WO1987003858A1 - Marking of gelatine capsules - Google Patents
Marking of gelatine capsules Download PDFInfo
- Publication number
- WO1987003858A1 WO1987003858A1 PCT/AU1986/000390 AU8600390W WO8703858A1 WO 1987003858 A1 WO1987003858 A1 WO 1987003858A1 AU 8600390 W AU8600390 W AU 8600390W WO 8703858 A1 WO8703858 A1 WO 8703858A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- marking
- gelatine capsule
- light
- capsule
- gelatine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/007—Marking tablets or the like
Definitions
- This invention relates to the encoding of data on gelatine capsules used for human and animal ingestion.
- gelatine as a concentrated protein product is well known as indeed is its use to form a thin capsule shell having a conventional wall thickness within the range of 0.1 to 0.2 millimetres.
- this material should have a high molecular weight and generally a bloom count of approximately 250 is indicated for a suitable material for this purpose.
- treatment of the material must conform to acceptable pharmaceutical standards but furthermore, the material must not be degraded or reduced in effectiveness by any marking procedure for instance by making a part of the shell so thin as to cause a fracturing of the shell and the integrity therefore of the shell as a container.
- the discovery of this invention is that the use of a very high energy light pulse for a very short duration will cause a pyrolysing of the surface of some of the gelatine material which does not appear to substantially degrade the surface thickness, does not provide mal-odour, any taste intrusion and which furthermore creates in the samples treated in this way thusfar a white clearly visible marked finish.
- Such a high energy light pulse is most effectively achieved by using an appropriate laser source which conveniently provides coherent light but more importantly provides a pulse of such leading edge characteristic and duration together with power concentration such that this effect is achieved.
- the invention can be said in one form then to reside in a method of marking a gelatine capsule which comprises subjecting the surface of the capsule to a high intensity short duration of light.
- the external surface of the gelatine capsule which is marked and the surface is subjected to light with sufficient intensity to ensure the formation of a white residue, and for a duration less than that which may cause undue penetration through the thickness of the capsule wall.
- the invention can also reside in a capsule comprises of gelatine which has been marked by being subjected to a high intensity short duration of light.
- such a capsule has the surface marking visible by a white specular finish.
- the gelatine is chosen so that it is appropriate as an edable gelatine and it is further chosen so as to have a bloom count of approximately 250.
- the method of marking the gelatine capsules includes locating a capsule within a target area triggering a pulse of light through a mask the light being in the form of high intensity light and being effected for a very short duration, and then ejecting the capsule from the target position.
- a carbon-dioxide laser which uses a mixture of helium, carbon-dioxide, carbon-monoxide and nitrogen is used to provide a light pulse which has an approximate energy concentration within the range of 1 to 3 multiplied by 10 10 joules per square centimetre with a leading edge rise time in the approximate range of 1 to 10 nanoseconds and with a pulse duration of 10 microseconds.
- This pulse for this period is focused through a mask containing appropriate indicia with the light then being focused onto a surface of a gelatine capsule having a bloom count of 250.
- the effect is to cause with temperatures raised to the approximate level of 15,000° Celcius a pyrolising of the surface of the gelatine capsule having a 0.2 millimetres shell thickness.
- Such a surface has a white slightly crystaline and therefore perhaps specular type surface finish which is easily visible for those subsequently needing to refer to the marking information.
- the white pyrolised surface material on such examination as can be conducted has shown itself to be stable and substantially long lasting and substantially adhering to the remaining surface of the gelatine.
- a rare gas halide laser source which will provide a light source in the ultraviolent range which provides a duration in the range of 10 to 20 nanoseconds with a rise time in the range of 1 to 10 nanoseconds and with an intensity of the range of 1 to 3 by 10 10 joules per square centimetre.
- a repetitive cycle rate of as much as 500 hertz can be appropriate and on such investigation as has been thus far conducted, this would provide also an effective marking method.
- a solid state so called VAG laser can be used providing for a 50 cycle per second repetition rate but once again from experiments thus far conducted, this will also provide an appropriate surface marking in accord with the previous descriptions.
- the marking in fact is easily visible, is white so that it does look satisfactory for consumer purposes and as previously stated would appear to comply with any foodstuff regulations.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermal Transfer Or Thermal Recording In General (AREA)
- Medicinal Preparation (AREA)
Abstract
A method of marking a gelatine capsule which comprises subjecting the surface of the capsule to a high intensity short duration of light.
Description
"MARKING OF GELATINE CAPSULES"
This invention relates to the encoding of data on gelatine capsules used for human and animal ingestion.
The use of gelatine as a concentrated protein product is well known as indeed is its use to form a thin capsule shell having a conventional wall thickness within the range of 0.1 to 0.2 millimetres.
For gelatine useful for this purpose it is preferable that this material should have a high molecular weight and generally a bloom count of approximately 250 is indicated for a suitable material for this purpose.
As the gelatine is actually consumed by the user for this purpose, treatment of the material must conform to acceptable pharmaceutical standards but furthermore, the material must not be degraded or reduced in effectiveness by any marking procedure for instance by making a part of the shell so thin as to cause a fracturing of the shell and the integrity therefore of the shell as a container.
The discovery of this invention is that the use of a very high energy light pulse for a very short duration will cause a pyrolysing of the surface of some of the gelatine material which does not appear to substantially degrade the surface thickness, does not provide mal-odour, any taste intrusion and which furthermore creates in the samples treated in this way thusfar a white clearly visible marked finish.
Such a high energy light pulse is most effectively achieved by using an appropriate laser source which conveniently provides coherent light but more importantly provides a pulse of such leading edge characteristic and duration together with power concentration such that this effect is achieved.
It is to be noted that in the ordinary heating or even burning of gelatine this will not apparently cause a clearly defined white surface and it is therefore the discovery that by using extremely high temperature effects but for a very limited time, causes the material to
form a different character which in the preferred instance creates a relatively hardened white specular surface.
The invention can be said in one form then to reside in a method of marking a gelatine capsule which comprises subjecting the surface of the capsule to a high intensity short duration of light.
The term "light" presumes that this can include ultra-violet and infrared sources and it therefore in its broadest sense not intended to be limited simply to optically visible light.
In preference, it is the external surface of the gelatine capsule which is marked and the surface is subjected to light with sufficient intensity to ensure the formation of a white residue, and for a duration less than that which may cause undue penetration through the thickness of the capsule wall.
The invention can also reside in a capsule comprises of gelatine which has been marked by being subjected to a high intensity short duration of light.
In preference such a capsule has the surface marking visible by a white specular finish. In preference, the gelatine is chosen so that it is appropriate as an edable gelatine and it is further chosen so as to have a bloom count of approximately 250.
in preference, the method of marking the gelatine capsules includes locating a capsule within a target area triggering a pulse of light through a mask the light being in the form of high intensity light and being effected for a very short duration, and then ejecting the capsule from the target position.
In the preferred embodiment, a carbon-dioxide laser which uses a mixture of helium, carbon-dioxide, carbon-monoxide and nitrogen is used to provide a light pulse which has an approximate energy concentration within the range of 1 to 3 multiplied by 1010 joules per square centimetre with a leading edge rise time in the approximate range of 1 to 10 nanoseconds and with a pulse duration of 10 microseconds.
This pulse for this period is focused through a mask containing appropriate indicia with the light then being focused onto a surface of a gelatine capsule having a bloom count of 250.
The effect is to cause with temperatures raised to the approximate level of 15,000° Celcius a pyrolising of the surface of the gelatine capsule having a 0.2 millimetres shell thickness.
With the rapid rise time, a plasma is created providing free electrons and free ions such as to provide apparently substantial energy separation to limit further melting and burning of the gelatine surface but providing for such surface as is immediately contacted, that this is converted into a white brittle expanded material which then protrudes slightly from the surface of the gelatine.
Such a surface has a white slightly crystaline and therefore perhaps specular type surface finish which is easily visible for those subsequently needing to refer to the marking information.
The white pyrolised surface material on such examination as can be conducted has shown itself to be stable and substantially long lasting and substantially adhering to the remaining surface of the gelatine.
It does not appear to provide any mal-odour and does not appear to be noxious and therefore the gelatine remains an edible component and suitable for pharmacological and suitable physiological purposes.
As an alternate marking system, further development is being conducted using a rare gas halide laser source which will provide a light source in the ultraviolent range which provides a duration in the range of 10 to 20 nanoseconds with a rise time in the range of 1 to 10 nanoseconds and with an intensity of the range of 1 to 3 by 1010 joules per square centimetre.
A repetitive cycle rate of as much as 500 hertz can be appropriate and on such investigation as has been thus far conducted, this would provide also an effective marking method.
In a further example, a solid state so called VAG laser can be used providing for a 50 cycle per second repetition rate but once again from experiments thus far conducted, this will also provide an appropriate surface marking in accord with the previous descriptions.
The advantage of being able to provide an edible gelatine which is able to be efficiently marked with an easily changeable marking provides for an extremely advantageous result especially where the edible container may be required to contain drugs having a limited shelf life so that a batch number or a date maybe efficiently marked thereon.
The marking in fact is easily visible, is white so that it does look satisfactory for consumer purposes and as previously stated would appear to comply with any foodstuff regulations.
Claims
1. A method of marking a gelatine capsule which comprises subjecting the surface of the capsule to a high intensity short duration of light.
2. A method of marking a gelatine capsule as in claim 1 wherein the high intensity is within the range of 1 to 3 multiplied by 1010 joules per square centimetre.
3. A method of marking a gelatine capsule as in either of claims 1 or 2 wherein the short duration is within the range of 1 nanosecond to 15 microseconds.
4. A method of marking a gelatine capsule as in any one of the preceding claims wherein the high intensity is to such an extent to cause a white surface marking to be effected.
5. A method of marking a gelatine capsule as in any one of the preceding claims wherein the short duration is of such a time as to be less than that required for the light to penetrate through the wall thickness of the gelatine capsule.
6. A method of marking a gelatine capsule as in any one of the preceding claims wherein the light is coherent light.
7. A method of marking a gelatine capsule as in any one of the preceding claims wherein the light is within the wavelength of either ultraviolet orvisible light.
8. A method of marking a gelatine capsule as in any one of the preceding claims wherein the light is first passed through a mask whereby to provide for marking indicia and thereafter being focused onto the surface of the gelatine capsule.
9. A method of marking a gelatine capsule as in any one of the preceding claims wherein the light is within the visible light range and has a rise time commencing such duration in the range of 1 to 10 nanoseconds and has a total duration between 10 to 20 nanoseconds.
10. A method of marking a gelatine capsule in which the pulse time is within the range of 20 nanoseconds to 10 microseconds.
11. A gelatine capsule having a marking thereon which has been created by subjecting the surface of the capsule to a high intensity short duration of light.
12. A gelatine capsule having a marking thereon wherein the method of marking is as characterised in any one of the preceding claims.
13. A method of marking a gelatine capsule substantially as described in the specification.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPH3945 | 1985-12-19 | ||
AU394585 | 1985-12-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1987003858A1 true WO1987003858A1 (en) | 1987-07-02 |
Family
ID=3694420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/AU1986/000390 WO1987003858A1 (en) | 1985-12-19 | 1986-12-19 | Marking of gelatine capsules |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0263831A1 (en) |
WO (1) | WO1987003858A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013023817A1 (en) * | 2011-08-15 | 2013-02-21 | Robert Bosch Gmbh | Method for marking capsules filled with pharmaceutical products by way of a laser beam arrangement, and use thereof |
-
1986
- 1986-12-19 WO PCT/AU1986/000390 patent/WO1987003858A1/en unknown
- 1986-12-19 EP EP19870900026 patent/EP0263831A1/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
Research Disclosure, September 1984, Number 245, Kenneth Mason Publications Ltd. (Hampshire, England), see page 407, disclosure 24503 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013023817A1 (en) * | 2011-08-15 | 2013-02-21 | Robert Bosch Gmbh | Method for marking capsules filled with pharmaceutical products by way of a laser beam arrangement, and use thereof |
Also Published As
Publication number | Publication date |
---|---|
EP0263831A1 (en) | 1988-04-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1055371A3 (en) | Method for treatment of containerised food | |
ATE40626T1 (en) | DEVICE FOR GENERATING SHORT-DURATION, INTENSIVE PULSE OF ELECTROMAGNETIC RADIATION IN THE WAVELENGTH RANGE BELOW ABOUT 100 NM. | |
GB2387842A (en) | Method and apparatus for ultrasonic treatment of fluids | |
EP0627240A3 (en) | Atrial defibrillator and method for providing T wave detection and interval timing prior to cardioversion. | |
NO307366B1 (en) | Process for the preparation of tablets containing paroxetine and tablet formulation prepared by the method | |
DK59991A (en) | NON-PEPTID PURE INHIBITORS AND PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SUCH AN INHIBITOR | |
NO954815L (en) | Method for sterilizing biological mixtures and products prepared therewith | |
SE9803627D0 (en) | Procedure and device for reducing the degradation of heat-sensitive constituents in medicinal substances during heat sterilization | |
AU524867B2 (en) | Method for improvement of aroma and/or effervescence of sparkling wine, champagne or pearl wine and so improved products | |
Acquaviva et al. | High-resolution investigations of C2 and CN optical emissions in laser-induced plasmas during graphite ablation | |
WO1987003858A1 (en) | Marking of gelatine capsules | |
ZA881061B (en) | Devices and apparatus for injecting gas into high temperature liquids,e.g.metal melts | |
AU5271386A (en) | Method of thermally processing seafood and package having the seafood therein | |
US20030044311A1 (en) | Applications for use of pulsed light | |
IL74322A (en) | Pulsed light selective photolysis process for treatment of biological media and products made thereby | |
PL305862A1 (en) | Derivatives of 1-(2-fluorocyclopropylo)-quinolinocarboxylic and-naphtyridonacarboxylic acids, method of obtaining such derivatives and drugs containing them | |
RU1519011C (en) | Chip breaking method | |
SU1308131A1 (en) | Method of obtaining laser active medium | |
SU548996A1 (en) | Virus destruction method | |
GB1202861A (en) | Investigation of the internal structure of an animal body | |
JPS544846A (en) | Solder supply method | |
Neev et al. | Two‐lasers assisted ablation: A method for enhancing conventional laser ablation of materials | |
JPS51121340A (en) | Recording method | |
Nishchenko et al. | Annealing of Defects in Laser Exposed Steel Kh 18 N 10 T-VD | |
JPS568641A (en) | Treatment of yam |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU BB BG BR DK FI HU JP KP KR LK MC MG MW NO RO SD SU US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LU NL SE |