US7549316B2 - Integrated sample cell and filter and system using same - Google Patents

Integrated sample cell and filter and system using same Download PDF

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Publication number
US7549316B2
US7549316B2 US11/519,041 US51904106A US7549316B2 US 7549316 B2 US7549316 B2 US 7549316B2 US 51904106 A US51904106 A US 51904106A US 7549316 B2 US7549316 B2 US 7549316B2
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United States
Prior art keywords
gas
housing
gas sampling
sample
sampling assembly
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US11/519,041
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English (en)
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US20070062313A1 (en
Inventor
David R. Rich
Brian M. Fudge
Patrick Tuxbury
Kirk Johnson
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Philips RS North America LLC
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RIC Investments LLC
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Publication date
Priority claimed from US10/678,692 external-priority patent/US7121134B2/en
Priority to US11/519,041 priority Critical patent/US7549316B2/en
Application filed by RIC Investments LLC filed Critical RIC Investments LLC
Assigned to RIC INVESTMENTS, LLC. reassignment RIC INVESTMENTS, LLC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: RICH, DAVID R., FUDGE, BRIAN M., JOHNSON, KIRK, TUXBURY, PATRICK
Publication of US20070062313A1 publication Critical patent/US20070062313A1/en
Priority to JP2009527591A priority patent/JP2010502995A/ja
Priority to PCT/US2007/077909 priority patent/WO2008033733A2/fr
Priority to RU2009113541/05A priority patent/RU2454650C2/ru
Priority to EP07842076A priority patent/EP2069748A4/fr
Priority to CN200780033522.XA priority patent/CN101548169B/zh
Priority to BRPI0716566-8A priority patent/BRPI0716566A2/pt
Publication of US7549316B2 publication Critical patent/US7549316B2/en
Application granted granted Critical
Priority to JP2012269988A priority patent/JP2013068630A/ja
Assigned to RESPIRONICS, INC.. reassignment RESPIRONICS, INC.. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: RIC INVESTMENTS, LLC
Assigned to PHILIPS RS NORTH AMERICA LLC reassignment PHILIPS RS NORTH AMERICA LLC CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: RESPIRONICS, INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/097—Devices for facilitating collection of breath or for directing breath into or through measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816—Joints or connectors
    • A61M16/0841—Joints or connectors for sampling
    • A61M16/085—Gas sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/105—Filters
    • A61M16/106—Filters in a path
    • A61M16/1065—Filters in a path in the expiratory path
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N1/2247—Sampling from a flowing stream of gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0808—Condensation traps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N1/2202—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling
    • G01N1/2205—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling with filters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/22—Devices for withdrawing samples in the gaseous state
    • G01N1/2247—Sampling from a flowing stream of gas
    • G01N2001/2267—Sampling from a flowing stream of gas separating gas from liquid, e.g. bubbles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath

Definitions

  • the present invention relates generally to a gas monitoring system, and, in particular, to an integrated sample cell and filter for use in a sidestream gas monitoring system, such filter for separating undesired liquid components from respiratory gases to be monitored in the sample cell.
  • a patient's exhalations it is often desirable to monitor and analyze a patient's exhalations to determine the gaseous composition of the exhalate. For instance, monitoring the carbon dioxide (CO 2 ) content of a patient's exhalations is often desirable.
  • the carbon dioxide (or other gaseous) content of a patient's exhalation is monitored by transferring a portion, or sample, of the patient's expired gases to a suitable sensing mechanism and monitoring system.
  • Monitoring of exhaled gases may be accomplished utilizing either mainstream or sidestream monitoring systems.
  • a mainstream monitoring system the gaseous content of a patient's exhalations is measured in-situ in the patient circuit or conduit coupled to the patient's airway.
  • the gas sample is transported from the patient circuit through a gas sampling line to a sensing mechanism located some distance from the main patient circuit for monitoring.
  • a sensing mechanism located some distance from the main patient circuit for monitoring.
  • Accurate analysis of the gaseous composition of a patient's exhalation is dependent upon a number of factors including collection of a gaseous sample that is substantially free of liquid condensate, which might distort the results of the analysis.
  • a gaseous sample that is substantially free of liquid condensate, which might distort the results of the analysis.
  • the water vapor contained in the sample may condense into liquid or condensate.
  • the liquid or condensate if permitted to reach the sensing mechanism, can have a detrimental effect on the functioning thereof and may lead to inaccurate monitoring results.
  • Condensed liquid in the gas sampling line may also contaminate subsequent expired gas samples by being re-entrained into such subsequent samples.
  • CO 2 carbon dioxide
  • the CO 2 in an exhaled gas sample transported through a gas sampling line to the sensing mechanism, fluctuates according to the CO 2 present at the point at which the sample is taken.
  • the CO 2 level also varies with the patient respiratory cycle. Disturbance to this fluctuation, i.e., decreases in the fidelity of the CO 2 waveform, are undesirable, because such disturbances can affect the accuracy of the CO 2 measurement and the graphical display of the waveform. For this reason, removal of liquids from the exhaled gas sample is desirably accomplished in such a way that it does not substantially degrade the fidelity of the CO 2 waveform.
  • conventional moisture traps often disturb the waveform to a substantial degree.
  • hydrophobic hollow fibers as a filter provides a disposable gas sample collection unit that connects to a reusable sensing mechanism. It this conventional filter arrangement, the gas sample collection unit, i.e., the sample cell, is physically located some distance from the filter. The gas passing through the filter is transported to the sample cell via a relatively long tube.
  • the present inventor recognized that the conventional technique of gathering and transporting the filtered gas sample to a remote sensing mechanism degrades the CO 2 waveform measured at the sample cell. More specifically, the present inventor recognized that by locating the filter element some distance from the sample cell and causing the filtered gas to pass through a relatively long conduit to get from the filter to the sample cell, this arrangement effectively dampens the fidelity of the CO 2 waveform, for example, by dulling the rising and falling edges of the waveform. Accordingly, a gas sampling assembly that effectively and efficiently separates moisture from a gas sample and that does not substantially degrade the waveform of expired gases measured at the sample would be advantageous.
  • This object is achieved according to one embodiment of the present invention by providing a gas sampling assembly that does not substantially degrade the waveform of expired gases, while separating undesired liquid condensate and other contaminants from the respiratory gases to be monitored.
  • the gas sampling assembly of the present invention includes a filter portion including a housing having an upstream first end, a downstream second end, and a gas flow path defined through the housing from the first end to the second end.
  • the gas sampling assembly also includes a sample collection portion having a body section with a sample chamber defined therein.
  • the body section is selectively coupled to the downstream second end of the housing such that the housing and the body section define a unitary assembly with the sample chamber being in fluid communication with the gas flow path in the housing responsive to the filter portion being coupled to the sample collection portion.
  • the body section includes an energy transmissive portion such that a constituent of a gas in the sample chamber is adapted to be monitored through the energy transmission portion. At least one filter element disposed in the housing.
  • the gas sampling assembly of the present invention includes a filter portion and a sample collection portion.
  • the filter portion includes a housing and the sample collection portion includes a body section having a sample chamber defined therein.
  • the body section is coupled to the downstream second end of the housing such that the housing and the body section define a unitary assembly with the sample chamber being in fluid communication with the gas flow path in the housing.
  • the body section includes an energy transmissive portion such that a constituent of a gas in the sample chamber is adapted to be monitored through the energy transmission portion.
  • a hydrophobic member disposed in at least a portion of the housing.
  • a hydrophilic member having an inlet is disposed in at least a portion of the housing such that fluid passing through the filter portion passes through at least a portion of the hydrophilic member before passing through at least a portion of the hydrophobic member.
  • gases that are substantially free of liquid condensate and contaminants pass through the hollow fiber elements and are collected in the sample chamber where desired measurements may be taken thereof, e.g., using optical sensing techniques and the like.
  • the gas is then exhausted through the conduit formed in the second side portion of the sample collection portion. In this manner, liquids are substantially prevented from reaching the sample chamber. Accordingly, measurements taken of the gases in the sample chamber are less likely to be distorted due to moisture or other contaminants in the gas sample.
  • the present invention also pertains to sidestream gas monitoring system that includes the above-described gas sampling assembly embodiments.
  • FIG. 1 is a schematic diagram of a gas monitoring system including a gas sampling assembly according to the principles of the present invention
  • FIG. 2 is a cross-sectional view of a first embodiment of a gas sampling assembly according to the principles of the present invention
  • FIG. 3 is a side view of a first embodiment for the outlet of the filter portion of the gas sampling assembly of FIG. 2 ;
  • FIG. 4 is a cross-sectional view of a second embodiment of a gas sampling assembly of the present invention.
  • FIG. 5 is a cross-sectional view of a third embodiment of a gas sampling assembly of the present invention.
  • FIG. 6 is a side view of a second embodiment for the outlet of the filter portion of the gas sampling assembly
  • FIG. 7 is a cross-sectional view of a third embodiment of a gas sampling assembly according to the principles of the present invention.
  • FIG. 8 is a side view of a cannula assembly that includes a fourth embodiment of a gas sampling assembly according to the principles of the present invention.
  • FIG. 9 is a cross-sectional view of the fourth embodiment of the gas sampling assembly.
  • FIG. 10 is a cross-sectional view of a supplemental gas adapter used in the cannula assembly of FIG. 8 .
  • Gas monitoring system includes a sampling line 26 that is coupled to a patient circuit 2 , which is, in turn, in connected to an airway of patient (not shown) so that a portion of the gas in the patient circuit is diverted into sampling line 26 .
  • sampling line is shown connected to patient circuit 2 , which is typically accomplished using an airway adapter. It is to be understood, however, that sampling line 26 can be connected to the patient's airway in any conventional manner, such as through a nasal cannula.
  • Filter assembly 10 is coupled to an end of the sample line distal from the patient circuit and proximate to a gas monitoring system, generally indicated at 3 .
  • gas monitoring system 3 is any conventional sidestream gas monitoring system, which typically includes a radiation emitter 5 and receiver 6 to detect the gas constituents within a sample cell placed in optical alignment with the emitter and receive using well know radiation absorption techniques.
  • Gas sampling assembly 10 includes a filter portion 12 and a sample collection portion 14 .
  • Filter portion 12 includes a housing 16 typically formed of a suitable polymer, such as PVC, having a first upstream end 18 and a second downstream end 20 .
  • housing 16 is cylindrical in shape.
  • housing 16 can have any suitable shape or length.
  • First upstream end 18 of housing 16 includes an inner perimeter defined by an inner wall 22 .
  • Inner wall 22 is configured to be coupled to an outer wall 24 of a gas sampling line 26 through which an expired gas sample to be monitored may be received.
  • Outer wall 24 of the gas sampling line 26 defines a perimeter that substantially approximates the inner perimeter defined by inner wall 22 such that outer wall 24 of gas sampling line 26 and inner wall 22 are coupled to one another in a fluid-tight and gas-tight manner.
  • fluid-tight and gas-tight coupling mechanisms are known to those of ordinary skill in the art and, accordingly, will not be discussed further herein.
  • Sample collection portion 14 includes a main body section 28 , a portion of the internal volume of which forms a sample chamber 30 in which the filtered, expired gases is collected for measurements to be taken thereof, as more fully described below. It is currently preferred that sample collection portion 14 is formed of polycarbonate. Sample collection portion 14 further includes a first side portion 32 , a portion of an outer surface 34 of that is coupled with second downstream end 20 of filter portion 12 in a fluid-tight and gas-tight manner. Similar to the coupling of outer wall 24 of gas sampling line 26 to inner wall 22 of first upstream end 18 of housing 16 , outer surface 34 of first side portion 32 defines a perimeter that substantially approximates the inner perimeter of second downstream end 20 of housing 16 , such inner perimeter of second downstream end 20 being defined by an inner wall 36 thereof. Accordingly, outer surface 34 and inner wall 36 are coupled by a fluid-tight and gas-tight arrangement, as known to those skilled in the art.
  • the inner perimeter of second downstream end 20 of housing 16 is greater than the inner perimeter of first upstream end 18 . It will be understood and appreciated by those skilled in the art, however, that, in addition to the illustrated relation, the respective inner perimeters of first and second ends 18 , 20 may approximate one another, or the inner perimeter of first upstream end 18 may exceed that of second downstream end 20 . Such relation of inner perimeters depends upon the desired application and such variations are contemplated to be within the scope hereof.
  • Termination block 38 Disposed within an upstream region of first side portion 32 of sample collection portion 14 is a termination block 38 .
  • Termination block 38 extends across the inner perimeter of first side portion 32 , the inner perimeter being defined by an inner surface 40 of first side portion 32 , such that a fluid-tight and gas-tight seal is created.
  • Sample collection portion 14 further includes a second side portion 42 , substantially longitudinally aligned with first side portion 32 .
  • Second side portion 42 includes an inner perimeter, defined by an inner surface 44 thereof, which is of a dimension less than the inner perimeter of sample chamber 30 , the inner perimeter of sample chamber 30 being defined by an inner wall 45 thereof.
  • expired, filtered gases once collected in sample chamber 30 , pass through second side portion 42 and are exhausted from sample chamber 30 .
  • Fiber elements 46 are, in the currently preferred embodiment, formed of a hydrophobic filter media having a pore size of less than or equal to 5 microns.
  • a hydrophobic filter media having a pore size of less than or equal to 5 microns.
  • One suitable example is polypropylene.
  • fiber elements 46 are hollow.
  • fiber elements 46 are folded back on themselves to form loops such that all open ends 48 thereof are located proximate second downstream end 20 of housing 16 and looped ends 50 are located in proximity to first upstream end 18 of housing 16 .
  • fiber elements 46 are disposed in housing 16 such that a length-wise axis of the fibers is substantially aligned with a length-wise axis of the housing.
  • downstream portions of fiber elements 46 are embedded in termination block 38 such that the open ends of the fiber elements extend beyond the termination block and into sample chamber 30 .
  • gases are communicated from fiber chamber 47 of housing 16 directly to the sample chamber only through the fiber elements, as more fully described below.
  • the hollow fiber elements may include a closed sealed end, such closed sealed end being positioned proximate first upstream end 18 of housing 16 .
  • communication of gases from fiber chamber 47 of housing 16 to sample chamber 30 is still accomplished only through fiber elements 46 , as more fully described below.
  • Such alternative is contemplated to be within the scope hereof.
  • FIG. 3 illustrates an outlet 52 of housing 16 disposed at the downstream end of termination block 38 . More specifically, FIG. 3 illustrates a downstream end of termination block 38 and the arrangement of the outlet of the fiber elements 46 . As is apparent, the bores or open ends 48 of fiber elements 46 are arranged in a substantially evenly spaced arrangement within the perimeter of outlet 52 . In this configuration, outlet 52 of filter portion 12 optimally fills and flushes the interior volume of sample chamber 30 with the filtered gases, as more fully described below.
  • a patient expires gases containing liquids such as water, blood, mucus, medications and the like, into a nasal cannula (not shown), gas mask (not shown) or the like. Downstream of the nasal cannula (or other such respiratory collection mechanism), the expired gases leave the mainstream conduit and enter gas sampling line 26 such that at least a portion of the gases are directed toward sidestream gas sampling assembly 10 .
  • Gas sampling line 26 forms a conduit through which the expired gases enters filter portion 12 of gas sampling assembly 10 .
  • the gases Upon entering filter portion 12 , the gases still contain liquids such as water, blood, mucus, medications and the like, which are desirably substantially filtered from the gases prior to the gases being directed toward sample chamber 30 .
  • fiber elements 46 are formed of a hydrophobic material, such as polypropylene, gases are permitted to pass therethrough but the passage of liquids is substantially prevented. Thus, gases substantially free of liquid condensate are permitted to pass only through fiber elements 46 , while any liquids present in the expired gases are substantially prevented from entering or passing into the interior of the fiber elements.
  • termination block 38 forms a gas-tight and fluid-tight seal across the inner perimeter of the first side portion of the sample collection portion 14 , and a fluid-tight and gas-tight seal is also formed between outer surface 34 of first side portion 32 of sample collection portion 14 and inner wall 36 of second downstream end 20 of filter portion 12 , the only way substances may be communicated from fiber chamber 47 of housing 16 to sample chamber 30 is through fiber elements 46 . Accordingly, gases substantially free of liquid condensate are permitted to pass through the fiber elements and directly into the sample chamber, while any liquids present in the expired gases are substantially prevented from leaving filter portion 12 of gas sampling assembly 10 . Liquids, instead, collect within fiber chamber 47 of housing 16 .
  • the gases free of liquid condensate pass through fiber elements 46 , through open ends 48 disposed at outlet 52 and into sample chamber 30 where measurements may be taken thereof, e.g., using optical sensing techniques and the like. Because open ends 48 of fiber elements 46 are in a substantially evenly spaced arrangement within the perimeter of outlet 52 , gases enter sample chamber 30 in a substantially uniform manner. In this way, there is prevented an accumulation of gases in one area or another of sample chamber 30 and more consistent and accurate measurements may be taken.
  • the substantially liquid-free gas is exhausted from sample chamber 30 through a conduit formed by inner surface 44 of second side portion 42 .
  • the substantially evenly spaced arrangement of open ends 48 of hollow fiber elements 46 within the perimeter of outlet 52 permits the filtered gases within sample chamber 30 to be substantially uniformly flushed from the sample chamber and into the conduit formed by inner surface 44 of second side portion 42 .
  • the present invention provides a gas sampling assembly that does not substantially disturb or degrade the waveform of expired gases. Furthermore, the gas sampling assembly is integrated with a filter for separating undesired liquid condensate and other contaminants from respiratory gases to be monitored.
  • gas sampling assembly 54 includes a filter portion 12 ′ and a sample collection portion 14 ′.
  • Filter portion 12 ′ includes a housing 16 ′, typically formed of a suitable polymer such as PVC, having a first upstream end 18 ′ end and a second end 20 ′.
  • First upstream end 18 ′ of housing 16 ′ includes an inner perimeter defined by an inner wall 22 ′ that is configured to be coupled to an outer wall 24 ′ of a gas sampling line 26 ′ through which an expired gas sample to be monitored may be received.
  • Outer wall 24 ′ and inner wall 22 ′ are coupled to one another in a fluid-tight and gas-tight manner.
  • Sample collection portion 14 ′ of gas sampling assembly 54 includes a main body section 28 ′, a portion of the internal volume of which forms a sample chamber 30 ′ in which the filtered, expired gases is collected for measurements to be taken thereof. It is currently preferred that main body section 28 ′ is formed of polycarbonate. Sample collection portion 14 ′ further includes a first side portion 32 ′, a portion of an outer surface 34 ′ of which is coupled with second downstream end 20 ′ of filter portion 12 ′ in a fluid-tight and gas-tight manner.
  • outer surface 34 ′ of first side portion 32 ′ defines a perimeter that substantially approximates the inner perimeter of second downstream end 20 ′ of housing 16 ′, such inner perimeter being defined by an inner wall 36 ′ thereof. Accordingly, outer surface 34 ′ of first side portion 32 ′ and inner wall 36 ′ of second downstream end 20 ′ of housing 16 ′ are coupled by a fluid-tight and gas-tight arrangement.
  • first upstream end 18 ′ may be less than the inner perimeter of second downstream end 20 ′, as shown, the respective inner perimeters may approximate one another, or the inner perimeter of first upstream end 18 ′ may be greater than the inner perimeter of second downstream end 20 ′.
  • Such relation of inner perimeters depends upon the desired application and all variations are contemplated to be within the scope of the present invention.
  • a termination block 38 ′ Disposed within a portion of first side portion 32 ′ of sample collection portion 14 ′ is a termination block 38 ′ that extends across the inner perimeter of a portion of first side portion 32 ′, the inner perimeter being defined by an inner surface 40 ′ of first side portion 32 ′. In this manner, a fluid-tight and gas-tight seal is created at the termination block.
  • gas sample collection chamber 56 disposed within an upstream region of first side portion 32 ′ of main body section 28 ′.
  • Gas sample collection chamber 56 is positioned downstream from termination block 38 ′ and conduit 58 is positioned downstream of gas sample collection chamber 56 .
  • Gas sample collection chamber 56 has a perimeter, defined by an inner surface 60 thereof, which substantially approximates the perimeter of termination block 38 ′, and conduit 58 has a perimeter, defined by an inner surface 62 thereof, which is smaller than the inner perimeter of gas sample collection chamber 56 .
  • filtered gases are communicated from a fiber chamber 47 ′ of housing 16 ′ into gas sample collection chamber 56 , and then into conduit 58 , and subsequently into sample chamber 30 ′. Such operation is more fully described below.
  • Sample collection portion 14 ′ further includes a second side portion 42 ′, axially aligned with first side portion 32 ′.
  • Second side portion 42 ′ includes an inner perimeter defined by an inner surface 44 ′ thereof that substantially approximates the inner perimeter of conduit 58 , the inner perimeter of conduit 58 being defined by the inner surface 62 thereof.
  • Hydrophobic fiber elements 46 ′ are, in the currently preferred embodiment, formed of a hydrophobic filter media having a pore size of less than or equal to 5 microns.
  • a hydrophobic filter media having a pore size of less than or equal to 5 microns.
  • One suitable example is polypropylene.
  • Hydrophobic fiber elements 46 ′ are folded back on themselves to form loops such that all of the open ends (not shown) thereof are located near second downstream end 20 ′ of housing 16 ′, and looped ends 50 ′ are located near first upstream end 18 ′ of the housing.
  • the downstream portions of fiber elements 46 ′, proximate the open ends 48 ′ thereof, are embedded in the termination block 38 ′.
  • open ends 48 ′ of fiber elements 46 ′ terminate coextensively with the downstream end of termination block 38 ′. It is to be understood, however, that the open ends of the fiber elements may extend beyond the termination block and into gas sample collection chamber 56 . In this manner, gases are communicated from fiber chamber 47 ′ of housing 16 ′ into gas sample collection chamber 56 only through fiber elements 46 ′.
  • fiber elements 46 ′ may include a closed sealed end, such closed sealed end being positioned proximate first upstream end 18 ′ of housing 16 ′.
  • a patient's expired gases enter the gas sampling line 26 ′ and filter portion 12 ′ of the gas sampling assembly 54 as described above with reference to FIGS. 1 and 2 .
  • the gases encounter looped ends 50 ′ of fiber elements 46 ′.
  • Fiber elements 46 ′ are formed of a hydrophobic material such that gases are permitted to pass therethrough but the passage of liquids is substantially prevented.
  • gases substantially free of liquid condensate are permitted to pass only through fiber elements 46 ′ and into gas sample collection chamber 56 , where they are initially collected prior to being directed toward sample chamber 30 ′.
  • the gases are then directed from gas sample collection chamber 56 into conduit 58 and, subsequently, into sample chamber 30 ′, where measurements may be taken thereof, e.g., using optical sensing techniques and the like.
  • the substantially liquid-free gas is exhausted from sample chamber 30 ′ as described above with reference to FIGS. 1 and 2 .
  • liquids are substantially prevented from reaching sample chamber 30 ′ and, accordingly, measurements taken of the gases in sample chamber 30 ′ are less likely to be distorted due to moisture in the gas sample.
  • the waveform of the exhaled gas sample is permitted to proceed substantially undisturbed from the point at which the sample is collected to the point at which the measurements are taken.
  • the waveform indicative of the level of monitored gas in the sample cell is not substantially degraded, as can be the case in conventional systems, where the filter element is located a relatively long distance from the sample cell where the constituent levels are measured and connected with a relatively long hose or conduit.
  • gas sampling assembly 70 includes a filter portion 12 ′′ and a sample collection portion 14 ′′.
  • Filter portion 12 ′′ includes a housing 16 ′′, typically formed of a suitable polymer such as PVC, having a first upstream end 18 ′′ end and a second end 20 ′′.
  • First upstream end 18 ′′ includes an inner perimeter defined by an inner wall 22 ′′ that is configured to be coupled to an outer wall 24 ′′ of a gas sampling line 26 ′′ through which an expired gas sample to be monitored may be received.
  • Outer wall 24 ′′ and inner wall 22 ′′ are coupled to one another in a fluid-tight and gas-tight manner.
  • Sample collection portion 14 ′′ includes a main body section 28 ′′, a portion of the internal volume of which forms a sample chamber 30 ′′ in which the filtered, expired gases is collected for measurements to be taken thereof. It is currently preferred that main body section 28 ′′ is formed of polycarbonate. Sample collection portion 14 ′′ further includes a first side portion 32 ′′, a portion of an inner surface 72 of which is coupled with second downstream end 20 ′′ of housing 16 ′′ in a fluid-tight and gas-tight manner.
  • inner surface 72 of first side portion 32 ′′ defines a perimeter that substantially approximates an outer perimeter of second downstream end 20 ′′ of housing 16 ′′. Accordingly, inner surface 72 of first side portion 32 ′′ and an outer wall of second downstream end 20 ′′ of housing 16 ′′ are coupled in a fluid-tight and gas-tight arrangement.
  • first upstream end 18 ′′ may be less than the inner perimeter of second downstream end 20 ′′, as shown, the respective inner perimeters may approximate one another, or the inner perimeter of first upstream end 18 ′′ may be greater than the inner perimeter of second downstream end 20 ′′.
  • Such relation of inner perimeters depends upon the desired application and all variations are contemplated to be within the scope of the present invention.
  • termination block 38 ′′ is disposed in second downstream end 20 ′′ of housing 16 ′′ so that a fluid-tight and gas-tight seal is created at the termination block.
  • a conduit 74 is defined within an upstream region of first side portion 32 ′′ of main body section 28 ′′ to communicate gas existing a downstream end of termination block 38 ′′ with sample chamber 30 ′′.
  • a diameter of conduit 74 is substantially the same as an inside diameter of downstream second end 20 ′′ of housing 16 ′′, which corresponds to an inside diameter of fiber chamber 47 ′′. Providing matching diameters between fiber chamber 47 ′′ and conduit 74 ′′ helps to reduce disturbances or turbulence in the flow gas passing through the gas sampling assembly.
  • Hydrophobic fiber elements 46 ′′ are, in the currently preferred embodiment, formed of a hydrophobic filter media having a pore size of less than or equal to 5 microns.
  • a hydrophobic filter media having a pore size of less than or equal to 5 microns.
  • One suitable example is polypropylene.
  • Hydrophobic fiber elements 46 ′′ are folded back on themselves to form loops such that all of the open ends (not shown) thereof are located near second downstream end 20 ′′ of housing 16 ′′, and looped ends 50 ′′ are located near first upstream end 18 ′′ of the housing.
  • the downstream portions of fiber elements 46 ′′ are embedded in the termination block 38 ′′.
  • downstream ends of fiber elements 46 ′′ terminate coextensively with the downstream end of termination block 38 ′′ or within the termination block so that they do not extend beyond the surface of the termination block. It is to be understood, however, that the open ends of the fiber elements may extend beyond the termination block and into conduit 74 . In this manner, gases are communicated from fiber chamber 47 ′′ of housing 16 ′′ via fiber elements 46 ′′ into conduit 74 , and then into sample chamber 30 ′′.
  • fiber elements 46 ′′ may include a closed sealed end, such closed sealed end being positioned proximate first upstream end 18 ′′ of housing 16 ′′.
  • gas sampling assembly 70 is similar to that described above with reference to FIGS. 1-4 . Thus, a detailed explanation is omitted for the sake of brevity.
  • liquids are substantially prevented from reaching sample chamber 30 ′′ and, accordingly, measurements taken of the gases in sample chamber 30 ′′ are less likely to be distorted due to moisture in the gas sample.
  • the waveform of the exhaled gas sample is permitted to proceed substantially undisturbed from the point at which the sample is collected to the point at which the measurements are taken.
  • the various portions of the gas sampling assemblies may be formed as separate components or may be integrally formed.
  • the present invention contemplates forming sample collection portion 14 ′′ and filter portion 12 ′′ of FIG. 5 as separate structures that are assembled during manufacture to form a unitary assembly for the gas sampling assembly.
  • the termination block, the sample chamber, the arrangement of the fiber elements and the termination block, and the conduits associated with the termination block and/or sample chamber can have any one of a variety of configurations.
  • FIG. 6 illustrates a second embodiment for a termination block 80 and shows a further configuration for the open ends 82 of the fiber elements coupled thereto. That is FIG. 6 is similar to FIG. 3 , except that it shows an alternative configuration for the termination block and fiber elements.
  • termination block 80 has a relatively rectangular configuration and the open ends of the fiber elements are disposed in a linear array.
  • the linear array is aligned relatively to the sample chamber such that the open ends of the fiber elements are disposed in a plane that is generally perpendicular to the direction in which radiation is passed through the sample chamber. This arrangement in that it presents a uniform wall of gas directly into the sample chamber for measurement by the gas monitoring system.
  • FIG. 7 illustrates a gas sampling assembly 90 that is similar to that shown in FIG. 5 , including a filter portion 12 ′′ and a sample collection portion 14 ′′.
  • the passage in main body section 28 ′′′ includes a “Z” shaped path through a sample chamber 30 ′′,′ as indicated by arrows 92 and 94 .
  • Sample chamber 30 includes open ends with window disposed at each open end so that irradiation 96 can be passed through the sample chamber.
  • An inlet portion 98 of the passage communicates the outlet of filter portion 12 ′′ with the sample chamber.
  • This “Z” shaped configuration for the optical sampling portion of the sample collection portion is described in co-pending U.S. patent application No. 60/416,875, the contents of which are incorporated herein by reference. It is to be understood that other configurations for the sample collection portion and the passage therethrough are contemplated by the present invention.
  • FIGS. 8 and 9 illustrate a seventh embodiment of a filter assembly 100 according to the principles of the present invention.
  • Filter assembly 100 includes a filter portion 102 and a sample collection portion 104 .
  • Filter portion 102 includes a housing 106 typically formed of a suitable polymer, such as PVC, having a first upstream end 108 and a second downstream end 110 .
  • housing 106 is cylindrical in shape.
  • a gas sampling line 112 is coupled to first upstream end 108 of the housing.
  • filter portion 102 and sample collection portion 104 can be joined in a permanent arrangement, such as being bonded to one another, or they can be selectively joined, so that they can be detached from one another.
  • Any suitable technique can be used to couple the filter portion with the sample collection portion in a selectable fashion.
  • a press-fit or friction-fit can be used.
  • Additional mechanical elements such as snaps, tongue-and-grooves, prongs, or other fastening devices can be used to couple the filter portion with sample collection portion.
  • the filter provided in the filter portion of the gas sampling assembly includes a hydrophilic member 120 and a hydrophobic member 130 , both of which are disposed in housing 106 .
  • hydrophilic member 120 be formed of a porous material suitable for wicking moisture from the gas passing through the filter portion.
  • An example of such a material is a fibrous material, having a pore volume ranging from approximately 40% to approximately 90%, where the pore volume is the ratio of a porous material's air volume to a porous material's total volume.
  • Exemplary fibrous materials include single component fibers as well as fiber blends, such as bi-component, multi-component and functional fibers.
  • hydrophilic member 120 An example of a fibrous material suitable for hydrophilic member 120 is disclosed in U.S. patent application Ser. No. 10/464,443 (publication no. 2003/0211799). Such fibers may possess absorbent properties that, in effect, create reservoirs with substantial liquid holding capacity.
  • the illustrated hydrophilic member 120 is cylindrical and constructed of thermally bonded fibers.
  • the fibers consist of a polyester core with a polyester sheath and are sintered to form the cylindrical structure.
  • Other shaped structures are contemplated that may enhance the water holding capacity.
  • hydrophilic member 120 has a diameter that is slightly greater than the diameter of housing 106 to assure a tight fit of the hydrophilic member in the housing without significant compression.
  • the length and width of the hydrophilic member varies with the desired water carrying capacity. That is, longer and wider hydrophilic members will have greater water carrying capacity. However, longer and wider hydrophilic members also have longer rise time associated with them. Therefore, the preferred range of lengths is approximately 0.5 in to 2.0 in for 0.138′′ diameter.
  • hydrophobic member 130 is a disc with a diameter that is greater than the diameter of the housing so that a sufficiently tight seal is made.
  • the length of the hydrophobic member is selected so as to prevent water from passing through the hydrophobic member when a pressure is being drawn on the outlet of the filter up to 5 psia.
  • Hydrophobic member 130 in one embodiment, is constructed of a porous plastic, such as polyethylene, with an additive coating that self seals upon wetting. Materials known in the art, such as cellulose gum, can serve this function.
  • a sufficiently large pore volume of hydrophilic member 102 permits not only moisture to be efficiently absorbed but also permits gas to flow substantially smoothly through and thereby minimizes the turbulence effects on the gas stream.
  • hydrophilic member 120 lines the inner wall of housing 106 generally from first end 108 to a point where a hydrophobic member 130 is located, which is proximate to second end 110 . It is to be understood, however, that hydrophilic member 120 need not extend along the entire length of the housing, need not fill the housing, and need not be formed from a single, unitary material. Rather, hydrophilic member 120 can be formed from multiple pieces of material, and each portion or piece of the hydrophilic member need not be formed from the same material. For example, the portions of the hydrophilic member can be formed such that the absorbency of the material changes along the length of the housing, in the radial direction or is maximized where it is more likely that condensation will gather.
  • Hydrophobic member 130 is positioned proximate second end 110 of housing 106 .
  • Hydrophobic member 130 has an outer diameter, defined by an outer surface thereof that may approximate or exceed the inner diameter of the housing such that the outer surface is closely coupled with the inner wall of the housing in a gas-tight and fluid-tight arrangement, as known to those of ordinary skill in the art. In this manner, only gases passing through the hydrophobic member 130 are permitted to reach the sensing mechanism.
  • an upstream surface of the hydrophobic member is in contact with a downstream edge of hydrophilic member 120 .
  • the present invention also contemplates that there need not be direct contact between these members. Instead, a gap can be provided between the hydrophobic and the hydrophilic member. This can gap can be used as a reservoir for materials that may accumulate in the filter assembly. It is generally, understood that the larger the gap, the more likely the waveform for the monitored gas will be adversely impacted. To address this concern, the present invention also contemplates providing an inert filler material between the hydrophobic and hydrophilic members.
  • hydrophilic member 120 In operation, the expired gases proceed through the internal volume of housing 100 , moisture is wicked out of the gas stream by hydrophilic member 120 and locked away from the gas stream. While hydrophilic member 120 is capable of absorbing a substantial portion of the moisture from the gas stream, some moisture will remain in the stream. Thus, hydrophobic member 130 is provided as a second line of defense against moisture reaching the sensing mechanism. Because hydrophobic member 130 is formed of a hydrophobic material, gases will be permitted to pass therethrough but liquids will be substantially prevented from passing through the hydrophobic member. Instead, any liquid remaining in the gas stream will remain within the spaces within hydrophilic member 120 and may be absorbed by the downstream-most portions of the hydrophilic member or wicked away from the hydrophobic member 130 using the hydrophilic member or a separate wicking material.
  • housing 106 As housing 106 is coupled in a gas-tight and fluid-tight arrangement with sample collection portion 104 , the only way that gases may exit the housing is through the hydrophobic member 130 .
  • gases substantially free of liquids pass through the hydrophobic member 130 , enter the sample collection portion to be monitored. In this manner, only gases substantially free of liquid condensate are permitted to reach the sensing mechanism.
  • the waveform of the exhaled gas sample is permitted to proceed substantially undisturbed from the point at which the sample is collected to the point at which the sensing mechanism readings are taken. Disturbance to the waveform which may be affected due to the hydrophobic member 130 is of minimal consequence.
  • Gas sampling line 112 ( 26 , 26 ′, 26 ′′ in the previous embodiments) is coupled to the user via a patient interface 140 .
  • patient interface 140 is a nasal cannula that includes a pair of hollow prongs 142 that insert into the nares of the user.
  • patient interface 140 can have any configuration.
  • a portion 144 of gas sampling 112 that is proximate to the patient interface is looped so that it can pass over the patient's ear.
  • a supplemental gas delivery line 150 is also coupled to patient interface 140 .
  • This line is used, for example, to deliver supplemental oxygen to the user.
  • one prong of the patient interface is physically isolated from the other so that gas can be sampled from one prong and the supplemental gas can be delivered through the other.
  • a connection terminal 152 is provided.
  • the connection terminal provides a connection to an oxygen delivery hose, for example, by friction fitting the oxygen hose into a cavity 154 defined in the connection portion of the connection terminal.
  • a plug 156 is provided in cavity 154 , which is removed when the supplemental gas hose is to be connected to the connection terminal.
  • the present invention also contemplates providing a filter element (not shown) in the connection terminal to filter the supplemental gas being delivered to the patient.
  • Gas sampling line 112 can be fixed to the connection terminal or slidable within it.
  • a collar 160 is provided for tubing management. Collar 160 is either fixed or slidable along the length of lines 112 and 150 to keep then together. Collar 160 can have any suitable configuration, and more than one collar can be used or it can be omitted entirely.

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US11/519,041 2002-10-08 2006-09-11 Integrated sample cell and filter and system using same Expired - Lifetime US7549316B2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US11/519,041 US7549316B2 (en) 2002-10-08 2006-09-11 Integrated sample cell and filter and system using same
BRPI0716566-8A BRPI0716566A2 (pt) 2006-09-11 2007-09-07 Conjunto de amostragem de gás
JP2009527591A JP2010502995A (ja) 2006-09-11 2007-09-07 一体型サンプルセル及びフィルタ並びにそれらを用いたシステム
CN200780033522.XA CN101548169B (zh) 2006-09-11 2007-09-07 集成化样品单元和过滤器以及使用该样品单元和过滤器的系统
PCT/US2007/077909 WO2008033733A2 (fr) 2006-09-11 2007-09-07 Cellule d'échantillon et filtre intégrés, et système les utilisant
RU2009113541/05A RU2454650C2 (ru) 2006-09-11 2007-09-07 Объединенная ячейка для образца с фильтром и система, использующая объединенную ячейку для образца с фильтром
EP07842076A EP2069748A4 (fr) 2006-09-11 2007-09-07 Cellule d'echantillon et filtre integres, et systeme les utilisant
JP2012269988A JP2013068630A (ja) 2006-09-11 2012-12-11 一体型サンプルセル及びフィルタ並びにそれらを用いたシステム

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US41687402P 2002-10-08 2002-10-08
US10/678,692 US7121134B2 (en) 2002-10-08 2003-10-03 Integrated sample cell and filter and system using same
US11/519,041 US7549316B2 (en) 2002-10-08 2006-09-11 Integrated sample cell and filter and system using same

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US7597733B2 (en) * 2004-01-23 2009-10-06 Ric Investments, Llc Liquid absorbing filter assembly and system
WO2007012140A1 (fr) 2005-07-29 2007-02-01 Resmed Limited Procédé et appareil pour gérer l'accumulation d'humidité dans des systèmes de respiration sous pression
EP2539002A4 (fr) * 2010-02-22 2015-06-24 Criticare Systems Inc Piège à eau en ligne
CN102305734B (zh) * 2011-08-23 2014-01-29 河南汉威电子股份有限公司 呼出气体采集装置
WO2014027290A1 (fr) * 2012-08-15 2014-02-20 Koninklijke Philips N.V. Système d'échantillonnage de gaz respiratoire à soutirage latéral avec accessoires flexibles et piège à eau amovible
EP2781917A1 (fr) * 2013-03-18 2014-09-24 Simone Cristoni Dispositif et procédé pour échantillonner et analyser l'haleine
SG11201601439QA (en) * 2013-08-30 2016-03-30 Capnia Inc Columnar flow gas sampling and measurement system
CN104257384B (zh) * 2014-09-29 2017-02-15 无锡市尚沃医疗电子股份有限公司 一种手持式吸气过滤装置

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JP2013068630A (ja) 2013-04-18
WO2008033733A2 (fr) 2008-03-20
RU2454650C2 (ru) 2012-06-27
CN101548169B (zh) 2013-03-06
EP2069748A2 (fr) 2009-06-17
JP2010502995A (ja) 2010-01-28
RU2009113541A (ru) 2010-10-20
BRPI0716566A2 (pt) 2013-10-15
US20070062313A1 (en) 2007-03-22
WO2008033733A3 (fr) 2008-06-26
EP2069748A4 (fr) 2011-07-20

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