UY25089A1 - Vacunas no acuosas - Google Patents

Vacunas no acuosas

Info

Publication number
UY25089A1
UY25089A1 UY25089A UY25089A UY25089A1 UY 25089 A1 UY25089 A1 UY 25089A1 UY 25089 A UY25089 A UY 25089A UY 25089 A UY25089 A UY 25089A UY 25089 A1 UY25089 A1 UY 25089A1
Authority
UY
Uruguay
Prior art keywords
solvent
polar
group
nonaqueous
immunogenic polypeptide
Prior art date
Application number
UY25089A
Other languages
English (en)
Inventor
Hungerford James
Albrecht Mark
Original Assignee
Hoechst Roussel Vet Gmbh
Biotech Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPO7792A external-priority patent/AUPO779297A0/en
Priority claimed from AUPO7791A external-priority patent/AUPO779197A0/en
Application filed by Hoechst Roussel Vet Gmbh, Biotech Australia Pty Ltd filed Critical Hoechst Roussel Vet Gmbh
Publication of UY25089A1 publication Critical patent/UY25089A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0003—Invertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una formulación de vacuna no acuosa de fase única que contiene un polipéptido inmunogénico disuelto en un solvente polar no acuoso. La formulación también puede contener adyuvantes y/o composiciones farmacéuticas que puedan administrarse conjuntamente con el polipéptido inmunogénico. Se relevan métodos para preparar dicha formulación de vacuna y se proporcionan métodos para utilizar las formulaciones a fin de prevenir y tratar enfermedades de mamíferos. El polipéptido inmunogénico proviene de un organismo parásito, preferentemente de un organismo seleccionado del grupo compuesto por los nematodos y los insectos. En una realización preferida, el solvente no acuoso comprende dimetilsulfóxido (DMSO),si bien pueden utilizarse también otros solventes polares no acuosos. En su forma más conveniente, el DMSO comprende de hasta un 6% de solvente no acuoso, y el resto comprende un solvente hidroxílico polar. El solvente hidroxílico polar se selecciona del grupo integrado por el glicerol formol y el propilén glicol, ó una mezcla de los mismos. En particular, las formulaciones de la presente invención pueden almacenarse durante períodos prolongados a temperaturas ambientes de hasta 40sC aproximadamente sin perder eficacia, es decir, la capacidad de inducir una respuesta inmune protectora. La presente invención es particularmente útil para la administración conjunta de sustancias farmacéuticas que son inestables en solución acuosa, como ser un compuesto antihelmíntico y de manera más preferida es una lactona marcocíclica del grupo de compuestos integrados por la avermectina y la milbemicina.
UY25089A 1997-07-10 1998-07-10 Vacunas no acuosas UY25089A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPO7792A AUPO779297A0 (en) 1997-07-10 1997-07-10 Novel vaccines
AUPO7791A AUPO779197A0 (en) 1997-07-10 1997-07-10 Novel vaccines

Publications (1)

Publication Number Publication Date
UY25089A1 true UY25089A1 (es) 2000-08-21

Family

ID=25645460

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25089A UY25089A1 (es) 1997-07-10 1998-07-10 Vacunas no acuosas

Country Status (3)

Country Link
AR (1) AR013202A1 (es)
UY (1) UY25089A1 (es)
WO (1) WO1999002182A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27412A1 (es) * 2002-08-12 2003-06-30 Carlson Internat Inc Un nuevo producto para el combate de garrapatas y el proceso para la prepaacinn.
CA2769221A1 (en) * 2009-08-04 2011-02-10 Genentech, Inc. Concentrated polypeptide formulations with reduced viscosity
US9101557B2 (en) 2011-04-13 2015-08-11 Auburn University Combination of protein forms for hornfly vaccination

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3711602A (en) * 1970-10-30 1973-01-16 Crown Zellerbach Corp Compositions for topical application for enhancing tissue penetration of physiologically active agents with dmso
NZ210505A (en) * 1983-12-22 1988-06-30 Merck & Co Inc Parasiticidal compositions containing avermectin or milbemycin derivatives
US4853372A (en) * 1983-12-22 1989-08-01 Merck & Co., Inc. Non-aqueous ivermectin formulation with improved antiparasitic activity
GB9422990D0 (en) * 1994-11-15 1995-01-04 Cortecs Ltd Immunogenic compositions
DE69619894T2 (de) * 1995-06-30 2002-11-14 American Cyanamid Co., Madison Stabile Makrolide und Makrolide Imptstoff-Zusammensetzungen

Also Published As

Publication number Publication date
WO1999002182A3 (en) 1999-04-01
AR013202A1 (es) 2000-12-13
WO1999002182A2 (en) 1999-01-21

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20121206