US6737525B2 - Electrophilic fluorination - Google Patents
Electrophilic fluorination Download PDFInfo
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- US6737525B2 US6737525B2 US10/044,049 US4404901A US6737525B2 US 6737525 B2 US6737525 B2 US 6737525B2 US 4404901 A US4404901 A US 4404901A US 6737525 B2 US6737525 B2 US 6737525B2
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- 0 F[N+]1=**=**=*1.[Y-] Chemical compound F[N+]1=**=**=*1.[Y-] 0.000 description 13
- PDQDOPNCYMBMRS-UHFFFAOYSA-N CC1=NC(C(F)(F)F)=NC(C(F)(F)F)=[N+]1F Chemical compound CC1=NC(C(F)(F)F)=NC(C(F)(F)F)=[N+]1F PDQDOPNCYMBMRS-UHFFFAOYSA-N 0.000 description 1
- YMPNIPRTFURWOO-UHFFFAOYSA-N CC1=NC(C)=[N+](F)C(C)=N1 Chemical compound CC1=NC(C)=[N+](F)C(C)=N1 YMPNIPRTFURWOO-UHFFFAOYSA-N 0.000 description 1
- PLTQXIVBTHDCFR-UHFFFAOYSA-N CC1=NC(C)=[N+](F)C(C)=N1.[Y-] Chemical compound CC1=NC(C)=[N+](F)C(C)=N1.[Y-] PLTQXIVBTHDCFR-UHFFFAOYSA-N 0.000 description 1
- CHLXNUMAMSEJKV-UHFFFAOYSA-N COC1=NC(OC)=[N+](F)C(OC)=N1 Chemical compound COC1=NC(OC)=[N+](F)C(OC)=N1 CHLXNUMAMSEJKV-UHFFFAOYSA-N 0.000 description 1
- NFAPWQHXXUKGHB-UHFFFAOYSA-N FC1=NC(F)=[N+](F)C(F)=N1 Chemical compound FC1=NC(F)=[N+](F)C(F)=N1 NFAPWQHXXUKGHB-UHFFFAOYSA-N 0.000 description 1
- JVMPXVOUWNZJDD-UHFFFAOYSA-N F[N+]1=C(Cl)N=C(Cl)N=C1Cl Chemical compound F[N+]1=C(Cl)N=C(Cl)N=C1Cl JVMPXVOUWNZJDD-UHFFFAOYSA-N 0.000 description 1
- BVEGSKBDQNRESW-UHFFFAOYSA-N F[N+]1=C(Cl)N=C(Cl)N=C1Cl.[Y-] Chemical compound F[N+]1=C(Cl)N=C(Cl)N=C1Cl.[Y-] BVEGSKBDQNRESW-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B39/00—Halogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/12—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the ring of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/22—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of halogens; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/28—Only halogen atoms, e.g. cyanuric chloride
Definitions
- This invention relates to electrophilic fluorination and in particular to the use of N-fluorotriazinium salts as electrophilic fluorinating agents.
- the invention provides a method of electophilically fluorinating a substrate, especially an organic substrate using N-fluorotriazinium salt fluorinating agents and has particularly, but not exclusive, application to the fluorination of electron-rich species, for example activated aromatic compounds (i.e. carrying electron-donating substituents) or overt or covert carbanions.
- At least the preferred tri(halo or trifluoromethyl)-substituted N-fluorotriazinium salts are sufficiently strong fluorinating agents to readily fluorinate unsubstituted aromatic substrates and aromatic substrates having one or more electron-withdrawing substituents.
- Fluorination is an important process in many areas of industry, in particular where the synthesis of specialty chemicals is concerned.
- Known fluorination methods are conveniently categorized according to the perceived manner in which the fluorinating agents provide fluorine for combination with an active site in an organic molecule, namely as fluorine atom (F • ), fluoride ion (F ⁇ ) or, conceptually, fluoronium ion (F + ).
- Fluorinations involving fluorine atom are notoriously exothermic and non-selective, hence “light” strategic fluorination of organic compounds (that is, the introduction of one or two fluorine substituents or a trifluoromethyl group at key molecular sites) rests on the availability of versatile ranges of nucleophilic and electrophilic sources of fluorine.
- N-fluoro compounds has become one of the most widely used methods for the selective formation of carbon-fluorine bonds via “electrophilic” mechanisms.
- a recent comprehensive review of this synthetic methodology contains no reference to N—F reagents derived from triazines (see G. G.
- F-TEDA-BF 4 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
- Selectfluor 1-Chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate)
- this material has only a moderate fluorinating power and is able to fluorinate benzene only under forcing conditions, for example under reflux for 24 hours.
- the chemistry of F-TEDA-BF 4 has been reviewed by R. E. Banks in J. Fluorine Chemistry 87 (1998) 1-17, the whole content of which is incorporated herein by reference.
- N-Fluoropyridinium salts and ring-substituted analogues thereof are known for use as a fluorinating agent but have relatively low fluorinating power.
- U.S. Pat. No. 4,828,764 discloses that certain N-fluoro-N-perfluoroalkyl or perfluoroaryl sulfonamides formula R f SO 2 NFR are electrophilic fluorinating agents.
- R f represents a perfluorinated C 1 -C 30 alkyl, C 3 -C 30 cycloalkyl, C 6 -C 14 aryl substituted C 1 -C 10 alkyl or a C 6 -C 14 aryl group and R represents a C 1 -C 30 alkyl, C 3 -C 30 cycloalkyl, C 6 -C14 aryl substituted C 1 -C 10 alkyl, or C 6 -C 14 aryl group optionally substituted with one or more inert substituents including, inter alia, fluorine and, when R f is trifluoromethyl, R alternatively can represent perfluoromethyl-sulfonamido.
- DesMarteau's Reagent is a powerful electrophilic fluorinating agent which is capable of converting benzene to fluorobenzene at room temperature but is hazardous, time-consuming and expensive to prepare requiring eight or nine reaction steps from readily available material.
- fluorinate benzene Only a very limited number of other known fluorinating agents are strong enough to fluorinate benzene without forcing conditions but they often provide relatively low yields or require special precautions. Those reported to fluorinate benzene include, in addition to DesMarteau's Reagent, CF 3 OF, XeF 2 , NF 4 + BF 4 ⁇ , N 2 F + AsF 6 ⁇ , N-fluoropentachloropyridinium triflate, perfluoro-[N-fluoro-N-(4-pyridyl)methanesulfonamide] and N-fluoro-2,6-bis(methoxycarbonyl)pyridinium triflate. Very few of these compounds, only NF 4 + BF 4 ⁇ and XeF 2 , are known to fluorinate aromatic substrates having electron-withdrawing substituents such as nitrobenzene.
- N-Fluorotriazinium salts of the following Formula A are known:
- N-fluorotriazinium salts of Formula A are reported to be oxidizing agents of use in, for example, organometallic chemistry.
- the cationic component of compounds of Formula A in which X is H, F and Cl have been described as “oxidative fluorinators” and a qualitative scale for their oxidizing strength and that of NF 4 + has been computed ab initio (Ref. 3—see below).
- each R is independently, hydrogen, halogen, hydroxyl, (primary, secondary or tertiary) amino, cyano, perfluorothio, hydroxysulfonyl, halosulfonyl, hydrocarbyloxysulfonyl, or a carbon-containing substituent selected from the group consisting of optionally substituted hydrocarbyl, hydrocarbyloxy, hydrocarbyloxycarbonyl, and hydrocarbylthio groups, and at least one R is neither hydrogen nor halogen;
- a moieties are independently Z, where each Z is independently nitrogen or a quaternary nitrogen atom;
- Y ⁇ is a counterion or group of counterions which are inert to chemical attack by fluorine
- N-fluorinated triazinium salts are excellent electrophilic fluorinating agents yet do not possess some of the drawbacks of known electrophilic fluorinating agents.
- These salts have a high fluorinating power which allows substrates which are difficult to fluorinate using known fluorinating agents to be fluorinated, especially electron-rich species such as, for example, carbanionic and/or activated aromatic substrates. Also they may be employed to fluorinate substrates which may presently be fluorinated electrophilically using known fluorinating agents but under milder reaction conditions due to the effective fluorinating power of the N-fluorotriazinium cation.
- N-fluorotriazinium salts can be presented by the following Formula I:
- each R is independently, hydrogen, halogen, hydroxyl, (primary, secondary or tertiary) amino, cyano, perfluorothio, hydroxysulfonyl, halosulfonyl, hydrocarbyloxysulfonyl, or a carbon-containing substituent selected from the group consisting of optionally substituted hydrocarbyl, hydrocarbyloxy, hydrocarbyloxycarbonyl, and hydrocarbylthio groups;
- a moieties are independently Z, where each Z is independently nitrogen or a quaternary nitrogen atom;
- Y ⁇ is a counterion or group of counterions which are inert to chemical attack by fluorine.
- the present invention provides a method of electrophilic fluorination which comprises contacting an organic substrate with a N-fluorotriazinium salt electrophilic fluorinating agent.
- N-fluorotriazinium salt as an electrophilic fluorinating agent.
- N-Fluorotriazinium salts have a high fluorinating power which allows substrates which are difficult to fluorinate using known fluorinating agents to be fluorinated especially electron-rich species for example carbanionic and/or activated aromatic substrates. Also they may be employed to fluorinate substrates which may presently be fluorinated electrophilically using known fluorinating agents but under milder reaction conditions due to the effective fluorinating power of the N-fluorotriazinium cation.
- N-fluorotriazinium salts are of the following Formula I:
- each R is independently, hydrogen, halogen, hydroxyl, (primary, secondary or tertiary) amino, cyano, perfluorothio, hydroxysulfonyl, halosulfonyl, hydrocarbyloxysulfonyl, or a carbon-containing substituent selected from the group consisting of optionally substituted hydrocarbyl, hydrocarbyloxy, hydrocarbyloxycarbonyl, and hydrocarbylthio groups;
- a moieties are independently Z, where each Z is independently nitrogen or a quaternary nitrogen atom;
- Y ⁇ is a counterion or group of counterions which are inert to chemical attack by fluorine
- triazinium compounds are 1,2,4-triazinium compounds of the following Formula IA or, especially, 1,3,5-triazinium compounds of the following Formula IB:
- R 1 , R 2 and R 3 are, independently, hydrogen, halogen, (primary, secondary or tertiary) amino, hydroxyl, cyano, perfluorothio, hydroxysulfonyl, halosulfonyl, hydrocarbyloxysulfonyl, or a carbon-containing substituent selected from the group consisting of optionally substituted hydrocarbyl, hydrocarbyloxy, hydrocarbyloxycarbonyl, and hydrocarbylthio groups;
- Z 1 and Z 2 are independently nitrogen or a quaternary nitrogen atom
- Y ⁇ is a counterion or group of counterions which are inert to chemical attack by fluorine
- each R substituent, or each of R 1 , R 2 and R 3 for Formulae IA and IB, is halogen or trifluoromethyl.
- the N-fluoro-trihalotriazinium and N-fluoro-tris (trifluoromethyl)triazinium salts are remarkably strong fluorinating agents capable of room temperature fluorination of unsubstituted aromatic substrates such as benzene and aromatic substrates having one or more electron-withdrawing substituents such as chlorobenzene or nitrobenzene.
- the said carbon-containing substituent(s) may be unsubstituted and contain only hydrogen and carbon atoms, and in the case of hydrocarbyloxy and hydrocarbylthio, also an oxygen or sulfur atom respectively, or they may be substituted and contain one or more heteroatoms for example oxygen, nitrogen, halogen and sulfur, and/or heterogroups, for example carbonyl, ester and amide links.
- the carbon-containing substituent(s) may contain a heteroatom in the carbon chain and/or may be substituted with a substituent containing a heteroatom such as, for example, OH, alkoxy and halogen, for example chlorine, bromine and especially fluorine.
- One or more (including all) hydrogen atoms in the said carbon-containing substituent(s) may be substituted as desired.
- the hydrocarbyl and hydrocarbyloxy groups may be alkyl, alkenyl, aryl, aryloxy and alkoxy groups which optionally are substituted.
- the alkyl and alkoxy group have from about 1 to about 12 carbon atoms, more preferably about 1 to about 8 carbon atoms and especially about 1 to about 4 carbon atoms, for example methyl, ethyl, methoxy and ethoxy.
- the alkenyl group and aryl group have from about 2 to about 12, especially about 2 to about 8, carbon atoms and from about 6 to about 12, especially about 6 to about 9, carbon atoms respectively.
- At least one R, or at least one of R 1 , R 2 and R 3 for Formulae IA and IB, is selected from the group consisting of hydrohaloalkyl groups, especially hydrofluoroalkyl groups, and perhaloalkyl groups, especially perfluoroalkyl groups.
- suitable perfluoroalkyl groups include trifluoromethyl, pentafluoroethyl and perfluorooctyl groups
- suitable hydrofluoroalkyl groups include 2,2,2-trifluoroethyl, 2,2,3,3-tetrafluoropropyl and H(CF 2 CF 2 ) p CH 2 groups (where p is at least 2).
- Perhaloalkyl groups may be preferred in some cases due to the absence of a carbon-hydrogen bond which may be susceptible to electrophilic fluorination.
- At least one R, or at least one of R 1 , R 2 and R 3 for Formulae IA and IB is selected from the group consisting of hydrohaloalkoxy groups, especially hydrofluoroalkoxy groups, and perhaloalkyl groups, especially perfluoroalkyl groups.
- suitable perfluoroalkoxy groups include trifluoromethoxy, pentafluoroethoxy and perfluorooctoxy groups
- suitable hydrofluoroalkoxy groups include 2,2,2-trifluoroethoxy and 2,2,3,3-tetrafluoropropoxy.
- Particularly preferred are H(CF 2 CF 2 ) p CH 2 O groups (where p is at least 2) which are readily available using known telomer alcohols of the corresponding formula H(CF 2 CF 2 ) p CH 2 OH.
- At least one R, or R 1 , R 2 and/or R 3 for Formulae IA and IB is a thio analogue of the aforementioned hydrohaloalkoxy and perhaloalkoxy groups, for example trifluoromethylthio (CF 3 S), or a perfluorothio group such as trifluorothio (SF 3 ) or pentafluorothio (SF 5 ).
- CF 3 S trifluoromethylthio
- SF 3 trifluorothio
- SF 5 pentafluorothio
- aryl and aryloxy include moieties which contain aliphatic as well as aromatic groups.
- Preferred aryl and aryloxy groups include phenyl, phenoxy, and groups of formula C 6 H 5 (CH 2 ) r [OC 2 H 4 ] q O t where q is 0 to 6, r is 0 to 8 and t is 0 or 1, which may be optionally substituted, preferably with fluorine.
- At least one of R, or at least one of R 1 , R 2 and R 3 for Formulae IA and IB is hydrocarbyl, hydrocarbyloxy, hydrohalocarbyl, hydrohalocarbyloxy, perhalocarbyl, or perhalocarbyloxy, and Z, or Z 1 and Z 2 for Formulae IA and IB, and Y ⁇ are as defined above.
- R substituents are identical in a given compound.
- examples of especially preferred compounds are those in which all R substituents, or all of R 1 , R 2 and R 3 are methyl, methoxy, trifluoromethoxy groups, or, most preferably, halogen or trifluoromethyl.
- a practical advantage of R 1 , R 2 and R 3 being the same group is the manufacture of the compound may be simplified and isomers or a mixture of compounds is less likely to be produced.
- R, or R 1 , R 2 and R 3 for Formulae IA and IB may be selected so as to provide technical advantages to the compound of Formula I in addition to the fluorination characteristics such as improving the solubility of the compound in non-polar solvents and solvents of low polarity.
- R, or R 1 , R 2 and R 3 for Formulae IA and IB may be selected so as to provide technical advantages to the compound of Formula I in addition to the fluorination characteristics such as improving the solubility of the compound in non-polar solvents and solvents of low polarity.
- greater flexibility in chemical synthesis involving electrophilic fluorination is also provided by the compounds of Formula I.
- the compounds of Formula I can be oligomers or polymers in which adjacent triazinium moieties are linked by a common R substituent, for example, a hydrocarbyl, perfluorohydrocarbyl or hydrocarbyloxy group.
- a common R substituent for example, a hydrocarbyl, perfluorohydrocarbyl or hydrocarbyloxy group.
- Presently preferred linking groups are dioxyphenyl, di(oxycarbyl)phenyl, alkylenedioxy or bis(oxyaryl)alkylene groups, such as, for example, 1,5-dioxypent-2,4-diyl (i.e. —O—CH 2 —CH—CH 2 —CH—CH 2 —O—), 1,3-bis(p-oxyphenyl)prop-1,3-diyl (i.e.
- the compounds of Formula I contain at least one fluorinated quaternary nitrogen atom in the triazinium ring and one or both of the other triazinium nitrogen atoms may be quaternary, preferably fluorinated, nitrogen.
- both Z, or both Z 1 and Z 2 for Formulae IA and IB are nitrogen and the most preferred compounds are those of the following Formula II:
- R 1 , R 2 , R 3 and Y ⁇ are as defined above.
- Examples of preferred compounds according to the invention are those having a triazinium cation as shown below in Formulae III to VII, especially those of Formulae IV, V and VI.
- the counterion Y ⁇ is resistant to chemical attack by fluorine and desirably, is thermally stable and possesses low environmental toxicity.
- the counterion(s) can be any anion(s) which can be counterion(s) to the triazinium cation.
- the counterion(s) may have a single charge or a multiple charge or be a group of counterions so as to balance the charge of the triazinium moiety.
- the counterion may be a counterion to more than one mole of the triazinium cation, for example where the cation has a single charge and the counterion has a multiple charge.
- the counterion is weakly nucleophilic.
- Suitable anions include fluoride; fluorosulfate (SO 3 F ⁇ ); alkanesulfonate, especially methanesulfonate (CH 3 SO 3 ⁇ ); alkyl sulfate, especially methyl sulfate (CH 3 SO 4 ⁇ ); perfluoroalkane-sulfonate, preferably triflate (CF 3 SO 3 ⁇ ) and nonaflate (C 4 F 9 SO 3 ⁇ ); arenesulfonate, especially tosylate (i.e.
- the compounds of Formula I are prepared using a solvent-based process which comprises contacting a triazine compound with a fluorine source under acidic conditions in a solvent which is inert under the process conditions.
- the fluorine source is an electrophilic fluorine source such as, for example, fluorine gas or a mixture of fluorine gas and a neutral compound derivable from a fluorine-containing counterion Y ⁇ by removing at least one fluoride ion from Y ⁇ , for example boron trifluoride.
- the fluorine source is fluorine gas. While the fluorine gas may be used without dilution, in general, it is preferable to use fluorine gas diluted with an inert gas so that the volume of the inert gas is between about 99.9% and about 50% for controlling the vigorous reaction. Suitable inert gases include nitrogen, helium and argon.
- the triazine compound to be fluorinated is suitably a compound of the Formula VIII and may be obtained by subjecting a compound or a mixture of compounds of formula RCN to a known process for producing a triazine compound of formula (RCN) 3 , wherein R is independently R ⁇ , R 2 or R 3 as described herein:
- the fluorination process is carried out in the presence of an acid which may be a Br ⁇ nsted acid (organic or mineral) or a Lewis acid.
- the level of acid is suitably adjusted so as to reduce and desirably avoid double protonation of the triazine compound and to provide a yield (as determined by 19 F NMR) of F—N 30 of at least about 20% and desirably of at least about 50%.
- the molar ratio of acid to triazine substrate is about 0.5 to about 2.5, preferably about 1 to about 2.2.
- Br ⁇ nsted acid have pKa in the range from about 12.4 to about 4.6 and include halogenated alcohols, for example chlorodifluoro-ethanol, dichlorofluoroethanol, chlorooctafluoro-t-butanol, trifluoroethanol, tetrafluoropropanol, pentafluoropropanol, hexafluoroisopropanol, octafluoro-pentathol, and nonafluoro-t-butanol.
- halogenated alcohols for example chlorodifluoro-ethanol, dichlorofluoroethanol, chlorooctafluoro-t-butanol, trifluoroethanol, tetrafluoropropanol, pentafluoropropanol, hexafluoroisopropanol, octafluoro-pentathol, and nonafluoro-t-butanol.
- acids of the counterion Y ⁇ described above for example anhydrous hydrofluoric acid, hexafluoro-antimonic acid, tetrafluoroboric acid and triflic acid, sulfuric acid, methanesulfonic acid, acetic acid and trifluoroacetic acid.
- Br ⁇ nsted acids may be used in the form of a complex with ethers, water, alcohols, nitriles, carboxylic acids and the like and may be used in the form of an aqueous solution.
- the solvent is non-aqueous and it is presently particularly preferred that the solvent is acetonitrile, a halogenated, especially fluorinated, alcohol or, especially, nitromethane.
- acetonitrile a halogenated, especially fluorinated, alcohol or, especially, nitromethane.
- the same material may be used as both the acid and the solvent.
- the reaction to produce compound of Formula I is carried out at a temperature at which the solvent is in the liquid phase and suitably at a sufficiently low temperature that reaction due to a free radical mechanism is reduced and suitably avoided.
- the particular temperature selected depends on the solvent and also the reactants.
- the reaction suitably may be carried out at a temperature of about ⁇ 40 to about 10° C.
- a temperature of about ⁇ 40 to about ⁇ 20° C. is preferred for acetonitrile and a temperature of about ⁇ 10 to about 5° C. is preferred for hexafluoroisopropyl alcohol.
- the reaction may be carried out at elevated pressure although this is not essential.
- Fluorination of the triazine compound may be carried out using a stirred-tank batch reactor.
- the fluorine source is gaseous
- the fluorine source is suitably admitted either as neat gas at sub-atmospheric pressure or as a continuous flow of fluorine blended with nitrogen or other inert diluent at about atmospheric pressure.
- the process for producing compound of Formula I may be operated as a continuous process.
- the invention also provides a method of producing a fluorinated substrate which comprises contacting a substrate with a compound of Formula I so as to fluorinate the substrate.
- the compounds of Formula I may be used as electrophilic fluorinating agents in a similar manner to SelectfluoTM and in manner know in the art (see, for example, R. E. Banks et al. J. Chem. Soc. Perkin Trans. I, 1996, 2069).
- the fluorinating agent may be contacted with the substrate neat and optionally at elevated temperature. If desired the fluorination process may be carried out in a solvent, for example acetonitrile or, especially, nitromethane.
- a solvent for example acetonitrile or, especially, nitromethane.
- the compounds of Formula I may be used to fluorinate organic compounds, for example nucleosides, nucleoside bases and steroids, or cationic organometallic compounds for example cyclopentadienides. They are especially useful in fluorinating carbanionic and/or aromatic substrates and in particular aromatic substrates having electron-withdrawing substituents, for example halo or nitro substituents.
- a fluorinated steroid is prepared by contacting a steroid or a suitable derivative such as a steroidal enol acetate or silyl enol ether with a fluorinating agent of Formula I optionally in the presence of a solvent and optionally at elevated temperature.
- a fluorinating agent of Formula I optionally in the presence of a solvent and optionally at elevated temperature.
- the steroid is fluorinated at the 6 and/or 16 position.
- Compounds of Formula I may be isolated or used without separation from the reaction mixture. If desired, the reaction mixture may be fed to a separate fluorination reactor or the compound of Formula I may be purified or otherwise treated prior to use.
- the invention also provides a method of producing a fluorinated substrate which comprises contacting, preferably under acidic conditions, a triazine compound with a fluorine source in a solvent, which is inert under the process conditions, such that at least one of the nitrogen atoms in the triazine compound is fluorinated to produce a compound of Formula I and contacting, in situ or subsequently, the compound with a substrate to be fluorinated.
- Cyanuric chloride (0.1 g, 0.54 mmol), triflic acid (0.08 g, 0.53 mmol) and acetonitrile (80 cm 3 ) were placed in the flow fluorination reactor, cooled to ⁇ 35° C., stirred vigorously and treated with a 1:9 (v/v) fluorine-nitrogen blend (flow rate of 130 cm 3 per minute) until the exit gas gave a strong positive test (Kl) for fluorine. A small sample (20 cm 3 ) of the resulting colorless reaction solution was tested for oxidation properties with aqueous Kl and gave a strong positive result.
- reaction was carried out on both a 1:1 and 2:1 molar ratio basis (methoxybenzene: + NF). In both experiments the reaction was immediate and exothermic, and the solution's changed color from yellow (at 0° C.) to dark violet at room temperature).
- the reaction was carried out using a 1:1 molar ratio of reactants. A progressive color change of the reaction solution was observed [colorless (0° C. to room temperature, 1.0 hour), pale yellow (room temperature, 2.0 to 4.0 hours), yellow to pale brown (room temperature, 4.0 to 8.0 hrs)], and after 8.0 hours the 19 F NMR (CFCl 3 ) spectrum was measured and found to contain only the characteristic absorption for fluorobenzene at ⁇ F ⁇ 115.2 (m) ppm and a BF 4 ⁇ peak.
- a suspension of 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate (0.1 g, 3.4 mmol) and an excess of the substrate was prepared in a sealed tube at room temperature (using an argon-filled dry box). The mixture was heated to about 60° C. for a few minutes, then cooled to room temperature, before a small sample was syringed out and filtered to remove any insoluble materials (i.e. 1-fluoro-2,4,6-trichloro-1,3,5-triazinium tetrafluoroborate) before its 19 F NMR (CFCl 3 ) spectrum was measured using D 2 O as an external lock.
- CFCl 3 19 F NMR
- the 19F NMR spectrum of the product was measured shortly after the reaction had been carried out and found to contain absorptions at ⁇ F ⁇ 111.0 (m, 3-F); ⁇ 115.7 (m, 2-F) and ⁇ 116.1 (m, 4-F) (the ratio of 2-:3-:4-isomers was about 1:0.3:2). After 14 days (negative Kl test), the 9 F NMR spectrum showed no evidence for the presence of any other products.
- the 19 F NMR spectrum of the reaction solution contained one weak absorption assignable to 3-fluoronitrobenzene at ⁇ F ⁇ 110.27 (m) after about 25 minutes. After 14 days (positive Kl test still) however, the 9 F NMR spectrum showed absorptions corresponding to 3-fluoronitrobenzene at ⁇ F ⁇ 110.3 (m) and 2-fluoronitrobenzene at ⁇ F ⁇ 119.1 (m) (ratio about 2:1); also, in keeping with the result of the Kl test, the + NF absorption of the reagent was still present.
- Cyanuric chloride (5.0 g, 27 mmol) was added dropwise to a cold ( ⁇ 5° C.) stirred solution of sodium methoxide (5.0 g, 93 mmol) in dry methanol (50 cm 3 ); the mixture was then allowed to warm to room temperature and then refluxed for 3.0 hours. The reaction mixture was filtered to isolate inorganic salts and the filtrate freed from solvent (RotavaporTM) yielding an off-white solid which was dissolved in diethyl ether (50 cm 3 ).
- Example 5 The procedure of Example 5 was repeated except that hexafluoro-isopropanol was used as the solvent and the reaction was carried out at ⁇ 5° C.
- the product (1-fluoro-2,4,6-trimethoxy-1,3,5-triazinium triflate) was characterized using elemental analysis and NMR spectroscopy and obtained in a yield of 98%.
- Example 6 The procedure of Example 6 was repeated except that the reactants employed were 2,4,6-trimethoxy-1,3,5-triazine (0.5 g; 2.92 mmol) and hexafluoroantimonic acid (0.69 g; 2.92 mmol) and diethyl ether (50 cm 3 ) instead of dichloromethane was used in the “work-up”.
- the product (1-fluoro-2,4,6-trimethoxy-1,3,5-triazinium hexafluoroantimonate) was characterized by NMR spectroscopy and elemental analysis and obtained in a yield (1.22 g; 2.86 mmol) of 98%.
- a stainless steel pressure vessel (100 cm 3 ) was charged with dry acetonitrile (10.0 g, 244 mmol) and yttrium triflate (1.07 g, 2 mmol). The vessel was cooled ( ⁇ 196° C.), evacuated and charged with anhydrous ammonia (4.2 cm 3 , 247 mmol), sealed and then heated for 24 hours at 200° C. The autoclave was cooled to room temperature before the volatile material (unchanged ammonia) was allowed to bleed off.
- Rotary evaporation of the ethereal solution provided 5.0 g (41 mmol, 17%) of an off-white solid; this was purified by vacuum sublimation to give pure 2,4,6-trimethyl-1,3,5-triazine as a crystalline white solid.
- Example 5 The procedure of Example 5 was repeated except that that the reactants employed were 2,4,6-trimethyl-1,3,5-triazine (0.1 g) and triflic acid (0.12 g).
- the yield of 1-fluoro-2,4,6-trimethoxy-1,3,5-triazinium salts was sensitive to the amount of Br ⁇ nsted acid used in the synthesis.
- a 1.5 or less molar equivalent of triflic acid was used, the simple triflate salt of the triazine was obtained in high yields.
- the use of more than 1.5 molar equivalents of triflic acid caused the yield of the + N—F salt to depreciate greatly and mainly the + N—H salt was produced. Similar results were obtained with other acids.
- the 19 F NMR spectrum of the product was measured immediately and showed the characteristic absorptions for monofluorobenzene at ⁇ F ⁇ 113.3 (m) ppm and 1,4-difluorobenzene at ⁇ F ⁇ 119.9 ppm, with a ratio of approximately 2:1.
- a Kl test on the reaction mixture gave a strong positive result, indicating that the reaction had not gone to completion at this stage, hence, the reaction mixture was heated to 70° C. and its 19 F NMR spectrum measured at intervals to determine the progress of reaction. After 2.0 hours, the spectrum showed only absorptions for fluorobenzene and 1,4-difluorobenzene and the reaction mixture still gave a positive Kl test.
- the 19 F NMR spectrum of the reaction solution was measured shortly after it had been prepared and found to contain absorptions at ⁇ F ⁇ 111.0 (m, 3-F); ⁇ 115.7 (m, 2-F) and ⁇ 116.1 (m, 4-F) (the ratio of 2-: 3-: 4-isomers was about 1:0.3:2). After heating the solution at 70° C. for 6.0 hours (negative Kl test), its 19 F NMR spectrum showed no evidence for the presence of any other products.
- the 19 F NMR spectrum of the reaction solution contained one weak absorption assignable to 3-fluoronitrobenzene at ⁇ F ⁇ 110.27 (m) after about 25 minutes. After 6.0 hours of heating at 70° C. (positive Kl test still) however, the 19 F NMR spectrum showed absorptions corresponding to 3-fluoronitrobenzene at ⁇ F ⁇ 110.3 (m) and 2-fluoronitrobenzene at ⁇ F ⁇ 119.1 (m) (ratio about 2:1); also, in keeping with the result of a Kl test (weakly positive), the + NF absorption of the reagent was still present.
- Cyanuric chloride (0.1 g, 0.54 mmol), triflic acid (0.08 g, 0.53 mmol) and nitromethane (80 cm 3 ) were placed in a flow fluorination reactor, cooled (about ⁇ 30° C.), stirred vigorously and treated with a 1:9 (v/v) fluorine-nitrogen blend (flow-rate 130 cm 3 per minute) until the exit gas gave a strong positive test (Kl) for fluorine. A small sample (20 cm 3 ) of the resulting colorless reaction solution was tested for oxidation properties with aqueous Kl and gave a strong positive result.
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GBGB0026012.5A GB0026012D0 (en) | 2000-10-24 | 2000-10-24 | Electrophilic fluorination |
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WO2015036504A1 (fr) * | 2013-09-12 | 2015-03-19 | Rhodia Operations | Procede de preparation de derives oxysulfures et fluores par sulfination |
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Citations (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1201782A (fr) | 1957-08-27 | 1960-01-06 | Bayer Ag | Procédé pour la production de composés n-hétérocycliques fluorés au noyau |
EP0204535A1 (de) | 1985-06-03 | 1986-12-10 | Sagami Chemical Research Center | N-Fluorpyridiniumsalz und Verfahren zur Herstellung |
US4828764A (en) | 1985-07-24 | 1989-05-09 | Research Corporation | N-Fluoro-N-Perfluoromethyl sulfonamides |
US5081249A (en) | 1985-06-03 | 1992-01-14 | Sagami Chemical Research Center | N-fluoropyridinium-Sulfonates and a process for their preparation |
US5086178A (en) | 1990-09-20 | 1992-02-04 | Air Products And Chemicals, Inc. | Fluorinated diazabicycloalkane derivatives |
US5336772A (en) | 1991-01-11 | 1994-08-09 | Onoda Cement Co., Ltd. | Method for preparing N-fluoropyridinium salt |
US5367071A (en) | 1993-12-07 | 1994-11-22 | Air Products And Chemicals, Inc. | Process for preparing difluorinated diazoniabicycloalkane derivatives |
US5459267A (en) | 1993-12-23 | 1995-10-17 | Alliedsignal Inc. | 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane salts and their application as fluorinating agents |
US5473065A (en) | 1993-12-07 | 1995-12-05 | Air Products And Chemicals, Inc. | Fluorinated diazabicycloalkane derivatives |
US5631372A (en) | 1993-12-23 | 1997-05-20 | Alliedsignal Inc. | Process for the manufacture of 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.] octane salts |
US6069114A (en) | 1996-02-28 | 2000-05-30 | Hoechst Schering Agrevo Gmbh | 2-amino-4-bicycloamino-1,3,5-Triazines, their preparation, and their use as herbicide and plant growth regulators |
-
2000
- 2000-10-24 GB GBGB0026012.5A patent/GB0026012D0/en not_active Ceased
-
2001
- 2001-10-19 EP EP01308932A patent/EP1201628B1/de not_active Expired - Lifetime
- 2001-10-19 AT AT01308932T patent/ATE312805T1/de not_active IP Right Cessation
- 2001-10-19 DE DE60115810T patent/DE60115810T2/de not_active Expired - Fee Related
- 2001-10-23 US US10/044,049 patent/US6737525B2/en not_active Expired - Fee Related
- 2001-10-24 JP JP2001326400A patent/JP2002201181A/ja not_active Withdrawn
Patent Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1201782A (fr) | 1957-08-27 | 1960-01-06 | Bayer Ag | Procédé pour la production de composés n-hétérocycliques fluorés au noyau |
EP0204535A1 (de) | 1985-06-03 | 1986-12-10 | Sagami Chemical Research Center | N-Fluorpyridiniumsalz und Verfahren zur Herstellung |
US4996320A (en) | 1985-06-03 | 1991-02-26 | Sagami Chemical Research Center | N-fluoropyridinium salt and process for preparing same |
US5081249A (en) | 1985-06-03 | 1992-01-14 | Sagami Chemical Research Center | N-fluoropyridinium-Sulfonates and a process for their preparation |
US4828764A (en) | 1985-07-24 | 1989-05-09 | Research Corporation | N-Fluoro-N-Perfluoromethyl sulfonamides |
US5086178A (en) | 1990-09-20 | 1992-02-04 | Air Products And Chemicals, Inc. | Fluorinated diazabicycloalkane derivatives |
US5336772A (en) | 1991-01-11 | 1994-08-09 | Onoda Cement Co., Ltd. | Method for preparing N-fluoropyridinium salt |
US5367071A (en) | 1993-12-07 | 1994-11-22 | Air Products And Chemicals, Inc. | Process for preparing difluorinated diazoniabicycloalkane derivatives |
US5473065A (en) | 1993-12-07 | 1995-12-05 | Air Products And Chemicals, Inc. | Fluorinated diazabicycloalkane derivatives |
US5459267A (en) | 1993-12-23 | 1995-10-17 | Alliedsignal Inc. | 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane salts and their application as fluorinating agents |
US5631372A (en) | 1993-12-23 | 1997-05-20 | Alliedsignal Inc. | Process for the manufacture of 1-substituted-4-fluoro-1,4-diazoniabicyclo[2.] octane salts |
US6069114A (en) | 1996-02-28 | 2000-05-30 | Hoechst Schering Agrevo Gmbh | 2-amino-4-bicycloamino-1,3,5-Triazines, their preparation, and their use as herbicide and plant growth regulators |
Non-Patent Citations (15)
Title |
---|
Banks, R. E. , et al.: N-Halogeno compounds. Part 18. 1-Alkyl-4-fluoro-1,4-diazoniabicyclo [2.2.2] octaine salts: user-friendly site-selective electrophilic fluorinating agents of the N-fluoroammonium class. J. Chem. Soc. Perkin Trans. l, 1996, 2069. |
Banks, R. E.: Selectfluor(TM) reagent F-Teda-BF4 in action: tamed fluorine at your service. Journal of Fluorine Chemistry 87 (1998) 1-17. |
Banks, R. E.: Selectfluor™ reagent F-Teda-BF4 in action: tamed fluorine at your service. Journal of Fluorine Chemistry 87 (1998) 1-17. |
Broschag, M. et al.: "Fluorination of cyanuric chloride and low-temperature crystal structure of '(C1CN)3F!+'AsF6!-." Z. Anorg. Allg. Chem. (1994), 620(6), 1132-6, XP001052965. |
Broschag, M. et al.: "Fluorination of cyanuric chloride and low-temperature crystal structure of ′(C1CN)3F!+′AsF6!-." Z. Anorg. Allg. Chem. (1994), 620(6), 1132-6, XP001052965. |
Broschag, Matthias, et al.: "Synthesis and characterization of novel halogeno(+l) adduct complexes containing malonitrile and 1,3,5-triazine." Inorganica Chimica Acta, (1993), 205(2), 167-73, XP001052954. |
Furin, G. G.: Methods of Organic Chemistry (Houen-Wey): vol. E10a; Organofluorine Compounds (ed. B. Baasner, et al.), Georg Thieme Verlag, Stuttgart, 1999, pp. 432-499. |
J. H. Forsberg, et al., "Lanthanide(III) Ion Catalyzed Reaction of Ammonia and Nitriles: Synthesis of 2,4,6-Trisubstituted-s-triazines," Department of Chemistry, St. Louis University, Oct. 21, 1987. |
Lal et al. "Electrophilic NF Fluorinating Agents," Chem. Rev. 1996, 96, pp1737-1755. |
R. D. Chambers, et al., "Polyfluoroheteroaromatic Compounds," Academic Press, Inc., Advances in Heterocyclic Chemistry, Vol 28, pp 1-71. |
Schleyer, Paul V. R. et al.: "Preparation of 1-Fluoro-2,4,6-trihalogeno-s-triazinium Hexafluoroarsenates: Structure of ′C3N3C13F!′AsF6! As Deduced by Experimental and ab Initio Methods." Inorg. Chem. (1993), 32(8), 1523-4, XP001041857. |
Schleyer, Paul V. R. et al.: "Preparation of 1-Fluoro-2,4,6-trihalogeno-s-triazinium Hexafluoroarsenates: Structure of 'C3N3C13F!'AsF6! As Deduced by Experimental and ab Initio Methods." Inorg. Chem. (1993), 32(8), 1523-4, XP001041857. |
Schulz et al. (DN 122:31666, CAPLUS, abstract of J. Organometallic Chemistry (1994), 480(1-2), 195-197).* * |
Schulz, A., et al.: Das Perfluortiazinium-Kaion als Oxidationsmittel in der metallorganischen Synthese-Ein neuer Weg zur Darstellung von (Cp2MC12)<2+>(M=Mo,W). Journal of Organometallic Chemistry, 480 (1994) 195-197. |
Schulz, A., et al.: Das Perfluortiazinium-Kaion als Oxidationsmittel in der metallorganischen Synthese—Ein neuer Weg zur Darstellung von (Cp2MC12)2+(M=Mo,W). Journal of Organometallic Chemistry, 480 (1994) 195-197. |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015036504A1 (fr) * | 2013-09-12 | 2015-03-19 | Rhodia Operations | Procede de preparation de derives oxysulfures et fluores par sulfination |
CN105722821A (zh) * | 2013-09-12 | 2016-06-29 | 罗地亚经营管理公司 | 用于通过亚磺化制备氧硫化物和氟化衍生物的方法 |
US9873666B2 (en) | 2013-09-12 | 2018-01-23 | Rhodia Operations | Method for preparing oxysulphide and fluorinated derivatives by sulphination |
CN105722821B (zh) * | 2013-09-12 | 2018-09-18 | 罗地亚经营管理公司 | 用于通过亚磺化制备氧硫化物和氟化衍生物的方法 |
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US20020123657A1 (en) | 2002-09-05 |
EP1201628B1 (de) | 2005-12-14 |
JP2002201181A (ja) | 2002-07-16 |
DE60115810T2 (de) | 2006-08-03 |
GB0026012D0 (en) | 2000-12-13 |
DE60115810D1 (de) | 2006-01-19 |
EP1201628A1 (de) | 2002-05-02 |
ATE312805T1 (de) | 2005-12-15 |
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