UY32561A - DERIVATIVES OF N - [(7-AZA-BICICLO [2.2.1] HEPT-1-IL) -ARIL-METIL] -BENZAMIDA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS. - Google Patents

DERIVATIVES OF N - [(7-AZA-BICICLO [2.2.1] HEPT-1-IL) -ARIL-METIL] -BENZAMIDA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS.

Info

Publication number
UY32561A
UY32561A UY0001032561A UY32561A UY32561A UY 32561 A UY32561 A UY 32561A UY 0001032561 A UY0001032561 A UY 0001032561A UY 32561 A UY32561 A UY 32561A UY 32561 A UY32561 A UY 32561A
Authority
UY
Uruguay
Prior art keywords
alkyl
groups
alkoxy
cycloalkyl
halo
Prior art date
Application number
UY0001032561A
Other languages
Spanish (es)
Inventor
Gihad Dargazanli
Estenne-Bouhtou Genevieve
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of UY32561A publication Critical patent/UY32561A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos de fórmula (I): en la que:- R representa un átomo de hidrógeno o un grupo elegido entre los grupos alquilo(C1-C6), cicloalquilo (C3-C7), opcionalmente sustituido con uno o varios grupos elegidos independientemente entre sí entre el átomo de flúor, los grupos cicloalquilo(C3-C7), alquenilo(C2-C4), fenilo, alcoxi(C1.C6), hidroxi; el grupo fenilo está opcionalmente sustituido con uno o varios grupos alcoxi(C1-C6);-R1 representa un grupo fenilo opcionalmente sustituido con uno o varios sustituyentes elegidos independientemente entre sí entre los átomos de halógeno, los grupos alquilo(C1-C6), alcoxi(C1-C6), halo-alquilo(C1-C6), hidroxi, halo.alcoxi(C1-C6)-SO2,-R2 representa uno o varios sustituyentes elegidos entre el átomo de hidrógeno, los átomos de halógeno, los grupos halo-alquilo(C1-C6), alquilo(C1-C6), cicloalquilo(C3-C7), cicloalqui(C3-C7)-alquilo(C1-C3), alcoxi(C1-C6), alquil(C1-C6)-tio, alquil(C1-C6)-SO2; en forma de base o de sal de adición a un ácido. Utilización en terapéutica y procedimiento de síntesis.Compounds of formula (I): in which: - R represents a hydrogen atom or a group selected from the (C1-C6) alkyl, cycloalkyl (C3-C7) groups, optionally substituted with one or more groups independently selected from each other among the fluorine atom, the cycloalkyl (C3-C7), alkenyl (C2-C4), phenyl, alkoxy (C1.C6), hydroxy groups; the phenyl group is optionally substituted with one or more (C1-C6) alkoxy groups; - R1 represents a phenyl group optionally substituted with one or more substituents independently selected from each other among the halogen atoms, the (C1-C6) alkyl groups, (C1-C6) alkoxy, halo (C1-C6) alkyl, hydroxy, halo.C1-C6 alkoxy -SO2, -R2 represents one or more substituents chosen from the hydrogen atom, the halogen atoms, the groups halo (C1-C6) alkyl, (C1-C6) alkyl, (C3-C7) cycloalkyl, (C3-C7) cycloalkyl (C1-C3) alkyl, (C1-C6) alkoxy, (C1-C6) alkyl -thio, (C1-C6) alkyl -SO2; as a base or an acid addition salt. Use in therapeutic and synthetic procedure.

UY0001032561A 2009-04-14 2010-04-14 DERIVATIVES OF N - [(7-AZA-BICICLO [2.2.1] HEPT-1-IL) -ARIL-METIL] -BENZAMIDA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS. UY32561A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0901809A FR2944284A1 (en) 2009-04-14 2009-04-14 N- (7-AZA-BICYCLO) 2.2.1! HEPT-1-YL) -LARYL-METHYL DERIVATIVES -BENZAMIDE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
UY32561A true UY32561A (en) 2010-11-30

Family

ID=41228015

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032561A UY32561A (en) 2009-04-14 2010-04-14 DERIVATIVES OF N - [(7-AZA-BICICLO [2.2.1] HEPT-1-IL) -ARIL-METIL] -BENZAMIDA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS.

Country Status (14)

Country Link
EP (1) EP2419431A1 (en)
JP (1) JP2012523448A (en)
KR (1) KR20120013378A (en)
AR (1) AR076276A1 (en)
AU (1) AU2010238409A1 (en)
BR (1) BRPI1015484A2 (en)
CA (1) CA2758367A1 (en)
FR (1) FR2944284A1 (en)
IL (1) IL215673A0 (en)
MX (1) MX2011010929A (en)
SG (1) SG175222A1 (en)
TW (1) TW201041581A (en)
UY (1) UY32561A (en)
WO (1) WO2010119222A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160045182A (en) 2014-10-16 2016-04-27 현대자동차주식회사 Gray cast iron for cylinder liner and method for manufacturing cylinder liner using the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2842804B1 (en) * 2002-07-29 2004-09-03 Sanofi Synthelabo N- [PHENYL (PIPERIDIN-2-YL) METHYL] BENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2861076B1 (en) * 2003-10-17 2006-01-06 Sanofi Synthelabo N-HETEROCYCLYMETHYLBENZAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
WO2008065500A2 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
WO2009013535A1 (en) * 2007-07-23 2009-01-29 Astrazeneca Ab 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor

Also Published As

Publication number Publication date
AU2010238409A1 (en) 2011-11-03
MX2011010929A (en) 2011-11-02
IL215673A0 (en) 2012-01-31
BRPI1015484A2 (en) 2016-04-26
JP2012523448A (en) 2012-10-04
EP2419431A1 (en) 2012-02-22
KR20120013378A (en) 2012-02-14
SG175222A1 (en) 2011-11-28
CA2758367A1 (en) 2010-10-21
TW201041581A (en) 2010-12-01
AR076276A1 (en) 2011-06-01
WO2010119222A1 (en) 2010-10-21
FR2944284A1 (en) 2010-10-15

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Effective date: 20150601