WO1988009818A3 - Recepteur d'hormone de croissance - Google Patents

Recepteur d'hormone de croissance Download PDF

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Publication number
WO1988009818A3
WO1988009818A3 PCT/US1988/002008 US8802008W WO8809818A3 WO 1988009818 A3 WO1988009818 A3 WO 1988009818A3 US 8802008 W US8802008 W US 8802008W WO 8809818 A3 WO8809818 A3 WO 8809818A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth hormone
hormone receptor
binding protein
receptor
hormone binding
Prior art date
Application number
PCT/US1988/002008
Other languages
English (en)
Other versions
WO1988009818A2 (fr
WO1988009818A1 (fr
Inventor
R Glenn Hammonds
David W Leungh
Steven A Spencer
William I Wood
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to EP88906383A priority Critical patent/EP0366710B1/fr
Priority to DE3855536T priority patent/DE3855536T2/de
Publication of WO1988009818A2 publication Critical patent/WO1988009818A2/fr
Publication of WO1988009818A1 publication Critical patent/WO1988009818A1/fr
Publication of WO1988009818A3 publication Critical patent/WO1988009818A3/fr
Priority to HK98107083A priority patent/HK1008021A1/xx

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

On purifie une protéine réceptrice d'hormone de croissance et une protéine liante d'hormone de croissance, ce qui permet d'obtenir des isolats de séquences d'acides aminés et d'ADN codant pour la protéine réceptrice d'hormone de croissance et la protéine liante d'hormone de croissance. Des procédés permettant d'obtenir un tel ADN sont décrits, ainsi que des systèmes d'expression permettant la production recombinante de protéine réceptrice d'hormone de croissance et de protéine liante d'hormone de croissance. Des formes thérapeutiquement utiles de la protéine réceptrice d'hormone de croissance, ainsi que de la protéine liante d'hormone de croissance et d'anticorps anti-récepteurs sont également décrites.
PCT/US1988/002008 1987-06-12 1988-06-10 Recepteur d'hormone de croissance WO1988009818A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP88906383A EP0366710B1 (fr) 1987-06-12 1988-06-10 Recepteur d'hormone de croissance
DE3855536T DE3855536T2 (de) 1987-06-12 1988-06-10 Rezeptoren für wachstumshormone
HK98107083A HK1008021A1 (en) 1987-06-12 1998-06-26 Growth hormone receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US062,542 1987-06-12
US07/062,542 US5057417A (en) 1987-06-12 1987-06-12 Compositions and methods for the synthesis of growth hormone receptor and growth hormone binding protein

Publications (3)

Publication Number Publication Date
WO1988009818A2 WO1988009818A2 (fr) 1988-12-15
WO1988009818A1 WO1988009818A1 (fr) 1988-12-15
WO1988009818A3 true WO1988009818A3 (fr) 1989-01-12

Family

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Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Biochemical and Biophysical Research Communications, volume 139, no. 1, 29 August 1986, Academic Press, Inc., (San Diego, US), A.C. Herington et al.: "Affinity purification and structural characterization of a specific binding protein for human growth hormone in human serum", pages 150-155 *
Biochemistry Journal, volume 237, no. 3, 1986, R. Barnard et al.: "Serum and liver cytosolic growth-hormone-binding proteins are antigenically identical with liver membrane 'receptor' types 1 and 2", pages 885-892 *
Human Growth Hormone, 1986, Ed. Raiti Salvatore, J.P. Hughes et al.: "Isolation of growth hormone receptor", pages 455-461 *
Molecular and Cellular Endrocrinology, volume 53, no. 3, 1987, Elsevier Scientific Publishers Ireland, Ltd, A.C. Herington et al.: "Partial purification from human serum of a specific binding protein for human growth hormone", pages 203-209 *
Nature, volume 330, no. 6148, 10-16 December 1987, D.W. Leung et al.: "Growth hormone receptor and serum binding protein: purification. cloning and expression", pages 537-543 *
The Journal of Biological Chemistry, volume 254, no. 14, 25 July 1979, (US), M.J. Waters et al.: "Purification and partial characterization of a nonprimate growth hormone receptor", pages 6815-6825 *
The Journal of Biological Chemistry, volume 263, no. 16, 5 June 1988, The American Society for Biochemistry and Molecular Biology, Inc., (US), S.A. Spencer et al.: "Rabbit liver growth hormone receptor and serum binding protein", pages 7862-7867 *

Also Published As

Publication number Publication date
ATE142645T1 (de) 1996-09-15
DE3855536T2 (de) 1997-02-27
AU616672B2 (en) 1991-11-07
CA1341382C (fr) 2002-08-13
WO1988009818A2 (fr) 1988-12-15
JP2879079B2 (ja) 1999-04-05
HK1008021A1 (en) 1999-04-30
US5057417A (en) 1991-10-15
EP0366710A1 (fr) 1990-05-09
JPH03500122A (ja) 1991-01-17
NZ224961A (en) 1992-02-25
EP0366710B1 (fr) 1996-09-11
DE3855536D1 (de) 1996-10-17
AU1986588A (en) 1989-01-04

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