US7534618B2 - Systems and methods for measuring glycated hemoglobin - Google Patents

Systems and methods for measuring glycated hemoglobin Download PDF

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Publication number
US7534618B2
US7534618B2 US11/881,531 US88153107A US7534618B2 US 7534618 B2 US7534618 B2 US 7534618B2 US 88153107 A US88153107 A US 88153107A US 7534618 B2 US7534618 B2 US 7534618B2
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United States
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sample
capillary channel
blood cells
red blood
age
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US11/881,531
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US20070267361A1 (en
Inventor
David A. Tyvoll
Kirk W. Norton
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Hewlett Packard Development Co LP
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Hewlett Packard Development Co LP
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Priority claimed from US11/261,741 external-priority patent/US8481323B2/en
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Priority to US11/881,531 priority Critical patent/US7534618B2/en
Assigned to HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. reassignment HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NORTON, KIRK W., TYVOLL, DAVID A.
Publication of US20070267361A1 publication Critical patent/US20070267361A1/en
Priority to EP08011948A priority patent/EP2019320B1/en
Priority to DE602008002498T priority patent/DE602008002498D1/de
Priority to CN200810131121.4A priority patent/CN101354327B/zh
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • G01N33/723—Glycosylated haemoglobin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Definitions

  • FIG. 4 An exemplary capillary barrier 24 is depicted in FIG. 4 .
  • a first solution 20 having a first density is separated from a second solution 22 having a second density by a barrier 24 , where the barrier is either a physical barrier, or a hydrophobic liquid valve.
  • the barrier is either a physical barrier, or a hydrophobic liquid valve.
  • a gradient capillary channel 82 containing gradient lysed blood cells includes multiple resistors 83 along the gradient microchannel with associated detector regions 84 and vents 86 accessed through individual valves 88 .
  • a variety of active and passive valves may be used for this purpose, as discussed above and as is known in the art.
  • the use of a wax plug having a relatively low melting point can be used to create access to the detector regions 84 upon at least partial removal of the plug.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US11/881,531 2005-10-28 2007-07-27 Systems and methods for measuring glycated hemoglobin Active US7534618B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US11/881,531 US7534618B2 (en) 2005-10-28 2007-07-27 Systems and methods for measuring glycated hemoglobin
EP08011948A EP2019320B1 (en) 2007-07-27 2008-07-02 Systems and methods for measuring glycated hemoglobin
DE602008002498T DE602008002498D1 (de) 2007-07-27 2008-07-02 Systeme und Verfahren zum Messen von glykiertem Hämoglobin
CN200810131121.4A CN101354327B (zh) 2007-07-27 2008-07-28 测量糖化血色素的系统和方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/261,741 US8481323B2 (en) 2005-10-28 2005-10-28 Systems and methods for measuring glycated hemoglobin
US11/881,531 US7534618B2 (en) 2005-10-28 2007-07-27 Systems and methods for measuring glycated hemoglobin

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/261,741 Continuation-In-Part US8481323B2 (en) 2005-10-28 2005-10-28 Systems and methods for measuring glycated hemoglobin

Publications (2)

Publication Number Publication Date
US20070267361A1 US20070267361A1 (en) 2007-11-22
US7534618B2 true US7534618B2 (en) 2009-05-19

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ID=39713878

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Country Status (4)

Country Link
US (1) US7534618B2 (zh)
EP (1) EP2019320B1 (zh)
CN (1) CN101354327B (zh)
DE (1) DE602008002498D1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120247964A1 (en) * 2011-04-01 2012-10-04 Electronics And Telecommunications Research Institute Microfluidic control device for measuring glycoslyated hemoglobin, method for manufacturing the same and method for operating the same
US10695759B2 (en) * 2016-07-18 2020-06-30 Tianjin Dexiang Biotechnology Co., Ltd. Microfluidic reagent card and detection method and application thereof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8481323B2 (en) * 2005-10-28 2013-07-09 Hewlett-Packard Development Company, L.P. Systems and methods for measuring glycated hemoglobin
US8221299B2 (en) * 2008-06-17 2012-07-17 Bio-Rad Laboratories, Inc. Centrifugal force-based system for detection/treatment of membrane-encased structures
EP3191848A1 (en) * 2014-09-12 2017-07-19 Beckman Coulter, Inc. Systems and methods to determine the age of cells
CN106492510B (zh) * 2016-10-31 2018-09-14 华南理工大学 聚合物分离方法
CN111466508A (zh) * 2020-04-10 2020-07-31 四川长虹电器股份有限公司 射频解冻装置、冰箱及射频解冻方法
WO2022125073A1 (en) * 2020-12-08 2022-06-16 Hp Health Solutions Inc. Fluidic devices
WO2022125074A1 (en) * 2020-12-08 2022-06-16 Hp Health Solutions Inc. Fluidic devices with non-newtonian plugging fluids
WO2022125072A1 (en) * 2020-12-08 2022-06-16 Hp Health Solutions Inc. Fluidic devices with reactant injection

Citations (12)

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US5284773A (en) * 1992-08-28 1994-02-08 The Uab Research Foundation Determination of lipoprotein concentration in blood by controlled dispersion flow analysis
US5550060A (en) * 1992-11-03 1996-08-27 Chronomed, Inc. Method and procedure for preparing red blood fractions
US5837546A (en) 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
WO1998053311A2 (en) 1997-05-23 1998-11-26 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US5932480A (en) 1996-03-14 1999-08-03 Tosoh Corporation Measurement method and kit for hemoglobin A1c
US5968839A (en) 1996-05-13 1999-10-19 Metrika, Inc. Method and device producing a predetermined distribution of detectable change in assays
US6174734B1 (en) 1997-10-24 2001-01-16 Abbott Laboratories Measurement of glycated hemoglobin
US6316265B1 (en) 1997-03-13 2001-11-13 Abbott Laboratories Determination of % glycated hemoglobin
US6399293B1 (en) 1998-09-21 2002-06-04 Roche Diagnostics Gmbh Methods and test devices for determination of glycated haemoglobin
US6582964B1 (en) 1999-05-12 2003-06-24 Cme Telemetrix Inc. Method and apparatus for rapid measurement of HbA1c
US6946100B2 (en) * 1997-09-16 2005-09-20 Sekisui Chemical Co., Ltd. Blood test container
US20070099301A1 (en) * 2005-10-28 2007-05-03 Tyvoll David A Systems and methods for measuring glycated hemoglobin

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US20050037221A1 (en) * 2002-07-31 2005-02-17 Fox Roger F. Penetration improvement of copper amine solutions into dried wood by addition of carbon dioxide
JP2004184138A (ja) * 2002-11-29 2004-07-02 Nec Corp 分離装置、分離方法、および質量分析システム
WO2004108051A2 (en) * 2003-06-11 2004-12-16 C-Boot Ltd Device and method for low pressure compresssion and valve for use in the system

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284773A (en) * 1992-08-28 1994-02-08 The Uab Research Foundation Determination of lipoprotein concentration in blood by controlled dispersion flow analysis
US5550060A (en) * 1992-11-03 1996-08-27 Chronomed, Inc. Method and procedure for preparing red blood fractions
US5837546A (en) 1993-08-24 1998-11-17 Metrika, Inc. Electronic assay device and method
US5932480A (en) 1996-03-14 1999-08-03 Tosoh Corporation Measurement method and kit for hemoglobin A1c
US5968839A (en) 1996-05-13 1999-10-19 Metrika, Inc. Method and device producing a predetermined distribution of detectable change in assays
US6316265B1 (en) 1997-03-13 2001-11-13 Abbott Laboratories Determination of % glycated hemoglobin
WO1998053311A2 (en) 1997-05-23 1998-11-26 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
US6946100B2 (en) * 1997-09-16 2005-09-20 Sekisui Chemical Co., Ltd. Blood test container
US6174734B1 (en) 1997-10-24 2001-01-16 Abbott Laboratories Measurement of glycated hemoglobin
US6818416B2 (en) 1998-09-21 2004-11-16 Rudolf Pachl Methods for determination of the ratio of glycated haemoglobin to nonglycated haemoglobin
US6399293B1 (en) 1998-09-21 2002-06-04 Roche Diagnostics Gmbh Methods and test devices for determination of glycated haemoglobin
US6582964B1 (en) 1999-05-12 2003-06-24 Cme Telemetrix Inc. Method and apparatus for rapid measurement of HbA1c
US20070099301A1 (en) * 2005-10-28 2007-05-03 Tyvoll David A Systems and methods for measuring glycated hemoglobin

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Gifford, Sean C., "Parallel Microchannel-Based Measurements of Individual Erythrocyte Areas and Volumes", Biophysical Journal, vol. 84, Jan. 2003, pp. 623-633.
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120247964A1 (en) * 2011-04-01 2012-10-04 Electronics And Telecommunications Research Institute Microfluidic control device for measuring glycoslyated hemoglobin, method for manufacturing the same and method for operating the same
US10695759B2 (en) * 2016-07-18 2020-06-30 Tianjin Dexiang Biotechnology Co., Ltd. Microfluidic reagent card and detection method and application thereof

Also Published As

Publication number Publication date
CN101354327B (zh) 2013-01-16
US20070267361A1 (en) 2007-11-22
EP2019320B1 (en) 2010-09-15
CN101354327A (zh) 2009-01-28
DE602008002498D1 (de) 2010-10-28
EP2019320A1 (en) 2009-01-28

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