UY24934A1 - Aplicacion oral de (+)-o-demetiltramadol como analgesico - Google Patents
Aplicacion oral de (+)-o-demetiltramadol como analgesicoInfo
- Publication number
- UY24934A1 UY24934A1 UY24934A UY24934A UY24934A1 UY 24934 A1 UY24934 A1 UY 24934A1 UY 24934 A UY24934 A UY 24934A UY 24934 A UY24934 A UY 24934A UY 24934 A1 UY24934 A1 UY 24934A1
- Authority
- UY
- Uruguay
- Prior art keywords
- demethyltramadol
- oral application
- analgesic
- demetiltramadol
- salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe la utilización de (+)-O-demetiltramadol para la aplicación oral en el tratamiento de algias intensas, agudas y/o crónicas. En la utilización del (+)-O-demetiltramadol como sustancia activa analgésica, se utilizan además del (+)-enantiómero y/o al menos una sal fisiológicamente aceptable, excipientes, cargas, solventes, diluyentes, colorantes y aglutinantes. En las formas de preparación administradas por vía oral el (+)-O-demetiltramadol puede utilizarse como base libre o también como sal, con ácidos orgánicos e inorgánicos, particularmente se prefieren las sales de ácidos orgánicos lipófilos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19712398A DE19712398A1 (de) | 1997-03-25 | 1997-03-25 | Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel |
Publications (1)
Publication Number | Publication Date |
---|---|
UY24934A1 true UY24934A1 (es) | 1998-04-21 |
Family
ID=7824498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY24934A UY24934A1 (es) | 1997-03-25 | 1998-03-24 | Aplicacion oral de (+)-o-demetiltramadol como analgesico |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0870499A1 (es) |
JP (1) | JPH1112166A (es) |
KR (1) | KR19980080580A (es) |
CN (1) | CN1196932A (es) |
AU (1) | AU5951798A (es) |
BR (1) | BR9801839A (es) |
CA (1) | CA2232930A1 (es) |
DE (1) | DE19712398A1 (es) |
HU (1) | HUP9800623A3 (es) |
IL (1) | IL123788A0 (es) |
NO (1) | NO981320L (es) |
PE (1) | PE62399A1 (es) |
PL (1) | PL325509A1 (es) |
UY (1) | UY24934A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20010623A1 (es) * | 1999-10-05 | 2001-07-07 | Gruenenthal Chemie | Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria |
DE10108123A1 (de) * | 2001-02-21 | 2002-10-02 | Gruenenthal Gmbh | Wirkstoffkombination |
WO2011110595A1 (de) | 2010-03-10 | 2011-09-15 | Grünenthal GmbH | Kristalline salze und/oder cokristalle von o-desmethyltramadol |
US10702485B2 (en) | 2011-07-09 | 2020-07-07 | Syntrix Biosystems Inc. | Compositions and methods for overcoming resistance to tramadol |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9205106A (es) * | 1991-09-06 | 1993-05-01 | Johnson & Johnson | Composiciones que comprenden un material de tramadol y cualquiera de codeina, oxicodona o hidrocodona y su uso |
AU661723B2 (en) * | 1991-10-30 | 1995-08-03 | Mcneilab, Inc. | Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug |
DE4315525B4 (de) * | 1993-05-10 | 2010-04-15 | Euro-Celtique S.A. | Pharmazeutische Zusammensetzung |
DE4329794C2 (de) * | 1993-09-03 | 1997-09-18 | Gruenenthal Gmbh | Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung |
DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
DE19601744C2 (de) * | 1996-01-19 | 1998-04-16 | Gruenenthal Gmbh | Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol |
-
1997
- 1997-03-25 DE DE19712398A patent/DE19712398A1/de not_active Ceased
-
1998
- 1998-03-05 EP EP98103874A patent/EP0870499A1/de not_active Withdrawn
- 1998-03-21 CN CN98107860A patent/CN1196932A/zh active Pending
- 1998-03-23 HU HU9800623A patent/HUP9800623A3/hu unknown
- 1998-03-23 IL IL12378898A patent/IL123788A0/xx unknown
- 1998-03-23 CA CA002232930A patent/CA2232930A1/en not_active Abandoned
- 1998-03-24 UY UY24934A patent/UY24934A1/es not_active Application Discontinuation
- 1998-03-24 KR KR1019980010058A patent/KR19980080580A/ko not_active Application Discontinuation
- 1998-03-24 JP JP10075995A patent/JPH1112166A/ja not_active Withdrawn
- 1998-03-24 PL PL98325509A patent/PL325509A1/xx unknown
- 1998-03-24 NO NO981320A patent/NO981320L/no unknown
- 1998-03-24 PE PE1998000210A patent/PE62399A1/es not_active Application Discontinuation
- 1998-03-25 AU AU59517/98A patent/AU5951798A/en not_active Abandoned
- 1998-03-25 BR BR9801839-6A patent/BR9801839A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN1196932A (zh) | 1998-10-28 |
NO981320L (no) | 1998-09-28 |
KR19980080580A (ko) | 1998-11-25 |
HUP9800623A3 (en) | 1999-03-29 |
PE62399A1 (es) | 1999-07-10 |
HU9800623D0 (en) | 1998-05-28 |
PL325509A1 (en) | 1998-09-28 |
CA2232930A1 (en) | 1998-09-25 |
AU5951798A (en) | 1998-10-01 |
DE19712398A1 (de) | 1998-10-01 |
NO981320D0 (no) | 1998-03-24 |
BR9801839A (pt) | 2000-01-18 |
HUP9800623A2 (hu) | 1999-01-28 |
EP0870499A1 (de) | 1998-10-14 |
JPH1112166A (ja) | 1999-01-19 |
IL123788A0 (en) | 1998-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RDES | Application refused |
Effective date: 20000721 |