WO1983000282A1 - Production d'un revetement poreux sur une prothese - Google Patents

Production d'un revetement poreux sur une prothese Download PDF

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Publication number
WO1983000282A1
WO1983000282A1 PCT/US1982/001016 US8201016W WO8300282A1 WO 1983000282 A1 WO1983000282 A1 WO 1983000282A1 US 8201016 W US8201016 W US 8201016W WO 8300282 A1 WO8300282 A1 WO 8300282A1
Authority
WO
WIPO (PCT)
Prior art keywords
particles
surface area
primary
prosthesis
metallic surface
Prior art date
Application number
PCT/US1982/001016
Other languages
English (en)
Inventor
Development Corporation Battelle
Kenneth Roy Sump
Original Assignee
Battelle Development Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Development Corp filed Critical Battelle Development Corp
Publication of WO1983000282A1 publication Critical patent/WO1983000282A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F7/00—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression
    • B22F7/002—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression of porous nature
    • B22F7/004—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression of porous nature comprising at least one non-porous part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108—Shapes
    • A61F2002/30199—Three-dimensional shapes
    • A61F2002/30242—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/32—Joints for the hip
    • A61F2/36—Femoral heads ; Femoral endoprostheses
    • A61F2/3609—Femoral heads or necks; Connections of endoprosthetic heads or necks to endoprosthetic femoral shafts
    • A61F2002/3625—Necks
    • A61F2002/3631—Necks with an integral complete or partial peripheral collar or bearing shoulder at its base
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0071—Three-dimensional shapes spherical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00395—Coating or prosthesis-covering structure made of metals or of alloys
    • A61F2310/00407—Coating made of titanium or of Ti-based alloys

Definitions

  • This disclosure relates to the coating of preselected metallic surface areas on a prosthesis for subsequent tissue ingrowth applications .
  • the coating is in the form of a porous material having interconnected pores through which hard or soft body tissues can grow .
  • U. S . Patent No. 3 ,855 ,638 granted on December 24 , 1974 to Robert M. Pilliar discloses a surgical prosthetic device that consists of a solid metallic material substrate with a porous coating over at least a part of its surface.
  • the coating has a thickness between one hundred to one thousand microns.
  • the coating is formed from metallic powder sized between -100 to +325 mesh.
  • the patent discloses production of the coating by using a slurry of metallic powder suspended in an - aqueous solution with organic binders. The particle size of the metallic powder and conditions of formation of - the porous coating are controlled to provide the desired interstitial pore size, porosity, strength and depth of coating.
  • the expendable material is removed from the coating, which will then have a surface configuration complementary to the mold. Controlled porosity throughout the coating results from a combination of the interstitial spaces between the primary and secondary particles and the voids that remain after removal of the expendable secondary particles.
  • Another object is to provide an effective method of controlling final coating density and porosity so as to permit design of the coating structure for tissue ingrowth requirements.
  • FIG. 1 is a perspective view of an implant element having porous coated surfaces
  • Fig. 5 is an enlarged (50X) side view of a cross-sectional slice through the coating and substrate in Fig. 4;
  • Fig. 6 is an enlarged (100X) side view taken at the center of Fig. 5 after etching out the grain . structure of the coating and substrate;
  • Fig. 7 is a further enlargement (250X) showing bonding at the substrate- surface
  • Fig. 10 is a similar view of the closed mold.
  • the outer surfaces of the shank 11 are covered by a porous metallic coating 12 that surrounds an inner solid metal substrate 13.
  • the coating 12 is bonded to the substrate 13 , and includes interconnected pores through which soft and hard living tissues can grow after implantation of the prosthesis 10.
  • the bonding temperature will be maintained below the beta transus temperature for the alloy (for example, 970°C) .
  • expendable particles will normally be metallic.
  • materials usable for this purpose are particles of copper, iron, steel, or molybdenum. Metals and alloys must be used which can be readily removed after the production of the coating has been completed. Low temperature eutectic reactions with the prosthesis and primary metallic particles should be avoided.
  • Spherical particles are preferred as starting materials for production of the coating, but spherical particle shapes are not essential to practice of the invention.
  • Spherical powders of the required metallic materials are readily available in closely defined size ranges. They are also easily handled and packed with minimum damage and resulting dust.
  • spheres of the same diameter for both the primary and expendable materials one can maximize the theoretical number of contact locations to be expected between adjacent particles. This leads to greater bonding of the primary particles and improved strength in the final coating.
  • non-spherical granular or p articulate powders of either the primary or expendable material can be utilized when available.
  • the expendable material discussed in the above example can be chemically removed by immersion in a bath of suitable acid.
  • the finished product would subsequently be treated to a low temperature vacuum outgassing to assure removal of any contaminants and to further promote metallurgical bonding.

Abstract

Procédé de production d'un revêtement poreux (26) sur des surfaces présélectionnées d'une prothèse (25) et organe d'implantation résultant (10) possédant un revêtement poreux unique (26). Des zones spécifiques présélectionnées sont recouvertes d'un mélange de particules métalliques primaires assorties de particules expansibles. Les particules sont comprimées (20) et chauffées (21) pour assurer que la déformation et la liaison métallurgique aient lieu entre elles ainsi qu'aux faces limites de surfaces de l'élément d'implantation (10). La porosité est obtenue en enlevant le matériau expansible (24). Il en résulte un revêtement (26) comprenant des particules liées discrètes séparées par un réseau de vides interconnectés présentant un revêtement poreux homogène (26) autour du substrat (10).
PCT/US1982/001016 1981-07-27 1982-07-23 Production d'un revetement poreux sur une prothese WO1983000282A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28716681A 1981-07-27 1981-07-27
US287,166810727 1981-07-27

Publications (1)

Publication Number Publication Date
WO1983000282A1 true WO1983000282A1 (fr) 1983-02-03

Family

ID=23101733

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1982/001016 WO1983000282A1 (fr) 1981-07-27 1982-07-23 Production d'un revetement poreux sur une prothese

Country Status (5)

Country Link
EP (1) EP0083655A4 (fr)
JP (1) JPS58501160A (fr)
CA (1) CA1199535A (fr)
WO (1) WO1983000282A1 (fr)
ZA (1) ZA825398B (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2142544A (en) * 1983-07-04 1985-01-23 Oec Orthopaedic Limited Surgical implant
FR2609936A1 (fr) * 1987-01-28 1988-07-29 Commissariat Energie Atomique Procede de fixation d'une couche poreuse sur un substrat et application de ce procede a la realisation d'une prothese
AU588724B2 (en) * 1987-02-26 1989-09-21 Pfizer Hospital Products Group, Inc. Spinal implant
EP0370618A1 (fr) * 1988-11-03 1990-05-30 Mixalloy Limited Composant de prothèse métallique revêtu
WO2002066693A1 (fr) * 2001-02-19 2002-08-29 Isotis N.V. Metaux poreux et revetements metalliques pour implants
EP1344537A1 (fr) * 2002-02-08 2003-09-17 Howmedica Osteonics Corp. Echafaudage métallique poreux pour la colonisation tissulaire
DE102005052354A1 (de) * 2005-11-02 2007-05-03 Plus Orthopedics Ag Offenporige biokompatible Oberflächenschicht für ein Implantat sowie Verfahren zur Herstellung und Verwendung

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4033291A1 (de) * 1990-10-19 1992-04-23 Draenert Klaus Werkstoff und verfahren zu seiner herstellung
US10709581B2 (en) * 2016-08-17 2020-07-14 Joint Innovation Technology Llc Thermally securing Morse taper
JP6918377B1 (ja) 2020-03-18 2021-08-11 株式会社トウネツ 金属溶湯炉

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB784124A (fr) *
GB717034A (en) * 1951-04-02 1954-10-20 Gen Electric Co Ltd Improvements in or relating to the manufacture of porous metal bodies
US3852045A (en) * 1972-08-14 1974-12-03 Battelle Memorial Institute Void metal composite material and method
US3855638A (en) * 1970-06-04 1974-12-24 Ontario Research Foundation Surgical prosthetic device with porous metal coating
US3986212A (en) * 1975-04-11 1976-10-19 Glasrock Products, Inc. Composite prosthetic device with porous polymeric coating
US4101984A (en) * 1975-05-09 1978-07-25 Macgregor David C Cardiovascular prosthetic devices and implants with porous systems
US4206516A (en) * 1976-12-15 1980-06-10 Ontario Research Foundation Surgical prosthetic device or implant having pure metal porous coating
US4309488A (en) * 1978-06-23 1982-01-05 Battelle-Institut E.V. Implantable bone replacement materials based on calcium phosphate ceramic material in a matrix and process for the production thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688139A (en) * 1950-03-09 1954-09-07 American Optical Corp Anatomical replacement means

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB784124A (fr) *
GB717034A (en) * 1951-04-02 1954-10-20 Gen Electric Co Ltd Improvements in or relating to the manufacture of porous metal bodies
US3855638A (en) * 1970-06-04 1974-12-24 Ontario Research Foundation Surgical prosthetic device with porous metal coating
US3852045A (en) * 1972-08-14 1974-12-03 Battelle Memorial Institute Void metal composite material and method
US3986212A (en) * 1975-04-11 1976-10-19 Glasrock Products, Inc. Composite prosthetic device with porous polymeric coating
US4101984A (en) * 1975-05-09 1978-07-25 Macgregor David C Cardiovascular prosthetic devices and implants with porous systems
US4206516A (en) * 1976-12-15 1980-06-10 Ontario Research Foundation Surgical prosthetic device or implant having pure metal porous coating
US4309488A (en) * 1978-06-23 1982-01-05 Battelle-Institut E.V. Implantable bone replacement materials based on calcium phosphate ceramic material in a matrix and process for the production thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Jones Fundamental Principles of Powder Metallurgy, 1960, pp. 309-311 *
Journal of Bone and Joint Surgery, vol. 53-A, No. 1, Jan 1971, pp. 101-114, GALANTE et al, "Sintered Fiber Metal Deposits as a Basis for Attachment of Implant Implants to Bone" *
See also references of EP0083655A4 *
Symposium on Research in Dental and Medical Material, Metallurgical Society of AIME, Oct. 2968, pp 137-150, KOROSTOFF, "Researcq in Dental and Medical Material *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2142544A (en) * 1983-07-04 1985-01-23 Oec Orthopaedic Limited Surgical implant
FR2609936A1 (fr) * 1987-01-28 1988-07-29 Commissariat Energie Atomique Procede de fixation d'une couche poreuse sur un substrat et application de ce procede a la realisation d'une prothese
EP0280592A2 (fr) * 1987-01-28 1988-08-31 Commissariat A L'energie Atomique Procédé de fixation d'une couche poreuse sur un substrat et application de ce procédé à la réalisation d'une prothèse
EP0280592A3 (fr) * 1987-01-28 1988-09-14 Commissariat A L'energie Atomique Procédé de fixation d'une couche poreuse sur un substrat et application de ce procédé à la réalisation d'une prothèse
AU588724B2 (en) * 1987-02-26 1989-09-21 Pfizer Hospital Products Group, Inc. Spinal implant
EP0370618A1 (fr) * 1988-11-03 1990-05-30 Mixalloy Limited Composant de prothèse métallique revêtu
WO2002066693A1 (fr) * 2001-02-19 2002-08-29 Isotis N.V. Metaux poreux et revetements metalliques pour implants
EP1344537A1 (fr) * 2002-02-08 2003-09-17 Howmedica Osteonics Corp. Echafaudage métallique poreux pour la colonisation tissulaire
AU2003200474B2 (en) * 2002-02-08 2004-10-07 Howmedica Osteonics Corp. Porous metallic scaffold for tissue ingrowth
US7458991B2 (en) 2002-02-08 2008-12-02 Howmedica Osteonics Corp. Porous metallic scaffold for tissue ingrowth
US7740795B2 (en) 2002-02-08 2010-06-22 Howmedica Osteonics Corp. Porous metallic scaffold for tissue ingrowth
DE102005052354A1 (de) * 2005-11-02 2007-05-03 Plus Orthopedics Ag Offenporige biokompatible Oberflächenschicht für ein Implantat sowie Verfahren zur Herstellung und Verwendung

Also Published As

Publication number Publication date
CA1199535A (fr) 1986-01-21
JPH0344776B2 (fr) 1991-07-09
EP0083655A4 (fr) 1985-02-28
EP0083655A1 (fr) 1983-07-20
JPS58501160A (ja) 1983-07-21
ZA825398B (en) 1983-06-29

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