UY26110A1 - Derivados de 2-alcoxi-ciclobuten-3,4-diona, su preparación y su aplicación en terapéutica - Google Patents

Derivados de 2-alcoxi-ciclobuten-3,4-diona, su preparación y su aplicación en terapéutica

Info

Publication number
UY26110A1
UY26110A1 UY26110A UY26110A UY26110A1 UY 26110 A1 UY26110 A1 UY 26110A1 UY 26110 A UY26110 A UY 26110A UY 26110 A UY26110 A UY 26110A UY 26110 A1 UY26110 A1 UY 26110A1
Authority
UY
Uruguay
Prior art keywords
carbon atoms
dioxocyclobut
methylamino
methyl
compounds
Prior art date
Application number
UY26110A
Other languages
English (en)
Inventor
Claudie Gauiter
Christophe Philippo
Philippe R Bovy
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of UY26110A1 publication Critical patent/UY26110A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos de fórmula general (I) (representada en la figura 1), así como procedimientos de preparación de los mismos, caracterizados porque: R1 y R2 representan, independientemente entre sí, un átomo de hidrógeno o un grupo alquilo de 1 a 3 átomos de carbono; R3 representa un átomo de hidrógeno o un grupo alquilo de 1 a 6 átomos de carbono; W representa un grupo OR4; y R4 representa un grupo alquilo de 1 a 10 átomos de carbono, alquenilo de 2 a 6 átomos de carbono, alquinilo de 2 a 6 átomos de carbono, C3-6 cicloalquilo-C1-3alquilo-, bencilo, o fluoroalquilo de 1 a 6 átomos de carbono. Ejemplos de compuestos de fórmula general (I): -4-[[[2-(1-etilpropoxi) -3,4- dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; -4-[[[2-(1-n-propilbutoxi) -3,4- dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; -4-[[[2-(1-metoxi)-3,4-dioxociclobut-1-en-1-il]metilamino]metil]ciclohexancarboxamida; entre otros. Los compuestos de fórmula (I) son de utilidad para la preparación de un medicamento destinado a tratar una patología donde la inhibición de la fosfodiesterasa 5 aporta un beneficio terapéutico, y más particularmente donde la patología consiste en: hipertrofia benigna de próstata, incontinencia, vesícula obstruida, dismenorrea, parto precoz o prematuro, disfunciones eréctiles, disfunciones sexuales en el hombre, disfunciones sexuales en la mujer, angina de pecho, hipertensión pulmonar, ataque de apoplejía, arteriosclerosis, insuficiencia ventricular, desórdenes vasculares periféricos, asma, bronquitis, rinitis alérgica, glaucoma o desórdenes de la mortalidad intestinal.
UY26110A 1999-04-20 2000-04-18 Derivados de 2-alcoxi-ciclobuten-3,4-diona, su preparación y su aplicación en terapéutica UY26110A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9904945A FR2792634B1 (fr) 1999-04-20 1999-04-20 Derives de 2-alcoxy-cyclobutene-3,4-dione leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
UY26110A1 true UY26110A1 (es) 2000-12-29

Family

ID=9544620

Family Applications (1)

Application Number Title Priority Date Filing Date
UY26110A UY26110A1 (es) 1999-04-20 2000-04-18 Derivados de 2-alcoxi-ciclobuten-3,4-diona, su preparación y su aplicación en terapéutica

Country Status (6)

Country Link
AR (1) AR023548A1 (es)
AU (1) AU3971800A (es)
CO (1) CO5160305A1 (es)
FR (1) FR2792634B1 (es)
UY (1) UY26110A1 (es)
WO (1) WO2000063160A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495576B2 (en) 2001-02-07 2002-12-17 Abbott Laboratories Aminal diones as potassium channel openers
DE10135815A1 (de) * 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
US20050107394A1 (en) * 2001-12-17 2005-05-19 Ardeschir Ghofrani Novel use of selective pde5 inhibitors
FR2842271B1 (fr) 2002-07-15 2004-09-10 Eurocopter France Boite de transmissiion de puissance basculante a transfert de charge par le carter

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9311282D0 (en) * 1993-06-01 1993-07-21 Rhone Poulenc Rorer Ltd New compositions of matter

Also Published As

Publication number Publication date
CO5160305A1 (es) 2002-05-30
FR2792634B1 (fr) 2001-06-01
WO2000063160A1 (fr) 2000-10-26
FR2792634A1 (fr) 2000-10-27
AR023548A1 (es) 2002-09-04
AU3971800A (en) 2000-11-02

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Legal Events

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Effective date: 20100426