US6462072B1 - Cyclic ester or amide derivatives - Google Patents
Cyclic ester or amide derivatives Download PDFInfo
- Publication number
- US6462072B1 US6462072B1 US09/157,566 US15756698A US6462072B1 US 6462072 B1 US6462072 B1 US 6462072B1 US 15756698 A US15756698 A US 15756698A US 6462072 B1 US6462072 B1 US 6462072B1
- Authority
- US
- United States
- Prior art keywords
- cycloalkenyl
- cycloalkyl
- substituted
- compound
- heteroatom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *~C(C(C)~[W])C(*)C(B)C(=[Y])*C Chemical compound *~C(C(C)~[W])C(*)C(B)C(=[Y])*C 0.000 description 8
- LJXDUBIKEZJTEJ-UHFFFAOYSA-N CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OC1CCC(C2=CC=CC=C2)(C2=CC=CC=C2)CC1 Chemical compound CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OC1CCC(C2=CC=CC=C2)(C2=CC=CC=C2)CC1 LJXDUBIKEZJTEJ-UHFFFAOYSA-N 0.000 description 5
- GGLORRXRRGTQCH-UHFFFAOYSA-N C1=CC=CC=C1.CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OC1CCC(C)(C2=CC=CC=C2)CC1 Chemical compound C1=CC=CC=C1.CCC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OC1CCC(C)(C2=CC=CC=C2)CC1 GGLORRXRRGTQCH-UHFFFAOYSA-N 0.000 description 1
- GDLXIVMGIKCUQI-UHFFFAOYSA-N CC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OC1CCC(C2=CC=CC=C2)(C2=CC=CC=C2)CC1 Chemical compound CC(C)(C)C(=O)C(=O)N1CCCC1C(=O)OC1CCC(C2=CC=CC=C2)(C2=CC=CC=C2)CC1 GDLXIVMGIKCUQI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/157,566 US6462072B1 (en) | 1998-09-21 | 1998-09-21 | Cyclic ester or amide derivatives |
AU63905/99A AU6390599A (en) | 1998-09-21 | 1999-09-17 | Cyclic ester or amide derivatives |
KR1020017003246A KR20010089253A (ko) | 1998-09-21 | 1999-09-17 | 시클릭 에스터 또는 아마이드 유도체 |
IL14155299A IL141552A0 (en) | 1998-09-21 | 1999-09-17 | Cyclic ester or amide derivatives |
HU0103565A HUP0103565A3 (en) | 1998-09-21 | 1999-09-17 | Cyclic ester or amide derivatives and pharmaceutical compositions containing them |
EP99951470A EP1115703A1 (en) | 1998-09-21 | 1999-09-17 | Cyclic ester or amide derivatives |
CA002341036A CA2341036A1 (en) | 1998-09-21 | 1999-09-17 | Cyclic ester or amide derivatives |
JP2000574071A JP2002526474A (ja) | 1998-09-21 | 1999-09-17 | 環状エステルまたはアミド誘導体 |
PCT/US1999/021290 WO2000017161A1 (en) | 1998-09-21 | 1999-09-17 | Cyclic ester or amide derivatives |
CN99810925A CN1323294A (zh) | 1998-09-21 | 1999-09-17 | 环状酯或酰胺衍生物 |
ZA200101934A ZA200101934B (en) | 1998-09-21 | 2001-03-08 | Cyclic ester or amide derivatives. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/157,566 US6462072B1 (en) | 1998-09-21 | 1998-09-21 | Cyclic ester or amide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
US6462072B1 true US6462072B1 (en) | 2002-10-08 |
Family
ID=22564303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/157,566 Expired - Fee Related US6462072B1 (en) | 1998-09-21 | 1998-09-21 | Cyclic ester or amide derivatives |
Country Status (11)
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6573293B2 (en) | 2000-02-15 | 2003-06-03 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
US6642232B2 (en) | 2001-10-10 | 2003-11-04 | Sugen, Inc. | 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors |
US6653308B2 (en) | 2001-02-15 | 2003-11-25 | Sugen, Inc. | 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors |
US20060063828A1 (en) * | 2004-06-28 | 2006-03-23 | Weingarten M D | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof |
Citations (86)
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US4070361A (en) | 1977-04-21 | 1978-01-24 | E. R. Squibb & Sons, Inc. | Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof |
US4206137A (en) | 1978-03-27 | 1980-06-03 | E. R. Squibb & Sons, Inc. | Thioalkanoylalkanoic acid compounds |
EP0012401A1 (en) | 1978-12-11 | 1980-06-25 | Merck & Co. Inc. | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them |
JPS55160757A (en) | 1979-05-31 | 1980-12-13 | Sumitomo Chem Co Ltd | Novel cyclopentanecarboxylic acid derivative and its preparation |
US4310461A (en) | 1980-06-23 | 1982-01-12 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
EP0048159A2 (en) | 1980-09-17 | 1982-03-24 | University Of Miami | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents |
EP0050800A1 (en) | 1980-10-23 | 1982-05-05 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
EP0073143A2 (en) | 1981-08-21 | 1983-03-02 | James Walter Ryan | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides |
US4390695A (en) | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
EP0088350A1 (en) | 1982-03-08 | 1983-09-14 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
US4531964A (en) | 1982-09-13 | 1985-07-30 | Nippon Kayaku Kabushiki Kaisha | Heterocyclic compound and a herbicidal composition containing said compound |
US4574079A (en) | 1983-05-27 | 1986-03-04 | Gavras Haralambos P | Radiolabeled angiotensin converting enzyme inhibitors for radiolabeling mammalian organ sites |
US4578474A (en) | 1980-06-23 | 1986-03-25 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4593102A (en) | 1984-04-10 | 1986-06-03 | A. H. Robins Company, Inc. | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position |
DE3508251A1 (de) | 1985-03-08 | 1986-09-11 | Merck Patent Gmbh, 6100 Darmstadt | Dipeptide |
EP0196841A1 (en) | 1985-03-22 | 1986-10-08 | Syntex (U.S.A.) Inc. | N,N-dialkylguanidino dipeptides |
EP0260118A1 (en) | 1986-09-10 | 1988-03-16 | Syntex (U.S.A.) Inc. | Selective amidination of diamines |
WO1988009789A2 (en) | 1987-06-03 | 1988-12-15 | Polifarma S.P.A. | 3-indolepyruvic acid derivatives and pharmaceutical use thereof |
US4808573A (en) | 1980-10-23 | 1989-02-28 | Schering Corporation | Carboxyalkyl dipeptides and anti-hypertensive use thereof |
EP0333174A2 (en) | 1988-03-16 | 1989-09-20 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same |
EP0352000A2 (en) | 1988-07-08 | 1990-01-24 | Smithkline Beecham Corporation | Retroviral protease binding peptides |
DE3931051A1 (de) | 1988-09-22 | 1990-03-29 | Hoechst Ag | Salze von herbizid-saeuren mit langkettigen stickstoffbasen |
EP0378318A1 (en) | 1989-01-11 | 1990-07-18 | Merck & Co. Inc. | Process for synthesis of FK-506 and tricarbonyl intermediates |
WO1990012805A1 (en) | 1989-04-15 | 1990-11-01 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Postostatin and related compound thereof, or their salts |
EP0405994A2 (en) | 1989-06-30 | 1991-01-02 | Merck & Co. Inc. | Synthetic process for FK-506 type macrolide intermediates |
EP0419049A1 (en) | 1989-08-22 | 1991-03-27 | Merck Frosst Canada Inc. | (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes |
WO1991004985A1 (en) | 1989-09-29 | 1991-04-18 | Pharma Mar S.A. | Dehydrodidemnin b |
WO1991013088A1 (en) | 1990-02-28 | 1991-09-05 | President And Fellows Of Harvard College | Terminally blocked antiviral peptides |
DE4015255A1 (de) | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
WO1992000278A1 (en) | 1990-07-02 | 1992-01-09 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
EP0468339A2 (en) | 1990-07-27 | 1992-01-29 | Nippon Kayaku Kabushiki Kaisha | Alpha-keto-amide derivatives having protease inhibiting activity |
GB2247456A (en) | 1990-09-03 | 1992-03-04 | Fujisawa Pharmaceutical Co | Tetrahydropyrane compounds, a process for their production and a pharmaceutical composition containing the same |
WO1992003472A1 (en) | 1990-08-24 | 1992-03-05 | The Upjohn Company | Peptides containing amino-polyols as transition-state mimics |
WO1992004370A1 (en) | 1990-08-29 | 1992-03-19 | Vertex Pharmaceuticals Incorporated | Modified di- and tripeptidyl immunosuppressive compounds |
JPH04149166A (ja) | 1990-10-12 | 1992-05-22 | Nippon Kayaku Co Ltd | 新規ケト酸アミド誘導体 |
US5147877A (en) | 1991-04-18 | 1992-09-15 | Merck & Co. Inc. | Semi-synthetic immunosuppressive macrolides |
WO1992016501A1 (en) | 1991-03-20 | 1992-10-01 | Vertex Pharmaceuticals Incorporated | Tetrahydroxyalkane derivatives as inhibitors of hiv aspartyl protease |
WO1992018478A1 (en) | 1991-04-09 | 1992-10-29 | Boehringer Mannheim Italia S.P.A. | Heterocyclic amines useful in the therapy of asthma and inflammation of the respiratory tract |
WO1992019593A1 (en) | 1991-05-09 | 1992-11-12 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
WO1992019745A1 (en) | 1991-05-08 | 1992-11-12 | Vertex Pharmaceuticals Incorporated | Rfkbp: a novel prolyl isomerase and rapamycin/fk506 binding protein |
WO1992021313A2 (en) | 1991-05-24 | 1992-12-10 | Vertex Pharmaceuticals Incorporated | Novel immunosuppressive compounds |
WO1993007269A1 (en) | 1991-10-11 | 1993-04-15 | Vertex Pharmaceuticals Incorporated | ISOLATION OF AN Mr 52,000 FK506 BINDING PROTEIN AND MOLECULAR CLONING OF A CORRESPONDING HUMAN cDNA |
ZA927782B (en) | 1991-10-11 | 1993-04-28 | Ciba Geigy | Novel herbicides. |
WO1993013066A1 (en) | 1991-12-20 | 1993-07-08 | Syntex (U.S.A.) Inc. | Cyclic amides of 3-amino-2-hydroxy-carboxylic acids as hiv-protease inhibitors |
JPH05178824A (ja) | 1991-08-05 | 1993-07-20 | Takeda Chem Ind Ltd | アスパラギン誘導体およびその用途 |
US5252579A (en) | 1993-02-16 | 1993-10-12 | American Home Products Corporation | Macrocyclic immunomodulators |
WO1993023548A2 (en) | 1992-05-20 | 1993-11-25 | Vertex Pharmaceuticals Incorporated | METHOD OF DETECTING TISSUE-SPECIFIC FK506 BINDING PROTEIN MESSENGER RNAs AND USES THEREOF |
EP0572365A2 (en) | 1992-05-29 | 1993-12-01 | NUOVO CONSORZIO SANITARIO NAZIONALE del Dott. Paolo Malizia & C. - S.A.S. | Heteroprostanoids, process for their production and therapeutical use thereof |
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US5294603A (en) | 1980-09-12 | 1994-03-15 | The Board Of Trustees Of The University Of Illinois | Pharmaceutical compositions containing didemnins |
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WO1994007858A1 (en) | 1992-09-28 | 1994-04-14 | Vertex Pharmaceuticals Incorporated | 1-(2-oxo-acetyl)-piperidine-2-carboxylic acid derivatives as multi-drug-resistent cancer cell sensitizers |
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WO1996033184A1 (en) | 1995-04-19 | 1996-10-24 | Vertex Pharmaceuticals Incorporated | Thf-containing sulfonamide inhibitors of aspartyl protease |
WO1996036630A1 (en) | 1995-05-19 | 1996-11-21 | Vertex Pharmaceuticals Incorporated | Tetralin compounds with mdr activity |
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WO1999029695A1 (en) | 1997-12-05 | 1999-06-17 | Astrazeneca Uk Limited | Novel compounds |
-
1998
- 1998-09-21 US US09/157,566 patent/US6462072B1/en not_active Expired - Fee Related
-
1999
- 1999-09-17 JP JP2000574071A patent/JP2002526474A/ja active Pending
- 1999-09-17 WO PCT/US1999/021290 patent/WO2000017161A1/en not_active Application Discontinuation
- 1999-09-17 CN CN99810925A patent/CN1323294A/zh active Pending
- 1999-09-17 IL IL14155299A patent/IL141552A0/xx unknown
- 1999-09-17 KR KR1020017003246A patent/KR20010089253A/ko not_active Application Discontinuation
- 1999-09-17 HU HU0103565A patent/HUP0103565A3/hu unknown
- 1999-09-17 AU AU63905/99A patent/AU6390599A/en not_active Abandoned
- 1999-09-17 EP EP99951470A patent/EP1115703A1/en not_active Withdrawn
- 1999-09-17 CA CA002341036A patent/CA2341036A1/en not_active Abandoned
-
2001
- 2001-03-08 ZA ZA200101934A patent/ZA200101934B/en unknown
Patent Citations (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4070361A (en) | 1977-04-21 | 1978-01-24 | E. R. Squibb & Sons, Inc. | Mercaptoalkylsulfonyl proline and pipecolic acid and esters thereof |
US4206137A (en) | 1978-03-27 | 1980-06-03 | E. R. Squibb & Sons, Inc. | Thioalkanoylalkanoic acid compounds |
EP0012401A1 (en) | 1978-12-11 | 1980-06-25 | Merck & Co. Inc. | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them |
US4374829A (en) | 1978-12-11 | 1983-02-22 | Merck & Co., Inc. | Aminoacid derivatives as antihypertensives |
JPS55160757A (en) | 1979-05-31 | 1980-12-13 | Sumitomo Chem Co Ltd | Novel cyclopentanecarboxylic acid derivative and its preparation |
US4390695A (en) | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4578474A (en) | 1980-06-23 | 1986-03-25 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US4310461A (en) | 1980-06-23 | 1982-01-12 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
US5294603A (en) | 1980-09-12 | 1994-03-15 | The Board Of Trustees Of The University Of Illinois | Pharmaceutical compositions containing didemnins |
EP0048159A2 (en) | 1980-09-17 | 1982-03-24 | University Of Miami | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents |
EP0050800A1 (en) | 1980-10-23 | 1982-05-05 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
US4808573A (en) | 1980-10-23 | 1989-02-28 | Schering Corporation | Carboxyalkyl dipeptides and anti-hypertensive use thereof |
US4818749A (en) | 1980-10-23 | 1989-04-04 | Schering Corporation | Carboxyalkyl dipeptides and medical use thereof in treating hypertension and congestive heart failure |
EP0073143A2 (en) | 1981-08-21 | 1983-03-02 | James Walter Ryan | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides |
EP0088350A1 (en) | 1982-03-08 | 1983-09-14 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
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HUP0103565A2 (hu) | 2002-01-28 |
HUP0103565A3 (en) | 2002-02-28 |
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AU6390599A (en) | 2000-04-10 |
CA2341036A1 (en) | 2000-03-30 |
CN1323294A (zh) | 2001-11-21 |
ZA200101934B (en) | 2002-09-18 |
EP1115703A1 (en) | 2001-07-18 |
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JP2002526474A (ja) | 2002-08-20 |
KR20010089253A (ko) | 2001-09-29 |
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