WO1987004428A3 - Prostaglandines - Google Patents
Prostaglandines Download PDFInfo
- Publication number
- WO1987004428A3 WO1987004428A3 PCT/GB1987/000020 GB8700020W WO8704428A3 WO 1987004428 A3 WO1987004428 A3 WO 1987004428A3 GB 8700020 W GB8700020 W GB 8700020W WO 8704428 A3 WO8704428 A3 WO 8704428A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aliphatic hydrocarbon
- hydrocarbon group
- group
- oxygen
- aromatic
- Prior art date
Links
- 229940094443 oxytocics prostaglandins Drugs 0.000 title 1
- 150000003180 prostaglandins Chemical class 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 10
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 229910052760 oxygen Inorganic materials 0.000 abstract 7
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 5
- 239000001301 oxygen Substances 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical class [H]OC(*)=O 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0091—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is bridged condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/80—Unsaturated compounds containing keto groups containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/30—Unsaturated compounds
- C07C62/36—Unsaturated compounds containing —CHO groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Nouveaux composés ayant la formule (I) dans laquelle (chi) représente un des groupes cycliques divalents, (alpha), (beta), (psi), (delta), (epsilon), (phi), (gamma), (eta), (iota), (xi), et (kappa), les lettres a et b indiquant dans chaque cas les points d'attache des substituants R1 et CV(R2)-NV'R, respectivement; R1 est un groupe -(CH2)(b)-(A)a-(CH2)c-B-CH2-CO2R' dans lequel A et B sont chacun séparément de l'oxygène ou du soufre, a est 0, b est 0 et c est un nombre entier compris entre 3 et 10, ou bien a est égal à 1, b est 0 ou un entier compris entre 1 et 7 et c est un entier compris entre 2 et 9, la somme de b et c étant comprise entre 2 et 9, et CO2R' est un groupe carboxy ou un amide, ester ou dérivé de sel de celui-ci; V et V' sont chacun séparément de l'hydrogène ou sont ensemble la seconde liaison d'une double liaison carbone-azote; R2 est hydrogène, un groupe hydrocarbure aliphatique ou un groupe hydrocarbure aliphatique substitué par un groupe aromatique directement ou par l'intermédiaire d'un atome d'oxygène ou de soufre; et R est un groupe -OR3, -OR4, -D-R3, -N=R5 ou -NW.G.W', dans lequel D est -NH-, -NH.CS-, -NH.CO-, -NH.CO.CH2N(R6)-, -NH.SO2-, -NH.CO.NH-, -NH.CS.NH-, -NH.CO.O- ou bien -NH.CS.O-, G est -CO- ou -CS- et W et W' ensemble sont un groupe -(CH2)d- dans lequel d vaut 3, 4 ou 5, R3 est un groupe hydrocarbure aliphatique, un groupe aromatique ou un groupe hydrocarbure aliphatique substitué par un ou plusieurs groupes aromatiques directement ou par l'intermédiaire d'un atome d'oxygène ou de soufre, R4 est un groupe hydrocarbure aliphatique qui est substitué par l'intermédiaire d'un atome d'oxygène par un groupe hydrocarbure aliphatique lequel est lui-même substitué directement par un ou plusieurs groupes aromatiques, R5 est un groupe hydrocarbure aliphatique, un groupe aromatique dans lequel le système de pi-électrons n'est pas complètement délocalisé sur la totalité du système cyclique, ou bien un groupe hydrocarbure aliphatique substitué par un ou plusieurs groupes aromatiques directement ou par l'intermédiaire d'un atome d'oxygène ou de soufre, et R6 est hydrogène, un groupe hydrocarbure aliphatique, un groupe aromatique ou un groupe hydrocarbure aliphatique substitué par un ou plusieurs groupes aromatiques directement ou par l'intermédiaire d'un atome d'oxygène ou de soufre. Les composés ci-décrits sont utiles dans des compositions pharmaceutiques, notamment dans le contexte de l'inhibition de l'activité de la thromboxane.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868600997A GB8600997D0 (en) | 1986-01-16 | 1986-01-16 | Prostaglandin synthesis |
| GB868601018A GB8601018D0 (en) | 1986-01-16 | 1986-01-16 | Prostaglandins |
| GB8601018 | 1986-01-16 | ||
| GB8600997 | 1986-01-16 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1987004428A2 WO1987004428A2 (fr) | 1987-07-30 |
| WO1987004428A3 true WO1987004428A3 (fr) | 1987-10-22 |
Family
ID=26290227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB1987/000020 WO1987004428A2 (fr) | 1986-01-16 | 1987-01-15 | Prostaglandines |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0231078B1 (fr) |
| AU (1) | AU598789B2 (fr) |
| CA (2) | CA1274512A (fr) |
| DE (1) | DE3762415D1 (fr) |
| GB (1) | GB2187451B (fr) |
| NZ (1) | NZ218881A (fr) |
| WO (1) | WO1987004428A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3280020D1 (en) * | 1981-12-23 | 1989-12-21 | Nat Res Dev | Prostaglandins |
| DE4010355A1 (de) * | 1990-03-28 | 1991-10-02 | Schering Ag | Bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung |
| US6664281B1 (en) * | 1998-08-27 | 2003-12-16 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0082646A1 (fr) * | 1981-12-23 | 1983-06-29 | National Research Development Corporation | Prostaglandines |
| WO1986004234A2 (fr) * | 1985-01-16 | 1986-07-31 | National Research Development Corporation | Antagonistes de la thromboxane dans le traitement des neoplasias dependant des hormones |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8500364D0 (en) * | 1985-01-08 | 1985-02-13 | Haberman M N | Self-sealing catheter |
| GB8600997D0 (en) * | 1986-01-16 | 1986-02-19 | Jones R L | Prostaglandin synthesis |
-
1987
- 1987-01-09 NZ NZ21888187A patent/NZ218881A/xx unknown
- 1987-01-15 EP EP19870300331 patent/EP0231078B1/fr not_active Expired
- 1987-01-15 AU AU68426/87A patent/AU598789B2/en not_active Ceased
- 1987-01-15 CA CA000527382A patent/CA1274512A/fr not_active Expired
- 1987-01-15 GB GB8700836A patent/GB2187451B/en not_active Expired - Fee Related
- 1987-01-15 WO PCT/GB1987/000020 patent/WO1987004428A2/fr unknown
- 1987-01-15 DE DE8787300331T patent/DE3762415D1/de not_active Expired - Lifetime
-
1989
- 1989-06-05 CA CA000601842A patent/CA1278311C/fr not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0082646A1 (fr) * | 1981-12-23 | 1983-06-29 | National Research Development Corporation | Prostaglandines |
| WO1986004234A2 (fr) * | 1985-01-16 | 1986-07-31 | National Research Development Corporation | Antagonistes de la thromboxane dans le traitement des neoplasias dependant des hormones |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ218881A (en) | 1989-05-29 |
| GB2187451A (en) | 1987-09-09 |
| GB8700836D0 (en) | 1987-02-18 |
| DE3762415D1 (de) | 1990-05-31 |
| AU598789B2 (en) | 1990-07-05 |
| AU6842687A (en) | 1987-08-14 |
| WO1987004428A2 (fr) | 1987-07-30 |
| CA1278311C (fr) | 1990-12-27 |
| GB2187451B (en) | 1990-02-14 |
| EP0231078A3 (en) | 1988-09-07 |
| CA1274512A (fr) | 1990-09-25 |
| EP0231078B1 (fr) | 1990-04-25 |
| EP0231078A2 (fr) | 1987-08-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP9900881A2 (hu) | 4,5-Difenil-oxazol-származékok és az ezeket tartalmazó gyógyszerkészítmények | |
| NO950849L (no) | Derivater av valproin og 2-valproensyreamider og anvendelse som antikonvulsanter | |
| MX9601072A (es) | Compuestos ciclicos, proceso para su produccion y su uso. | |
| DE69111029D1 (de) | Kondensierte heterocyclische Verbindungen, ihre Herstellung und Verwendung. | |
| HUP0002476A2 (hu) | Aminvegyületek, előállításuk és alkalmazásuk | |
| MY107890A (en) | New ureido derivatives of poly-4-amino-2-carboxy-1- methyl compounds. | |
| SG64296A1 (en) | Anticonvulsant fructopyranose cyclic sulfites and sulfates | |
| ES8605511A1 (es) | Un procedimiento para la preparacion de derivados de tiazol,2, 4, disustituidos. | |
| ATE53585T1 (de) | Penemverbindungen, ihre herstellung und verwendung. | |
| ES8801242A1 (es) | Un procedimiento para la preparacion de metanosulfonatos de dioxolano. | |
| HUP0000894A2 (hu) | Szubsztituált (1,3-bisz(ciklohexilmetil)-1,2,3,6-tetrahidro-2,6-dioxo-9H-purin-8-il)fenil-származékok és eljárás előállításukra | |
| EP0190356A4 (fr) | Nouveaux composes d'amidine. | |
| WO1987004428A3 (fr) | Prostaglandines | |
| HUP0104942A2 (hu) | Policiklusos tiazolidin-2-ilidén-aminok, eljárás a vegyületek előállítására és gyógyszerként történő alkalmazásuk | |
| ES8300768A1 (es) | "procedimiento para la preparacion de nuevas pirimido (5,4-d) pirimidinas trisustituidas". | |
| IE781144L (en) | Amido penicillanic acids | |
| ES8606880A1 (es) | Un procedimiento para la preparacion de nuevos peptidos. | |
| WO1986004234A3 (fr) | Antagonistes de la thromboxane dans le traitement des neoplasias dependant des hormones | |
| HUP0100453A1 (hu) | Eljárás izokarbamidok előállítására | |
| MXPA99009882A (es) | Derivados de amidina como inhibidores de la oxidonitrico sintasa. | |
| IE56020B1 (en) | Dioxocyclobutene compounds | |
| ATE37393T1 (de) | Mikroorganismusstamm chromobacterium violaceum, aus diesem hergestellte pharmazeutisch aktive verbindungen, ein verfahren zu deren herstellung und deren verwendung als medikamente. | |
| DE3689762D1 (de) | Antibakterielle Verbindungen, ihre Herstellung und Verwendung. | |
| IE821943L (en) | Decarboxylase-inhibiting fluorinated alkane diamine¹derivatives | |
| MY107827A (en) | Isoquinolline compounds, compositions and use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AK | Designated states |
Kind code of ref document: A2 Designated state(s): AU JP |
|
| AK | Designated states |
Kind code of ref document: A3 Designated state(s): AU JP |