UY24934A1 - Aplicacion oral de (+)-o-demetiltramadol como analgesico - Google Patents

Aplicacion oral de (+)-o-demetiltramadol como analgesico

Info

Publication number
UY24934A1
UY24934A1 UY24934A UY24934A UY24934A1 UY 24934 A1 UY24934 A1 UY 24934A1 UY 24934 A UY24934 A UY 24934A UY 24934 A UY24934 A UY 24934A UY 24934 A1 UY24934 A1 UY 24934A1
Authority
UY
Uruguay
Prior art keywords
demethyltramadol
oral application
analgesic
demetiltramadol
salt
Prior art date
Application number
UY24934A
Other languages
English (en)
Inventor
Elmar Josef Friderichs Dr
Dr Werner Winter Prof
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of UY24934A1 publication Critical patent/UY24934A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describe la utilización de (+)-O-demetiltramadol para la aplicación oral en el tratamiento de algias intensas, agudas y/o crónicas. En la utilización del (+)-O-demetiltramadol como sustancia activa analgésica, se utilizan además del (+)-enantiómero y/o al menos una sal fisiológicamente aceptable, excipientes, cargas, solventes, diluyentes, colorantes y aglutinantes. En las formas de preparación administradas por vía oral el (+)-O-demetiltramadol puede utilizarse como base libre o también como sal, con ácidos orgánicos e inorgánicos, particularmente se prefieren las sales de ácidos orgánicos lipófilos.
UY24934A 1997-03-25 1998-03-24 Aplicacion oral de (+)-o-demetiltramadol como analgesico UY24934A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712398A DE19712398A1 (de) 1997-03-25 1997-03-25 Orale Anwendung von (+)-0-Demethyltramadol als Schmerzmittel

Publications (1)

Publication Number Publication Date
UY24934A1 true UY24934A1 (es) 1998-04-21

Family

ID=7824498

Family Applications (1)

Application Number Title Priority Date Filing Date
UY24934A UY24934A1 (es) 1997-03-25 1998-03-24 Aplicacion oral de (+)-o-demetiltramadol como analgesico

Country Status (14)

Country Link
EP (1) EP0870499A1 (es)
JP (1) JPH1112166A (es)
KR (1) KR19980080580A (es)
CN (1) CN1196932A (es)
AU (1) AU5951798A (es)
BR (1) BR9801839A (es)
CA (1) CA2232930A1 (es)
DE (1) DE19712398A1 (es)
HU (1) HUP9800623A3 (es)
IL (1) IL123788A0 (es)
NO (1) NO981320L (es)
PE (1) PE62399A1 (es)
PL (1) PL325509A1 (es)
UY (1) UY24934A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20010623A1 (es) * 1999-10-05 2001-07-07 Gruenenthal Chemie Uso de (+)-tramadol y/o o-demetiltramadol para tratamiento de urgencia urinaria incrementada y/o incontinencia urinaria
DE10108123A1 (de) * 2001-02-21 2002-10-02 Gruenenthal Gmbh Wirkstoffkombination
WO2011110595A1 (de) 2010-03-10 2011-09-15 Grünenthal GmbH Kristalline salze und/oder cokristalle von o-desmethyltramadol
US10702485B2 (en) 2011-07-09 2020-07-07 Syntrix Biosystems Inc. Compositions and methods for overcoming resistance to tramadol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9205106A (es) * 1991-09-06 1993-05-01 Johnson & Johnson Composiciones que comprenden un material de tramadol y cualquiera de codeina, oxicodona o hidrocodona y su uso
AU661723B2 (en) * 1991-10-30 1995-08-03 Mcneilab, Inc. Composition comprising a tramadol material and a non-steroidal anti-inflammatory drug
DE4315525B4 (de) * 1993-05-10 2010-04-15 Euro-Celtique S.A. Pharmazeutische Zusammensetzung
DE4329794C2 (de) * 1993-09-03 1997-09-18 Gruenenthal Gmbh Tramadolsalz enthaltende Arzneimittel mit verzögerter Wirkstofffreisetzung
DE19525137C2 (de) * 1995-07-11 2003-02-27 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe
DE19601744C2 (de) * 1996-01-19 1998-04-16 Gruenenthal Gmbh Verfahren zur Herstellung der Enantiomeren von O-Demethyltramadol

Also Published As

Publication number Publication date
CN1196932A (zh) 1998-10-28
NO981320L (no) 1998-09-28
KR19980080580A (ko) 1998-11-25
HUP9800623A3 (en) 1999-03-29
PE62399A1 (es) 1999-07-10
HU9800623D0 (en) 1998-05-28
PL325509A1 (en) 1998-09-28
CA2232930A1 (en) 1998-09-25
AU5951798A (en) 1998-10-01
DE19712398A1 (de) 1998-10-01
NO981320D0 (no) 1998-03-24
BR9801839A (pt) 2000-01-18
HUP9800623A2 (hu) 1999-01-28
EP0870499A1 (de) 1998-10-14
JPH1112166A (ja) 1999-01-19
IL123788A0 (en) 1998-10-30

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Legal Events

Date Code Title Description
RDES Application refused

Effective date: 20000721