UY26991A1 - FORMULATION IN INHALABLE SOLUTION WITH A TIOTROPIO SALT - Google Patents

FORMULATION IN INHALABLE SOLUTION WITH A TIOTROPIO SALT

Info

Publication number
UY26991A1
UY26991A1 UY26991A UY26991A UY26991A1 UY 26991 A1 UY26991 A1 UY 26991A1 UY 26991 A UY26991 A UY 26991A UY 26991 A UY26991 A UY 26991A UY 26991 A1 UY26991 A1 UY 26991A1
Authority
UY
Uruguay
Prior art keywords
formulation
tiotropio
salt
inhalable solution
free
Prior art date
Application number
UY26991A
Other languages
Spanish (es)
Inventor
Petra Barth
Karin Drechsel
Barbara Niklaus-Humke
Christel Schmelzer
Original Assignee
Boehringer Ingelheim Pharma
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7661727&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY26991(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY26991A1 publication Critical patent/UY26991A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

El presente invento se refiere a una formulación para inhalación, exenta de gas propulsor, de bromuro de tiotropio o monohidrato de bromuro de tiotropio disuelto en agua o en una mezcla de agua y etanol, y a los aerosoles inhalables exentos de gas propulsor, que resultan de ello.The present invention relates to a formulation for inhalation, free of propellant gas, tiotropium bromide or tiotropium bromide monohydrate dissolved in water or in a mixture of water and ethanol, and to inhalable aerosols free of propellant gas, resulting from it.

UY26991A 2000-10-31 2001-10-29 FORMULATION IN INHALABLE SOLUTION WITH A TIOTROPIO SALT UY26991A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10054042 2000-10-31

Publications (1)

Publication Number Publication Date
UY26991A1 true UY26991A1 (en) 2002-06-20

Family

ID=7661727

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26991A UY26991A1 (en) 2000-10-31 2001-10-29 FORMULATION IN INHALABLE SOLUTION WITH A TIOTROPIO SALT

Country Status (33)

Country Link
EP (1) EP1335729A2 (en)
JP (1) JP4559703B2 (en)
KR (1) KR100983208B1 (en)
CN (1) CN1237970C (en)
AR (1) AR038765A1 (en)
AU (2) AU2174102A (en)
BG (1) BG66425B1 (en)
BR (1) BR0115016A (en)
CA (1) CA2427583C (en)
CZ (1) CZ305033B6 (en)
DE (1) DE10152369A1 (en)
EA (1) EA009068B1 (en)
EC (1) ECSP034570A (en)
EE (1) EE05343B1 (en)
HK (1) HK1060569A1 (en)
HR (1) HRP20030337A2 (en)
HU (1) HUP0301377A3 (en)
IL (2) IL155676A0 (en)
ME (1) ME00242B (en)
MX (1) MXPA03003750A (en)
MY (1) MY132777A (en)
NO (1) NO332524B1 (en)
NZ (1) NZ526024A (en)
PE (1) PE20020518A1 (en)
PL (1) PL361001A1 (en)
SA (1) SA01220503B1 (en)
SK (1) SK288031B6 (en)
TW (1) TWI296934B (en)
UA (1) UA76435C2 (en)
UY (1) UY26991A1 (en)
WO (1) WO2002036591A2 (en)
YU (1) YU33103A (en)
ZA (1) ZA200303045B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02010565A (en) 2000-04-28 2004-05-17 Kosan Biosciences Inc Production of polyketides.
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
AU2004279438A1 (en) * 2003-10-09 2005-04-21 Inverseon, Inc. Methods for treating diseases and conditions with inverse agonists
SE0303269L (en) * 2003-12-03 2005-06-04 Microdrug Ag Medical product
MX2007011273A (en) * 2005-03-16 2007-11-08 Meda Pharma Gmbh & Co Kg The combination of anticholinergics and leukotriene recptor antagonists for the treatment of repiratory diseases.
EP2034990A4 (en) * 2006-05-26 2013-03-06 Dey L P Nebulizable compositions of quaternary ammonium muscarinic receptor antagonists
CN100446770C (en) * 2007-01-10 2008-12-31 上海现代药物制剂工程研究中心有限公司 Water aerosol containing beclomethasone dipropionate
TR200907237A2 (en) * 2009-09-23 2011-04-21 Bi̇lgi̇ç Mahmut Tiotropium dry powder combination
CN111936124A (en) * 2018-07-26 2020-11-13 四川海思科制药有限公司 Aerosol pharmaceutical composition containing glycopyrronium salt and indacaterol salt, and preparation method and application thereof
CN111971034A (en) * 2018-07-26 2020-11-20 四川海思科制药有限公司 Aerosol pharmaceutical composition containing glycopyrronium salt and preparation method and application thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0504112A3 (en) * 1991-03-14 1993-04-21 Ciba-Geigy Ag Pharmaceutical aerosol formulations
DE4203306A1 (en) * 1992-02-06 1993-08-12 Ig Spruehtechnik Gmbh ASTHMA OR PULMONAL AEROSOL PREPARATIONS WITH LECITHIN
DK0835098T3 (en) * 1995-06-27 2002-10-07 Boehringer Ingelheim Pharma Stable drug preparation to produce propellant-free aerosols
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
CA2256721A1 (en) * 1996-06-04 1997-12-11 The Procter & Gamble Company A nasal spray containing an intranasal steroid and an antihistamine
DE19653969A1 (en) * 1996-12-20 1998-06-25 Boehringer Ingelheim Kg New aqueous pharmaceutical preparation for the production of propellant-free aerosols
JPH10298107A (en) * 1997-04-25 1998-11-10 Taisho Pharmaceut Co Ltd Pharmaceutical composition
ATE234604T1 (en) * 1998-08-04 2003-04-15 Jago Res Ag MEDICAL AEROSOL FORMULATIONS
DE19847968A1 (en) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Separate storage of an active material and a solvent comprises a closure cap and a container, with a chamber attached to the unit.

Also Published As

Publication number Publication date
HK1060569A1 (en) 2004-08-13
PE20020518A1 (en) 2002-07-12
EA009068B1 (en) 2007-10-26
PL361001A1 (en) 2004-09-20
HUP0301377A3 (en) 2005-12-28
EP1335729A2 (en) 2003-08-20
NO332524B1 (en) 2012-10-08
SK5262003A3 (en) 2003-10-07
ZA200303045B (en) 2004-04-22
HUP0301377A2 (en) 2003-10-28
SK288031B6 (en) 2012-12-03
KR100983208B1 (en) 2010-09-20
EA200300483A1 (en) 2003-12-25
MXPA03003750A (en) 2004-10-15
IL155676A0 (en) 2003-11-23
ECSP034570A (en) 2003-06-25
DE10152369A1 (en) 2002-05-08
JP2004523482A (en) 2004-08-05
CA2427583A1 (en) 2002-05-10
YU33103A (en) 2006-05-25
JP4559703B2 (en) 2010-10-13
CZ305033B6 (en) 2015-04-08
IL155676A (en) 2012-05-31
BR0115016A (en) 2005-05-03
UA76435C2 (en) 2006-08-15
BG107726A (en) 2004-11-30
ME00242B (en) 2011-05-10
CZ20031487A3 (en) 2003-09-17
CN1237970C (en) 2006-01-25
NZ526024A (en) 2005-10-28
SA01220503B1 (en) 2007-03-10
CA2427583C (en) 2008-02-12
NO20031914D0 (en) 2003-04-29
EE05343B1 (en) 2010-10-15
EE200300202A (en) 2003-10-15
BG66425B1 (en) 2014-04-30
AU2002221741B2 (en) 2007-04-05
CN1473044A (en) 2004-02-04
AR038765A1 (en) 2005-01-26
KR20040010552A (en) 2004-01-31
NO20031914L (en) 2003-06-23
WO2002036591A2 (en) 2002-05-10
AU2174102A (en) 2002-05-15
TWI296934B (en) 2008-05-21
HRP20030337A2 (en) 2005-04-30
WO2002036591A3 (en) 2002-07-25
MY132777A (en) 2007-10-31
MEP40708A (en) 2011-02-10

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Effective date: 20150615