WO1982002835A1 - Vacuum-compression injector - Google Patents
Vacuum-compression injector Download PDFInfo
- Publication number
- WO1982002835A1 WO1982002835A1 PCT/US1982/000230 US8200230W WO8202835A1 WO 1982002835 A1 WO1982002835 A1 WO 1982002835A1 US 8200230 W US8200230 W US 8200230W WO 8202835 A1 WO8202835 A1 WO 8202835A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medicament
- tissue
- pressurized air
- vacuum
- holding
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3148—Means for causing or aiding aspiration or plunger retraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
- A61M5/425—Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/48—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for varying, regulating, indicating or limiting injection pressure
- A61M5/484—Regulating injection pressure
Definitions
- VACUUM-COMPRESSION INJECTOR This invention is in the field of hypodermic and hypomucosal injectors using pressurized air to force a medicament into the tissue.
- U.S. Patent 3,140,713 to Ismach discloses a conventional jet injection device with an intradermal nozzle designed to inject fluid at an angle of 45° to control the depth of penetration and prevent tearing or rupturing of the skin.
- the pressure entry of liquid into non-fixed, movable soft tissue at various angles creates undesirable tearing, hemorrhage and subsequent post-operative pain.
- the use of existing jet injectors have not overcome the physical and psychological traumatic effects of a syringe and needle — particularly in the field of oral injections into mucosa.
- the present invention overcomes the above objections to jet hypodermic injector devices by using a vacuum to stabilize a nozzle of the device over the tissue to be penetrated.
- the suction pulls the tissue taut and draws it over an orifice of the nozzle so that the nozzle and tissue are essentially immobile relative to each other. This then eliminates the entry of medicament liquids at various angles; eliminates the resultant tearing of the soft tissue; and, reduces the accompanying pain.
- the structure of the invention also includes an air driven piston which provides for a smooth delivery of the medicament into the tissue and precludes the undesirable shock wave that is generated in the soft tissue by prior art spring-driven-piston devices.
- structure of the invention includes a means for regulating the air pressure exerted on the air driven piston in order to control the depth of penetration of the medicament into the tissue.
- the vacuum pressure is also controllable.
- FIG. 1 is a partial cross-sectional view of a vacuum compression injector according to principles of this invention
- FIG. 2 is a schematic partial cross-sectional view of a medicament insert
- FIG. 3 is a cross-sectional view of an embodiment of the invention taken along lines 3-3 of FIG. 1;
- FIG. 4 is a schematic partial cross-sectional view of an alternate embodiment of a medicament insert;
- FIG. 5 is a schematic partial cross-sectional view of a FIG. 4 embodiment installed in the housing of FIG. 1 and surrounded by a removable sleeve;
- FIG. 6 is a view of FIG. 5 taken along the lines 6-6 thereof;
- FIG. 7 is an alternate embodiment of the FIG. 5 structure.
- FIG. 8 is a view of the FIG. 7 structure taken along the lines 8-8 thereof.
- FIG. 1 A vacuum-compression injector 11 of the invention is illustrated in FIG. 1.
- an exterior cylindrical housing 13 contains a vacuum chamber 15 and an interior cylindrical chamber 17.
- the interior cylindrical chamber 17 contains a movable piston 19 with an o-ring 21 providing an air-tight seal between the piston 19 and the interior of cylindrical chamber 17.
- the piston 19 has a piston rod or plunger 23 extending forwardly in the interior chamber 17 and maintained in an axial position by a guide bushing 25 which is held in position by a retaining ring 27 at the right end of the interior chamber 17 in FIG. 1.
- the other end of the interior cylindrical chamber 17 contains a port 29 through which air under pressure enters and impinges upon a face 31 of the piston 19.
- the right end of the interior cylindrical chamber 27 adjacent to the piston rod guide bushing 25 has a plurality of vents 33 opening through the cylindrical housing 13 to the atmosphere.
- the air supply port 29 is connected by an air supply line 35 to a two-phase pneumatic switch 37 which, in turn, is connected through an air pressure regulator valve 34 to an air supply source (not shown) .
- the air pressure regulator valve 34 has a dial with a central handle 36 to regulate the air pressure
- the right end of the cylindrical housing 13 in FIG. 1 has interior threads 38 for threadably joining the tapered base 39 of a generally cylindrical nozzle housing 41.
- the cylindrical nozzle housing 41 contains a hollow concentric cylindrical medicament- insert-holder 43 which is spaced from the interior of the cylindrical housing 41 leaving an annular passageway 45 extending from a forward end 47 of the housing 41 back through a plurality of vacuum ports 49 to the vacuum chamber 15.
- the vacuum chamber 15 is connected to a second annular passageway- 51 contained within the cylindrical housing 13. This second passageway 51 extends to the end of the housing 13 where it joins a vacuum line 53.
- the vacuum line 53 is connected through the two phase pneumatic switch 37 and a vacuum pressure regulator valve 52 to a source of vacuum (not shown) .
- the vacuum pressure regulator valve 52 has a dial with a control handle 54 to regulate the vacuum pressure to the switch 37 and the vacuum line 53.
- a cylindrical medicament insert 55 (FIG. 2) has an interior cavity 57 for storing a supply of medicament.
- the medicament insert 55 has an orifice 59 at its forward end 61 and is sealed at its other end by a plunger-plug 63.
- the forward end 47 of the nozzle housing 41 is spaced from the medicament insert holder 43 by a plurality of spacers 65 defining the annular vacuum passageway 45.
- the forward end 61 of the medicament insert 55 protrudes through the forward end wall of the insert holder 43, as shown in FIGS. 1 and 3.
- the medicament orifice 59 in the insert 55 is centrally located in the forward end 61 of the insert 55 to form a nozzle as can be seen in FIGS. 2 and 3.
- the nozzle is formed integrally with the holder 43 and the insert 55 located therebehind but; of course, in communication with the passageway leading to orifice 59.
- the insert is essentially stationary with medicament being supplied thereto from an outside source as required.
- a disposable medicament insert 71 has a plurality of nodules 73 positioned about the periphery of its outer surface.
- the nodules 73 hold the medicament insert 71 in position inside the nozzle housing 41 and a removable forward-end section 75 which is slidably or threadably engaged in the housing 41.
- the nodules 73 provide spacing between the medicament insert 71 and the nozzle housing 41 and its forward end section 75 for an annular vacuum passageway 77.
- a forward end 79 of the medicament insert 71 contains an orifice 81 and protrudes beyond a cylindrical end 83 of the removable forward end section 75 of the nozzle housing 41.
- the removable forward-end section 75 of the nozzle housing 41 has an oval-shaped end 85 or the like to permit access to somewhat elongated surface areas in an oral cavity, for example.
- Other end-shapes are used to accommodate confined or other areas into which medicament is to be injected.
- the medicament inserts shown in Figs. 4 through .8 may be constructed from a plastic, or a metal or the like and are preferably disposable.
- the two phase pneumatic switch 37 is initially depressed halfway to open the vacuum source through line 53 and intervening passageway 51, chamber 15, and passageway 45 to the forward end 47 of the nozzle housing 41 to draw a patient's tissue firmly over the
- the nozzle housing 41 is unscrewed from the cylindrical housing 13 and the cylindrical medicament insert 55 is removed from the insert holder 43 and disposed of. A new medicament insert 55 containing a medicament charge is then inserted into the holder 43. Pressure is then exerted against the piston rod 23 to return the piston 19 to its aft position in the cylindrical housing 13 and then the housing 41 is again threaded into the cylindrical housing 13.
- the patient's tissue is immobilized by using an annular ring of vacuum to draw the patient's tissue tightly over the orifice of a pressure injector prior to discharging it through the dermis or mucosa so as to prevent the trauma of tearing the tissue and the related post-operative pain.
- replaceable medicament insert 55 with its forward end 61 and orifice 59 provide a completely sanitary and safe means for using the injector on a series of patients or for interchanging the medicaments between injections.
- forward-end sections 75 may be removed from the nozzle housing 41 after use on one patient and either disposed of and replaced by a new end section 75 or sterilized before treating a second patient.
- the medicament insert 71 may also be disposed of after use on one patient.
- the amount of vacuum employed to draw a patient's tissue over the forward end section of the medicament insert 55 is controlled by adjusting the control handle 54 of the vacuum pressure regulator valve 52 with reference to the dial on the regulator 52.
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU82735/82A AU8273582A (en) | 1981-02-24 | 1982-02-24 | Vacuum-compression injector |
DE19823233720 DE3233720A1 (de) | 1981-02-24 | 1982-02-24 | Vakuum-druckinjektor |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/237,563 US4403609A (en) | 1981-02-24 | 1981-02-24 | Vacuum-compression injector |
US237563 | 1981-02-24 | ||
US06/281,436 US4421508A (en) | 1981-02-24 | 1981-07-08 | Vacuum-compression injector |
US281436810708 | 1981-07-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1982002835A1 true WO1982002835A1 (en) | 1982-09-02 |
Family
ID=26930813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1982/000230 WO1982002835A1 (en) | 1981-02-24 | 1982-02-24 | Vacuum-compression injector |
Country Status (7)
Country | Link |
---|---|
US (1) | US4421508A (sl) |
CA (1) | CA1166537A (sl) |
FR (1) | FR2500308A1 (sl) |
GB (1) | GB2109243B (sl) |
IE (1) | IE52560B1 (sl) |
IT (1) | IT1190701B (sl) |
WO (1) | WO1982002835A1 (sl) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0560856A1 (en) * | 1990-12-07 | 1993-09-22 | Sy-Quest International Limited | Jet injector for mass inoculation |
US5480381A (en) * | 1991-08-23 | 1996-01-02 | Weston Medical Limited | Needle-less injector |
EP2676691A2 (en) | 2005-11-17 | 2013-12-25 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
US8734384B2 (en) | 2010-09-15 | 2014-05-27 | Zogenix, Inc. | Needle-free injectors and design parameters thereof that optimize injection performance |
EP2756756A1 (en) | 2008-04-28 | 2014-07-23 | Zogenix, Inc. | Novel formulations for treatment of migraine |
WO2014164754A1 (en) | 2013-03-11 | 2014-10-09 | Durect Corporation | Injectable controlled release composition comprising high viscosity liquid carrier |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US4666430A (en) * | 1984-12-05 | 1987-05-19 | I-Flow Corporation | Infusion pump |
US4664635A (en) * | 1985-09-12 | 1987-05-12 | Divetronic Ag | Simulation device |
US4680027A (en) * | 1985-12-12 | 1987-07-14 | Injet Medical Products, Inc. | Needleless hypodermic injection device |
US5073165A (en) * | 1988-02-05 | 1991-12-17 | Marpam International, Inc. | Hypodermic jet injector and cartridge therefor |
WO1989007953A1 (en) * | 1988-02-26 | 1989-09-08 | Vci Corporation | Improved vacuum-compression injector cartridge |
US4913699A (en) * | 1988-03-14 | 1990-04-03 | Parsons James S | Disposable needleless injection system |
EP0347190A1 (en) * | 1988-06-14 | 1989-12-20 | Vci Corporation | Needleless vacuum-compression injector |
US5024656A (en) * | 1988-08-30 | 1991-06-18 | Injet Medical Products, Inc. | Gas-pressure-regulated needleless injection system |
US5064413A (en) * | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5571178A (en) * | 1991-02-22 | 1996-11-05 | Ledergerber; Walter J. | Breast implant introducer |
US5723006A (en) * | 1991-02-22 | 1998-03-03 | Ledergerber; Walter J. | Breast implant introducer |
US5176642A (en) * | 1991-03-11 | 1993-01-05 | Mectra Labs, Inc. | Vacuum powdered syringe |
US5746714A (en) * | 1993-04-05 | 1998-05-05 | P.A.T.H. | Air powered needleless hypodermic injector |
CA2167586C (en) * | 1993-07-31 | 2005-01-25 | Terence Edward Weston | Needle-less injector |
US5599302A (en) * | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
US5899879A (en) * | 1995-12-19 | 1999-05-04 | Genesis Medical Technologies, Inc. | Spring-actuated needleless injector |
US5865795A (en) * | 1996-02-29 | 1999-02-02 | Medi-Ject Corporation | Safety mechanism for injection devices |
US5643211A (en) * | 1996-02-29 | 1997-07-01 | Medi-Ject Corporation | Nozzle assembly having a frangible plunger |
US5800388A (en) * | 1996-02-29 | 1998-09-01 | Medi-Ject Corporation | Plunger/ram assembly adapted for a fluid injector |
US5697917A (en) * | 1996-02-29 | 1997-12-16 | Medi-Ject Corporation | Nozzle assembly with adjustable plunger travel gap |
US5722953A (en) * | 1996-02-29 | 1998-03-03 | Medi-Ject Corporation | Nozzle assembly for injection device |
US5921967A (en) * | 1996-02-29 | 1999-07-13 | Medi-Ject Corporation | Plunger for nozzle assembly |
US5769138A (en) | 1996-04-01 | 1998-06-23 | Medi-Ject Corporation | Nozzle and adapter for loading medicament into an injector |
JP4054381B2 (ja) * | 1996-09-17 | 2008-02-27 | デカ・プロダクツ・リミテッド・パートナーシップ | 移送による薬伝達システム |
US5875976A (en) | 1996-12-24 | 1999-03-02 | Medi-Ject Corporation | Locking mechanism for nozzle assembly |
US5993412A (en) * | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
US5911703A (en) * | 1997-05-22 | 1999-06-15 | Avant Drug Delivery Systems, Inc. | Two-stage fluid medicament jet injector |
US6610042B2 (en) | 1997-12-05 | 2003-08-26 | Felton Medical, Inc. | Disposable unit-dose jet-injection syringe for pre-filled and/or transfilled liquid injectable medical drug or vaccine products and method thereof |
US6258062B1 (en) | 1999-02-25 | 2001-07-10 | Joseph M. Thielen | Enclosed container power supply for a needleless injector |
AU4656000A (en) * | 1999-04-22 | 2000-11-10 | Gilbert Garitano | Needleless permanent makeup and tattoo device |
US6210359B1 (en) | 2000-01-21 | 2001-04-03 | Jet Medica, L.L.C. | Needleless syringe |
US6406456B1 (en) * | 2000-06-08 | 2002-06-18 | Avant Drug Delivery Systems, Inc. | Jet injector |
US6669664B2 (en) * | 2001-09-07 | 2003-12-30 | Avant Drug Delivery Systems, Inc. | Vacuum control cycle for jet injector |
US6942638B1 (en) * | 2002-05-30 | 2005-09-13 | Kerry Quinn | Needleless injector and ampule system |
US20070027428A1 (en) * | 2005-05-03 | 2007-02-01 | Pharmajet, Inc. | Vial system and method for needle-less injector |
US7618393B2 (en) * | 2005-05-03 | 2009-11-17 | Pharmajet, Inc. | Needle-less injector and method of fluid delivery |
US7699802B2 (en) | 2005-05-03 | 2010-04-20 | Pharmajet, Inc. | Needle-less injector |
US20070055199A1 (en) | 2005-08-10 | 2007-03-08 | Gilbert Scott J | Drug delivery device for buccal and aural applications and other areas of the body difficult to access |
JP6032892B2 (ja) * | 2008-07-18 | 2016-11-30 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 皮内投与システムのためのカートリッジストッパー |
US9408972B2 (en) | 2011-08-02 | 2016-08-09 | Pharmajet, Inc. | Needle-free injection device |
KR102102176B1 (ko) | 2011-12-13 | 2020-04-21 | 파마젯 인코포레이티드 | 니들 프리 피내 주입 장치 |
WO2014150376A1 (en) * | 2013-03-15 | 2014-09-25 | Muffin Incorporated | Internal ultrasound assembly fluid seal |
TWI532511B (zh) * | 2013-08-16 | 2016-05-11 | 京華堂實業股份有限公司 | 無針型注射系統及其注射方法 |
CN106620966B (zh) * | 2016-11-28 | 2019-12-27 | 杨延萍 | 自动复位的无针注射器 |
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US1934046A (en) * | 1931-10-30 | 1933-11-07 | Demarchi Mario | Syringe for hypodermic medical injections |
US2743723A (en) * | 1954-06-03 | 1956-05-01 | George N Hein | Hypodermic injection apparatus |
DE957598C (de) * | 1954-02-02 | 1957-02-07 | Anton Batliner | Strahlinjektionsampulle |
US2945496A (en) * | 1958-08-18 | 1960-07-19 | Fosdal Alfred | Dental instrument for immobilizing tissue |
US3057349A (en) * | 1959-12-14 | 1962-10-09 | Ismach Aaron | Multi-dose jet injection device |
US3140713A (en) * | 1963-03-25 | 1964-07-14 | Ismach Aaron | Intradermal nozzle for jet injection devices |
US3167071A (en) * | 1961-07-17 | 1965-01-26 | Scherer Corp R P | Apparatus for administering intradermal injections |
US3189029A (en) * | 1960-08-04 | 1965-06-15 | Amalgamated Dental Co Ltd | Hypodermic injection apparatus |
US3424154A (en) * | 1965-11-08 | 1969-01-28 | Charles W Kinsley | Injection system |
US3490451A (en) * | 1967-11-13 | 1970-01-20 | Scherer Corp R P | Hypodermic jet injector nozzle |
US3515130A (en) * | 1966-09-21 | 1970-06-02 | Yuryo Kikakuhin Kenkyusho Kk | Jet-injection hypodermic device |
US3548830A (en) * | 1967-11-15 | 1970-12-22 | Dmb Apparatebau & Hans Mueller | Device for puncturing of stretched membrane skins |
US3688765A (en) * | 1969-10-03 | 1972-09-05 | Jack S Gasaway | Hypodermic injection device |
US3933155A (en) * | 1975-01-23 | 1976-01-20 | Mizzy Inc. | Pressure injector apparatus having improved trigger mechanism |
US3945383A (en) * | 1974-08-08 | 1976-03-23 | Smithkline Corporation | Unit dose ampul for jet injector |
US4284077A (en) * | 1974-11-19 | 1981-08-18 | Wolfgang Wagner | Suction injector having an adjustable dosing device |
-
1981
- 1981-07-08 US US06/281,436 patent/US4421508A/en not_active Expired - Fee Related
-
1982
- 1982-02-22 CA CA000396737A patent/CA1166537A/en not_active Expired
- 1982-02-23 IE IE387/82A patent/IE52560B1/en unknown
- 1982-02-23 FR FR8202942A patent/FR2500308A1/fr active Granted
- 1982-02-24 IT IT19841/82A patent/IT1190701B/it active
- 1982-02-24 GB GB08230416A patent/GB2109243B/en not_active Expired
- 1982-02-24 WO PCT/US1982/000230 patent/WO1982002835A1/en active Application Filing
Patent Citations (16)
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DE957598C (de) * | 1954-02-02 | 1957-02-07 | Anton Batliner | Strahlinjektionsampulle |
US2743723A (en) * | 1954-06-03 | 1956-05-01 | George N Hein | Hypodermic injection apparatus |
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US3167071A (en) * | 1961-07-17 | 1965-01-26 | Scherer Corp R P | Apparatus for administering intradermal injections |
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US3424154A (en) * | 1965-11-08 | 1969-01-28 | Charles W Kinsley | Injection system |
US3515130A (en) * | 1966-09-21 | 1970-06-02 | Yuryo Kikakuhin Kenkyusho Kk | Jet-injection hypodermic device |
US3490451A (en) * | 1967-11-13 | 1970-01-20 | Scherer Corp R P | Hypodermic jet injector nozzle |
US3548830A (en) * | 1967-11-15 | 1970-12-22 | Dmb Apparatebau & Hans Mueller | Device for puncturing of stretched membrane skins |
US3688765A (en) * | 1969-10-03 | 1972-09-05 | Jack S Gasaway | Hypodermic injection device |
US3945383A (en) * | 1974-08-08 | 1976-03-23 | Smithkline Corporation | Unit dose ampul for jet injector |
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US3933155A (en) * | 1975-01-23 | 1976-01-20 | Mizzy Inc. | Pressure injector apparatus having improved trigger mechanism |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0560856A1 (en) * | 1990-12-07 | 1993-09-22 | Sy-Quest International Limited | Jet injector for mass inoculation |
EP0560856A4 (en) * | 1990-12-07 | 1994-06-01 | Sy Quest Int Ltd | Jet injector for mass inoculation |
US5480381A (en) * | 1991-08-23 | 1996-01-02 | Weston Medical Limited | Needle-less injector |
EP2676691A2 (en) | 2005-11-17 | 2013-12-25 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
EP3058972A1 (en) | 2005-11-17 | 2016-08-24 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
EP2756756A1 (en) | 2008-04-28 | 2014-07-23 | Zogenix, Inc. | Novel formulations for treatment of migraine |
EP2829265A2 (en) | 2008-04-28 | 2015-01-28 | Zogenix, Inc. | Novel formulations for treatment of migraine |
EP3000462A1 (en) | 2008-04-28 | 2016-03-30 | Zogenix, Inc. | Novel formulations for treatment of migraine |
US8734384B2 (en) | 2010-09-15 | 2014-05-27 | Zogenix, Inc. | Needle-free injectors and design parameters thereof that optimize injection performance |
US9265888B2 (en) | 2010-09-15 | 2016-02-23 | Zogenix, Inc. | Needle-free injectors and design parameters thereof that optimize injection performance |
US9662449B2 (en) | 2010-09-15 | 2017-05-30 | Zogenix, Inc. | Needle-free injectors and design parameters thereof that optimize injection performance |
WO2014164754A1 (en) | 2013-03-11 | 2014-10-09 | Durect Corporation | Injectable controlled release composition comprising high viscosity liquid carrier |
Also Published As
Publication number | Publication date |
---|---|
IT1190701B (it) | 1988-02-24 |
GB2109243B (en) | 1985-01-16 |
US4421508A (en) | 1983-12-20 |
GB2109243A (en) | 1983-06-02 |
FR2500308B3 (sl) | 1984-01-06 |
FR2500308A1 (fr) | 1982-08-27 |
IT8219841A0 (it) | 1982-02-24 |
IE820387L (en) | 1982-08-24 |
CA1166537A (en) | 1984-05-01 |
IE52560B1 (en) | 1987-12-09 |
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