AU6989687A - Preparation of factor XIIIa by gene manipulation - Google Patents

Preparation of factor XIIIa by gene manipulation

Info

Publication number
AU6989687A
AU6989687A AU69896/87A AU6989687A AU6989687A AU 6989687 A AU6989687 A AU 6989687A AU 69896/87 A AU69896/87 A AU 69896/87A AU 6989687 A AU6989687 A AU 6989687A AU 6989687 A AU6989687 A AU 6989687A
Authority
AU
Australia
Prior art keywords
factor xiiia
preparation
gene manipulation
new
transformed cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU69896/87A
Other versions
AU605757B2 (en
Inventor
Egon Amann
Ulrich Grundmann
Gerd Zettlmeissl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring GmbH Deutschland
Original Assignee
Aventis Behring GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Behring GmbH filed Critical Aventis Behring GmbH
Publication of AU6989687A publication Critical patent/AU6989687A/en
Application granted granted Critical
Publication of AU605757B2 publication Critical patent/AU605757B2/en
Assigned to CENTEON PHARMA GMBH reassignment CENTEON PHARMA GMBH Alteration of Name(s) in Register under S187 Assignors: BEHRINGWERKE AKTIENGESELLSCHAFT
Assigned to AVENTIS BEHRING GMBH reassignment AVENTIS BEHRING GMBH Request to Amend Deed and Register Assignors: CENTEON PHARMA GMBH
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91045—Acyltransferases (2.3)
    • G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
    • G01N2333/9108—Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91045—Acyltransferases (2.3)
    • G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
    • G01N2333/9108—Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)
    • G01N2333/91085—Transglutaminases; Factor XIIIq (2.3.2.13)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Food Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A DNA sequence (I) coding for factor XIIIa is new. It contains a coding strand with about 3900 bases; the complete structure of this sequence, and of the corresponding amino acid sequence, are reproduced in the specification. Also new are (1) gene structures, vectors and transformed cells contg. (I); (2) crude proteins expressed by (I), transformed cells and (3) antibodies (Ab) specific for factor XIIIa.
AU69896/87A 1986-03-12 1987-03-11 Preparation of factor XIIIa by gene manipulation Expired AU605757B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3608280 1986-03-12
DE3608280 1986-03-12
DE3621371 1986-06-26
DE19863621371 DE3621371A1 (en) 1986-03-12 1986-06-26 GENETIC PRODUCTION OF FACTOR XIIIA

Publications (2)

Publication Number Publication Date
AU6989687A true AU6989687A (en) 1987-09-17
AU605757B2 AU605757B2 (en) 1991-01-24

Family

ID=25841904

Family Applications (1)

Application Number Title Priority Date Filing Date
AU69896/87A Expired AU605757B2 (en) 1986-03-12 1987-03-11 Preparation of factor XIIIa by gene manipulation

Country Status (7)

Country Link
EP (2) EP0236978B1 (en)
JP (2) JPH0640825B2 (en)
AT (2) ATE124454T1 (en)
AU (1) AU605757B2 (en)
CA (1) CA1341516C (en)
DE (3) DE3621371A1 (en)
ES (2) ES2140398T3 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU615634B2 (en) * 1986-09-19 1991-10-10 University Of Washington Expression of biologically active factor XIII
US5612456A (en) * 1988-11-14 1997-03-18 Zymogenetics, Inc. Factor XIII compositions
US6207877B1 (en) 1998-09-23 2001-03-27 Aventis Behring Gmbh Transgenic coagulation factor XIII defective animal and its use for testing wound healing and bleeding
WO2006056575A1 (en) 2004-11-23 2006-06-01 Zymogenetics, Inc. Purification of recombinant human factor xiii

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3808048A1 (en) * 1988-03-11 1989-09-21 Behringwerke Ag METHOD FOR THE AFFINITY CHROMATOGRAPHIC CLEANING OF FACTOR XIII
DE3819463A1 (en) * 1988-06-08 1989-12-14 Behringwerke Ag EXPRESSION VECTORS FOR THE PRODUCTION OF UNFUSIONED PROTEINS IN MICROORGANISMS
US5204447A (en) * 1988-11-14 1993-04-20 Zymogenetics, Inc. Purification of factor xiii
DE3905674A1 (en) * 1989-02-24 1990-08-30 Bosch Gmbh Robert LIGHTING IN PARTICULAR FOR MOTOR VEHICLES
CS136091A3 (en) * 1990-05-10 1992-04-15 Zymo Genetics Agents for determining thrombi and their application
EP0726956A1 (en) * 1991-12-31 1996-08-21 Zymogenetics, Inc. Novel human transglutaminases
GB9424823D0 (en) * 1994-12-08 1995-02-08 Univ Leeds Genetic basis of factor XIII activity
WO1996021025A1 (en) * 1994-12-30 1996-07-11 Zymogenetics, Inc. Bovine factor xiii
ATE414765T1 (en) * 1998-09-23 2008-12-15 Csl Behring Gmbh TRANSGENIC ANIMAL WITH A DEFECTIVE GENE FOR CLOTTING FACTOR XIII AND ITS USE FOR TESTING WOUND HEALING AND BLEEDING
EP1045026A1 (en) * 1999-04-16 2000-10-18 Aventis Behring Gesellschaft mit beschränkter Haftung A transgenic coagulation factor XIII defective animal and its use for testing wound healing and bleeding
ES2303561T3 (en) 2001-10-09 2008-08-16 Zymogenetics, Inc. METHOD FOR INHIBITING SEROMAS FORMATION USING FACTOR XIII.
EP1515142A1 (en) * 2003-09-12 2005-03-16 BioVisioN AG Mass spectrometry methods for direct phenotyping of factor XIIIA polymorphisms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2916711A1 (en) * 1979-04-25 1980-11-06 Behringwerke Ag Blood coagulation factors and process for their manufacture
GB2125409B (en) * 1982-08-04 1985-11-13 Nat Res Dev Genetic engineering
DE3419581A1 (en) * 1984-05-25 1985-11-28 Behringwerke Ag, 3550 Marburg METHOD FOR OBTAINING A FACTOR XIII PRAEPARATION AND ITS USE
ATE121776T1 (en) * 1986-09-19 1995-05-15 Zymogenetics Inc EXPRESSION OF BIOLOGICALLY ACTIVE FACTOR XIII.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU615634B2 (en) * 1986-09-19 1991-10-10 University Of Washington Expression of biologically active factor XIII
US5612456A (en) * 1988-11-14 1997-03-18 Zymogenetics, Inc. Factor XIII compositions
US6207877B1 (en) 1998-09-23 2001-03-27 Aventis Behring Gmbh Transgenic coagulation factor XIII defective animal and its use for testing wound healing and bleeding
WO2006056575A1 (en) 2004-11-23 2006-06-01 Zymogenetics, Inc. Purification of recombinant human factor xiii

Also Published As

Publication number Publication date
ATE124454T1 (en) 1995-07-15
EP0236978B1 (en) 1995-06-28
EP0236978A3 (en) 1988-12-21
DE3621371A1 (en) 1987-09-17
JPS6339585A (en) 1988-02-20
EP0494702A2 (en) 1992-07-15
DE3751368D1 (en) 1995-08-03
JPH05192141A (en) 1993-08-03
ATE185604T1 (en) 1999-10-15
JPH0640825B2 (en) 1994-06-01
AU605757B2 (en) 1991-01-24
JPH0761262B2 (en) 1995-07-05
EP0494702A3 (en) 1992-11-19
EP0236978A2 (en) 1987-09-16
DE3752298D1 (en) 1999-11-18
ES2076926T3 (en) 1995-11-16
ES2140398T3 (en) 2000-03-01
CA1341516C (en) 2006-11-28
EP0494702B1 (en) 1999-10-13

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Legal Events

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PC Assignment registered

Free format text: CENTEON PHARMA GMBH

HB Alteration of name in register

Owner name: AVENTIS BEHRING GMBH

Free format text: FORMER NAME WAS: CENTEON PHARMA GMBH