UY25089A1 - NON-WATER VACCINES - Google Patents
NON-WATER VACCINESInfo
- Publication number
- UY25089A1 UY25089A1 UY25089A UY25089A UY25089A1 UY 25089 A1 UY25089 A1 UY 25089A1 UY 25089 A UY25089 A UY 25089A UY 25089 A UY25089 A UY 25089A UY 25089 A1 UY25089 A1 UY 25089A1
- Authority
- UY
- Uruguay
- Prior art keywords
- solvent
- polar
- group
- nonaqueous
- immunogenic polypeptide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0003—Invertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una formulación de vacuna no acuosa de fase única que contiene un polipéptido inmunogénico disuelto en un solvente polar no acuoso. La formulación también puede contener adyuvantes y/o composiciones farmacéuticas que puedan administrarse conjuntamente con el polipéptido inmunogénico. Se relevan métodos para preparar dicha formulación de vacuna y se proporcionan métodos para utilizar las formulaciones a fin de prevenir y tratar enfermedades de mamíferos. El polipéptido inmunogénico proviene de un organismo parásito, preferentemente de un organismo seleccionado del grupo compuesto por los nematodos y los insectos. En una realización preferida, el solvente no acuoso comprende dimetilsulfóxido (DMSO),si bien pueden utilizarse también otros solventes polares no acuosos. En su forma más conveniente, el DMSO comprende de hasta un 6% de solvente no acuoso, y el resto comprende un solvente hidroxílico polar. El solvente hidroxílico polar se selecciona del grupo integrado por el glicerol formol y el propilén glicol, ó una mezcla de los mismos. En particular, las formulaciones de la presente invención pueden almacenarse durante períodos prolongados a temperaturas ambientes de hasta 40sC aproximadamente sin perder eficacia, es decir, la capacidad de inducir una respuesta inmune protectora. La presente invención es particularmente útil para la administración conjunta de sustancias farmacéuticas que son inestables en solución acuosa, como ser un compuesto antihelmíntico y de manera más preferida es una lactona marcocíclica del grupo de compuestos integrados por la avermectina y la milbemicina.A single phase nonaqueous vaccine formulation containing an immunogenic polypeptide dissolved in a nonaqueous polar solvent. The formulation may also contain adjuvants and / or pharmaceutical compositions that can be co-administered with the immunogenic polypeptide. Methods of preparing such a vaccine formulation are discussed and methods of using the formulations to prevent and treat mammalian diseases are provided. The immunogenic polypeptide comes from a parasitic organism, preferably from an organism selected from the group consisting of nematodes and insects. In a preferred embodiment, the nonaqueous solvent comprises dimethylsulfoxide (DMSO), although other non-aqueous polar solvents can also be used. In its most convenient form, DMSO comprises up to 6% non-aqueous solvent, and the remainder comprises a polar hydroxylic solvent. The polar hydroxylic solvent is selected from the group consisting of glycerol formaldehyde and propylene glycol, or a mixture thereof. In particular, the formulations of the present invention can be stored for prolonged periods at ambient temperatures of up to about 40sC without losing efficacy, i.e., the ability to induce a protective immune response. The present invention is particularly useful for the co-administration of pharmaceutical substances that are unstable in aqueous solution, such as being an anthelmintic compound and more preferably it is a framework cyclic lactone from the group of compounds composed of avermectin and milbemycin.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPO7792A AUPO779297A0 (en) | 1997-07-10 | 1997-07-10 | Novel vaccines |
AUPO7791A AUPO779197A0 (en) | 1997-07-10 | 1997-07-10 | Novel vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25089A1 true UY25089A1 (en) | 2000-08-21 |
Family
ID=25645460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25089A UY25089A1 (en) | 1997-07-10 | 1998-07-10 | NON-WATER VACCINES |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR013202A1 (en) |
UY (1) | UY25089A1 (en) |
WO (1) | WO1999002182A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY27412A1 (en) * | 2002-08-12 | 2003-06-30 | Carlson Internat Inc | A NEW PRODUCT FOR TICKET FIGHTING AND THE PREPAACINN PROCESS. |
CA2769221A1 (en) * | 2009-08-04 | 2011-02-10 | Genentech, Inc. | Concentrated polypeptide formulations with reduced viscosity |
US9101557B2 (en) | 2011-04-13 | 2015-08-11 | Auburn University | Combination of protein forms for hornfly vaccination |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3711602A (en) * | 1970-10-30 | 1973-01-16 | Crown Zellerbach Corp | Compositions for topical application for enhancing tissue penetration of physiologically active agents with dmso |
NZ210505A (en) * | 1983-12-22 | 1988-06-30 | Merck & Co Inc | Parasiticidal compositions containing avermectin or milbemycin derivatives |
US4853372A (en) * | 1983-12-22 | 1989-08-01 | Merck & Co., Inc. | Non-aqueous ivermectin formulation with improved antiparasitic activity |
GB9422990D0 (en) * | 1994-11-15 | 1995-01-04 | Cortecs Ltd | Immunogenic compositions |
DE69619894T2 (en) * | 1995-06-30 | 2002-11-14 | American Cyanamid Co., Madison | Stable macrolides and macrolide vaccine compositions |
-
1998
- 1998-07-10 UY UY25089A patent/UY25089A1/en not_active Application Discontinuation
- 1998-07-10 AR ARP980103379A patent/AR013202A1/en not_active Application Discontinuation
- 1998-07-10 WO PCT/IB1998/001327 patent/WO1999002182A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999002182A3 (en) | 1999-04-01 |
AR013202A1 (en) | 2000-12-13 |
WO1999002182A2 (en) | 1999-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20121206 |