UY31666A1 - Clorotiofeno-amidas como inhibidores de los factores de coagulación xa y trombina - Google Patents
Clorotiofeno-amidas como inhibidores de los factores de coagulación xa y trombinaInfo
- Publication number
- UY31666A1 UY31666A1 UY031666A UY31666A UY31666A1 UY 31666 A1 UY31666 A1 UY 31666A1 UY 031666 A UY031666 A UY 031666A UY 31666 A UY31666 A UY 31666A UY 31666 A1 UY31666 A1 UY 31666A1
- Authority
- UY
- Uruguay
- Prior art keywords
- inhibitors
- chlorotiophen
- thrombine
- amidas
- coagulation factors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 102000015081 Blood Coagulation Factors Human genes 0.000 title abstract 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 title abstract 2
- 239000003114 blood coagulation factor Substances 0.000 title abstract 2
- PUKKVMZZENXNSR-UHFFFAOYSA-N 3-chlorothiophene-2-carboxamide Chemical class NC(=O)C=1SC=CC=1Cl PUKKVMZZENXNSR-UHFFFAOYSA-N 0.000 abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D333/40—Thiophene-2-carboxylic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290279 | 2008-02-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY31666A1 true UY31666A1 (es) | 2009-09-30 |
Family
ID=39637695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY031666A UY31666A1 (es) | 2008-02-21 | 2009-02-19 | Clorotiofeno-amidas como inhibidores de los factores de coagulación xa y trombina |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8378092B2 (enExample) |
| EP (1) | EP2254881B1 (enExample) |
| JP (1) | JP5422570B2 (enExample) |
| CN (1) | CN102015675B (enExample) |
| AR (1) | AR070441A1 (enExample) |
| AU (1) | AU2009217075B2 (enExample) |
| CA (1) | CA2714654A1 (enExample) |
| CL (1) | CL2009000367A1 (enExample) |
| DK (1) | DK2254881T3 (enExample) |
| ES (1) | ES2394550T3 (enExample) |
| PA (1) | PA8816101A1 (enExample) |
| PE (1) | PE20091729A1 (enExample) |
| PT (1) | PT2254881E (enExample) |
| TW (1) | TW200948366A (enExample) |
| UY (1) | UY31666A1 (enExample) |
| WO (1) | WO2009103440A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103732589B (zh) | 2011-05-25 | 2016-03-30 | 百时美施贵宝公司 | 可用作抗细胞凋亡bcl抑制剂的取代的磺酰胺 |
| CN102924442B (zh) * | 2012-11-15 | 2014-10-29 | 沈阳药科大学 | 含有噻唑环的色满类化合物及其类似物和医药用途 |
| WO2014174102A1 (en) * | 2013-04-26 | 2014-10-30 | Sanofi | Tartrate salt of 5-chloro-thiophene-2-carboxylic acid [(s)-2-[methyl-3-(2-oxo-pyrrolidin-1-yl)-benzenesulfonylamino]-3-(4-methyl piperazin-1 -yl)-3-oxo-propryl]amide |
| CN104557928B (zh) * | 2015-02-14 | 2016-08-24 | 佛山市赛维斯医药科技有限公司 | 一种含二环酰胺结构凝血因子Xa抑制剂、其制备方法及其用途 |
| US9701671B2 (en) * | 2015-02-20 | 2017-07-11 | Canon Kabushiki Kaisha | Organic compound, electrochromic element containing the same, optical filter, lens unit, imaging device, and window component |
| US10851051B2 (en) | 2015-08-14 | 2020-12-01 | The Broad Institute, Inc. | Compositions and methods for treating multiple myeloma |
| US20250002483A1 (en) | 2021-09-03 | 2025-01-02 | Bayer Aktiengesellschaft | Substituted s-alaninate derivatives |
| WO2024175450A1 (en) | 2023-02-21 | 2024-08-29 | Bayer Aktiengesellschaft | Substituted s-alaninate derivatives |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9322976D0 (en) | 1993-11-08 | 1994-01-05 | Pfizer Ltd | Therapeutic agents |
| US6313242B1 (en) | 1996-05-20 | 2001-11-06 | Fina Technology, Inc. | Stereorigid bis-fluorenyl metallocenes |
| CA2279927A1 (en) * | 1997-02-06 | 1998-08-13 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
| WO2000075129A1 (en) * | 1999-06-07 | 2000-12-14 | Shire Biochem Inc. | Thiophene integrin inhibitors |
| CA2392576A1 (en) | 1999-11-24 | 2001-05-31 | Lingyan Wang | .beta.-amino acid-, aspartic acid- and diaminopropionic-based inhibitors of factor xa |
| GB0228552D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Chemical compounds |
| CA2511500A1 (en) | 2002-12-24 | 2004-07-15 | Daiichi Pharmaceutical Co., Ltd. | Novel ethylenediamine derivatives |
| US20070197640A1 (en) | 2005-11-02 | 2007-08-23 | Cytokinetics, Inc. | Certain chemical entities, compositions, and methods |
-
2009
- 2009-02-10 ES ES09712426T patent/ES2394550T3/es active Active
- 2009-02-10 WO PCT/EP2009/000903 patent/WO2009103440A1/en not_active Ceased
- 2009-02-10 EP EP09712426A patent/EP2254881B1/en active Active
- 2009-02-10 PT PT97124267T patent/PT2254881E/pt unknown
- 2009-02-10 DK DK09712426.7T patent/DK2254881T3/da active
- 2009-02-10 CA CA2714654A patent/CA2714654A1/en not_active Abandoned
- 2009-02-10 AU AU2009217075A patent/AU2009217075B2/en not_active Ceased
- 2009-02-10 CN CN200980114013.9A patent/CN102015675B/zh active Active
- 2009-02-10 JP JP2010547079A patent/JP5422570B2/ja not_active Expired - Fee Related
- 2009-02-16 PA PA20098816101A patent/PA8816101A1/es unknown
- 2009-02-18 CL CL2009000367A patent/CL2009000367A1/es unknown
- 2009-02-19 TW TW098105198A patent/TW200948366A/zh unknown
- 2009-02-19 PE PE2009000243A patent/PE20091729A1/es not_active Application Discontinuation
- 2009-02-19 UY UY031666A patent/UY31666A1/es not_active Application Discontinuation
- 2009-02-19 AR ARP090100576A patent/AR070441A1/es unknown
-
2010
- 2010-08-18 US US12/858,991 patent/US8378092B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PA8816101A1 (es) | 2009-09-17 |
| US20110112075A1 (en) | 2011-05-12 |
| EP2254881B1 (en) | 2012-09-12 |
| US8378092B2 (en) | 2013-02-19 |
| CN102015675A (zh) | 2011-04-13 |
| HK1156607A1 (en) | 2012-06-15 |
| ES2394550T3 (es) | 2013-02-01 |
| JP5422570B2 (ja) | 2014-02-19 |
| PT2254881E (pt) | 2012-12-10 |
| CN102015675B (zh) | 2014-07-02 |
| AU2009217075A1 (en) | 2009-08-27 |
| CL2009000367A1 (es) | 2009-06-26 |
| DK2254881T3 (da) | 2012-12-10 |
| CA2714654A1 (en) | 2009-08-27 |
| JP2011512368A (ja) | 2011-04-21 |
| WO2009103440A1 (en) | 2009-08-27 |
| EP2254881A1 (en) | 2010-12-01 |
| AR070441A1 (es) | 2010-04-07 |
| PE20091729A1 (es) | 2009-12-01 |
| TW200948366A (en) | 2009-12-01 |
| AU2009217075B2 (en) | 2013-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UY30481A1 (es) | Isoxazolinas sustituidas, composiciones farmaccuticas que contienen a las mismas, metodos de preparacion y usos. | |
| ECSP10010463A (es) | Pirrolo[2,3-d]piridinas y usos de las mismas como inhibidores de cinasa de tirosina | |
| CO6450612A2 (es) | Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750 | |
| CU20120084A7 (es) | Compuestos derivados de triazolopiridina sustituidos como inhibidores de la quinasa mps-1 y compuestos intermediarios para su preparación | |
| ECSP14004812A (es) | Triazolopiridinas sustituidas | |
| CR11623A (es) | Compuestos | |
| UY29469A1 (es) | Compuestos sulfoximino-macrocíclicos y sus sales, composiciones farmacéuticas que comprenden dichos compuestos, métodos de preparación y usos de los mismos. | |
| UA111770C2 (uk) | Інгібітори бромдомену | |
| ECSP13013011A (es) | Triazolopiridinas | |
| ECSP12012338A (es) | Triazolopiridinas sustituidas | |
| UY29002A1 (es) | Nuevos derivados de hidantoína, procesos parasu preparación, composiciones farmacéuticas que los contienen y su uso en terapia | |
| EA201200850A1 (ru) | Фармацевтическая композиция, содержащая олигопептиды | |
| UY33634A (es) | ?combinaciones sinérgicas de triazoles, estrobirulinas y benzimidazoles, usos, formulaciones, procedimientos de producción y aplicaciones utilizando las mismas?. | |
| EA201490653A1 (ru) | Производные эстра-1,3,5(10),16-тетраен-3-карбоксамида, способ их получения, содержащие их фармацевтические препараты, а также их применение для получения лекарственных средств | |
| UY33200A (es) | Derivados de ácido 3-heteroaroilamino-propiónico sustituidos con oxígeno y su uso como productos farmacéuticos | |
| UY33014A (es) | Nuevos compuestos de diazinil-pirazolilo | |
| CO6761373A2 (es) | Derivados de ácido 3-heteroaroilamino-propiónico sustituidos y su uso como sustancias farmacéuticas | |
| CO6311057A2 (es) | Composicion de nisina liquida | |
| PA8816101A1 (es) | Clorotiofeno - amidas como inhibidores de los factores de coagulacion xa y trombina | |
| UY29003A1 (es) | Nuevos derivados de hidantoína, procesos para su preparación, composiciones farmacéuticas que los contienen y su uso en terapia | |
| UY33745A (es) | Derivados de difenilamina: usos, procedimiento de síntesis y composiciones farmacéuticas | |
| UY30482A1 (es) | Sulfoximinas sustituidas como inhibidores de tie2 y sus sales, composiciones farmaceuticas que comprenden las mismas, metodos para prepararlas y sus usos. | |
| UY32154A (es) | Derivados de isoquinolinona, procesos para su preparacion, composiciones farmaceuticas que los contiene y su uso en terapia | |
| UY29550A1 (es) | Derivados de (sulfamoil-alquil)-amida de ácido heteroaril-carboxílico como inhibidores del factor xa | |
| UY35514A (es) | Derivados de ácido biaril-propiónico y su uso como productos farmacéuticos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 109 | Application deemed to be withdrawn |
Effective date: 20130225 |