WO1987007609A1 - 1,1,2-triaryl-1-butene derivatives - Google Patents
1,1,2-triaryl-1-butene derivatives Download PDFInfo
- Publication number
- WO1987007609A1 WO1987007609A1 PCT/JP1987/000385 JP8700385W WO8707609A1 WO 1987007609 A1 WO1987007609 A1 WO 1987007609A1 JP 8700385 W JP8700385 W JP 8700385W WO 8707609 A1 WO8707609 A1 WO 8707609A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- triaryl
- lower alkyl
- alkyl group
- butene derivatives
- group
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000002513 anti-ovulatory effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000036512 infertility Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE8787903918T DE3770251D1 (de) | 1986-06-16 | 1987-06-12 | 1,1,2-triaryl-1-buten-derivate. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61/139897 | 1986-06-16 | ||
JP13989786 | 1986-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1987007609A1 true WO1987007609A1 (en) | 1987-12-17 |
Family
ID=15256159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1987/000385 WO1987007609A1 (en) | 1986-06-16 | 1987-06-12 | 1,1,2-triaryl-1-butene derivatives |
Country Status (7)
Country | Link |
---|---|
US (1) | US4897503A (ja) |
EP (1) | EP0272330B1 (ja) |
JP (1) | JPH0557277B1 (ja) |
AU (1) | AU611090B2 (ja) |
CA (1) | CA1289570C (ja) |
ES (1) | ES2007052A6 (ja) |
WO (1) | WO1987007609A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4897503A (en) * | 1986-06-16 | 1990-01-30 | Taiho Pharmaceutical | 1,1,2-triaryl-1-alkene derivatives |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681835A (en) * | 1994-04-25 | 1997-10-28 | Glaxo Wellcome Inc. | Non-steroidal ligands for the estrogen receptor |
RU2214236C2 (ru) | 1997-08-15 | 2003-10-20 | Дьюк Юниверсити | Способ профилактики или лечения эстрогензависимых заболеваний и расстройств |
SI2989110T1 (sl) * | 2013-04-24 | 2019-01-31 | Smart Brain s.r.o. | Derivati tamoksifena za zdravljenje neoplastičnih bolezni, predvsem z višjo stopnjo proteina HER2 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE637389A (ja) * | 1962-09-13 | |||
GB1013907A (en) * | 1962-09-13 | 1965-12-22 | Ici Ltd | Alkene derivatives |
US3288806A (en) * | 1964-03-23 | 1966-11-29 | Parke Davis & Co | Alpha-(aminoethoxyphenyl)-alpha-alkylstilbenes |
GB1560274A (en) * | 1977-02-28 | 1980-02-06 | Ici Ltd | Phenylbut 1-ene derivatives having antiostrogenicactivity |
EP0002097B1 (en) * | 1977-08-22 | 1981-08-05 | Imperial Chemical Industries Plc | Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them |
GB2003855B (en) * | 1977-08-22 | 1982-10-27 | Ici Ltd | Triphenylbut-1-ene derivatives |
US4206234A (en) * | 1977-08-22 | 1980-06-03 | Imperial Chemical Industries Limited | Triphenylbut-1-ene derivatives and pharmaceutical compositions and uses thereof |
CA1289570C (en) * | 1986-06-16 | 1991-09-24 | Tetsuji Asao | 1,1,2-triaryl-1-alkene derivatives |
-
1987
- 1987-06-10 CA CA000539337A patent/CA1289570C/en not_active Expired - Fee Related
- 1987-06-12 US US07/159,590 patent/US4897503A/en not_active Expired - Lifetime
- 1987-06-12 JP JP62503618A patent/JPH0557277B1/ja not_active Expired - Lifetime
- 1987-06-12 WO PCT/JP1987/000385 patent/WO1987007609A1/ja active IP Right Grant
- 1987-06-12 EP EP87903918A patent/EP0272330B1/en not_active Expired
- 1987-06-12 ES ES8701742A patent/ES2007052A6/es not_active Expired
- 1987-06-12 AU AU75199/87A patent/AU611090B2/en not_active Ceased
Non-Patent Citations (1)
Title |
---|
See also references of EP0272330A4 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4897503A (en) * | 1986-06-16 | 1990-01-30 | Taiho Pharmaceutical | 1,1,2-triaryl-1-alkene derivatives |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
Also Published As
Publication number | Publication date |
---|---|
ES2007052A6 (es) | 1989-06-01 |
EP0272330A4 (en) | 1988-10-20 |
US4897503A (en) | 1990-01-30 |
JPH0557277B1 (ja) | 1993-08-23 |
AU611090B2 (en) | 1991-06-06 |
CA1289570C (en) | 1991-09-24 |
EP0272330B1 (en) | 1991-05-22 |
EP0272330A1 (en) | 1988-06-29 |
AU7519987A (en) | 1988-01-11 |
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