UY36664A - Procedimiento para la preparación de 2-{4-[2-({[2-(4-clorofenil)-1,3-tiazol-4-il]metil}sulfanil)-3,5-diciano-6-(pirrolidin-1-il)piridina-4-il]fenoxi}etil-l-alanil-l-alaninato-monohidrocloruro - Google Patents
Procedimiento para la preparación de 2-{4-[2-({[2-(4-clorofenil)-1,3-tiazol-4-il]metil}sulfanil)-3,5-diciano-6-(pirrolidin-1-il)piridina-4-il]fenoxi}etil-l-alanil-l-alaninato-monohidrocloruroInfo
- Publication number
- UY36664A UY36664A UY0001036664A UY36664A UY36664A UY 36664 A UY36664 A UY 36664A UY 0001036664 A UY0001036664 A UY 0001036664A UY 36664 A UY36664 A UY 36664A UY 36664 A UY36664 A UY 36664A
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- chlorophenyl
- methyl
- monohidrocloruro
- dician
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
La presente solicitud se refiere a un procedimiento nuevo y mejorado para la preparación del compuesto 2- {4-[2-({[2-(4-clorofenil)-1,3-tiazol-4-il]metil}sulfanil)-3,5-diciano-6-(pirrolidin-1-il)piridina-4- 5 il]fenoxi}etil-L-alanil-L-alaninato-monohidrocloruro de la fórmula (I),nuevas fases previas para su preparación y la preparación y uso de la modificación cristalina I de 2-{4-[2-({[2- (4-clorofenil)-1,3-tiazol-4-il]metil}sulfanil)-3,5-diciano-6-(pirrolidin-1-il)piridina-4-il]fenoxi}etil-L-alanil-Lalaninato-monohidrocloruro de la fórmula (I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15166606 | 2015-05-06 | ||
EP15192030 | 2015-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY36664A true UY36664A (es) | 2016-11-30 |
Family
ID=55969107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001036664A UY36664A (es) | 2015-05-06 | 2016-05-02 | Procedimiento para la preparación de 2-{4-[2-({[2-(4-clorofenil)-1,3-tiazol-4-il]metil}sulfanil)-3,5-diciano-6-(pirrolidin-1-il)piridina-4-il]fenoxi}etil-l-alanil-l-alaninato-monohidrocloruro |
Country Status (32)
Country | Link |
---|---|
US (1) | US20180155336A1 (es) |
EP (1) | EP3292133B1 (es) |
JP (1) | JP2018516882A (es) |
KR (1) | KR20180002698A (es) |
CN (1) | CN107531688A (es) |
AU (1) | AU2016268920A1 (es) |
BR (1) | BR112017023852A2 (es) |
CA (1) | CA2984984A1 (es) |
CL (1) | CL2017002764A1 (es) |
CO (1) | CO2017011294A2 (es) |
CU (1) | CU20170136A7 (es) |
DK (1) | DK3292133T3 (es) |
EA (1) | EA201792422A1 (es) |
EC (1) | ECSP17072780A (es) |
ES (1) | ES2744227T3 (es) |
HK (1) | HK1246290A1 (es) |
HR (1) | HRP20191596T1 (es) |
HU (1) | HUE044787T2 (es) |
IL (1) | IL255208A0 (es) |
LT (1) | LT3292133T (es) |
MA (1) | MA42039A (es) |
MX (1) | MX2017014134A (es) |
PE (1) | PE20180204A1 (es) |
PH (1) | PH12017502010A1 (es) |
PL (1) | PL3292133T3 (es) |
PT (1) | PT3292133T (es) |
SG (1) | SG11201708747PA (es) |
SI (1) | SI3292133T1 (es) |
TN (1) | TN2017000466A1 (es) |
TW (1) | TW201713651A (es) |
UY (1) | UY36664A (es) |
WO (1) | WO2016188711A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018108884A1 (de) | 2016-12-16 | 2018-06-21 | Bayer Pharma Aktiengesellschaft | Pharmazeutische tablettenformulierung |
WO2019180072A1 (en) | 2018-03-22 | 2019-09-26 | Bayer Pharma Aktiengesellschaft | Parenteral pharmaceutical composition comprising neladenoson bialanate |
TWI721449B (zh) * | 2019-06-11 | 2021-03-11 | 行政院原子能委員會核能研究所 | 2-[[2-[[[3-(4-氯苯基)-8-甲基-8-氮雜雙環[3.2.1]-辛-2-基]-甲基](2-巰基乙基)胺基]乙基]胺基]乙硫醇-[1r(外向-外向)]三鹽酸化物之純化方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10238113A1 (de) * | 2001-12-11 | 2003-06-18 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung |
DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
US20120058983A1 (en) * | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
-
2016
- 2016-05-02 PL PL16722584T patent/PL3292133T3/pl unknown
- 2016-05-02 UY UY0001036664A patent/UY36664A/es not_active Application Discontinuation
- 2016-05-02 ES ES16722584T patent/ES2744227T3/es active Active
- 2016-05-02 KR KR1020177033435A patent/KR20180002698A/ko unknown
- 2016-05-02 DK DK16722584.6T patent/DK3292133T3/da active
- 2016-05-02 WO PCT/EP2016/059779 patent/WO2016188711A1/de active Application Filing
- 2016-05-02 JP JP2017557439A patent/JP2018516882A/ja active Pending
- 2016-05-02 SI SI201630320T patent/SI3292133T1/sl unknown
- 2016-05-02 TN TNP/2017/000466A patent/TN2017000466A1/en unknown
- 2016-05-02 BR BR112017023852-7A patent/BR112017023852A2/pt not_active Application Discontinuation
- 2016-05-02 MA MA042039A patent/MA42039A/fr unknown
- 2016-05-02 US US15/568,575 patent/US20180155336A1/en not_active Abandoned
- 2016-05-02 EP EP16722584.6A patent/EP3292133B1/de active Active
- 2016-05-02 PE PE2017002369A patent/PE20180204A1/es unknown
- 2016-05-02 CN CN201680026200.1A patent/CN107531688A/zh active Pending
- 2016-05-02 PT PT16722584T patent/PT3292133T/pt unknown
- 2016-05-02 CA CA2984984A patent/CA2984984A1/en not_active Abandoned
- 2016-05-02 LT LTEP16722584.6T patent/LT3292133T/lt unknown
- 2016-05-02 HU HUE16722584 patent/HUE044787T2/hu unknown
- 2016-05-02 SG SG11201708747PA patent/SG11201708747PA/en unknown
- 2016-05-02 AU AU2016268920A patent/AU2016268920A1/en not_active Abandoned
- 2016-05-02 CU CUP2017000136A patent/CU20170136A7/es unknown
- 2016-05-02 MX MX2017014134A patent/MX2017014134A/es unknown
- 2016-05-02 EA EA201792422A patent/EA201792422A1/ru unknown
- 2016-05-04 TW TW105113790A patent/TW201713651A/zh unknown
-
2017
- 2017-10-23 IL IL255208A patent/IL255208A0/en unknown
- 2017-10-31 EC ECIEPI201772780A patent/ECSP17072780A/es unknown
- 2017-11-02 CL CL2017002764A patent/CL2017002764A1/es unknown
- 2017-11-02 CO CONC2017/0011294A patent/CO2017011294A2/es unknown
- 2017-11-03 PH PH12017502010A patent/PH12017502010A1/en unknown
-
2018
- 2018-05-07 HK HK18105816.1A patent/HK1246290A1/zh unknown
-
2019
- 2019-09-04 HR HRP20191596 patent/HRP20191596T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
HK1246290A1 (zh) | 2018-09-07 |
AU2016268920A1 (en) | 2017-11-09 |
PT3292133T (pt) | 2019-09-18 |
CA2984984A1 (en) | 2016-12-01 |
SG11201708747PA (en) | 2017-11-29 |
CU20170136A7 (es) | 2018-02-08 |
CN107531688A (zh) | 2018-01-02 |
TN2017000466A1 (en) | 2019-04-12 |
BR112017023852A2 (pt) | 2018-07-17 |
HRP20191596T1 (hr) | 2019-11-29 |
SI3292133T1 (sl) | 2019-08-30 |
CL2017002764A1 (es) | 2018-05-25 |
JP2018516882A (ja) | 2018-06-28 |
MA42039A (fr) | 2018-03-14 |
MX2017014134A (es) | 2018-03-15 |
IL255208A0 (en) | 2017-12-31 |
EP3292133A1 (de) | 2018-03-14 |
EA201792422A1 (ru) | 2018-02-28 |
ES2744227T3 (es) | 2020-02-24 |
WO2016188711A1 (de) | 2016-12-01 |
PE20180204A1 (es) | 2018-01-31 |
TW201713651A (zh) | 2017-04-16 |
EP3292133B1 (de) | 2019-06-26 |
DK3292133T3 (da) | 2019-09-23 |
KR20180002698A (ko) | 2018-01-08 |
PL3292133T3 (pl) | 2019-12-31 |
PH12017502010A1 (en) | 2018-03-26 |
CO2017011294A2 (es) | 2018-01-16 |
ECSP17072780A (es) | 2017-12-01 |
LT3292133T (lt) | 2019-08-26 |
US20180155336A1 (en) | 2018-06-07 |
HUE044787T2 (hu) | 2019-11-28 |
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Legal Events
Date | Code | Title | Description |
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109 | Application deemed to be withdrawn |
Effective date: 20221114 |