-25 1996-03-12 Banyu Pharmaceutical Co., Ltd. 6,7-dialkoxy-3,4-diydroisoquinolin-8-yl compounds
WO2002051842A1 (fr) * 2000-12-23 2002-07-04 F. Hoffmann-La Roche Ag Derives de tetrahydropyridine, leur preparation et leur utilisation en tant qu'inhibiteurs de proliferation cellulaire
US6800638B2 (en) 2000-12-23 2004-10-05 Hoffman-La Roche Inc. Tetrahydropyridine derivatives, their preparation and their use as cell proliferation inhibitors
WO2003077874A2 (fr) * 2002-03-13 2003-09-25 The University Of Tennessee Research Foundation Composes tetrahydroisoquinoleine substitues, procedes de preparation et utilisation de ceux-ci
WO2003077874A3 (fr) * 2002-03-13 2004-08-05 Univ Tennessee Res Foundation Composes tetrahydroisoquinoleine substitues, procedes de preparation et utilisation de ceux-ci
JP2005526770A (ja) * 2002-03-13 2005-09-08 ザ ユニバーシティ オブ テネシー リサーチ ファウンデイション 置換テトラヒドロイソキノリン化合物、調製方法、およびその使用
US7241774B2 (en) 2002-03-13 2007-07-10 University Of Tennessee Research Foundation Substituted tetrahydroisoquinoline compounds, methods of making, and their use
AU2003230665B2 (en) * 2002-03-13 2010-02-18 University Of Tennessee Research Foundation Substituted tetrahydroisoquinoline compounds, methods of making, and their use
JP2007528877A (ja) * 2004-03-12 2007-10-18 アナリットコン エス アー Ｉｇｆ−１ｒ阻害剤としてのテトラヒドロイソキノリンおよびテトラヒドロベンゾアゼピン誘導体

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