US8455462B2 - Ophthalmic compositions based on tamarind seed polysaccharide and hyaluronic acid - Google Patents

Ophthalmic compositions based on tamarind seed polysaccharide and hyaluronic acid Download PDF

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Publication number
US8455462B2
US8455462B2 US12/681,256 US68125608A US8455462B2 US 8455462 B2 US8455462 B2 US 8455462B2 US 68125608 A US68125608 A US 68125608A US 8455462 B2 US8455462 B2 US 8455462B2
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United States
Prior art keywords
tsp
hyaluronic acid
weight
tamarind seed
polysaccharide
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US12/681,256
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US20100279981A1 (en
Inventor
Antonio Del Prete
Marco Sanso
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Farmigea SpA
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RMFA Trading SA
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Assigned to RMFA TRADING S.A. reassignment RMFA TRADING S.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SANSO, MARCO, DEL PRETE, ANTONIO
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Assigned to HMFRA HUNGARY KORLATOLT FELELOSSEGU TARSASAG reassignment HMFRA HUNGARY KORLATOLT FELELOSSEGU TARSASAG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: RMFA TRADING S.A.
Assigned to ITH S.R.L. reassignment ITH S.R.L. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HMFRA HUNGARY KORLATOLT FELELOSSEGU TARSASAG
Assigned to FARMIGEA S.P.A. reassignment FARMIGEA S.P.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ITH S.R.L
Assigned to FARMIGEA S.P.A. reassignment FARMIGEA S.P.A. CORRECTIVE ASSIGNMENT TO CORRECT THE EXECUTION DATE OF THE CONVEYING PARTY'S SIGNATURE FROM 07/05/2019 TO 05/07/2019 PREVIOUSLY RECORDED ON REEL 050462 FRAME 0576. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: ITH S.R.L
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • FIGS. 3 and 4 show, using a scanning electron microscope, the development of the microvilli presence on the conjunctival epithelium in a female patient aged 64 treated for 60 days with TSP+HA.
  • FIG. 3 allows to appreciate a glabrus epithelial surface due to the almost complete absence of microvilli, based on the criteria described before, to this histological frame a score of 4 (maximal reduction of the microvilli presence) had been assigned.
  • FIG. 4 shows a rich vegetation of microvilli, which allow to assign to this frame a score of 1, substantially typical of a normal condition.
US12/681,256 2007-10-02 2008-10-02 Ophthalmic compositions based on tamarind seed polysaccharide and hyaluronic acid Active 2029-04-27 US8455462B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT000510A ITRM20070510A1 (it) 2007-10-02 2007-10-02 Composizioni oftalmiche a base di polisaccaride del seme di tamarindo e acido ialuronico.
ITRM2007A000510 2007-10-02
ITRM2007A0510 2007-10-02
PCT/IT2008/000626 WO2009044423A1 (en) 2007-10-02 2008-10-02 Ophthalmic compositions based on tamarind seed polysaccharide and hyaluronic acid

Publications (2)

Publication Number Publication Date
US20100279981A1 US20100279981A1 (en) 2010-11-04
US8455462B2 true US8455462B2 (en) 2013-06-04

Family

ID=40314052

Family Applications (1)

Application Number Title Priority Date Filing Date
US12/681,256 Active 2029-04-27 US8455462B2 (en) 2007-10-02 2008-10-02 Ophthalmic compositions based on tamarind seed polysaccharide and hyaluronic acid

Country Status (14)

Country Link
US (1) US8455462B2 (it)
EP (1) EP2197456B1 (it)
JP (1) JP5542674B2 (it)
KR (1) KR101570966B1 (it)
AT (1) ATE499106T1 (it)
CA (1) CA2701721C (it)
DE (1) DE602008005173D1 (it)
ES (1) ES2361529T3 (it)
IT (1) ITRM20070510A1 (it)
MX (1) MX2010003488A (it)
PL (1) PL2197456T3 (it)
PT (1) PT2197456E (it)
RU (1) RU2493855C2 (it)
WO (1) WO2009044423A1 (it)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3182986A4 (en) * 2014-08-20 2018-01-24 Professional Compounding Centers Of America (PCCA) Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan
US10702578B2 (en) * 2017-08-02 2020-07-07 Shilpa Medicare Limited Ophthalmic compositions of cyclosporine
US11129862B2 (en) * 2017-08-30 2021-09-28 Johnson & Johnson Consumer Inc. Ophthalmic compositions

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE429209T1 (de) * 2005-02-09 2009-05-15 Safilens S R L Kontaktlinse, verfahren zu ihrer herstellung und packung zur aufbewahrung und pflege einer kontaktlinse
IT1396607B1 (it) * 2009-11-16 2012-12-14 Hmfra Hungary Ltd Liability Company Preparazioni oftalmiche a base di bdnf (brain-derived neurotrophic factor) e loro uso.
HUE026862T2 (en) 2010-05-24 2016-07-28 Indena Spa Combined vegetable extracts for use in the treatment of microbiological infections
SI2575973T1 (sl) * 2010-05-24 2017-10-30 Indena S.P.A. Polisaharid semen tamarinde in ekstrakt iz ferula hermonis, za uporabo pri zdravljenju vnetnih bolezni
FR2963240B1 (fr) * 2010-07-28 2013-03-15 Horus Pharma Composition a usage topique sans conservateur comprenant de l'acide hyaluronique
IT1404145B1 (it) * 2010-12-27 2013-11-15 Altergon Sa Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi
EP2883931A1 (en) * 2013-12-12 2015-06-17 Omya International AG Improved gel stability
US20170027980A1 (en) 2014-04-15 2017-02-02 Novintethical Pharma Sa Composition based on xyloglucan and proteins for the treatment of intestinal disorders
ES2705692T3 (es) 2015-06-11 2019-03-26 Novintethical Pharma Sa Composiciones nasales tópicas que contienen xiloglucanos para usar como descongestionantes
US10849918B2 (en) * 2015-07-13 2020-12-01 Tohoku Techno Arch Co., Ltd. Composition for optic nerve protection
AR108280A1 (es) 2016-05-05 2018-08-08 Acraf Composición oftálmica que comprende una combinación sinérgica de glucógeno y ácido hialurónico o sal del mismo
IT201600108848A1 (it) * 2016-10-27 2018-04-27 Giuliani Spa Composizioni dermatologiche
EA202190014A1 (ru) * 2018-07-18 2021-06-29 Атг 20 С.Р.Л. Композиция, содержащая глицирризин, и ее косметическое средство и фармацевтические применения

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106615A (en) * 1986-10-14 1992-04-21 Shabtay Dikstein Eyedrops having non-newtonian rheological properties
WO1997028787A1 (en) 1996-02-05 1997-08-14 Farmigea S.P.A. Ophthalmic solutions viscosified with tamarind seed polysaccharide
WO2006085351A1 (en) 2005-02-09 2006-08-17 Safilens S.R.L. Contact lens, method for producing same, and pack for storage and maintenance of a contact lens
US20060222623A1 (en) * 2005-03-31 2006-10-05 Bausch & Lomb Incorporated Composition for treating dry eye and related methods of manufacture and methods of use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1021204B1 (en) * 1997-09-26 2005-12-28 Noven Pharmaceuticals, Inc. Bioadhesive compositions and methods for topical administration of active agents
TR200101790T2 (tr) * 1998-12-23 2001-10-22 Idea Ag. Yayılgan olmayan in vivo topik uygulamalar için geliştirilmiş formül
AU2004283091A1 (en) * 2003-10-03 2005-05-06 Allergan, Inc. Compositions and methods comprising prostaglandin-related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106615A (en) * 1986-10-14 1992-04-21 Shabtay Dikstein Eyedrops having non-newtonian rheological properties
WO1997028787A1 (en) 1996-02-05 1997-08-14 Farmigea S.P.A. Ophthalmic solutions viscosified with tamarind seed polysaccharide
WO2006085351A1 (en) 2005-02-09 2006-08-17 Safilens S.R.L. Contact lens, method for producing same, and pack for storage and maintenance of a contact lens
US20060222623A1 (en) * 2005-03-31 2006-10-05 Bausch & Lomb Incorporated Composition for treating dry eye and related methods of manufacture and methods of use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Burgalassi S et al.: Development of a Simple Dry Eye Model in the Albino Rabbit and Evaluation of Some Tear Substitutes, Jan. 1, 1999, vol. 31, No. 3, Ophthalmic Research, Basel, CH.
M. J. O'Neil et al. (I), "The Merck Index, 14th Edition," Merck & Co., Whitehouse Station, NJ, 2006, only pp. 822-823 supplied (see "Hyaluronic Acid"). *
M. J. O'Neil et al. (II), "The Merck Index, 14th Edition," Merck & Co., Whitehouse Station, NJ, 2006, only p. 1554 supplied (see "Tamarind"). *
M. J. O'Neil et al. (III), "The Merck Index, 14th Edition," Merck & Co., Whitehouse Station, NJ, 2006, only p. 1218 supplied (see "Pectin"). *
Mullins et al., "Ophthalmic Preparations," Chapter 86 in Remington's Pharmaceutical Sciences, 18th Edition, Gennaro et al (eds.), Mack Publishing Co., Easton, PA, 1990, only pp. 1581-1595 supplied. *
Rolando Maurizio et al.: Establishing the Tolerability and Performance of Tamarind Seed Polysaccharide (TSP) in Treating Dry Eye Syndrome: Results of a Clinical Study, Mar. 29, 2007, vol. 7, No. 1, BMC Ophthalmology, Biomed Central, London, GB.

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3182986A4 (en) * 2014-08-20 2018-01-24 Professional Compounding Centers Of America (PCCA) Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan
AU2015305424B2 (en) * 2014-08-20 2021-05-20 Professional Compounding Centers Of America (Pcca) Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan
US11623008B2 (en) 2014-08-20 2023-04-11 Professional Compounding Centers Of America Excipient compositions for mucoadhesive pharmaceutical compositions including a synergistic combination of amylopectin, pullulan, hyaluronic acid, and xyloglucan
US10702578B2 (en) * 2017-08-02 2020-07-07 Shilpa Medicare Limited Ophthalmic compositions of cyclosporine
US11129862B2 (en) * 2017-08-30 2021-09-28 Johnson & Johnson Consumer Inc. Ophthalmic compositions
US20210401919A1 (en) * 2017-08-30 2021-12-30 Johnson & Johnson Consumer Inc. Ophthalmic Compositions

Also Published As

Publication number Publication date
KR20100091151A (ko) 2010-08-18
JP5542674B2 (ja) 2014-07-09
RU2010117173A (ru) 2011-11-10
RU2493855C2 (ru) 2013-09-27
JP2010540619A (ja) 2010-12-24
KR101570966B1 (ko) 2015-11-23
US20100279981A1 (en) 2010-11-04
WO2009044423A1 (en) 2009-04-09
CA2701721C (en) 2016-02-23
ES2361529T3 (es) 2011-06-17
DE602008005173D1 (de) 2011-04-07
ITRM20070510A1 (it) 2009-04-03
EP2197456A1 (en) 2010-06-23
ATE499106T1 (de) 2011-03-15
EP2197456B1 (en) 2011-02-23
CA2701721A1 (en) 2009-04-09
MX2010003488A (es) 2010-08-31
PT2197456E (pt) 2011-05-18
PL2197456T3 (pl) 2012-07-31

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