WO1983000623A1

WO1983000623A1 - Composition for oral use

Info

Publication number: WO1983000623A1
Application number: PCT/JP1981/000194
Authority: WO
Inventors: Corporation Lion; Isao Iioka; Keiiti Yamagishi; Hiroshi Sato; Nobuo Suganuma
Original assignee: Lion Corp
Priority date: 1981-08-27
Filing date: 1981-08-27
Publication date: 1983-03-03

Abstract

A dextranase-containing composition for oral use, which contains carvone and -menthol at a weight ratio of 1:9 to 8:2 and, preferably, in a total amount of 0.1 to 5 wt.% of the composition. This composition is stable, feels good, and can be used for dentifrice.

Description

Specification

Oral composition

Technical field

The present invention relates to a dextranase-containing oral composition having an excellent feeling in use.

Background art

Conventionally, as an active ingredient for preventing dental caries, dextranase has been incorporated into oral compositions to prevent the formation of dental plaque (US Pat. No. 3,686,393).

However, there is a problem that dextranase is easily deactivated due to the influence of water, a-on activator, etc. contained in the oral composition! U.S. Pat. Nos. 3,981,989, 3,991,177, 4,115,546 and 4,140,750 and British Patent 1,427,3 Various techniques for stabilizing dextranase have been proposed as disclosed in No. 00 o

Japanese Patent Publication No. 50-33778 states that in order to stabilize dextranase, there is a certain flavor component, namely C17-C17 lunar aliphatic alcohol or its alcohol. It is disclosed that ester, terpenic hydrocarbon, phenol ether, and -lactone are used in combination with dextranase o

However, oral compositions are used in the oral cavity Since it is a product, it should be excellent in usability, but it is not enough to blend the above-mentioned perfume components in terms of usability. For this reason, according to the type of consumer's taste, etc., in order to improve usability, carbon, oike, knoll, methyl, methyl salicylate, cigarette It is necessary to mix fragrance components such as natural aldehyde. However, as described in Japanese Patent Publication No. 50-33778, these fragrance components such as carbon have a bad influence on the stability of dextranase. Therefore, there was a problem in stabilizing the dextranase without impairing the use of the oral composition.

Disclosure of the invention

An object of the present invention is to provide an oral composition having excellent stability of dextranase and excellent use feeling.

According to the present invention, the following is true:

1: 9 to 8: 2, preferably 2: 8 to 7: 3 (weight ratio)], and dextranase is stably blended and used. A good oral composition can be obtained. In this case, even if a flavor such as soda, knoll, methyl salicylate, and cinnamaldehyde is added to these oral compositions, dextran It may impair the stability of Ize. Therefore, the conventionally known index Uses flavors such as carbohydrate, nitrogen, eugenol, methyl salicylate, and cinnamic aldehyde in addition to the tranase stabilized fragrance. This can broaden the range of choices of flavor components that can be added to the oral composition.

The above and other objects, features and advantages of the present invention will be described below. 2) The best mode for carrying out the present invention can be clearly and understood. Includes liquid mouth fresheners such as toothpaste, powdered toothpaste, liquid toothpaste, and mouthwash, solid mouth fresheners such as troches, and chewing gum. . According to the present invention, in this type of oral composition, carbon and -menthol are contained in a weight ratio.

1: 9 to 8: 2, 3] preferably in a ratio of 2: 8 to 7: 3. By using the ratio of carbon and -menthol in the ratio of 1: 9 to 8: 2, it is possible to stably combine dextranase in the oral composition. The composition for oral cavity with good refreshing feeling, good body feeling, good taste, etc.]) and improved usability is obtained. On the other hand, when the proportion of carbon is low, the taste is insufficient and the use is reduced, and when the proportion of carbon is high, the dextranase content is low. The stability is reduced, and the cooling sensation of the oral composition is also insufficient. The purpose of the present invention is to determine the weight ratio between carbon and ^ 1 meter. Achieved only if in the specific range described above.

In the present invention, calcium and -menthol are defined as having a total content of oral cavity from the viewpoint of improving the stability of dextranase and improving the feeling of use of the oral composition. The composition for use. It is preferably used in a total of 0.1 to 5 (weight, the same applies hereinafter), etc.), or preferably 0.3 to 3 as desired. 0.1% yo jp A small amount of the mixture will not give a sufficient body and refreshing sensation, while a higher amount of 5 will have a too strong and too rich taste, and will have a good balance between carbon and menthol. Even if it is added to 'excess', the stability of dextranase will not be further improved.

In addition, carbon and -menthol may be blended in the oral composition as a single substance or as a synthetic product.

Essential oils containing menthol, such as spearmint oil (which contains caron), ぺ ha. It may be compounded in the form of a mint oil (containing -menthol).

The present invention thus uses a combination of carnone and -menthol, but additionally contains other usual fragrance ingredients, such as carbon number? To 17 alcohols or their esters, terpenic hydrocarbons, phenol ethers, and lactones. it can . In addition, fragrances which are conventionally considered to inhibit dextranase, such as eugenol, methyl salicylate,

C;- In addition, 0.001 to 0.5 of the whole oral composition may be mixed with natural aldehyde. This means that the choice of perfume components is increased, and it is possible to easily produce an oral composition having an excellent feeling in use. It is also advisable to add 0.01 to 0.5 of an ether to the oral composition in order to improve the quality of the sweetness and further improve the composition.

In the present invention, the amount of dextranase to be added is not particularly limited, but is usually 1 ^ per oral composition. ? 100-: 100,000 units (uZ9 oral composition :), particularly preferably 1,000-50,000 u / 9-oral composition. Here, 1 unit means the amount of the enzyme that produces free reducing sugars equivalent to 1 g of glucose 1 ^ when the reaction is performed using dextran as a substrate. U.

In the composition for the oral cavity of the present invention, in addition to dextranase, enzymes such as amylase, protease, mutanase, lysozyme, lithogenzyme, etc. Metal metal fluorophosphates (for example, disposable monolithic phosphates, dipotteric monolithic phosphates, etc.) G: Fluoride, such as metal fluorides (eg, sodium fluoride, 1st metal fluoride), etc. 1 Tin compounds, chlorhexidine salts, ip Silicone power probe Tranexam, aluminum chlorohydroxide Alantoin ヅ Hydrocholester

O PI Or one or more active ingredients such as sodium chloride, glycerin salts, glycerol phosphite, sodium chloride, and water-soluble inorganic phosphoric acid compounds. . In particular, when an aluminum metal monophosphate such as a sodium monofluorophosphate is used in combination with a dextranase, the dextran is reduced. Desirable because it stabilizes lanase and can maintain a high residual ratio of dextranase in the dentifrice composition after long-term storage. In addition, when mutanase is combined with dextranase, a synergistic effect of dissolving plaque and preventing plaque reattachment occurs, and dextranase and reticlase are combined with dextranase. The combination enhances the effectiveness of the reticulation. Examples of the water-soluble inorganic phosphoric acid compounds include potassium phosphate, pyrrolic acid, and boron phosphate, and sodium phosphate. I like it.

As other components of the oral composition according to the present invention, commonly used components can be blended according to the type and the like.

For example, when the oral composition of the present invention is a dentifrice composition, the abrasive is usually used in a total amount of 20 to 90, especially 20 to 60 in the case of toothpaste. Can be. Examples of the abrasive include aluminum oxide compounds, calcium phosphate dibasic dihydrate and anhydrous silica, aluminum silicate, and carbonate. Le Shium, Pi Calcium phosphate, aluminum silicate, insoluble sodium metaphosphate, tertiary linoleic acid, magnesium, magnesium carbonate One or more of um, calcium sulphate, synthetic resin and the like are selected.

The preferred main engraving agent is an aluminum oxide compound.

Jo This can help improve the stability of dextranase and the toothpaste itself. Is an oxidizing § Le mini © beam compound oxide A Le mini U beam (§ Le Mi Na, Α / · ₂ 0 ₅₎ and hydrated oxide A Le Mi Yoo c arm (A Le Mi Na _{_{_{hydrates, Α 2 0 3 · ηΗ 2}}} 0, 0 <η, 3 preferred to rather the Ku 1 rather _eta) is employed.

Here, as the aluminum and the hydrated aluminum, α, Γ, 8, κ,%, ρ, and ^ types are known from their crystal systems and physical properties. However, among these, stable 0: alumina and hydrated alumina are desirable. Also, in the A Le Mi Na hydrate, Jipusa wells, pie catcher La wells (both represented by _{_{_{Α 2 0 5 · 3H 2 0}}} ) and Bae Mai DOO, die Aboa (ii deviation also A ₂ O _s · H ₂₀ ) can be used. Of these aluminum oxide compounds, aluminum hydrate is preferred from the viewpoints of abrasiveness and abrasion of teeth, and in particular, aluminum hydrate is particularly preferred.

A ₂₀ , 3H ₂₀ or Α (OH) J

The aluminum trihydrate represented by And is excellent. As this aluminum trihydrate, it is preferable to use -cupsite because of its industrial availability. In this case, the above-mentioned aluminum oxide compound may be used alone or in combination of two or more. In addition, the particle size of the aluminum oxide-aluminum compound (value determined by the sedimentation method) may be 1 to 50 H, particularly 3 to 25, from the viewpoint of the cleaning effect and the abrasion of the teeth. I like it. -In addition, when producing dentifrice compositions, as a binder, Ragengan, Canoleboxyl methylcellulose, sodium sodium, etc. Sodium phosphate ¾ Which alkaline metal alginate, Vegam, Xanthan gam: ¾ Which gamms, polyvinyl alcohol, Which synthetic binders, silica gel, Aluminum silica gel One or more inorganic binders and the like can be blended in a blending amount of usually 0.3 to 5. In particular, when alkaline metal monofluorophosphate is blended as an active ingredient, when the dentifrice composition has stability and feeling of use, it can be used in combination with lagenan and algin. It is preferable to use a combination with an acid metal salt. In this case, the dentist composition is more effective in preventing skin roughness of the dentifrice composition than the usual copper-Ziota one-component stimulant ragnan. In terms of the stability of the sword, it is a must. -Preference is given to using caragunnan.

C? I Also, as a thickener, sorbit, glycerin, ethylene, silicone, propylenelink, silicone, 1,3-butylene, One or two or more types of coconut, coconut, coconut, coconut, lacquer, etc. are blended at a blending amount of usually 10 to 70. Get. In this case, it is desirable to use 1 to 5% of propylene alcohol as the binder dispersion, but if it is used in a large amount, the residual ratio of dextranase due to storage can be reduced. Therefore, it is desirable to mix sorbit as a main thickener and to use sorbit in combination with lipoline and alcohol.

Furthermore, the water solubility of higher alkyl sulfates having 8 to 18 carbon atoms in the alkyl group, such as sodium raurylsulfate and sodium myristyl sulfate, Salts, soybean plastic monoko, lycetone snore honey, coconut coconut moss honey, lysolide sulhonate etc. Water-soluble salt of higher fatty acid monoglyceride sulfonate having 10 to 18 carbon atoms in the fatty acid group, higher fatty acid sodium monoxide, and higher fatty acid sodium monosulfide E over doorゝSoviet di ©-time - N - methyltransferase one N - c ⁰ Le Mi Doo Lee Le data window La Lee de, the Soviet Union 'di ©-time one N - La © b A Norezanore co-VALUE over door, the Soviet Union diと This is an amide salt of a high fatty acid having 12 to 18 carbon atoms in a fatty acid group such as π-yl-β-ara-an and a lower aliphatic amino acid. Anio down active agents, La window opening Fatty acid groups such as alkyl phenol amides such as alcohol phenol amides, stearyl monoglycerides, sucrose monosaccharides, and dilates Carbon number

12 to 18 sucrose fatty acid ester, lactose fatty acid ester, lactotol fatty acid ester, maltitol per month fatty acid Ethanol, ethylene glycol, and solvitanomonostearate condensate to which about 60 mol has been added, ethylene oxide and propylene Nonionic activators such as polymers of oxosides and derivatives such as polyoxyethylene propylene glycol monoesters; One or more kinds of amphoteric surfactants such as betaine type and amino acid type. Surfactants can be blended in a blending amount of usually 0.5 to 7. Saccharin Triumum, Steviaside, Neo-Hesperidyl Dihydrocarbon, Taumatine, Glycilitin,ラ Reraltin, p-methoxycinnamic aldehyde, sweetener, p-hydroxyshethyl penzoic acid, P-hydroxybutyrate Benzozide can contain any preservatives, gelatin, peptone, and other ingredients. In the case of toothpaste, the desired component is prepared by combining the desired component with an appropriate amount of water or another solvent.

The dentifrice compositions of the present invention generally have a density of 4.5 to 10, preferably! ^ 6 to 8.5.

C: PI WIFC The dentifrice composition thus obtained is a laminate obtained by laminating both sides of an aluminum foil or aluminum foil with a plastic or the like. Used in tubes, plastic tubes, bottles, aerosol containers, etc.

In addition, in the case of other composition for baking, it can be manufactured according to a usual method using a commonly used base material.

Next, examples are shown, but the present invention is not limited to the following examples. Or both are weight.

[Example 1]

Toothpaste compositions (the dentifrices of the present invention and comparative dentifrices A and B) having the formulations shown in Table 1 were prepared, and the dextran content in the composition immediately after preparation and after storage at 40 ° C for one month was measured. The amount of dextranase was measured to determine the residual ratio of dextranase.

Furthermore, they specialize in the feeling of use of these toothpaste compositions. The evaluation was performed by a sensory test in the cell. The results are shown in Table 1.

CMPI_ WIPO l

Next, in the above formulation, the total amount of carbon and -menthol was set to 1.0 ^, and the weight ratio of carbon and -menthol was changed. The same experiment was conducted on the dentifrice as to the residual ratio of dextranase and the feeling of use. The evaluation criteria are the same as in Table 1.

Table 2

Table 2 shows that Karun and -menthol should be used together at a ratio of 1¾ to 8Ζ2, especially 2Ζ8 to 7Ζ3.]? Stabilize the dextranase and improve the usability. It is shown to be good.

In addition, methyl salicylate and 0.2% of cinnamic aldehyde were further added to the dentifrice formulation of the present invention, and the dextranase residual ratio was similarly examined. At that time, the results were all “〇” in the same evaluation criteria as above.

[Example 2] toothpaste

Alumina hydrate (-Cupsite, average particle size 10 ") 50 Propylene glycol 2

G Solbit 20% Sodium, Coumraurilusulfate 1.5 Rauric acid-Quetananol P 1.0 Force lagenan 1.0 Saccharin sodium Trium 0.1-Menthol 0.7 Calpon 0.3 Dextranase 200 00 u / 9 Toothpaste

0 0.0

[Example 3] toothpaste

Alumina hydrate (pylumite, average particle size I Qu) 40 ^ Silicon force 3 Solvite 15 Glycerin 15 Sodium sulphate sodium sulfate 1.0 Diethanolamide laurate 1.5 Al Sodium formate 1.0 sodium monofluorophospho-phosphate 0.76 gelatin 0.3 saccharin sodium 0.1 • 6-menthol 0.5 carbo 0.3 Anet 0.2 Dextranase 5000 u / 9 Toothpaste Water

1 0 0.0

[Example 4] toothpaste

Aluminum (average particle size 5 M) 45 ^

Sol bit 25

Somewhere Ruri Salfate 1.5

Lauric acid Zoetanol amide 0.5

Force lagennan 0.3

Alginate sodium 0.7

Chlorhexyne hydrochloride 0.0 1

Saccharin sodium 0.1

-0.5

Can Repon 0.5

Net 0.1

Cool, Knoll 0.05 Dextranase 000 u / 9 Toothpaste

1 0 0.0 ^

[Example 5] toothpaste

Calcium phosphate 2 50 ^

Carbonate 2 0

Glycerin 1 0

, Kuumururi Rulsarfet 1.0

OM? I Cutitol monolaurate 1.0 Zetine 0.3 Saccharin sodium Trium 0.2 ^ 1 meter 0.5 Carbon 0.9-ぺ C. Mint oil 0.4 Dextranase 0000 Vi / 9 Toothpaste water

1 0 0.0

[Example 6] toothpaste

'Carbon carbonate 50 ^ ^ Solvite 20 Lactic tol mono-laurette 2.0 Power lagenan 1.0 Sodium mono-full-year old L-phospho-0.75 Gelatin 0.5 Saccharin sodium 0.1

•-Menthonre 0.3 Carbon 0.4 Anetole 0.05 Spare Mint Oil 0.5 Dextranase 3000 V / 9 Toothpaste

0 0.0 [Embodiment 7] toothpaste brush force 20 ^

Sol bit 40

Glycerin 20

N 'Kuum Rau Ril Sulfur-1.0

Alginate sodium 1.0

Gelatin 0.5

Saccharin sodium 0.2

-0.3

Power report, 0.3

ぺ Ha. — Mint oil 0.5

Spare mint oil 0.5

Dextranase 20000 uZ Toothpaste Water

100.0

[Example 8] Toothpaste Alumina hydrate (-Cupsite, average particle size 10 /) 50 lots

Solubi, Kut 30

Seo, Kuumbura Ril Salfate 1.0

Lauric acid quaternamide 1.2

Force lagennan 0.6

Sodium alginate 0.4

Gelatin 0.1

Saccharin sodium 0.1

OMPI VIPO -Center 0.75δ

Power report, 0.3

Anethole 0.3

Talent Ken 0.1

Na σ — le 0.05

Cineol 0.0 5

Dextranase 2000 Toothpaste

water

0 0.0

[Example 9] Liquid dentifrice

Glycerin 3 5 Bolidium sodium acrylate 5 Sodium liquor sulfate Saccharin sodium 0. Ethanol 3-mentor 0.7

Carbon 0.3 Dextranase 5000 uZ Toothpaste

water

00.05έ

[Example 10] Mouthwash ethanol (90 ^) 205 g Saccharin sodium 0.3

Rate 0.5

OMPI ー mentor 1.5

Carbon 0.5

Ending 0.4

IKE * NORTH 0.2

Linalool 0.1

Cinema age 0.1

Dextranase 30000

Mouse ゥ:

water

00.0%

[Example:] Liquid mouth freshener

Ethanol 30%

Glycerin 1 5

Saccharin sodium 0.3

Boiled oil, hydrogenated castor oil 0.5

-Mentor 1.5

Carbon 0.5

Anet 0.4

Cool, know 0.2

Cineol 0.1

Orange oil 0.2

Dextranase • 3000 u / n M

water

00.0 ^

Ο ΡΙ WIPO [Example 12] Troche

6 K> Bud sugar 7 2

-Mentor 0.6

Calpon 0.4

Spare mint oil 0.2

Dex Tranase 3 0 0 0 / S Lozenge

water

[Example 13] Solid mouth freshener

ぺ C. 1 mint oil. 1 9

Lemon oil 0.2〃 years old, Knoll 0.1 // Anethole 0.2 "Cal τί? 0.3 0.3 //

Oris root end 4 //

Kiss lit 7 //

Licorice powder 3 0 //

Cake powder 3 //

Showy powder 2 //

Powder

Arabic rubber liquid appropriate amount

Dextranase 200 nZ cooling agent After the solid raw material is sufficiently pulverized and mixed,

O PI Liquid raw material was added and kneaded well.] [Example 14] Chewing gum

Gum space 20 parts by weight Calcium carbonate 2

Water 15

-Powdered sugar 60

-0.5

Carbon 0.5

Network 0.1

Dextranase 2000 u ^ gum

All of the oral compositions of Examples 2 to 14 have good dextranase stability and feeling of use.

ΟΜ? Ι 1PO

Claims

The scope of the claims

1. In an oral composition containing dextranase, the ratio of carbon to -menthol is defined by weight.

An oral composition used in a ratio of 1: 9 to 8: 2.

2. The oral composition according to claim 1, wherein the weight ratio of carbon to -menthol is S2: 8 to 7: 3.

3. The claim wherein the total amount of carbon and -menthol is 0.1 to 5 weight by weight of the whole composition.

Item 3. The oral composition according to Item 1 or 2.

4. The oral composition according to claim 3, wherein the total amount of carbon and JL-ment ^ is 0.3 to 3% by weight of the whole composition.

5. The oral composition according to claim 1, wherein the ether is incorporated in a total amount of from 0.01 to 0.5% by weight.

6. The scope of the claim which contains a fragrance selected from genius, knoll, methyl salicylate, cinnamic aldehyde and a mixture thereof. An oral composition according to claim 1.

7. The oral composition according to claim 1, wherein the amount of the dextranase is 100 to 100,000 cut-out Z composition.

8. Claim 1 GREA using aluminum oxide compound as main abrasive and dentifrice composition The oral composition according to the above item.

9. Aluminum oxide compound becomes aluminum oxide ''

The oral composition according to claim 8, which is a trihydrate o

10. Patents wherein the composition is toothpaste, powdered toothpaste, liquid dentifrice, mouse mouthwash, liquid mouth freshener, pi-chi, solid mouth freshener, or chewing gum The oral composition according to claim 1.

OMPI WIPO