UY27657A1 - USEFUL NICOTINAMIDE DERIVATIVES AS PDE4 INHIBITORS - Google Patents
USEFUL NICOTINAMIDE DERIVATIVES AS PDE4 INHIBITORSInfo
- Publication number
- UY27657A1 UY27657A1 UY27657A UY27657A UY27657A1 UY 27657 A1 UY27657 A1 UY 27657A1 UY 27657 A UY27657 A UY 27657A UY 27657 A UY27657 A UY 27657A UY 27657 A1 UY27657 A1 UY 27657A1
- Authority
- UY
- Uruguay
- Prior art keywords
- useful
- nicotinamide derivatives
- pde4 inhibitors
- derivatives
- nicotinamide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
Abstract
La invención se refiere a derivados de nicotinamida y a procedimientos para su preparación y a intermedios utilizados en su preparación, a composiciones que los contienen y a los usos de dichos derivados. Los derivados de nicotinamida de acuerdo con la presente invención son útiles en numerosas enfermedades, trastornos y dolencias, en particular en enfermedades, trastornos y dolencias inflamatorios, alérgicos, respiratorios, así como en heridas.The invention relates to nicotinamide derivatives and processes for their preparation and intermediates used in their preparation, compositions containing them and the uses of said derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and ailments, in particular in inflammatory, allergic, respiratory diseases, disorders and ailments, as well as in wounds.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0203193.8A GB0203193D0 (en) | 2002-02-11 | 2002-02-11 | Nicotinamide derivatives useful as pde4 inhibitors |
Publications (1)
Publication Number | Publication Date |
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UY27657A1 true UY27657A1 (en) | 2003-09-30 |
Family
ID=9930842
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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UY27658A UY27658A1 (en) | 2002-02-11 | 2003-02-11 | NICOTINAMIDE DERIVATIVES AND A COMBINATION TIOTROPIO SALT FOR THE TREATMENT OF DISEASES |
UY27657A UY27657A1 (en) | 2002-02-11 | 2003-02-11 | USEFUL NICOTINAMIDE DERIVATIVES AS PDE4 INHIBITORS |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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UY27658A UY27658A1 (en) | 2002-02-11 | 2003-02-11 | NICOTINAMIDE DERIVATIVES AND A COMBINATION TIOTROPIO SALT FOR THE TREATMENT OF DISEASES |
Country Status (16)
Country | Link |
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EP (1) | EP1476157A1 (en) |
JP (1) | JP2005522449A (en) |
AR (1) | AR038404A1 (en) |
AU (2) | AU2003202116A1 (en) |
BR (1) | BR0307574A (en) |
CA (1) | CA2475708A1 (en) |
GB (1) | GB0203193D0 (en) |
GT (2) | GT200300033A (en) |
HN (1) | HN2003000062A (en) |
MX (1) | MXPA04007736A (en) |
PA (2) | PA8566501A1 (en) |
PE (2) | PE20030860A1 (en) |
SV (1) | SV2004001481A (en) |
TW (2) | TW200307545A (en) |
UY (2) | UY27658A1 (en) |
WO (2) | WO2003068232A1 (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
CA2475712C (en) | 2002-02-11 | 2009-11-24 | Simon Bailey | Nicotinamide derivatives useful as pde4 inhibitors |
US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317509D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
JPWO2005026132A1 (en) * | 2003-09-17 | 2007-11-08 | 日本新薬株式会社 | CAMP substrate-specific inhibitors of phosphodiesterase |
ATE460414T1 (en) | 2003-11-03 | 2010-03-15 | Boehringer Ingelheim Int | METHOD FOR PRODUCING TIOTROPIUM SALTS |
WO2005067929A1 (en) * | 2004-01-09 | 2005-07-28 | Boehringer Ingelheim International Gmbh | New pharmaceutical compositions based on a scopineester and nicotinamide derivatives |
EP1864980A4 (en) * | 2005-03-30 | 2010-08-18 | Eisai R&D Man Co Ltd | Antifungal agent containing pyridine derivative |
EP1915152A2 (en) * | 2005-08-08 | 2008-04-30 | Boehringer Ingelheim International GmbH | Method for the protection against the risk of cardiac disorders comprising administration of tiotropium salts |
DE102005049429A1 (en) | 2005-10-15 | 2007-04-19 | Cognis Ip Management Gmbh | Process for finishing textiles |
BRPI0617673C1 (en) * | 2005-10-19 | 2012-05-22 | Ranbaxy Lab Ltd | phosphodiesterase type iv inhibitor compositions |
US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
TWI385169B (en) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | Heterocyclic substituted pyridine derivatives and antifungal agent containing same |
US20100184811A1 (en) * | 2006-09-14 | 2010-07-22 | Finn Buxbom | Isoniazid mediated healing of wounds and ulcers |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
CN109020825B (en) * | 2017-06-12 | 2021-03-19 | 重庆医科大学 | Anti-influenza virus compound and preparation method thereof |
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DE3931041C2 (en) * | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them |
AU738037B2 (en) * | 1997-04-04 | 2001-09-06 | Pfizer Products Inc. | Nicotinamide derivatives |
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2002
- 2002-02-11 GB GBGB0203193.8A patent/GB0203193D0/en not_active Ceased
-
2003
- 2003-02-03 AU AU2003202116A patent/AU2003202116A1/en not_active Abandoned
- 2003-02-03 AU AU2003245812A patent/AU2003245812A1/en not_active Abandoned
- 2003-02-03 EP EP03700974A patent/EP1476157A1/en not_active Withdrawn
- 2003-02-03 CA CA002475708A patent/CA2475708A1/en not_active Abandoned
- 2003-02-03 JP JP2003567414A patent/JP2005522449A/en not_active Withdrawn
- 2003-02-03 WO PCT/IB2003/000377 patent/WO2003068232A1/en not_active Application Discontinuation
- 2003-02-03 BR BR0307574-5A patent/BR0307574A/en not_active IP Right Cessation
- 2003-02-03 MX MXPA04007736A patent/MXPA04007736A/en active IP Right Grant
- 2003-02-03 WO PCT/IB2003/000379 patent/WO2003068234A1/en not_active Application Discontinuation
- 2003-02-06 TW TW092102422A patent/TW200307545A/en unknown
- 2003-02-06 TW TW092102415A patent/TW200304824A/en unknown
- 2003-02-10 AR ARP030100406A patent/AR038404A1/en not_active Application Discontinuation
- 2003-02-10 GT GT200300033A patent/GT200300033A/en unknown
- 2003-02-10 SV SV2003001481A patent/SV2004001481A/en not_active Application Discontinuation
- 2003-02-10 HN HN2003000062A patent/HN2003000062A/en unknown
- 2003-02-10 GT GT200300034A patent/GT200300034A/en unknown
- 2003-02-11 UY UY27658A patent/UY27658A1/en not_active Application Discontinuation
- 2003-02-11 PA PA20038566501A patent/PA8566501A1/en unknown
- 2003-02-11 UY UY27657A patent/UY27657A1/en not_active Application Discontinuation
- 2003-02-11 PE PE2003000149A patent/PE20030860A1/en not_active Application Discontinuation
- 2003-02-11 PA PA20038566601A patent/PA8566601A1/en unknown
- 2003-02-11 PE PE2003000148A patent/PE20030921A1/en not_active Application Discontinuation
Also Published As
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PA8566601A1 (en) | 2003-11-12 |
WO2003068232A1 (en) | 2003-08-21 |
TW200304824A (en) | 2003-10-16 |
AU2003202116A1 (en) | 2003-09-04 |
TW200307545A (en) | 2003-12-16 |
SV2004001481A (en) | 2004-05-07 |
GB0203193D0 (en) | 2002-03-27 |
CA2475708A1 (en) | 2003-08-21 |
GT200300034A (en) | 2003-09-11 |
MXPA04007736A (en) | 2004-10-15 |
PE20030921A1 (en) | 2003-11-05 |
AU2003245812A1 (en) | 2003-09-04 |
GT200300033A (en) | 2003-10-11 |
PA8566501A1 (en) | 2003-11-12 |
BR0307574A (en) | 2004-12-21 |
JP2005522449A (en) | 2005-07-28 |
UY27658A1 (en) | 2003-09-30 |
EP1476157A1 (en) | 2004-11-17 |
HN2003000062A (en) | 2003-09-24 |
WO2003068234A1 (en) | 2003-08-21 |
AR038404A1 (en) | 2005-01-12 |
PE20030860A1 (en) | 2003-10-25 |
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