WO1987003858A1 - Marquage de capsules de gelatine - Google Patents

Marquage de capsules de gelatine Download PDF

Info

Publication number
WO1987003858A1
WO1987003858A1 PCT/AU1986/000390 AU8600390W WO8703858A1 WO 1987003858 A1 WO1987003858 A1 WO 1987003858A1 AU 8600390 W AU8600390 W AU 8600390W WO 8703858 A1 WO8703858 A1 WO 8703858A1
Authority
WO
WIPO (PCT)
Prior art keywords
marking
gelatine capsule
light
capsule
gelatine
Prior art date
Application number
PCT/AU1986/000390
Other languages
English (en)
Inventor
Peter John Proudman
Original Assignee
F.H. Faulding & Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.H. Faulding & Co. Ltd. filed Critical F.H. Faulding & Co. Ltd.
Publication of WO1987003858A1 publication Critical patent/WO1987003858A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/007—Marking tablets or the like

Definitions

  • This invention relates to the encoding of data on gelatine capsules used for human and animal ingestion.
  • gelatine as a concentrated protein product is well known as indeed is its use to form a thin capsule shell having a conventional wall thickness within the range of 0.1 to 0.2 millimetres.
  • this material should have a high molecular weight and generally a bloom count of approximately 250 is indicated for a suitable material for this purpose.
  • treatment of the material must conform to acceptable pharmaceutical standards but furthermore, the material must not be degraded or reduced in effectiveness by any marking procedure for instance by making a part of the shell so thin as to cause a fracturing of the shell and the integrity therefore of the shell as a container.
  • the discovery of this invention is that the use of a very high energy light pulse for a very short duration will cause a pyrolysing of the surface of some of the gelatine material which does not appear to substantially degrade the surface thickness, does not provide mal-odour, any taste intrusion and which furthermore creates in the samples treated in this way thusfar a white clearly visible marked finish.
  • Such a high energy light pulse is most effectively achieved by using an appropriate laser source which conveniently provides coherent light but more importantly provides a pulse of such leading edge characteristic and duration together with power concentration such that this effect is achieved.
  • the invention can be said in one form then to reside in a method of marking a gelatine capsule which comprises subjecting the surface of the capsule to a high intensity short duration of light.
  • the external surface of the gelatine capsule which is marked and the surface is subjected to light with sufficient intensity to ensure the formation of a white residue, and for a duration less than that which may cause undue penetration through the thickness of the capsule wall.
  • the invention can also reside in a capsule comprises of gelatine which has been marked by being subjected to a high intensity short duration of light.
  • such a capsule has the surface marking visible by a white specular finish.
  • the gelatine is chosen so that it is appropriate as an edable gelatine and it is further chosen so as to have a bloom count of approximately 250.
  • the method of marking the gelatine capsules includes locating a capsule within a target area triggering a pulse of light through a mask the light being in the form of high intensity light and being effected for a very short duration, and then ejecting the capsule from the target position.
  • a carbon-dioxide laser which uses a mixture of helium, carbon-dioxide, carbon-monoxide and nitrogen is used to provide a light pulse which has an approximate energy concentration within the range of 1 to 3 multiplied by 10 10 joules per square centimetre with a leading edge rise time in the approximate range of 1 to 10 nanoseconds and with a pulse duration of 10 microseconds.
  • This pulse for this period is focused through a mask containing appropriate indicia with the light then being focused onto a surface of a gelatine capsule having a bloom count of 250.
  • the effect is to cause with temperatures raised to the approximate level of 15,000° Celcius a pyrolising of the surface of the gelatine capsule having a 0.2 millimetres shell thickness.
  • Such a surface has a white slightly crystaline and therefore perhaps specular type surface finish which is easily visible for those subsequently needing to refer to the marking information.
  • the white pyrolised surface material on such examination as can be conducted has shown itself to be stable and substantially long lasting and substantially adhering to the remaining surface of the gelatine.
  • a rare gas halide laser source which will provide a light source in the ultraviolent range which provides a duration in the range of 10 to 20 nanoseconds with a rise time in the range of 1 to 10 nanoseconds and with an intensity of the range of 1 to 3 by 10 10 joules per square centimetre.
  • a repetitive cycle rate of as much as 500 hertz can be appropriate and on such investigation as has been thus far conducted, this would provide also an effective marking method.
  • a solid state so called VAG laser can be used providing for a 50 cycle per second repetition rate but once again from experiments thus far conducted, this will also provide an appropriate surface marking in accord with the previous descriptions.
  • the marking in fact is easily visible, is white so that it does look satisfactory for consumer purposes and as previously stated would appear to comply with any foodstuff regulations.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un procédé de marquage d'une capsule de gélatine consiste à soumettre la surface de la capsule à de la lumière très forte durant une courte période.
PCT/AU1986/000390 1985-12-19 1986-12-19 Marquage de capsules de gelatine WO1987003858A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPH3945 1985-12-19
AU394585 1985-12-19

Publications (1)

Publication Number Publication Date
WO1987003858A1 true WO1987003858A1 (fr) 1987-07-02

Family

ID=3694420

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU1986/000390 WO1987003858A1 (fr) 1985-12-19 1986-12-19 Marquage de capsules de gelatine

Country Status (2)

Country Link
EP (1) EP0263831A1 (fr)
WO (1) WO1987003858A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013023817A1 (fr) * 2011-08-15 2013-02-21 Robert Bosch Gmbh Procédé de marquage de capsules remplies de produits pharmaceutiques au moyen d'un dispositif de rayonnement laser et utilisation dudit procédé

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Research Disclosure, September 1984, Number 245, Kenneth Mason Publications Ltd. (Hampshire, England), see page 407, disclosure 24503 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013023817A1 (fr) * 2011-08-15 2013-02-21 Robert Bosch Gmbh Procédé de marquage de capsules remplies de produits pharmaceutiques au moyen d'un dispositif de rayonnement laser et utilisation dudit procédé

Also Published As

Publication number Publication date
EP0263831A1 (fr) 1988-04-20

Similar Documents

Publication Publication Date Title
PT90660A (pt) Processo para a preparacao de composicoes farmaceuticas compreendendo a associacao de substancias que libertam tnf (factor de necrose tumoral)e de inibidores de tnf
AU656206B2 (en) Process and apparatus for pulsed combustion
ATE40626T1 (de) Einrichtung zum erzeugen von kurzdauernden, intensiven impulsen elektromagnetischer strahlung im wellenlaengenbereich unter etwa 100 nm.
AU4969990A (en) Stabilized sterilizing or disinfecting halogen containing composition, method and apparatus
GB2387842A (en) Method and apparatus for ultrasonic treatment of fluids
NO307366B1 (no) Fremgangsmåte for fremstilling av tabletter inneholdende paroxetin og tablettformulering fremstilt ved fremgangsmåten
NO954815L (no) Fremgangsmåte for sterilisering av biologiske blandinger og produkter fremstilt med denne
AU524867B2 (en) Method for improvement of aroma and/or effervescence of sparkling wine, champagne or pearl wine and so improved products
WO1987003858A1 (fr) Marquage de capsules de gelatine
AU5271386A (en) Method of thermally processing seafood and package having the seafood therein
IL74322A0 (en) Pulsed light selective photolysis process for treatment of biological media and products made thereby
AU4094989A (en) Method and apparatus for electrothermal atomization of samples
DK163495C (da) Fremgangsmaade og apparat til termisk behandling af finkornet gods, isaer til braending af cementraamel
EP0134247A4 (fr) Proteine a effet oncostatique, son procede de preparation et mediament oncostatique la contenant.
JPS5276414A (en) Method of recovering medicament contained in capsules
SU1308131A1 (ru) Способ получени активной среды лазера
Kanazawa et al. Improvement on the Breakage and Chipping of Cutting Tools Using Nitrogen-Ion Implantation
SU548996A1 (ru) Способ разрушени вирусов
JPS544846A (en) Solder supply method
Neev et al. Two‐lasers assisted ablation: A method for enhancing conventional laser ablation of materials
JPS51121340A (en) Recording method
Schnur Application of time-resolved spectroscopies to the study of energetic materials, 1982
JPS5231965A (en) Removing method of bad smell noxious substances and its apparatus
Nishchenko et al. Annealing of Defects in Laser Exposed Steel Kh 18 N 10 T-VD
JPS5233235A (en) Method of manufacturing mirror head

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BB BG BR DK FI HU JP KP KR LK MC MG MW NO RO SD SU US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE FR GB IT LU NL SE