UY26110A1 - Derivados de 2-alcoxi-ciclobuten-3,4-diona, su preparación y su aplicación en terapéutica - Google Patents
Derivados de 2-alcoxi-ciclobuten-3,4-diona, su preparación y su aplicación en terapéuticaInfo
- Publication number
- UY26110A1 UY26110A1 UY26110A UY26110A UY26110A1 UY 26110 A1 UY26110 A1 UY 26110A1 UY 26110 A UY26110 A UY 26110A UY 26110 A UY26110 A UY 26110A UY 26110 A1 UY26110 A1 UY 26110A1
- Authority
- UY
- Uruguay
- Prior art keywords
- carbon atoms
- dioxocyclobut
- methylamino
- methyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compuestos de fórmula general (I) (representada en la figura 1), así como procedimientos de preparación de los mismos, caracterizados porque: R1 y R2 representan, independientemente entre sí, un átomo de hidrógeno o un grupo alquilo de 1 a 3 átomos de carbono; R3 representa un átomo de hidrógeno o un grupo alquilo de 1 a 6 átomos de carbono; W representa un grupo OR4; y R4 representa un grupo alquilo de 1 a 10 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, C3-6 cicloalquilo-C1-3alquilo-, bencilo, o fluoroalquilo de 1 a 6 átomos de carbono. Ejemplos de compuestos de fórmula general (I): -4-[[[2-(1-etilpropoxi) -3,4- dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; -4-[[[2-(1-n-propilbutoxi) -3,4- dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; -4-[[[2-(1-metoxi)-3,4-dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; entre otros. Los compuestos de fórmula (I) son de utilidad para la preparación de un medicamento destinado a tratar una patología donde la inhibición de la fosfodiesterasa 5 aporta un beneficio terapéutico, y más particularmente donde la patología consiste en: hipertrofia benigna de próstata, incontinencia, vesícula obstruida, dismenorrea, parto precoz o prematuro, disfunciones eréctiles, disfunciones sexuales en el hombre, disfunciones sexuales en la mujer, angina de pecho, hipertensión pulmonar, ataque de apoplejía, arteriosclerosis, insuficiencia ventricular, desórdenes vasculares periféricos, asma, bronquitis, rinitis alérgica, glaucoma o desórdenes de la mortalidad intestinal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9904945A FR2792634B1 (fr) | 1999-04-20 | 1999-04-20 | Derives de 2-alcoxy-cyclobutene-3,4-dione leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
UY26110A1 true UY26110A1 (es) | 2000-12-29 |
Family
ID=9544620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY26110A UY26110A1 (es) | 1999-04-20 | 2000-04-18 | Derivados de 2-alcoxi-ciclobuten-3,4-diona, su preparación y su aplicación en terapéutica |
Country Status (6)
Country | Link |
---|---|
AR (1) | AR023548A1 (es) |
AU (1) | AU3971800A (es) |
CO (1) | CO5160305A1 (es) |
FR (1) | FR2792634B1 (es) |
UY (1) | UY26110A1 (es) |
WO (1) | WO2000063160A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495576B2 (en) | 2001-02-07 | 2002-12-17 | Abbott Laboratories | Aminal diones as potassium channel openers |
DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
JP2005513060A (ja) * | 2001-12-17 | 2005-05-12 | アルタナ ファルマ アクチエンゲゼルシャフト | 選択的pde5阻害剤の新規使用 |
FR2842271B1 (fr) | 2002-07-15 | 2004-09-10 | Eurocopter France | Boite de transmissiion de puissance basculante a transfert de charge par le carter |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9311282D0 (en) * | 1993-06-01 | 1993-07-21 | Rhone Poulenc Rorer Ltd | New compositions of matter |
-
1999
- 1999-04-20 FR FR9904945A patent/FR2792634B1/fr not_active Expired - Fee Related
-
2000
- 2000-04-11 WO PCT/FR2000/000926 patent/WO2000063160A1/fr active Application Filing
- 2000-04-11 AU AU39718/00A patent/AU3971800A/en not_active Abandoned
- 2000-04-17 CO CO00028248A patent/CO5160305A1/es unknown
- 2000-04-18 UY UY26110A patent/UY26110A1/es not_active Application Discontinuation
- 2000-04-19 AR ARP000101828A patent/AR023548A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
AR023548A1 (es) | 2002-09-04 |
FR2792634A1 (fr) | 2000-10-27 |
FR2792634B1 (fr) | 2001-06-01 |
AU3971800A (en) | 2000-11-02 |
WO2000063160A1 (fr) | 2000-10-26 |
CO5160305A1 (es) | 2002-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20100426 |