MX2009002802A - 2-aryl-6-phenylimidazo[1,2-î±]pyridine derivatives, preparation thereof and therapeutic use thereof. - Google Patents

2-aryl-6-phenylimidazo[1,2-î±]pyridine derivatives, preparation thereof and therapeutic use thereof.

Info

Publication number
MX2009002802A
MX2009002802A MX2009002802A MX2009002802A MX2009002802A MX 2009002802 A MX2009002802 A MX 2009002802A MX 2009002802 A MX2009002802 A MX 2009002802A MX 2009002802 A MX2009002802 A MX 2009002802A MX 2009002802 A MX2009002802 A MX 2009002802A
Authority
MX
Mexico
Prior art keywords
optionally substituted
cycloalkyl
aryl
phenylimidazo
preparation
Prior art date
Application number
MX2009002802A
Other languages
Spanish (es)
Inventor
Antonio Almario Garcia
Patrick Lardenois
Anne Olivier
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2009002802A publication Critical patent/MX2009002802A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

The invention relates to the derivatives of general formula (I) in which: R1 is: a phenyl group or a naphthyl group, it being possible for these two groups to be optionally substituted; R2 and R3 are, independently of one another, a hydrogen atom, a (C1-C6)alkyl, (C3-C7)cycloalkyl or (C3-C7)cycloalkyl(C1-C3) alkylene group, which is optionally substituted; an optionally substituted aryl group; R4 is: a hydrogen atom, a (C1-C6)alkyl, (C3-C7)cycloalkyl or (C3-C7)cycloalkyl(C1-C3) alkylene group, which is optionally substituted; an aryl group optionally substituted with one or more substituents in the form of a base or of an addition salt with an acid.
MX2009002802A 2006-09-22 2007-09-19 2-aryl-6-phenylimidazo[1,2-î±]pyridine derivatives, preparation thereof and therapeutic use thereof. MX2009002802A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0608350A FR2906250B1 (en) 2006-09-22 2006-09-22 DERIVATIVES OF 2-ARYL-6PHENYL-IMIDAZO (1,2-A) PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
PCT/FR2007/001517 WO2008034974A1 (en) 2006-09-22 2007-09-19 2-ARYL-6-PHENYLIMIDAZO[1,2-α]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

Publications (1)

Publication Number Publication Date
MX2009002802A true MX2009002802A (en) 2009-04-01

Family

ID=37841968

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002802A MX2009002802A (en) 2006-09-22 2007-09-19 2-aryl-6-phenylimidazo[1,2-î±]pyridine derivatives, preparation thereof and therapeutic use thereof.

Country Status (44)

Country Link
US (1) US7915284B2 (en)
EP (1) EP2069342B1 (en)
JP (1) JP5336378B2 (en)
KR (1) KR101470039B1 (en)
CN (1) CN101516881B (en)
AR (1) AR062897A1 (en)
AT (1) ATE467633T1 (en)
AU (1) AU2007298856B2 (en)
BR (1) BRPI0718517A2 (en)
CA (1) CA2662848C (en)
CL (1) CL2007002733A1 (en)
CO (1) CO6160308A2 (en)
CR (1) CR10643A (en)
CY (1) CY1110232T1 (en)
DE (1) DE602007006525D1 (en)
DK (1) DK2069342T3 (en)
EA (1) EA017442B1 (en)
ES (1) ES2345016T3 (en)
FR (1) FR2906250B1 (en)
GT (1) GT200900049A (en)
HK (1) HK1135388A1 (en)
HN (1) HN2009000502A (en)
HR (1) HRP20100408T1 (en)
IL (1) IL197352A (en)
JO (1) JO2643B1 (en)
MA (1) MA30792B1 (en)
ME (1) ME00615B (en)
MX (1) MX2009002802A (en)
MY (1) MY145603A (en)
NI (1) NI200900037A (en)
NO (1) NO20091562L (en)
NZ (1) NZ575337A (en)
PE (1) PE20080671A1 (en)
PL (1) PL2069342T3 (en)
PT (1) PT2069342E (en)
RS (1) RS51412B (en)
SI (1) SI2069342T1 (en)
SV (1) SV2009003193A (en)
TN (1) TN2009000081A1 (en)
TW (1) TWI381837B (en)
UA (1) UA95976C2 (en)
UY (1) UY30603A1 (en)
WO (1) WO2008034974A1 (en)
ZA (1) ZA200901551B (en)

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FR2928922B1 (en) * 2008-03-21 2010-04-23 Sanofi Aventis DERIVATIVES OF POLYSUBSTITUTED 2-ARYL-6-PHENYL-IMIDAZO-1,2-A! PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2928924B1 (en) 2008-03-21 2010-04-23 Sanofi Aventis POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO-1,2-A! PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2928921B1 (en) * 2008-03-21 2010-04-23 Sanofi Aventis POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO-1,2-A! PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2928923B1 (en) * 2008-03-21 2010-04-23 Sanofi Aventis POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYL-IMIDAZO-1,2-A! PYRIDINES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS
FR2933609B1 (en) * 2008-07-10 2010-08-27 Fournier Lab Sa USE OF INDOLE DERIVATIVES AS NURR-1 ACTIVATORS FOR THE TREATMENT OF PARKINSON'S DISEASE.
FR2950344B1 (en) * 2009-09-18 2011-11-25 Sanofi Aventis 5-PHENYL-PYRAZOLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS.
FR2950345B1 (en) * 2009-09-18 2011-09-23 Sanofi Aventis ACETYLENE DERIVATIVES OF 5-PHENYL-PYRAZOLOPYRIDINE, THEIR PREPARATION AND THEIR THERAPEUTIC USE
FR2953520B1 (en) * 2009-12-04 2011-11-25 Sanofi Aventis DIPHENYL-PYRAZOLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
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ES2883565T3 (en) * 2013-08-02 2021-12-09 Pasteur Institut Korea Anti-infective compounds
US10280163B2 (en) 2015-04-10 2019-05-07 Beigene, Ltd. 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases
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MA55194A (en) 2015-12-22 2022-05-04 Incyte Corp HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
WO2017192961A1 (en) 2016-05-06 2017-11-09 Incyte Corporation Heterocyclic compounds as immunomodulators
MA45116A (en) 2016-05-26 2021-06-02 Incyte Corp HETEROCYCLIC COMPOUNDS AS IMMUNOMODULATORS
UA125391C2 (en) 2016-06-20 2022-03-02 Інсайт Корпорейшн Heterocyclic compounds as immunomodulators
US20180016260A1 (en) 2016-07-14 2018-01-18 Incyte Corporation Heterocyclic compounds as immunomodulators
MA46045A (en) 2016-08-29 2021-04-28 Incyte Corp HETEROCYCLIC COMPOUNDS USED AS IMMUNOMODULATORS
US10882856B2 (en) 2016-09-24 2021-01-05 Beigene, Ltd. 5 or 8-substituted imidazo [1,5-a] pyridines as selective inhibitors of indoleamine and/or tryptophane 2,3-dioxygenases
WO2018119236A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
US20180179179A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Heterocyclic compounds as immunomodulators
ES2934230T3 (en) 2016-12-22 2023-02-20 Incyte Corp Benzooxazole derivatives as immunomodulators
HRP20221216T1 (en) 2016-12-22 2022-12-23 Incyte Corporation Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers
CN111386114A (en) 2017-11-25 2020-07-07 百济神州有限公司 Novel benzimidazoles as selective inhibitors of indoleamine 2, 3-dioxygenase
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Publication number Publication date
CL2007002733A1 (en) 2008-04-11
DE602007006525D1 (en) 2010-06-24
ES2345016T3 (en) 2010-09-13
MA30792B1 (en) 2009-10-01
RS51412B (en) 2011-02-28
IL197352A (en) 2014-11-30
CO6160308A2 (en) 2010-05-20
CR10643A (en) 2009-04-29
CA2662848A1 (en) 2008-03-27
MEP10709A (en) 2011-12-20
TWI381837B (en) 2013-01-11
MY145603A (en) 2012-03-15
PE20080671A1 (en) 2008-07-14
JP2010504309A (en) 2010-02-12
GT200900049A (en) 2010-03-04
EP2069342A1 (en) 2009-06-17
PL2069342T3 (en) 2010-10-29
ATE467633T1 (en) 2010-05-15
CN101516881A (en) 2009-08-26
HRP20100408T1 (en) 2010-09-30
NO20091562L (en) 2009-04-20
AU2007298856B2 (en) 2012-08-09
JO2643B1 (en) 2012-06-17
EA017442B1 (en) 2012-12-28
EP2069342B1 (en) 2010-05-12
JP5336378B2 (en) 2013-11-06
FR2906250A1 (en) 2008-03-28
CA2662848C (en) 2014-12-23
NI200900037A (en) 2014-02-20
US20090253735A1 (en) 2009-10-08
FR2906250B1 (en) 2008-10-31
TW200833329A (en) 2008-08-16
CY1110232T1 (en) 2015-01-14
ZA200901551B (en) 2010-06-30
SV2009003193A (en) 2010-02-01
DK2069342T3 (en) 2010-08-23
KR101470039B1 (en) 2014-12-05
HN2009000502A (en) 2011-07-11
AU2007298856A1 (en) 2008-03-27
CN101516881B (en) 2012-07-18
ME00615B (en) 2011-12-20
US7915284B2 (en) 2011-03-29
AR062897A1 (en) 2008-12-10
BRPI0718517A2 (en) 2013-11-19
WO2008034974A1 (en) 2008-03-27
KR20090054449A (en) 2009-05-29
NZ575337A (en) 2011-12-22
HK1135388A1 (en) 2010-06-04
TN2009000081A1 (en) 2010-08-19
UA95976C2 (en) 2011-09-26
EA200970311A1 (en) 2009-08-28
UY30603A1 (en) 2008-05-02
SI2069342T1 (en) 2010-09-30
PT2069342E (en) 2010-07-19
IL197352A0 (en) 2009-12-24

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