JPS55160757A - Novel cyclopentanecarboxylic acid derivative and its preparation - Google Patents
Novel cyclopentanecarboxylic acid derivative and its preparationInfo
- Publication number
- JPS55160757A JPS55160757A JP6849679A JP6849679A JPS55160757A JP S55160757 A JPS55160757 A JP S55160757A JP 6849679 A JP6849679 A JP 6849679A JP 6849679 A JP6849679 A JP 6849679A JP S55160757 A JPS55160757 A JP S55160757A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- derivative
- novel
- cyclopentanecarboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A cyclopentanecarboxylic acid derivative shown by the formula I (R1 and R2 are H or lowe alkyl; R3 is H, lowe alkanoyl, or benzoyl) or its salt.
EXAMPLE: 2-(2'-Methyl-3'-mercapto-propanoyl)-cyclopentanecarboxylic acid.
USE: A remedy or diagnositc drug for angiotensin related hypertension. The derivatives has inhibiting action on angiotensin I converting enzyme.
PROCESS: A compound shown by the formula II and one shown by the formula III are subjected to addition reaction in the presence of a base, e.g., butyl lithium to give a novel compound shown by the formula IV. This compound shown by the formula IV is hydrolyzed in the presence of an acid catalyst, and subjected to aminomethylation with formaldehyde and an amino, e.g., dimethylamine to give a novel cyclopentane derivative. This derivative is deaminated by heat, a sulfur compound shown by the formula R3SH is added to the derivative to give a compound shown by the formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6849679A JPS55160757A (en) | 1979-05-31 | 1979-05-31 | Novel cyclopentanecarboxylic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6849679A JPS55160757A (en) | 1979-05-31 | 1979-05-31 | Novel cyclopentanecarboxylic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55160757A true JPS55160757A (en) | 1980-12-13 |
Family
ID=13375355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6849679A Pending JPS55160757A (en) | 1979-05-31 | 1979-05-31 | Novel cyclopentanecarboxylic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55160757A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
-
1979
- 1979-05-31 JP JP6849679A patent/JPS55160757A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6462072B1 (en) | 1998-09-21 | 2002-10-08 | Gpi Nil Holdings, Inc. | Cyclic ester or amide derivatives |
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