US5510621A - Apparatus and method for measuring components in a bag - Google Patents

Apparatus and method for measuring components in a bag Download PDF

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US5510621A
US5510621A US08/317,114 US31711494A US5510621A US 5510621 A US5510621 A US 5510621A US 31711494 A US31711494 A US 31711494A US 5510621 A US5510621 A US 5510621A
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bag
electromagnetic radiation
chamber
components
analyzing
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Don S. Goldman
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Baxter International Inc
Optical Solutions Inc
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Optical Solutions Inc
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Priority to US08/317,114 priority Critical patent/US5510621A/en
Priority to CA002159235A priority patent/CA2159235C/en
Priority to EP95306954A priority patent/EP0706043B1/de
Priority to DE69516620T priority patent/DE69516620T2/de
Priority to AT95306954T priority patent/ATE192572T1/de
Priority to JP7256640A priority patent/JPH08210973A/ja
Priority to AU33040/95A priority patent/AU693926B2/en
Priority to US08/602,620 priority patent/US5750998A/en
Publication of US5510621A publication Critical patent/US5510621A/en
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Assigned to BAXTER INTERNATIONAL INC. reassignment BAXTER INTERNATIONAL INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CLINTEC NUTRITION COMPANY
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0364—Cuvette constructions flexible, compressible
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light

Definitions

  • the present invention relates to a novel and useful apparatus and method for non-invasively analyzing liquid medium components in a bag.
  • Liquid compounds are often placed in bags for various purposes. For example, the use of total parenteral nutrients (TPN), which are eventually the source of intravenous feeding, are stored in transparent or translucent flexible bags. TPN compounds are commonly mixed in pharmacies using commercially available compounders which accept three or more TPN compounds and automatically mix these compounds into an appropriate container such as an intravenous (I.V.) bag. Intravenous use of the bags usually takes place at a later time in a hospital or medical facility. Typical compounds include 70% dextrose injection U.S.P., 10% Travasol (amino acid) injection, Intralipid 20% fat I.V. emulsion, sterile water, and many others.
  • TPN total parenteral nutrients
  • I.V. intravenous
  • Intravenous use of the bags usually takes place at a later time in a hospital or medical facility.
  • Typical compounds include 70% dextrose injection U.S.P., 10% Travasol (amino acid) injection, Intralipid 20% fat I.V.
  • TPN compounds are clear liquids. That is to say, water, amino acid injection, dextrose injection, and electrolytes are clear liquids precluding visual distinction among them. Furthermore, it is preferable to perform identification of TPN components non-invasively and rapidly to minimize potential contamination and to minimize analysis time by personnel.
  • a writing entitled, Simple Methods For Quantitative Determination of Procaine Hydrochloride In Parenteral Products by Das Gupta et al. presents calibrations in the ultraviolet region of spectrophotometry. Specifically, the Das Gupta reference obtained calibrations at 228 nanometers for buffered solutions of procaine hydrochloride in the 0-20 microgram/ml concentration range.
  • U.S. Pat. No. 4,872,868 shows an analyzer for collection bags which provides an envelope that permits the insertion of reagent's test strips and the like.
  • U.S. Pat. Nos. 3,857,485 and 3,924,128 teach a method of analyzing sample containers by liquid scintillation spectrometry which utilizes light transmission sealing means to prevent entry of ambient light or the escape of light from the photomultiplier tube detection devices.
  • U.S. Pat. No. 5,239,860 describes a sensor for continuously measuring alcohol and gasoline fuel mixtures in a clear Teflon tube using a pre-determined optical path and electromagnetic radiation at a pair of wavelengths which are generated by rapidly switching currents through a light-source.
  • Thermopile detectors are used to detect an increase in temperature due to light transmitted through the flowing gasoline/alcohol mixture.
  • An apparatus and method for identifying solutions in a translucent transparent or semi-transparent plastic bag, such as parenteral nutrients, non-invasively, qualitatively and quantitatively would be a notable advance in the chemical analysis field.
  • the apparatus of the present invention employs spacer means for supporting a flexible transparent or translucent bag and for determining the optical patch across the bag chamber.
  • the spacer means includes a passage for electromagnetic radiation.
  • the spacer means may take the form of a pair of rigid elements or fences and a mechanism for shortening or lengthening the distance between the rigid fences.
  • the rigid fences may support the bag against vertical movement and also be capable of exerting compressive force on the bag to a precisely determined dimension between the rigid fences. Such dimension would correspond to a particular optical path, which may include the bag wall alone or the bag wall and the bag filled with components in a liquid medium.
  • a source of electromagnetic radiation directs electromagnetic radiation through the spacer passage and to the wall portion of the bag.
  • the source of electromagnetic radiation may produce coherent light, ultraviolet radiation, x-rays, infrared radiation, broad band radiation e.g., a tungsten source, and the like.
  • Detector means is also employed in the present invention for analyzing the electromagnetic radiation passed through the spacer passage and along a determined optical path which is through a dimension of the bag chamber.
  • the optical path may pass completely across the bag such that the detector is receiving light which has been transmitted through the bag.
  • the detector may be placed on the same side of the bag as the source of electromagnetic radiation and receive light which has interacted with the contents of the bag by diffuse reflectance.
  • the detector may receive light by diffuse reflectance and/or by diffuse transflectance, i.e., where light passes through the bag and then is reflected back through the bag by a diffuse reflector or mirror located on the opposite side of the bag relative to the detector.
  • near-infrared radiation is particularly useful in detecting parenteral nutrients in a flexible I.V. bag.
  • specific wavelengths rather than a continuum of wavelengths, may be used as the radiation sought for analysis to enable the use of simpler and less expensive instrumentation comprised of several discrete detectors, each covered by a narrow wavelength filter.
  • Fiber optics may also be utilized to carry light to and from the I.V. bag.
  • Mathematical models may be employed to quantitatively and qualitatively detect components within the I.V. bag accurately and quickly.
  • transmittance measurements may be taken of the bag alone, squeezed to eliminate a chamber and to expel the liquid components, and along a determined optical path of the bag filled with certain components.
  • Absorbance for a sample may be accurately determined under the Beer's Law relationship.
  • Chemical concentration can be directly related to an absorbance difference obtained from a spectral measurement using two different path lengths. This technique minimizes or eliminates common spectroscopic measurement problems due to contamination, changes in the spectroscopic windows holding the sample, instrument problems due to temperature changes on internal optical elements, the source of electromagnetic radiation, and the like.
  • Another object of the present invention is to provide a method and apparatus for analyzing components in a liquid medium within a flexible transparent or translucent container to prevent misuse of such components in treating patients in a medical facility.
  • a further object of the present invention is to provide a method and apparatus for analyzing components in a liquid medium found in a transparent or translucent plastic container which is accurate and may include qualitative as well as quantitative measurements of the components therein.
  • a further object of the present invention is to provide a method and apparatus for analyzing components in a liquid medium found in a transparent or translucent flexible bag where such components are parenteral or enteral nutrients typically used for intravenous feeding.
  • a further object of the present invention is to provide a method and apparatus for analyzing components in a liquid medium found in a translucent flexible bag which is capable of detecting light from a source after interaction with the bag alone and after interaction with the bag and the components in the bag.
  • Another object of the present invention is to provide a method and apparatus for analyzing components in a liquid medium within a flexible bag employing either transmittance or diffuse reflectance techniques.
  • FIG. 1 is a sectional view of a first embodiment of the apparatus of the present invention.
  • FIG. 2 is a sectional view of the apparatus of FIG. 1 taken along line 2--2 of FIG. 1.
  • FIG. 2A is a sectional view taken along line 2A--2A of FIG. 2.
  • FIG. 2B is a sectional view of an I.V. bag collapsed by the apparatus of the present invention.
  • FIG. 3 is a side sectional view of another embodiment of the apparatus of the present invention.
  • FIG. 4 is a graphical representation with experimental results described in Example 1.
  • FIG. 5 is a graphical representation of the experimental results described in Example 2.
  • FIG. 6 is a graphical representation of experimental results described in Example 3.
  • FIG. 7 is a graphical representation of an experimental result described in Example 4.
  • FIG. 8 is a graphical representation of PCA plot of scores described in Example 5.
  • FIGS. 9 and 10 are graphical representations depicting predictions using PLS analysis described in Example 4.
  • FIG. 11 is a graphical representation of a PLS model utilizing data found in Example 4.
  • FIGS. 12, 13, and 14 are graphical representations of MLR methods applied to the data shown in Table 2 of Example 4.
  • FIG. 15 is a graphical representation of a step wise MLR program utilizing the data of Table 1 of Example 4.
  • apparatus 10 is shown in the drawings as including multiple embodiments, denoted by the addition of an upper case letter.
  • apparatus 10A is depicted in which spacer means 12 is provided to hold a flexible transparent or semi transparent bag 14 in place.
  • the term "translucent" is used herein to indicate a transparent, semi-transparent, or non-opaque bag.
  • Bag 14 includes a chamber 16 which is capable of holding components in a liquid medium 18. Liquid medium including such components 18 are passed through tube 20, shown partially in FIG. 1, which is ultimately clamped or sealed when the bag 14 is filled.
  • Bag 14 may take the form of a plastic intravenous bag (I.V.
  • bag formed of polyvinyl chloride (PVC), ethylene vinyl acetate (EVA), and like materials.
  • PVC polyvinyl chloride
  • EVA ethylene vinyl acetate
  • other containers may be employed herein.
  • the liquid medium and components 18 found within bag 14 may consist of mixtures of parenteral or enteral nutrients which may be intravenously fed to a patient.
  • such nutrients may include sterile water, 70% dextrose injection U.S.P., 10% Travasol (amino acid) Aminosyn or FreeAmine injection, Intralipid 20% fat I.V. emulsion, potassium chloride, and the like, individually or in various combinations.
  • Spacer means 12 includes a pair of elements 22 and 24 which are shown in FIGS. 1 and 2 as a pair of solid fences placed in opposition to one another.
  • Fences 22 and 24 are slidingly supported by rods 26 and 28 which are supported to a surface by stands 30 and 32, depicted in phantom on FIGS. 1 and 2.
  • Rods 26 and 28 serve as a guide for fences 22 and 24.
  • a threaded screw 34 is fixed to fence 22 through a boss 36.
  • Knurled wheel and bearing unit 38 is capable of turning relative to boss 36. The turning of wheel 38 also rotates threaded connect screw 34 which threadingly engages a threaded bore 40 through fence 24.
  • fence 22 is stationary relative to rods 26 and 28 while fence 24 is moveable thereto, manually or by motor means, such as a solenoid, directional arrow 25.
  • Unit 38 serves to measure or to stop the relative movement of fences 22 and 24, to determine the optical path through bag 14 or sequentially determine a plurality of optical paths through bag 14. It should be noted that fences 22 and 24 may be hingedly attached to one another to determine the distance therebetween, like a clamshell.
  • optical path (O.P.) of components 18 within bag 14 may be easily adjusted by the movement of fence 24 relative to fence 22.
  • the O.P. may vary between 1.0 millimeter to 15 millimeters in many cases.
  • an empty bag 14 may be compressed by fences 22 and 24 such that walls 42 and 44 touch one another, FIG. 2B, eliminating chamber 16.
  • This configuration is useful in obtaining a reference value for the bag without medium 18 in chamber 16.
  • Inner surfaces 42 and 44 of fences 22 and 24, respectively provide sufficient friction to prevent the slippage of bag 14 downwardly between fences 22 and 24.
  • other structures may be employed to prevent the slippage of bag 14 within spacer means 12 such as a floor, or suspension device pulling upwardly on bag 14 while bag 14 is within spacer means 12, and the like.
  • Apparatus 10 further possesses a source of electromagnetic radiation 46.
  • Source 46 may take the form of laser light, infrared radiation, ultraviolet radiation, visible radiation, or any other electromagnetic radiation found in the spectrum.
  • Light 46 is passed to bag chamber 16 through passage 48 in fence 22 and from chamber 16 of bag 14 through passage 50 of fence 24.
  • Electromagnetic radiation from source 46 may be filtered by filter 52 and led to passage way 48 by optical fiber or fiber bundle 54.
  • Fitting 56 directs radiation from fiber optical bundle 54 to collimating lens 58.
  • Parallel rays of electromagnetic radiation are then passed through bag 14 and liquid medium 18 containing various components to converging lens 60.
  • Fitting 62 directs the electromagnetic radiation through optical fiber or fiber optic bundle 64 to a detector 66 for analysis.
  • Detector means 66 in its broadest sense may take the form of any suitable spectrophotometer, single or multiple detectors, or sources being appropriately filtered for the wavelength of interest, in combination with a computer employing an appropriate software program such as Gram 386, available from Galactic Industries, Inc. of Salem N.H.
  • Apparatus 10B possesses a pair of opposing elements or fences 68 and 70.
  • guide 72 may take the form of a pair of rods supported by stands on a surface, a hinged clamshell configuration, or the like.
  • Fence 68 is fixed to guide 72 while fence 70 is moved and the distance between fences 68 and 70 is set by threaded screws 74, in the same manner as threaded screw 34 found in embodiment 10A.
  • Fence 68 includes a diffuse reflector 76 on one side of bag 14 containing liquid medium 18 having various components therewithin. Of course, diffuse reflector may be formed integrally with bag 14.
  • Diffuse reflector 76 may take the form of a white ceramic disk or other suitable reflector.
  • Light from source 46 passes through outer fiber or fiber bundle 78, from bag 14 containing a liquid medium having various components 18, and through fiber optic bundle 80, which is formed concentrically with fiber optic bundle 78.
  • Analysis of the components within bag chamber 16 takes place by interaction of the electromagnetic radiation from fiber optic bundle 78 by diffuse reflectance, by diffuse transflectance, in conjunction with diffuse reflector 76, or a combination of both. The latter is especially useful where liquid medium is murky to an uncertain degree.
  • diffuse reflectance measurements may be obtained simply by pressing an I.V. bag filled with light scattering material against fence 70 without the use of fence 68.
  • fiber optic bundles 78 and 80 may be angularly disposed with respect to each other i.e., 30 degrees, to minimize specular components of electromagnetic radiation reflected from bag 14.
  • embodiments 10A and 10B take place by supporting bag 14 within spacer means 12, which may include elements 22 and 24 of embodiment 10A, or fences 68 and 70 of embodiment 10B.
  • Spacer means 12 is then adjusted to solely determine the desired optical path within bag 14 or to sequentially determine the optical path through a plurality of bags such as bag 14.
  • liquid medium 18 is not perfectly clear, as in the case of lipids, the optical path would be short.
  • the space between fences 68 and 70 is not critical. The converse is true with clear liquid medium 18.
  • Electromagnetic radiation from source 46 is then directed through passages 48 and 50 of elements 22 and 24, or simply directed through passage 82 of fence 70 of embodiment 10B.
  • electromagnetic radiation is passed from bag 14 to detector 66 for analysis by a suitable software program in conjunction with a personal computer. Where bag 14 is collapsed by fences 22 and 24, electromagnetic radiation may be passed through bag 14 to obtain a reference reading for use with spectral analyses of liquid in bag 14.
  • This spectroscopic method and apparatus of the present invention is capable of identifying and measuring many components in a liquid medium 18.
  • Colorless materials, such as parenteral nutrients have distinctive spectral characteristics in regions outside the visible electromagnetic spectrum (400-700 nm).
  • infrared (3000-25,000 nm) regions of the electromagnetic spectrum produces distinctive spectral features arising from specific molecular structures that are characteristics of the compounds.
  • Such features derive from molecular vibrations of bonded atoms such as oxygen-hydrogen, carbon-hydrogen, nitrogen-hydrogen, and oxygen-carbon.
  • Different types of carbon-hydrogen bonds can be distinguished, such as those arising from terminal C--H groups or CH 3 groups, i.e., fundamental molecular vibrations.
  • vibrational overtones such as the first and second overtones of carbon-hydrogen near 1700 and 1100 nm, respectively.
  • a combination mode ie., such as oxygen and hydrogen in molecular water near 1900 nm. Therefore, many regions of the electromagnetic spectrum may be used to obtain useful spectral data.
  • the near infrared spectra of several parental nutrient compounds i.e., water, 70% dextrose injection USP and 10% Travasol amino acid injection was measured individually or in various combinations to illustrate spectral characteristics.
  • Such compounds formed an optically clear solution, which was placed in a fused quartz cuvette having an optical path of one (1) millimeter.
  • the spectral data were acquired with a germanium detector found in a spectrophotometer, Model 200, manufactured by Guided Wave, Inc. of El Dorado Hills, Calif.
  • Two (2) one meter long, 500 micron core diameter, silica-clad low-OH optical fibers and collimating lenses were connected to the spectrophotometer. Collimating lenses were placed between one end of each fiber and the cuvette.
  • One fiber transmitted light from the tungsten light source inside the spectrophotometer through collimating lens and cuvette.
  • the second collimating lens received light passing through the cuvette and focused the light into the second fiber, which transmitted the light back to the monochrometer and detector in the spectrophotometer.
  • the absorbance characteristics obtained are charted in FIG. 4. Water reaches a maximum absorbance between 1400 and 1500 nanometers. The remaining components produce additional changes on the long wavelength side of the main water peak in the 1500-1800 nanometer region in FIG. 4.
  • a polyvinyl chloride bag used for intravenous feeding (IV bag) was filled with sterile water, 70% dextrose injection, USP, and 10% Travasol amino acid injection, which are typical parenteral nutrients. These components formed an optically clear solution.
  • spectral data were attained with a germanium detector found in a spectrophotometer distributed by Guided Wave, Inc. under the designation model 200.
  • a pair of one meter long, 500 micron core diameter, silica-clad low-OH optical fiber and collimating lenses were employed with the subject detector.
  • the IV bag was compressed to an optical path of 15 millimeters. Distinguishing characteristics were uncovered in the compounds within the I.V. bag in the 800 to 1100 nanometer region of an electromagnetic source of radiation. Reference analysis was also performed on an empty I.V. bag.
  • FIG. 5 represents the results of this analysis.
  • FIG. 6 shows that, in spite of the light scattering characteristics of the milky solution found in the IV bag containing the fat compounds, transmission may still be performed, through 1-2 millimeters of an optical path of the bag.
  • the bag shown in FIG. 6 represents a squeezing of the bag to a smaller optical path, (1.5 to 2 millimeters) than the optical path represented in FIG. 5.
  • the apparatus shown in FIG. 3 was employed to conduct diffuse reflectant/transmittance measurements through I.V. bags constructed of polyvinyl chloride (PVC) filled with mixtures of parenteral nutrients.
  • PVC polyvinyl chloride
  • the mixtures were composed of 20% Intralipid I.V. fat emulsion, 10% Travasol (amino acid injection solution), 70% dextrose injection solution, and sterile water. Nutrients were measured volumetrically with a graduated cylinder mixed, and placed in one (1) liter PVC I.V. bags.
  • the device depicted in FIG. 3 was set to provide an optical path, excluding the thickness of the I.V. bag material, of about 15 millimeters through the solution in the filled I.V. bag.
  • a spectrophotometer was employed, similar to the spectrophotometer utilized in Example 1 using an InGaAs detector.
  • the source of light was a tungsten lamp.
  • the light was delivered through a 6 mm dia. hole in a white Spectralon block available from Labsphere, Inc., North Sutton, N.H. from a 20 watt tungsten source. This block was attached to the stationary fence 70 in FIG. 3.
  • FIG. 7 depicts the results obtained where the various mixtures used were clearly recognizable, with the exception of the 75:25 Travasol and lipid mixture, which, generally, is only slightly different from the 75:25 water and lipid mixture.
  • PCA Principal Component Analysis
  • FACTORS are a set of orthogonal eigenvectors whose lengths represent the percentage of variation in spectral data. SCORES are obtained by multiplying the elements of each eigenvector, referred to as a LOADING (each of which is a co-efficient for the spectral data at a specific wavelength) times the absorbance at that wavelength, and summing the results. Essentially, each sample is projected on each eigenvector and the distance from the origin i.e., the intersection of all eigenvectors is thus measured.
  • LOADING each of which is a co-efficient for the spectral data at a specific wavelength
  • Partial-Least Squares (PLS) method was also employed in the diffuse reflectance method for the samples shown in FIG. 8. The results of this method are shown in FIGS. 9-10 of the present invention.
  • Partial-Least Squares (PLS) multivariate procedure is commonly used to determine chemical or physical property information from spectral data.
  • Computer programs such as UNSCRAMBLER are available from Camo of Norway.
  • SPECTRACALC, and GRAMS/386 are available from Galactic Industries, Inc., of Salem, N.H. Pirouette is available from Infometrics of Redmond, Wash. GRAMS/386 was used in the present analysis with a personal computer.
  • PLS incorporates the benefits of PCA and attempts to provide a model of the data with as few a number of FACTORS as is needed.
  • a six FACTOR PLS model of the diffuse reflectance data of Table I represents a strong indication that mixtures in IV bags can be analyzed non-invasively.
  • FIGS. 9 and 10 show predictions of 70% dextrose injection and 20% intra
  • MLR multi linear Regression Method
  • wavelengths of 1566 and 1716 nanometers were employed for dextrose.
  • the wavelengths employed for water and Travasol are also shown on Table 2. The indication is that a simpler and less expensive system having several discrete detectors, each covered by a narrow wavelength filter or a device having means to switch between several discrete wavelengths, could be built to quantitatively predict the composition of mixtures as these shown in FIG. 4.
  • a stepwise multiple linear regression program was also used to determine a small set of wavelengths which could be used to predict the intralipid and 70% dextrose mixture in IV bags filled with the samples identified in Table II, analyzed by the embodiment of 10A of FIG. 1 (transmittance).
  • the optical path was set to a distance of approximately 1.6 mm. Actual versus predicted values were plotted as shown on FIG. 15. It should be noted that a perfect calibration would plot on the diagonal line found in FIG. 15.
  • Three (3) and five (5) wavelengths were used to produce excellent fits with standard errors of prediction of 2.1 and 3.7% for the 20% intralipid component and the 70% dextrose component in the mixture, respectively.
  • the three (3) wavelengths used for the 20% intralipid were 1606, 1536, and 1532 nanometers which are listed in decreasing order of importance.
  • the five (5) lengths employed for the 70% dextrose were 1414, 1610, 1212, 1424, and 1200 nanometers, also listed in order of importance.
  • Each mathematical solution also included a constant term.

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Application Number Priority Date Filing Date Title
US08/317,114 US5510621A (en) 1994-10-03 1994-10-03 Apparatus and method for measuring components in a bag
CA002159235A CA2159235C (en) 1994-10-03 1995-09-27 Apparatus and method for measuring components in a bag
AT95306954T ATE192572T1 (de) 1994-10-03 1995-10-02 Vorrichtung und verfahren zur messung der komponenten in einer tasche
DE69516620T DE69516620T2 (de) 1994-10-03 1995-10-02 Vorrichtung und Verfahren zur Messung der Komponenten in einer Tasche
EP95306954A EP0706043B1 (de) 1994-10-03 1995-10-02 Vorrichtung und Verfahren zur Messung der Komponenten in einer Tasche
JP7256640A JPH08210973A (ja) 1994-10-03 1995-10-03 液体の成分分析装置及び分析方法
AU33040/95A AU693926B2 (en) 1994-10-03 1995-10-03 Apparatus and method for measuring components in a bag
US08/602,620 US5750998A (en) 1994-10-03 1996-02-16 Apparatus and method for non invasively identifying components of liquid medium within a bag

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WO1998007018A1 (en) * 1996-08-16 1998-02-19 Coors Brewing Company Method for measurement of light transmittance
US5927349A (en) * 1996-12-09 1999-07-27 Baxter International Inc. Compounding assembly for nutritional fluids
US5935285A (en) * 1997-12-30 1999-08-10 Coors Brewing Company Method for inspecting manufactured articles
US6025910A (en) * 1995-09-12 2000-02-15 Coors Brewing Company Object inspection method utilizing a corrected image to find unknown characteristic
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JP2018179982A (ja) * 2017-04-07 2018-11-15 グリーントロピズム サンプル特性評価用の改良分光デバイス及び方法
CN107941741A (zh) * 2017-10-23 2018-04-20 苏州市中心血站 利用近红外光谱检测血浆灭活袋中亚甲蓝释放量的方法
US11413378B2 (en) * 2018-05-08 2022-08-16 Biomagnetic Solutions Llc Rigid chamber for cell separation from a flexible disposable bag
WO2024173966A1 (de) * 2023-02-20 2024-08-29 Research Center For Non Destructive Testing Gmbh Verfahren zum bestimmen der quantität einer psychoaktiven substanz in einer probe

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AU693926B2 (en) 1998-07-09
EP0706043B1 (de) 2000-05-03
ATE192572T1 (de) 2000-05-15
EP0706043A2 (de) 1996-04-10
US5750998A (en) 1998-05-12
AU3304095A (en) 1996-04-18
JPH08210973A (ja) 1996-08-20
CA2159235A1 (en) 1996-04-04
DE69516620T2 (de) 2001-01-11
DE69516620D1 (de) 2000-06-08
CA2159235C (en) 2005-11-22
EP0706043A3 (de) 1998-05-20

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