Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
  • A61B10/02—Instruments for taking cell samples or for biopsy

Definitions

• the present invention relates to a cell collection instrument used for collecting cells as a specimen, for example, when performing cytodiagnosis for uterine cancer. . Background art
• Such cervical cancer screening is performed by collecting cells such as the cervix and cervix using a cell collection device, but early stage cancer such as cervical cancer is performed. It is especially important to make a cytological diagnosis in the cervix for the discovery of the disease.
• cancers as cervical cancer have a depth of 100 to 300.
• basal cells and parabasal cells located in B and gradually appear in middle cells and surface cells located at depths of 30 to 100 ⁇ , ⁇ . Reliable collection of these cells, especially basal cells and parabasal cells, will lead directly to early detection of cancer.
• instruments used for collecting such seed cells include a cotton swab as shown in FIG. 7 and a snorter shown in FIG. Or brushes as shown in Fig. 9, but each had the drawbacks listed below.
• Abrasions are likely to occur at the sampling site and blood is often bleeding.
• the tip is sharp, it is very dangerous to accidentally pierce the uterus or vagina, etc., which is extremely dangerous.
• the main purpose of the present invention is to narrow the insertion site, such as the cervix, or to detect uterine aging or menopause after menopause. Even if the insertion site is hardened and becomes difficult to spread due to the onset of the disease, painful re-scaling may occur at the site.
• An object of the present invention is to provide a cell collection device that can be safely and securely inserted without difficulty.
• Another object of the present invention is to provide a cell collection device that can reliably collect cells at a depth effective for the detection of early stage cancer by a simple operation. .
• Another object of the present invention is to obtain a cell collection device that has good adherence of the collected cells and has excellent smearability on slide glass. .
• the cell-collecting device of the present invention uses a small rod-shaped handle at the tip of a handle to remove cells.
• the scraping portion as a whole is formed in a tapered cone shape, and a hand is provided on a side surface of the cone-shaped scraping portion. It is characterized in that a saw-tooth-shaped projection rising toward the base end side of the drill is formed in a spiral shape, and the edge is formed on one side of the projection. It is something.
• the scraping portion is formed in a helical shape, and a spiral edge is formed on the side surface of the rubbing portion. Even if the insertion site is narrow, such as the cervix, or if the site is hardened due to cancer, etc. By simply pressing the tip of the insertion part into the entrance of the insertion site and rotating it, it can be inserted smoothly in a screw-in manner. There is little worry about occasional pain or damage to the insertion site.
• the edge can easily remove cells around the entire inner wall of the insertion site.
• FIG. 1 is a plan view of the whole showing one embodiment of the present invention
• FIG. 2 is an enlarged view of a conical scraping portion
• FIG. 3 is a cross-sectional view taken along line AA in FIG. 4 and 5 are enlarged views of the spatula and its side view
• FIG. 6 is a side view of the main part showing the method of smearing the collected cells
• FIGS. 9 The figure shows The best mode for carrying out the invention, which is a plan view of a conventional cell collection device.
• the sampling device 1 shown in its entirety in FIG. 1 has a configuration in which a cone-shaped scraping portion 3 and a spatular scraping portion 4 are provided at both ends of a nozzle 2 having a small-diameter rod shape. These are formed integrally from a relatively flexible and elastically deformable synthetic resin.
• the handle 2 is easy to hold because the cross section is circular or polygonal and the surface is roughened by fine irregularities.
• the structure is easy to operate, but still retains a degree of flexibility that does not cause unnecessary deformation during operation.
• the above-mentioned conical scraping part 3 is for separating cells in the cervix and collecting them, and is a thin part for facilitating elastic deformation at the tip of the above-mentioned handle 2. It is formed via the diameter portion 2a, and has a structure as specifically shown in FIGS. 2 and 3. That is, the conical abrasion portion 3 is formed to be thick enough to be inserted into the cervix without pain, and it is possible to cope with individual differences in the insertion site.
• the conical or pyramid-shaped taper is formed in a conical shape, such as a cone or a pyramid, and on the side surface of the conical scraping portion 3, a spiral is formed around the scraping portion. Edge 5 is formed.
• This edge 5 ' A saw-tooth-shaped projection S rising up toward the base end side of the handle 2 on the side surface of the scraping portion 3 in a spiral shape, and formed on the ridge portion of the projection S. It is what you do.
• a plurality of grooves 7 extending in the X-axis direction of the rubbing part are formed at regular intervals around the rubbing part 3 on the side surface of the conical rubbing part 3,
• An edge 8 is formed at the groove edge of the groove ⁇ so as to face in the circumferential direction of the rubbing part.
• the tip 3a of the conical abrasion 3 is formed in a spherical shape so that it can be safely inserted into the cervix.
• the degree of softness of the small-diameter portion 2a does not unnecessarily deform when the conical abrasion portion 3 is inserted into the cervix.
• FIG. 6 when the rubbing part 3 is pressed onto the slide glass when the rubbing is applied to the slide glass and the slide glass, as shown in FIG. Gulf is preferable to be able to bend
• the spatula 4 formed at the proximal end of the node 2 is for collecting cells in the posterior fornix or uterine vagina, and has a certain width.
• a flexible plate-shaped member having an arc-shaped tip at the top and bottom of the plate-shaped member 4a.
• a large number of saw-toothed ribs 10 long in the width direction are formed at regular intervals, and the ribs 10 are formed by these ribs 10.
• the edge 11 is formed so as to face the tip side of the dollar 2.
• the plate-shaped body 4a is located at a position between the edge and the edge forming part 4b.
• a plurality of cuts 12 are provided to increase the height of the edge, and the edge forming portion 4b of the plate-like body 4a is formed to be thinner than the edge non-forming portion 4c. It has been.
• the height of the edges 5, 8, and 11 in the conical scraping part 3 and the spatula-like scraping part 4 may damage the stroma even from the superficial cells to the basal cells. It is preferable to set the range from 30 to 500a, so that the sample can be collected without any trouble. The range is 50 to 350m in the middle. Is most preferred.
• a synthetic resin material forming the above-mentioned collection instrument 1 a synthetic resin which has good cell adhesion and is superior in transferability to slide glass is preferable, for example.
• polyolefins such as polystyrene, polyvinylene, * ⁇ acid vinyl copolymer, polyethylenevinyl alcohol copolymer, etc.
• Polystyrene, Polystyrene, Polystyrene such as ABS, Polyimide, Polyvinyl Alcohol copolymer resin, etc. is there .
• these surfaces are formed as a rough surface having minute concaves and convexes as a whole. You can do that too.
• the conical abrasion part 3 When the cells in the cervix cervix are collected by the conical abrasion part 3 in the above-described cell collection instrument 1, the conical abrasion part 3 is pressed against the resection of the cervix and the collection instrument is pressed. Screw it into the cervix by rotating 1. Therefore, in cases where the cervix was narrow, cancer or other parts of the cervix were hardened and became difficult to spread. Even so, the conical abrasion portion 3 is gradually pushed down to the portion, and can be smoothly inserted with a widespread force S. There is no risk of damaging the site.
• the spiral edge 5 removes the cells on the inner wall of the cervix cervix. Are collected and collected. At this time, if the handle 2 is slightly rotated, and the cells are removed by the edge 8 at the groove edge, the entire circumference of the inner wall of the cervix and cervix can be spread. The cells can be reliably collected.
• the tip of the sampler 1 is deformed as shown in FIG. Press the side surface of the conical rubbing part 3 against the slide glass 15 with a slight force, and turn the conical rubbing part 3 forward while turning the handle 2. Let it slide. As a result, the cells adhered to the edges 5 and 8 are detached, and are reliably smeared on the slide glass 5.
• the spatula 4 When the cells of the posterior fornix of the vagina or the vagina are to be collected by the spatula 4, use the spatula 4.
• the edge-forming portion 4b is pressed against the collection site, and the cells are removed by the edge 11 thereof.
• the cells collected at the spatula scraping part 4 are pressed against the slide glass 15 to slide the cells forward. S can be applied to slide glass.

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• Health & Medical Sciences (AREA)
• Life Sciences & Earth Sciences (AREA)
• Surgery (AREA)
• Animal Behavior & Ethology (AREA)
• Biomedical Technology (AREA)
• Heart & Thoracic Surgery (AREA)
• Medical Informatics (AREA)
• Molecular Biology (AREA)
• Pathology (AREA)
• Engineering & Computer Science (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Sampling And Sample Adjustment (AREA)
• Investigating Or Analysing Biological Materials (AREA)
• Apparatus Associated With Microorganisms And Enzymes (AREA)

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• 1987
  • 1987-04-15 WO PCT/JP1987/000238 patent/WO1987006114A1/ja not_active Ceased
  • 1987-04-15 DE DE19873790193 patent/DE3790193T1/de active Pending
  • 1987-04-15 DE DE19873790193 patent/DE3790193C2/de not_active Expired - Fee Related

Patent Citations (1)

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