WO1981001445A1 - Pompe du type a systeme d'ecoulement continu a double effet - Google Patents

Pompe du type a systeme d'ecoulement continu a double effet Download PDF

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Publication number
WO1981001445A1
WO1981001445A1 PCT/US1980/001538 US8001538W WO8101445A1 WO 1981001445 A1 WO1981001445 A1 WO 1981001445A1 US 8001538 W US8001538 W US 8001538W WO 8101445 A1 WO8101445 A1 WO 8101445A1
Authority
WO
WIPO (PCT)
Prior art keywords
barrel
piston
rod
inlet
closed end
Prior art date
Application number
PCT/US1980/001538
Other languages
English (en)
Inventor
R Buckles
Original Assignee
Bionostics Sa
R Buckles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionostics Sa, R Buckles filed Critical Bionostics Sa
Priority to DE19803050038 priority Critical patent/DE3050038A1/de
Priority to NL8020473A priority patent/NL8020473A/nl
Publication of WO1981001445A1 publication Critical patent/WO1981001445A1/fr

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B5/00—Machines or pumps with differential-surface pistons
    • F04B5/02—Machines or pumps with differential-surface pistons with double-acting pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14212—Pumping with an aspiration and an expulsion action
    • A61M5/14216—Reciprocating piston type
    • A61M5/1422—Reciprocating piston type with double acting or multiple pistons

Definitions

  • This invention relates to a continuous pump and a system employing such a pump for the delivery of liquids to human patients and for veterinary purposes, for example, for blood and plasma transfusions, for the delivery of medication, for the supply of nutrients, etc.
  • One such apparatus or system which is one of the oldest, if not the oldest, is the fa ilar syringe having a fitting at its delivery and for a needle or for a tube leading to a catheter or needle.
  • the syringe may be mounted on a motor device designed to move the syringe barrel.
  • the piston In its simplest and most familar form, assuming that a needle is attached, the piston being in its bottom ⁇ most position and the rod and piston are then pulled out to draw in the desired quantity of the fluid to be dis ⁇ claimedd. Then the needle is inserted, for example,
  • OMPI intravenously or a catheter is inserted after having been fitted to a fitting at the delivery end of the barrel of the syringe.
  • the rod is then pushed inwardly by the mech ⁇ anized action of the motor carrying with it the piston and dispensing the fluid in the syringe.
  • a further disadvantage of such an apparatus derives from the need to make syringes with a long stroke, This leads to the need to assemble a rigid mechanical drive system that contains a high precision threaded shaft in order to move the rod at a constant rate over its full length of travel. In order to achieve the desired accu ⁇ racy these electromechanical devices must be fairly heavy and expensive.
  • Such a device would have the advantage of simplicity and it would obviate some of the more significant drawbacks of the syringe type of delivery apparatus. It is also desirable to provide such a pump which precludes microbial contamination.
  • the plunger has a rod which is reciprocated manually or which may be operated by machinery, As the plunger is lifted water is drawn by suction into the space in the barrel between the first check valve and the plunger, return of such water being prevented by the first check valve. During this upstroke water in the barrel occupying the annular space between the inner wall of the barrel and the rod is displaced and constitutes the por ⁇ tion of water delivered on the upstroke of the plunger. When the rod and plunger are caused to descend, the space between the rod and the aforesaid first check valve is diminished and the water displaced thereby flows upwardly through the valve in the plunger and into the annular space.
  • the invention presented herein is a pumping system for continuous delivery of fluid from a renewable source to a point of delivery, more particularly for delivery of medi ⁇ caments and biological fluids to human patients and animals.
  • the pumping system consists primarily of a syringe- type apparatus with an inlet end connected to a renewable reservoir of the fluid to be delivered, an outlet for egress of liquid from the barrel of the syringe to the patient or other point of delivery and a power source and mechanism which drives a reciprocating piston within the barrel.
  • the pum is also fitted with a fluid by-pass means connecting the inlet chamber in front of the piston to the annular chamber behind the piston, and appropriate valving such that fluid is delivered to the outlet continuously and at a substantially constant rate throughout the recipro ⁇ cating forward and return strokes of the piston.
  • the reciprocating action of the pump provides several advantages over the prior art.
  • This feature is a distinct improvement over certain devices in the prior art which deliver fluid only during the forward stroke of the piston, and thus require frequent refilling of the syringe, which can lead to contamination and entrapment of air.
  • the reciprocating action of the pump permits a rela- tively short piston stroke.
  • this improved pump and pumping system possesses a sealing means for sealing off that portion of the rod which projects from the barrel, such that contamina ⁇ tion of the fluid via exposure of the rod to external con ⁇ taminants is prevented.
  • sealing means allows recipro- eating movement of the rod, and may be in the form of ex ⁇ ternal flexible bellows, or an elastomeric sheath enclosing the rod within the barrel and attached to the end of the barrel.
  • This improvement is an advantage over prior art in that it prevents communication of contaminants to the con- tents of the syringe barrel during the working of the pump.
  • These seals further permit supplying the syringe in sterile form, completely enclosed and hermetically sealed so that when delivered it is completely sterile and can be connected with a drive means or piston and drive means without breaking the seal or exposing the working elements of the pump to contamination.
  • An additional advantage of the elastomeric sheath-type seal is the elimination of one sliding seal, and the consequent diminution of a shearing effect which may have a damaging effect on blood cells.
  • a further improvement consists in a fail-safe exter ⁇ nal valving system that ensures that liquid is not sup ⁇ plied to the patient by gravity in the event of any failure of the syringe pump described herein.
  • FIGURE 1 is a diagrammatic view of a system employing a continuous syringe pump
  • FIGURE 2 is a longitudinal section taken through the syringe pump
  • FIGURE 3 is a view similar to that of FIGURE 2 but showing a different valving system
  • FIGURE 4 is a longitudinal section through a syringe pump having yet a different design
  • FIGURE 5 is a fragmentary view of a modification of FIGURE 4.
  • FIGURE 6 is a fragmentary view of a different type of seal for the rod which operates the piston.
  • FIGURE 7 is a diagrammatic view of a valving system which is failsafe in that it ensures that one of two valves between the source of liquid and the patient is always closed.
  • FIGURE 8 illustrates another embodiment of the failsafe feature.
  • the system as a whole is designted by the reference numeral 10 and is comprises a syringe pump 11 connected by a tube 12 containing a check valve 13 to a supply of the fluid to be delivered, which is in a vessel, tank or other suitable container 14.
  • An outlet is shown at 15 which is connected to a hypodermic needle, to a catheter or other delivery instrument of well-known construction requiring no further description herein.
  • the rod of the syringe 11 (not shown in FIGURE 1) is connected by connecting means 16 to driving means 17 which is capable of imparting a reciprocating motion
  • the syringe 11 is shown as having a barrel 25 within which is a piston 26 having sealing lips 27 which seal against the interior surface of the barrel in sliding contact, and to which is attached a rod 28.
  • the rear end of the rod passes through and is in sliding contact with a stationary seal 29 having sealing lips 30 which seal against the rod.
  • a bellows type of seal 31 made of suit ⁇ able material such as rubber which is sealed circumfer- entially about the rear end of the barrel at 32 and is sealed at 32a to the rear surface of the rod 28.
  • the pur ⁇ pose of this seal is to keep the.rod sterile at all times and out of contact with the atmosphere as it moves in and out of the barrel.
  • the driving means 17 is shown as an electric motor 33 having a shaft 34 to which is affixed a cam 35.
  • the connector means 16 is shown as being con ⁇ nected at one end to the end of the rod 28 with the bellows intervening between the end of the connector member 16 and the rod.
  • a cam follower 36 which is held against the cam 35, as for example, by a spring or by a spring or by being received in a groove formed in a grooved cam.
  • the driving means 17, although shown in the form of a motor 33 and a cam 35, may be any other type of driving means such as, for example, a crank or a motor which is reversible and, by suitable con ⁇ trol means is caused to operate first in one direction and then in the other direction and having suitable means for converting rotary motion of the motor shaft into linear motion of the connecting member 16.
  • suitable gear reduction means may be employed or that the motor may be a variable speed motor, all to the end of operating the rod 28, the piston
  • an inlet pass ⁇ age 41 is provided at the front end (or lefthand end as ' viewed in FIGURE 2) of the rod 28, which is connected by a check valve 42 to an outlet passage 43, thus providing a one-way path (from left to right as viewed in FIGURE 2) from the interior of the barrel on the left of the piston (space A) to the annular space (space B) on the right of the piston.
  • the fluid displaced in space A by such forward stroke is equal to the product of the cross-sectional area of space A (that is to say, the cross-sectional area of the interior of the syringe barrel) and the length of the forward stroke of the pis ⁇ ton.
  • This displaced liquid can pass only through one-way passages 41 and 43 and check valve 42 into space B.. In ⁇ asmuch as this volume of liquid exceeds the expansion of space B due to the difference is cross-sectional areas of A and B, the surplus will be delivered through the outlet 15 to the patient.
  • the syringe pump is a true, double acting piston pump which can be made to operate very slowly or fast and, if an adequate supply of liquid is maintained in vessel 1 14, delivery can be main ⁇ tained for a long period of time.
  • the fluid is vessel 14 can be replenished without interrupting the delivery of liquid to a patient, e.g,. by refilling it when the liquid level is low. Such refilling can be carried out under controlled, sterile conditions, and the frequency of re ⁇ filling diminishes the chance of contamination.
  • the bellows 31 isolates the only part of the pump which alter ⁇ nately contacts the liquid being delivered and the exterior air space around the syringe.
  • A signifies the space in barrel 25 to the left of the piston 26. This is a variable quantity depending upon the position of the piston.
  • B signifies the annular space within the barrel to the right of the piston and surrounding the rod 28 and to the left of the seal 29. This is also a variable space depending upon the position of the piston.
  • D is the inside diameter of the barrel 25.
  • d is the outside diameter of the rod 28.
  • L is the length of stroke of piston 26.
  • V- is the volume of liquid delivered to the outlet 15 by the stroke of piston 28 from left to right, herein called the "return" stroke.
  • V,- Is the volume of liquid delivered to the outlet 15 by the stroke from right to left, herein called the "forward" stroke.
  • V. TT D L IT D 2 - IT d 2 IT
  • FIGURE 3 depicts an alternative design.
  • the syringe is very similar to the syringe 11 of FIGURE 2. Similar or identical parts bear the same reference numerals.
  • the inlet conduit 12 is connected by check valve 13 to a con ⁇ duit segment 50 which is fitted at one end to the check valve 13 and at its other end to the inlet of the barrel 25.
  • This conduit segment has a branch conduit 51.
  • this syringe functions as follows: on the forward stroke liquid in space A is forced to the left into the conduit segment 50 and through conduit 51 to the junction with outlet conduit 15. A portion of this
  • the. barrel 25 may be of glass or suitable plastic such as polyethylene, polystyrene, polystyrene acrylonitrile, or polypropylene. It is generally considered important to use a material with adequate transparency to permit visual inspection.
  • the rod 28 may be constructed of metal, for example, stainless steel or an aluminum alloy or plastic material such as polystyrene or polyethylene.
  • the piston 26 and the seal 29 may be constructed of rubber, either synthetic or natural, having a suitable balance between hardness and flexibility to permit their proper operation. Syringes available commercially, of which there are a variety, may be adapted for use in the present invention.
  • the bellows may be constructed of rubber and it may also be constructed of a plastic material such as polyethylene, poly(ethylene-vinyl acetate), polyvinyl- chloride, polypropylene, etc., such being constructed to act as a bellows.
  • the various valves may be constructed of materials suitable for valves brought into contact with biological and other fluids intended to be injected into a human patient.
  • the syringe 11, with or without the motive means 17 may be supplied in sterile form and completely enclosed and hermetically sealed so that when delivered, it is com ⁇ pletely sterile. It may be rigidly attached to reservoir 14 or it may be equipped with a means to connect to a separate reservoir.
  • the syringe may be provided with the inlet and outlet tubes 12 (fitted with a check valve) and 15 which in turn may have fittings to * connect to a vessel 14 (in the case of conduit 12) or to a needle or catheter (in the case of conduit 15) .
  • the embodiment shown in FIGURE 3 may be similarly provided such that only two connections need be made, i.e., to a supply of liquid to be delivered and to a needle or catheter.
  • the syringe may also be packaged with the drive ready to plug into a power source.
  • the syringe and all of the spaces through which liquid flows are primed. This is easily accomplished with the fluid from the reservoir by moving the plunger to and fro. Once primed the tubing is attached to the patient and infusion therapy begun.
  • FIGURE 4 an alternative form of syringe is there shown and is denerally designated by the reference numeral 60. It comprises a barrel 61 having an inside diameter D. Within the barrel is a piston 62 com ⁇ prising a disc 63 which may be integral with the rod 64.
  • O.V. Affixed to the piston is a combined seal and valve 65 whose inner lips 66 are fixed to the rod 64 and whose outer lips 67 are in sliding contact with the inner sur ⁇ face of the barrel 61 such that upon the down or forward stroke fluid displaced from chamber A passes into chamber B. On the up or return stroke the outer lips 67 seal against the barrel. Also shown is a stationary seal 68 affixed to the barrel and in sliding, sealing contact with the rod 54. An inlet conduit 69 is shown which may con- tain a check valve as in FIGURE 2 or as shown in FIGURE 3.
  • the check valve may be in the form of a simple disc 70 whose buoyancy is such that it will easily float and be forced upwardly on the upward stroke of the piston 63 to allow entry of the fluid to be dispensed, and such that upon the down or forward stroke of the piston it will seal the conduit 69 and prevent flow- of liquid through that conduit.
  • a check valve such as shown in FIGURE 2 may be incorporated in the conduit 69 or the valve disc 70 may be provided with a stem to extend into the conduit 69. An outlet 71 is shown. The operation of the valve will be apparent from the description above and the description of FIGURE 2.
  • FIGURE 5 an alternative type of seal and valve is shown, generally designated by the reference symbol 75 which is received in a groove 76 at the junction of the rod 64 and the disc 63, and which has an outer cylindrical lip 77 which functions as a combined seal and valve as in FIGURE 4.
  • cylindrical barrels, pistons and such are preferred, other shapes, e.g., ellip ⁇ tical and polygonal, may be used, so long as a reliable sliding seal may be achieved.
  • a syringe pump is shown and is generally designated by the reference number 80. It comprises a barrel 81 and a piston 82 reciprocable in the barrel, and to which a rod 83 is attached as des- cribed hereinafter.
  • An end fitting 84 is provided having an axial opening 85 within which the rod 83 may freely slide. This fitting need not be a tight fitting and need serve only as a guide for the rod 83.
  • a combined seal and closure is provided by an elastomeric sheath 86 which is anchored at 87 in an annular groove 88 formed in the fitting 84. The sheath 86 extends around the inner end of the rod 83.
  • the inner end of the rod is connected to the piston 82 by, for example, a ball and socket joint consisting of a -ball 89 formed at the inner extremity of the rod and a socket 90 formed in the piston.
  • Valving such as shown in FIGURE 2 or in FIGURE 3 is provided, such valving not being shown in FIGURE 6.
  • An advantage of this construction is that it elim ⁇ inates one sliding seal, namely, the seal 29 in FIGURES 2 and 3. Such seals may have a shearing effect on liquid which may have a damaging effect on blood cells.
  • the seal provided by the sheath 86 does not have a shear ⁇ ing effect.
  • This construction is especially suited to a low volume rate of pumping which does not require an ex- cessive rate of stretching of the sheath.
  • the sheath may be made of rubber or any other suitable elastomeric material which is capable of repeated stretching to a sufficient degree to provide the necessary pumping action without imposing excessive strain on the material of the seal.
  • the ball and socket connection between rod 83 and piston 82 may be a snap fit permitting attachment and detachment of the rod.
  • the rod 83 may be an integral part of the drive, e.g., it may be connected to a motor such as 33, and a cam such as 34 (see FIGURE 2).
  • the barrel 81, piston 82, sheath 86 and necessary inlet and outlet ducts and valving may be a disposable unit to which the rod 83 is fitted at the time of use and disconected after use.
  • FIGURE 7 a system is shown which is designated by the reference numbe a1 100 and which com ⁇ prises an external valving system 101.
  • a syringe 102 having a barrel 102a, a piston 103 and a rod 104 is pro ⁇ vided.
  • the barrel is connected at one end to a duct 105 which communicates with chamber A and at its other end it is connected to a duct 106 which communicates with chamber B. These ducts in turn connect with a tube 107 having an inlet 108 and an outlet 109.
  • the external, fail-safe valving system 101 includes the tube 107 and a pair of valves 110 and 111. Valve 110 is upstream from duct 105 and the valve 111 is downstream from duct 105 but upstream from duct 106. Each valve includes a valve seat 112 and a valve member 113. The valve members 113 are connected by a rigid rod 114 such that the two valves operate in unison. The arrangement is such that when one valve is closed, the other valve is open.
  • a spring 115 anchored at one end to valve member 113 of valve 110 and at its other end to the tube 101 acts normally tc open valve 110 and to close valve 111.
  • piston 103 makes its forward stroke to the left, it forces liquid through duct 105 Into duct 107 and acts against the force of spring 115 to open valve 111 and to close valve 110. This supplies liquid to outlet 109 and thence to the patient.
  • piston 103 makes its return stroke to the right, it forces liquid through duct 106.
  • FIGURE 8 another valving system Is shown, generally designated by the reference numeral 130. Its purpose is the same as that in FIGURE ⁇ i ⁇ , but the method of construction is intrinsically cheaper.
  • the syringe pump comprises a barrel 131, a piston 132 and a rod 133.
  • An inlet tube is shown at 134 and an outlet tube at 135, these being connected by a segment of tube 136 which is located between inlet duct 137 to the syringe barrel and outlet duct 138 from the syringe barrel.
  • These two ducts are connected to the tubing 134, 136, 135.
  • Tubing 134 and 136 are made of thin-walled collapsible material.
  • An automatic valving system is provided by a solenoid operated device generally designated by the reference number 140.
  • This comprises pads 141 and 142 connected by a rigid rod 143 and rocking on a fulcrum 144. These pads are of magnetic material and are acted upon by coils 145 and 146 respectively having cores 145a and 146a.
  • the apparatus 140 may be of any known commercially avail ⁇ able type in which direct electric current is supplied alternately to the coils 145 and 146 at a frequency which is adjustable and is compatible with the desired pumping rate.
  • FIGURES 7 and 8 are similar to that of FIGURE 3 but that by reason of their fail-safe valving one valve is always closed. Therefore if, , by chance, the vessel 14 is suspended at an excessive height above the connection to the patient, the danger of bypassing the syringe pump should it fail is prevented.
  • FIGURES 7 and 8 could be used with syringes of alternative design such as in FIGURES 3 and 6. It will be understood that in the embodiment of FIGURES 4, 5, 7 and 8 seals such as shown in FIGURES 2, 3 and 6 may be used to prevent contamination of that part of the rod which pro ⁇ jects from the syringe barrel.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Mechanical Engineering (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Systeme ameliore d'alimentation de fluide (10) pour l'alimentation en continu et sensiblement constante de liquides tels que des liquides medicamenteux, nutritifs, sanguins, de plasma, etc. a partir d'un reservoir (14) a des animaux ou des patients, lesquels systemes utilisent un mecanisme du type a seringue (11) avec un piston a mouvements alternatifs (26). Un passage (43) et une soupape appropriee (13 et 42) permettent une alimentation constante et reguliere de fluide par le mouvement alternatif du piston. Un autre objet est de fournir des moyens d'etancheite qui empechent la contamination du fluide et des elements internes de travail de la pompe a tous les stades d'utilisation et de fonctionnement de la pompe, par exposition de la tige d'entrainement aux substances contaminantes exterieures. Un autre objet est de fournir un systeme de soupape externe sans defaillance (101) qui assure que le fluide n'aille pas au patient par gravite depuis le reservoir dans le cas d'une defaillance de la pompe.
PCT/US1980/001538 1979-11-19 1980-11-18 Pompe du type a systeme d'ecoulement continu a double effet WO1981001445A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE19803050038 DE3050038A1 (de) 1979-11-19 1980-11-18 Double acting continuous flow system type pump
NL8020473A NL8020473A (fr) 1979-11-19 1980-11-18

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9523079A 1979-11-19 1979-11-19
US95230 1979-11-19

Publications (1)

Publication Number Publication Date
WO1981001445A1 true WO1981001445A1 (fr) 1981-05-28

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ID=22250808

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1980/001538 WO1981001445A1 (fr) 1979-11-19 1980-11-18 Pompe du type a systeme d'ecoulement continu a double effet

Country Status (5)

Country Link
EP (1) EP0040250A4 (fr)
CA (1) CA1170532A (fr)
GB (1) GB2074665B (fr)
NL (1) NL8020473A (fr)
WO (1) WO1981001445A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0471782A1 (fr) * 1989-05-04 1992-02-26 Leocor Inc Pompe sanguine.
EP0477172A1 (fr) * 1987-06-26 1992-04-01 Pump Controller Corporation Pompe de transfusion
EP0654278A2 (fr) * 1993-11-23 1995-05-24 Sarcos Group Pompe volumétrique et soupape
EP0901386A1 (fr) * 1995-05-04 1999-03-17 Sarcos, Inc. Systeme d'administration topique de fluide a piston et a montage rapide
WO2013038164A3 (fr) * 2011-09-15 2013-12-27 Oxford Nanopore Technologies Limited Joint de piston
US9593370B2 (en) 2010-10-01 2017-03-14 Oxford Nanopore Technologies Ltd. Biochemical analysis apparatus and rotary valve
US10054234B2 (en) 2011-07-13 2018-08-21 Oxford Nanopore Technologies Limited One-way valve

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ304230B6 (cs) * 2009-08-11 2014-01-15 Vysoké učení technické v Brně, Fakulta strojního inženýrství Pístové čerpadlo, zejména čerpadlo na krev

Citations (3)

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US1128089A (en) * 1913-03-17 1915-02-09 Fort Wayne Engineering And Mfg Company Differential pump.
US4116115A (en) * 1976-03-30 1978-09-26 Wabco Westinghouse Gmbh Bellows for sealing off the piston rod passage in an operating cylinder
US4162616A (en) * 1976-04-02 1979-07-31 Tokico Ltd. Hydraulic master cylinder

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DE835239C (de) * 1944-12-03 1952-03-31 Maschf Augsburg Nuernberg Ag Dichtung
FR1075780A (fr) * 1952-04-26 1954-10-20 Perfectionnements aux pompes différentielles
CH348049A (fr) * 1958-09-22 1960-07-31 Berthoud & Cie S A Pompe à piston, notamment pour pulvérisateur de liquide
GB958171A (en) * 1962-07-27 1964-05-13 Weltis Engineering Company Ltd Improvements in or relating to double-acting reciprocating pumps for liquids
DE1557074A1 (de) * 1966-09-16 1971-04-29 Reece Corp Chemische Einrichtung fuer proportionales Mischen von Fluessigkeiten
US3391646A (en) * 1967-09-28 1968-07-09 Paul W. Schlosser Piston assembly for pump
ES234032Y (es) * 1978-02-17 1979-01-01 Dispositivo de bombeo para infusiones en aplicaciones medi- cas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1128089A (en) * 1913-03-17 1915-02-09 Fort Wayne Engineering And Mfg Company Differential pump.
US4116115A (en) * 1976-03-30 1978-09-26 Wabco Westinghouse Gmbh Bellows for sealing off the piston rod passage in an operating cylinder
US4162616A (en) * 1976-04-02 1979-07-31 Tokico Ltd. Hydraulic master cylinder

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP0040250A4 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0477172A1 (fr) * 1987-06-26 1992-04-01 Pump Controller Corporation Pompe de transfusion
EP0477172A4 (en) * 1987-06-26 1992-08-12 Pump Controller Corporation Infusion pump
EP0471782A1 (fr) * 1989-05-04 1992-02-26 Leocor Inc Pompe sanguine.
EP0471782A4 (en) * 1989-05-04 1992-06-24 Leocor, Inc. Blood pump
EP0654278A2 (fr) * 1993-11-23 1995-05-24 Sarcos Group Pompe volumétrique et soupape
EP0654278A3 (fr) * 1993-11-23 1996-03-13 Sarcos Group Pompe volumétrique et soupape.
US6224572B1 (en) 1995-05-04 2001-05-01 Sarcos L.C. Piston-actuated attachable topical fluid delivery system
EP0901386A4 (fr) * 1995-05-04 1999-03-17
EP0901386A1 (fr) * 1995-05-04 1999-03-17 Sarcos, Inc. Systeme d'administration topique de fluide a piston et a montage rapide
US9593370B2 (en) 2010-10-01 2017-03-14 Oxford Nanopore Technologies Ltd. Biochemical analysis apparatus and rotary valve
US10036065B2 (en) 2010-10-01 2018-07-31 Oxford Nanopore Technologies Limited Biochemical analysis apparatus and rotary valve
US10054234B2 (en) 2011-07-13 2018-08-21 Oxford Nanopore Technologies Limited One-way valve
WO2013038164A3 (fr) * 2011-09-15 2013-12-27 Oxford Nanopore Technologies Limited Joint de piston
CN103930144A (zh) * 2011-09-15 2014-07-16 牛津纳米孔技术有限公司 活塞密封件
US9551338B2 (en) 2011-09-15 2017-01-24 Oxford Nanopore Technologies Ltd. Pump
US10342589B2 (en) 2011-09-15 2019-07-09 Oxford Nanopore Technologies Ltd. Pump
US10596322B2 (en) 2011-09-15 2020-03-24 Oxford Nanopore Technologies Ltd. Pump
US10675412B2 (en) 2011-09-15 2020-06-09 Oxford Nanopore Technologies Limited Piston seal

Also Published As

Publication number Publication date
GB2074665A (en) 1981-11-04
NL8020473A (fr) 1981-10-01
EP0040250A4 (fr) 1982-03-10
EP0040250A1 (fr) 1981-11-25
GB2074665B (en) 1983-11-09
CA1170532A (fr) 1984-07-10

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