WO1983003550A1 - Filtre sanguin - Google Patents

Filtre sanguin Download PDF

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Publication number
WO1983003550A1
WO1983003550A1 PCT/JP1983/000124 JP8300124W WO8303550A1 WO 1983003550 A1 WO1983003550 A1 WO 1983003550A1 JP 8300124 W JP8300124 W JP 8300124W WO 8303550 A1 WO8303550 A1 WO 8303550A1
Authority
WO
WIPO (PCT)
Prior art keywords
blood
filter
porous
filtration
thickness
Prior art date
Application number
PCT/JP1983/000124
Other languages
English (en)
Japanese (ja)
Inventor
Ltd. Daicel Chemical Industries
Original Assignee
Higashi, Tatsuo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Higashi, Tatsuo filed Critical Higashi, Tatsuo
Publication of WO1983003550A1 publication Critical patent/WO1983003550A1/fr
Priority to SE8306986A priority Critical patent/SE441894B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • B01D39/1669—Cellular material
    • B01D39/1676—Cellular material of synthetic origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403—Regulation parameters
    • A61M1/3406—Physical characteristics of the filtrate, e.g. urea

Definitions

  • Taishiki is related to the filtration of stored blood for transfusion (or thick red blood cells for transfusion), and has a small clogging and microscopic blood coagulation (microa ggggre gat). O blood filters that can effectively remove o
  • the size of aggregates to be removed from the blood is considered as follows: ⁇ Among the formed components in the blood, erythrocytes have a maximum diameter of about 8 ⁇ , and the sizes of leukocytes and platelets are 6 ⁇ 20 each
  • the life span of red blood cells is about 120 days, while that of white blood cells and platelets is 1 to 7 days and 7 to 14 days, respectively.
  • the target ⁇ storing date to the ring blood ⁇ is around 10 days ago, the majority of leukocytes and platelets can be considered to be dead components that have already lost their function. According to 1 0 ⁇ ]]? Large 3 ⁇ 4 particles are not useful 3 ⁇ 4 but are not S, j ?, and should be removed o
  • O Screen filters are used to remove micro-aggregates from the lattice-like weave of monofilament yarns of thin synthetic fibers by simple sieving.
  • the size of the clean pores determines the size of the particles to be filtered. 0 Due to such an effect, the ellipticity (removal rate of the particles) of the filtration is very high.
  • Ruta is made of fibrous packing, non-woven fabric, soft sponge, etc.), and has a very large blood contact area.
  • the large processing capacity which is the advantage of a deb-filter, and the high accuracy of the screen filter are combined, and the coarse filter is used as a deb-filter, and the final filter is used as a filter. 0 those of the multilayer was a clean filter has been increasing
  • the present inventors have conducted intensive studies on such a material for a blood filter, and as a result, have found that a porcelain ⁇ mec '' porous body made of a relatively hard plastic and having a specific mesh-like continuous structure having a high U-voiding rate is used. I filter Ichie Leme emissions reaching fact that excellent heading invention as bets 0
  • the filter made of the plastic porous body of the invention has a large blood-passing capacity, which is a characteristic of a deb-strainer, and is filtered by deformation or the like, which is a drawback of a debs filter such as a conventional soft sponge. It is a solution to the problem of low accuracy.
  • Sintered bodies such as resin particles can be considered as a porous material with sufficient self-supporting properties, but the sintered body has a limitation on body to porosity. Oh, even if the same amount of material is used, the filtering surface ridge is substantially smaller.] Also, the pore channels are uniform and it is difficult to make the inner surface smooth.
  • a filter material comprising one or a plurality of filter elements
  • at least one of the filter elements has a pore diameter of 200 having a continuous eyelet.
  • a blood filter characterized by comprising a porous body is provided.
  • the blood filter of the present invention does not require a multi-stage element as in the case of a conventional filter, such as a general commercially available filter. It is useful from the standpoint of size and weight reduction, as it is possible to obtain filament o
  • a plastic resin obtained by a dissolution method using a thermoplastic resin as a material is suitable.
  • the dissolution method is a treatment of a plastic sheet containing a solvent-soluble powdered powder with a solvent; (4) The powder is eluted to obtain a continuously open porous body.
  • the volume porosity of the porous body can be determined by the size and addition amount of the fine powder particles. Use of powder with a uniform particle size results in a uniform pore size and relatively uniform pore channels.
  • a thermoplastic resin a porous material with a high porosity is constructed. Any material that exhibits sufficient compressive strength when used can be used.o
  • a relatively hard, mature plastic resin having such properties includes Bolibul formal o.
  • the polybulformal sponge prepared by the dissolution method is reticulated (branched). It has a structure, and has a structure that is mechanically stable in spite of its high porosity, and can be suitably used in the present invention.
  • This plastic porous body is different from a conventional Debs filter / Screen filter. They may be used in combination. It is better to combine them in terms of removal rate o
  • the blood just before the expiration date (U 21 days after blood collection) expires in a single ring blood is usually 1000 or more. It is practically preferable to be able to perform filtration without any problems. O In this case, it is sufficient that the filtration speed is (25 min). In actual blood blood, filtration is performed at a reduced speed. lever use in any Bayoi 0 filter Ereme down bets even state that is achieved can the speed has opened the D grain having a small pore diameter, the removal rate is naturally improved, deformability such as blood In systems with a large number of particles, the ease with which pores are clogged U increases sharply as the pore size of the filter element decreases.o
  • the thickness of the porous porosity of the Proterozoic plastic with a continuous open pore with a pore diameter of 50 to -150 on the controlled side of the porosity and a more reticulated 3 ⁇ 4 gun tissue 0. ⁇ ⁇ 5.0 « ⁇ blast
  • ⁇ ⁇ Blood filter consisting of a filter element combined with a porous porous material, and a reticulated continuous gun tissue with a continuous open pore with a pore diameter of 100 to 200 ⁇ 0.5 to 5. 0 It turned out that a blood filter in which a plastic porous body was interposed was preferred.
  • Bolibullformal porous sheet as a plastic porous body having continuous pores having a pore diameter of 50 to 150 Z ⁇ m or 100 to 200 or 0 or 2 kinds.
  • High filter accuracy and large size ⁇ Blood filtration capacity can be obtained by using a filter composed of 8 types of porous materials o
  • the pore diameter of the invention is the apparent diameter when observing with a microscope the size of the open pore size on the surface or cut surface of the porous body. Even if a filter element (pore diameter: 200-500 / im or 50-: 150i) is used, particles that are much smaller than the pore diameter (micro-aggregates, etc.) will be entrapped and reach the purpose of filtration. O This is because the porous porcelain of the present invention has a uniform, continuous, open eye-like (dendritic) structure from continuous open pores, and is liable to deform, such as microaggregates.
  • the vertical surface between the liquid level of the blood tank and the bottom of the filter unit is 50 to 60 «B. o
  • the filter element used for filtration. the elution method 0 both made of Helsingborg Byuruhoru Mar shown in table 1
  • Subonjishi bets (Bae Louis one coater, Kanebo synthetic chemical Co., Ltd.) Aru o
  • FIG. 1 is a schematic diagram showing a partial cross section of a test device using blood 7-liters of the present invention.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • External Artificial Organs (AREA)
  • Filtering Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Filtre sanguin indiqué pour le filtrage du sang conservé destiné à la transfusion, comprenant un élément unique de filtre ou une pluralité d'éléments de filtres, au moins un des éléments de filtres comprenant un matériau plastique d'une épaisseur comprise entre 0,5 et 5,0 mm et ayant une structure continue de réseau et des cellules ouvertes continues d'un diamètre allant de 200 à 500 mum.
PCT/JP1983/000124 1982-04-16 1983-04-15 Filtre sanguin WO1983003550A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SE8306986A SE441894B (sv) 1982-04-16 1983-12-16 Blodfilter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP57/64237820416 1982-04-16
JP57064237A JPS58180425A (ja) 1982-04-16 1982-04-16 血液フイルタ−

Publications (1)

Publication Number Publication Date
WO1983003550A1 true WO1983003550A1 (fr) 1983-10-27

Family

ID=13252318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1983/000124 WO1983003550A1 (fr) 1982-04-16 1983-04-15 Filtre sanguin

Country Status (4)

Country Link
JP (1) JPS58180425A (fr)
DE (1) DE3340221T1 (fr)
SE (1) SE441894B (fr)
WO (1) WO1983003550A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU610264B2 (en) * 1987-09-18 1991-05-16 Terumo Kabushiki Kaisha Leucocyte-separating filter

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62181056A (ja) * 1985-10-07 1987-08-08 アメリカン・ホスピタル・サプライ・コ−ポレイシヨン ヘパリン被覆された濾過要素を有する血液濾過装置
CA1329559C (fr) * 1988-03-03 1994-05-17 Keiji Naoi Separateur de leucocytes et methode de fabrication
JP5586842B2 (ja) * 2006-10-19 2014-09-10 デンカ生研株式会社 試料ろ過フィルターを用いる簡易メンブレンアッセイ方法及びキット

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5239997A (en) * 1975-09-26 1977-03-28 Asahi Chemical Ind Blood processor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5239997A (en) * 1975-09-26 1977-03-28 Asahi Chemical Ind Blood processor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU610264B2 (en) * 1987-09-18 1991-05-16 Terumo Kabushiki Kaisha Leucocyte-separating filter

Also Published As

Publication number Publication date
DE3340221T1 (de) 1984-10-18
SE8306986L (sv) 1983-12-16
SE441894B (sv) 1985-11-18
SE8306986D0 (sv) 1983-12-16
JPS58180425A (ja) 1983-10-21

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