WO1984001710A1 - Cosmetic preparation - Google Patents

Cosmetic preparation Download PDF

Info

Publication number
WO1984001710A1
WO1984001710A1 PCT/US1983/001679 US8301679W WO8401710A1 WO 1984001710 A1 WO1984001710 A1 WO 1984001710A1 US 8301679 W US8301679 W US 8301679W WO 8401710 A1 WO8401710 A1 WO 8401710A1
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
cosmetic
cosmetic preparation
accordance
skin
Prior art date
Application number
PCT/US1983/001679
Other languages
French (fr)
Inventor
Richard W Parkinson
Original Assignee
Redken Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Redken Laboratories Inc filed Critical Redken Laboratories Inc
Priority to JP84500001A priority Critical patent/JPS59501986A/en
Priority to AU23399/84A priority patent/AU2339984A/en
Publication of WO1984001710A1 publication Critical patent/WO1984001710A1/en
Priority to DK324584A priority patent/DK324584D0/en
Priority to FI842697A priority patent/FI842697A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations

Definitions

  • the present invention relates to cosmetic preparations and in particular to cremes, lotions and liquids for moisturizing the skin.
  • emolients and surface active agents have been incorporated in the emulsions, including stearates, such as potassium stearate, glycol stearate, sodium stearate, PEG 40 stearate and glyceryl stearate; laurates, such as sodium laurate and potassium laurate; alcohols, such as cetyl alcohol and lanolin alcohol; triethanolamine; myristates, such as isopropyl myristate, sodium myristate andpotassium myristate; cetyl palmitate; cholesterol; stearic acid; and sorbitan sesquioleate.
  • Stabilizers such as methyl paraben and propyl paraben, are commonly incorporated in the cosmetic preparations.
  • a principal object of the present invention is to provide an improved cosmetic preparation of either the liquid or of the emulsion type wherein the improved preparation is most effective in moisturizing the epidermis, softening the skin, improving the texture and feel of the skin and diminishing superficial and deep wrinkles in the skin.
  • the above objective is achieved in accordance with the present invention by providing a cosmetic preparation of the creme, lotion, or liquid variety which has incor porated therein from about 0.1% up to about 1% gibberellic acid and frcm about 0% up to 5% lysine.
  • the lysine utilized in the preparation is L-lysine which is a natural occurring form of lysine.
  • the dextro isomer can be used as well as analog of lysine, such as hydroxy lysine.
  • the improved preparation may also contain frcm about 0.01% to 5% gliadin, from about 0.005% to 1% ascorbic acid, from about 0.01% to 5% urea and up to 1% calcium.
  • the performance of the liquid water base preparations and the water-oil emulsion type preparation can be substantially and markedly enhanced with respect to moisturizing the epidermis, softening the skin, improving the texture and feel of the skin and in diminishing superficial and deep wrinkles in the skin by incorporating the above mentioned ingredients into the cosmetic preparations.
  • Cosmetic preparations can be prepared in accordance with the present invention from numerous cosmetic base ingredients which are well known in prior art.
  • Such bases may comprise emulsions containing various emolient ingredients.
  • Lanolin or other oils from the group consisting of animal oils, vegetable oils and mineral oils are emulsified with water as is well known in the art.
  • other emolients and surface active agents such as those mentioned hereinbefore can be incorporated in the emulsions as is also well known in the art.
  • Stabilizers and preservatives can be included within the cosmetic preparation as is also well known in the art.
  • the essence of the present invention is not within the composition of the base per se, and any of extremely many base formulations or ccmpcsitions of the water or emulsion type currently used in cosmetic skin preparations can be employed.
  • the essence of the present invention is in the incorporation of specific ingredients within the creme, lotion, or liquid preparation which substantially and markedly enhance the performance of the cosmetic preparation in moisturizing the epidermis, softening the skin, improving the texture and feel of the skin and in diminishing superficial and deep wrinkles in the skin.
  • the cosmetic preparation comprises a creme, lotion or liquid base which has incorporated therein about 0.01% up to about 1% gibberellic acid and from about 0% up to about 5% lysine.
  • the improved cosmetic preparation may also contain, in addition to the gibberellic acid and lysine, up to about 5% gliadin, up to about 1% ascorbic acid and up to 5% urea.
  • Preferable concentrations of the latter ingredients when used in the cosmetic preparation are from about 0.03% to 1% gliadin, from about 0.01% to 0.05% L-ascorbic acid and from about 0.03% to 1% urea.
  • the improved cosmetic preparation may also contain, in addition to the abovementioned ingredients up to about 1% calcium. All percentages given throughout the specification and claims are by weight.
  • a specific formulation of a preferred embodiment of a cosmetic creme in accordance with the invention is as follows:
  • the women were given a container of creme in accordance with the invention and a container of the creme base of the test product of this invention, i.e., the same creme but lacking the lysine, urea, gliadin, ascorbic acid and the gibberellic acid.
  • the only markings on the containers given the women were instructions to apply the creme from the respective containers to one side of their faces with the creme in the other container being applied to the other side of their faces. All subjects were assessed after one month. Almost unanimously, the women reported a substantial improvement in visual appearance of the side of their faces to which the creme of this invention had been applied in comparison to the side to which the commercially available skin cremes and the creme base had been applied.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

A cosmetic preparation which is effective in moisturizing and softening skin, improving texture and feel of skin, and diminishing superficial and deep wrinkles in skin. The preparation comprises gibberellic acid and lysine as active ingredients. The preparation can contain as additional active ingredients gliadin, ascorbic acid and urea.

Description

COSMETIC PREPARATION
FIELD OF THE INVENTION The present invention relates to cosmetic preparations and in particular to cremes, lotions and liquids for moisturizing the skin.
BACKGROUND ART Many cosmetic preparations of the creme, lotion, and liquid type are currently in use. There is considerable variation in the specific formulations making up the oil and water phases of such preparations. Mineral oils, animal oils and vegetable oils have all been used in cosmetic cremes and lotions of the emulsion type. In addition to such oils, other emolients and surface active agents have been incorporated in the emulsions, including stearates, such as potassium stearate, glycol stearate, sodium stearate, PEG 40 stearate and glyceryl stearate; laurates, such as sodium laurate and potassium laurate; alcohols, such as cetyl alcohol and lanolin alcohol; triethanolamine; myristates, such as isopropyl myristate, sodium myristate andpotassium myristate; cetyl palmitate; cholesterol; stearic acid; and sorbitan sesquioleate. Stabilizers, such as methyl paraben and propyl paraben, are commonly incorporated in the cosmetic preparations. DISCLOSURE OF INVENTION
A principal object of the present invention is to provide an improved cosmetic preparation of either the liquid or of the emulsion type wherein the improved preparation is most effective in moisturizing the epidermis, softening the skin, improving the texture and feel of the skin and diminishing superficial and deep wrinkles in the skin.
The above objective is achieved in accordance with the present invention by providing a cosmetic preparation of the creme, lotion, or liquid variety which has incor porated therein from about 0.1% up to about 1% gibberellic acid and frcm about 0% up to 5% lysine. Advantageously, the lysine utilized in the preparation is L-lysine which is a natural occurring form of lysine. However, the dextro isomer can be used as well as analog of lysine, such as hydroxy lysine. The improved preparation may also contain frcm about 0.01% to 5% gliadin, from about 0.005% to 1% ascorbic acid, from about 0.01% to 5% urea and up to 1% calcium. It has been found that the performance of the liquid water base preparations and the water-oil emulsion type preparation, can be substantially and markedly enhanced with respect to moisturizing the epidermis, softening the skin, improving the texture and feel of the skin and in diminishing superficial and deep wrinkles in the skin by incorporating the above mentioned ingredients into the cosmetic preparations.
DESCRIPTION OF PREFERRED EMBODIMENTS Cosmetic preparations, either cremes, lotions or liquids can be prepared in accordance with the present invention from numerous cosmetic base ingredients which are well known in prior art. Such bases may comprise emulsions containing various emolient ingredients. Lanolin or other oils from the group consisting of animal oils, vegetable oils and mineral oils are emulsified with water as is well known in the art. In addition to the oils, other emolients and surface active agents such as those mentioned hereinbefore can be incorporated in the emulsions as is also well known in the art. Stabilizers and preservatives can be included within the cosmetic preparation as is also well known in the art.
The essence of the present invention is not within the composition of the base per se, and any of extremely many base formulations or ccmpcsitions of the water or emulsion type currently used in cosmetic skin preparations can be employed. The essence of the present invention is in the incorporation of specific ingredients within the creme, lotion, or liquid preparation which substantially and markedly enhance the performance of the cosmetic preparation in moisturizing the epidermis, softening the skin, improving the texture and feel of the skin and in diminishing superficial and deep wrinkles in the skin. There has heretofore, to the best of my knowledge, been no suggestions of the use of the combination of specific active ingredients as disclosed herein in a cosmetic preparation.
In accordance with the invention, a cosmetic preparation of exceptional performance is achieved. The cosmetic preparation comprises a creme, lotion or liquid base which has incorporated therein about 0.01% up to about 1% gibberellic acid and from about 0% up to about 5% lysine. The improved cosmetic preparation may also contain, in addition to the gibberellic acid and lysine, up to about 5% gliadin, up to about 1% ascorbic acid and up to 5% urea. Preferable concentrations of the latter ingredients when used in the cosmetic preparation are from about 0.03% to 1% gliadin, from about 0.01% to 0.05% L-ascorbic acid and from about 0.03% to 1% urea. The improved cosmetic preparation may also contain, in addition to the abovementioned ingredients up to about 1% calcium. All percentages given throughout the specification and claims are by weight.
As an aid to practicing the present invention, a specific formulation of a preferred embodiment of a cosmetic creme in accordance with the invention is as follows:
Component Parts By Weight
Water 85.0 Safflower Oil 6.0 Mineral Oil 4.5 Ceraphyl 847 4.0
Sorbitol (70% aqueous solution) 3.0
Stearic Acid 2.5 Lysine 2.0
Acetylated Lanolin Alcohol 1.5
Cetyl Alcohol 1.2
Acetylated Lanolin 1.0
Pur-Cellin Oil 1.0 Brij 700 1.0
Triethanolamine 1.0
Glyceryl Monostearate 0.9
Urea 0.5
Methyl Paraben 0.2 Dawcil-200 0.15
Propyl Paraben 0.05
Gliadin 0.04
Ascorbic Acid 0.01
Gibberellic Acid 0.05 Using the cosmetic creme of the above formula, comparative tests were made in which 50 women between the ages of 24 and 68, all of whom were in good health with no relevent skin diseases, tested the creme of this invention in comparison to four commercially available cosmetic skin cremes. The women were divided into five groups of ten subjects. In four of the groups, each women was given a container of creme in accordance with this invention and a container of a commercially available skin creme. In the fifth group, the women were given a container of creme in accordance with the invention and a container of the creme base of the test product of this invention, i.e., the same creme but lacking the lysine, urea, gliadin, ascorbic acid and the gibberellic acid. The only markings on the containers given the women were instructions to apply the creme from the respective containers to one side of their faces with the creme in the other container being applied to the other side of their faces. All subjects were assessed after one month. Almost unanimously, the women reported a substantial improvement in visual appearance of the side of their faces to which the creme of this invention had been applied in comparison to the side to which the commercially available skin cremes and the creme base had been applied. A majority of the test subjects also reported a substantial improvement in the tactile condition of the side of their faces to which the creme of this invention had been applied in comparison to the side to which the commercially available skin cremes and the creme base had been applied. The subjects, when asked to select which creme they preferred, selected virtually unanimously the product of this invention.
Although preferred embodiments of the invention have been disclosed, it is to be understood that various changes and modifications can be made without departing from the subject matter coming within the scope of the following claims, which subject matter I regard as my invention.

Claims

1. A cosmetic preparation which is highly effective in softening the skin, improving texture and feel of the skin, moisturizing the epidermis and diminishing superficial and deep wrinkles in the skin, said preparation comprising a cosmetic base having further incorporated therein from about 0.01% to 1% gibberellic acid and from 0% up to about 5% lysine, all based on the weight of the finished cosmetic preparation.
2. A cosmetic preparation in accordance with Claim 1, wherein said preparation contains from about 0.1% to about 5% lysine.
3. A cosmetic preparation in accordance with Claim 1, wherein said preparation further contains from about 0.01% to 5% gliadin, from about 0.005% to 1% ascorbic acid and from about 0.01% to 5% urea, all based on the weight of the finished cosmetic preparation.
4. A cosmetic preparation in accordance with Claim 1, wherein the cosmetic base is an emulsion containing water; at least one oil selected from the group consisting of mineral oil, vegetable oil and animal oil; and at least one emolient selected from the group consisting of potassium stearate, sodium stearate, cholesterol cetyl palmitate, sodium laurate, potassium laurate, sodium myristate, potassium myristate, stearic acid, glycerin cetyl alcohol, PEG 40 stearate, sorbitan sesquioleate, lanolin alcohol, pentasodium penetate, glycol stearate, triethanolamine, glyceryl stearate, isopropyl myristate, sorbitol, acetylated lanolin alcohol and acetylated lanolin.
5. A cosmetic preparation in accordance with Claim 4, further including a compound selected from the group consisting of methyl paraben, propyl paraben and mixtures thereof.
6. A cosmetic preparation in accordance with Claim 1, wherein the preparation is a creme.
7. A cosmetic preparation in accordance with Claim 1, wherein the preparation is a liquid.
PCT/US1983/001679 1982-11-04 1983-10-28 Cosmetic preparation WO1984001710A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP84500001A JPS59501986A (en) 1982-11-04 1983-10-28 cosmetic formulations
AU23399/84A AU2339984A (en) 1982-11-04 1983-10-28 Cosmetic preparation
DK324584A DK324584D0 (en) 1982-11-04 1984-07-02 COSMETIC PREPARATION
FI842697A FI842697A (en) 1982-11-04 1984-07-04 COSMETIC PREPARATION.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43911382A 1982-11-04 1982-11-04

Publications (1)

Publication Number Publication Date
WO1984001710A1 true WO1984001710A1 (en) 1984-05-10

Family

ID=23743346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1983/001679 WO1984001710A1 (en) 1982-11-04 1983-10-28 Cosmetic preparation

Country Status (7)

Country Link
EP (1) EP0126138A1 (en)
JP (1) JPS59501986A (en)
DK (1) DK324584D0 (en)
FI (1) FI842697A (en)
NO (1) NO842674L (en)
WO (1) WO1984001710A1 (en)
ZA (1) ZA838207B (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2608425A1 (en) * 1986-12-17 1988-06-24 Rofsa Cerd Cosmetic composition for the selective partial depigmentation of the skin and process for manufacturing it
WO1992021321A1 (en) * 1991-05-27 1992-12-10 Laboratoires Inocosm Method for separating a vegetable compound
EP0588379A2 (en) * 1987-07-02 1994-03-23 Cellegy Pharmaceuticals, Inc. Treatment of wrinkling
US5580857A (en) * 1989-12-12 1996-12-03 Oden; Per Use of gibberellins for the treatment of prostatitis
US6121317A (en) * 1995-01-06 2000-09-19 Australian Biomedical Company Pty. Ltd. Gibberellins (including gibberellins A3 and A7) used in ulcer or wound healing
WO2003094907A1 (en) * 2002-05-06 2003-11-20 Kimberly-Clark Worldwide, Inc. Cell proliferating agents
WO2013091684A1 (en) * 2011-12-20 2013-06-27 Oriflame Research And Development Ltd. Compounds with anti-aging activities
EP2716651A2 (en) * 2011-05-23 2014-04-09 Incospharm Corporation Peptide derivatives having a superior moisturizing effect and uses thereof
US9775908B2 (en) 2007-07-10 2017-10-03 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Pharmaceutical preparations containing highly volatile silicones
EP3158989A3 (en) * 2017-02-01 2017-10-11 SanderStrothmann GmbH Cosmetic skin treatment composition
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB844549A (en) * 1958-02-07 1960-08-17 Ici Ltd Stabilised gibberellic acid compositions and their preparation
GB910004A (en) * 1960-03-10 1962-11-07 Thomas Jenkins Lewis Cosmetic skin preparations containing low gel strength, low viscosity gelatin
GB1228888A (en) * 1968-10-08 1971-04-21
US3970759A (en) * 1972-12-11 1976-07-20 Exxon Research And Engineering Company Aliphatic diols as preservatives for cosmetics and related products
US4154823A (en) * 1976-06-10 1979-05-15 Schutt Steven R Skin treatment compositions and methods of using same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB844549A (en) * 1958-02-07 1960-08-17 Ici Ltd Stabilised gibberellic acid compositions and their preparation
GB910004A (en) * 1960-03-10 1962-11-07 Thomas Jenkins Lewis Cosmetic skin preparations containing low gel strength, low viscosity gelatin
GB1228888A (en) * 1968-10-08 1971-04-21
US3970759A (en) * 1972-12-11 1976-07-20 Exxon Research And Engineering Company Aliphatic diols as preservatives for cosmetics and related products
US4154823A (en) * 1976-06-10 1979-05-15 Schutt Steven R Skin treatment compositions and methods of using same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The Cosmetic Formulary, issued 11 August 1941, H. BENNETT, see pages 2 to 15, 36 and 37. *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2608425A1 (en) * 1986-12-17 1988-06-24 Rofsa Cerd Cosmetic composition for the selective partial depigmentation of the skin and process for manufacturing it
EP0588379A2 (en) * 1987-07-02 1994-03-23 Cellegy Pharmaceuticals, Inc. Treatment of wrinkling
EP0588379A3 (en) * 1987-07-02 1994-06-01 Thornfeldt Carl R Treatment of wrinkling
US5580857A (en) * 1989-12-12 1996-12-03 Oden; Per Use of gibberellins for the treatment of prostatitis
WO1992021321A1 (en) * 1991-05-27 1992-12-10 Laboratoires Inocosm Method for separating a vegetable compound
US5466782A (en) * 1991-05-27 1995-11-14 Laboratoires Inocosm Method for separating a compound containing glycolipids, lysophospholipids, sphingolipids and ceramides of plant origin
US6121317A (en) * 1995-01-06 2000-09-19 Australian Biomedical Company Pty. Ltd. Gibberellins (including gibberellins A3 and A7) used in ulcer or wound healing
WO2003094907A1 (en) * 2002-05-06 2003-11-20 Kimberly-Clark Worldwide, Inc. Cell proliferating agents
US9775908B2 (en) 2007-07-10 2017-10-03 Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag Pharmaceutical preparations containing highly volatile silicones
EP2716651A2 (en) * 2011-05-23 2014-04-09 Incospharm Corporation Peptide derivatives having a superior moisturizing effect and uses thereof
EP2716651A4 (en) * 2011-05-23 2014-10-15 Incospharm Corp Peptide derivatives having a superior moisturizing effect and uses thereof
US9359401B2 (en) 2011-05-23 2016-06-07 Incospharm Corporation Peptide analogues with an excellent moisturizing effect and use thereof
WO2013091684A1 (en) * 2011-12-20 2013-06-27 Oriflame Research And Development Ltd. Compounds with anti-aging activities
EA031552B1 (en) * 2011-12-20 2019-01-31 Орифлейм Ресёрч Энд Девелопмент Лтд. Non-therapeutic cosmetic topical application of n-acetyl-l-aspartic acid
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
EP3158989A3 (en) * 2017-02-01 2017-10-11 SanderStrothmann GmbH Cosmetic skin treatment composition

Also Published As

Publication number Publication date
FI842697A0 (en) 1984-07-04
JPS59501986A (en) 1984-11-29
EP0126138A1 (en) 1984-11-28
DK324584A (en) 1984-07-02
DK324584D0 (en) 1984-07-02
ZA838207B (en) 1984-12-24
NO842674L (en) 1984-07-02
FI842697A (en) 1984-07-04

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