US5383850A - Inhaler - Google Patents

Inhaler Download PDF

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Publication number
US5383850A
US5383850A US08/072,326 US7232693A US5383850A US 5383850 A US5383850 A US 5383850A US 7232693 A US7232693 A US 7232693A US 5383850 A US5383850 A US 5383850A
Authority
US
United States
Prior art keywords
mouthpiece
housing
inhaler
intermediate floor
lid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US08/072,326
Other languages
English (en)
Inventor
Egon Schwab
Hans-Joachim Loos
Gunter Ziegert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Assigned to HOECHST AKTIENGESELLSCHAFT reassignment HOECHST AKTIENGESELLSCHAFT ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LOOS, HANS-JOACHIM, SCHWAB, EGON, ZIEGERT, GUNTER
Application granted granted Critical
Publication of US5383850A publication Critical patent/US5383850A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/07—General characteristics of the apparatus having air pumping means
    • A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073—Syringe, piston type

Definitions

  • the invention relates to an inhaler for the repeated inhalation of pulverulent pharmaceuticals.
  • Inhalation appliances of the said type are known. Disadvantages of these appliances are their complicated mechanical construction and the tendency to form conglomerates, as a consequence of air humidity, which can penetrate into their channel system.
  • the invention aims to provide a remedy for these problems.
  • the invention achieves the object by means of an inhaler having the features of the claim 1.
  • the whirling-up of the pharmaceuticals in the blow-out channel can be further improved by drilled holes extending radially in the mouthpiece and by a nebulizing device in the blow-out channel.
  • the pharmaceutical supply can be checked through a viewing window in the supply chamber.
  • the inhaler permits optimal dosing accuracy. It can be adjusted to the dosing requirements by the simple exchange of the dosing wheel. It does not require maintenance and can be easily cleaned.
  • FIGURE shows a longitudinal sectional view of an inhaler of the invention.
  • the housing (13) has an intermediate floor (21) and is closed with a lid (17) and a baseplate (14).
  • a rotatable cap (4) is supported on the lid (17) via a spring (12), the edge of which cap encloses the upper edge of the housing wall.
  • the rotatable cap (4) has an axially arranged cylinder (7) which projects through the lid (17), the intermediate floor (21) and a frame (20) into the housing (13).
  • the cylinder (7) is, at the same time, the drive shaft for a dosing wheel (1) which has dosing chambers (22) and which is arranged in the housing (13) concentrically relative to the cylinder (7) and between intermediate floor (21) and frame (20).
  • the housing (13) has a supply chamber (2) for the pharmaceutical which, for its part, can be contained in a cartridge.
  • the supply chamber is provided with a viewing window (3) and has an opening (23) whose cross-section corresponds to that of the dosing chamber (22).
  • the baseplate (14) is provided with a mouthpiece (9) which extends radially and contains a blow-out channel (6) with valve (8).
  • the blow-out channel (6) can be closed at one end with a cap (15) and opens out by the other end into a tubular piston (16) which extends into the cylinder (7), starting from the baseplate (14).
  • the blow-out channel (6) is connected for flow with the inner space of the cylinder (7) via an opening (24) and valve (8).
  • the frame (20) has a shaft (5) which connects the dosing chambers (22) with the blow-out channel (6) via a corresponding opening (25) in the mouthpiece (9).
  • the mouthpiece (9) can be provided with drilled holes (10) which run radially and which open out into the blow-out channel (6).
  • the blow-out channel (6) can have a nebulizing device (sieve plate) (11).
  • the pharmaceutical falls through opening (23) out of the supply chamber (2) into the dosing chamber (22) of the dosing wheel (1).
  • the rotatable cap (4) By means of rotating the rotatable cap (4), the metered quantity of powder is transported to the discharge shaft (5), and falls through this via opening (25) into the blow-out channel (6).
  • the inhaler is provided with a blocking device (e.g. a coupling which disengages on pressing down the rotatable cap--not shown), so that a new dosing can only take place once the blow-out process is complete.
  • a blocking device e.g. a coupling which disengages on pressing down the rotatable cap--not shown

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Weting (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
US08/072,326 1992-06-05 1993-06-03 Inhaler Expired - Lifetime US5383850A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4218517 1992-06-05
DE4218517 1992-06-05

Publications (1)

Publication Number Publication Date
US5383850A true US5383850A (en) 1995-01-24

Family

ID=6460434

Family Applications (1)

Application Number Title Priority Date Filing Date
US08/072,326 Expired - Lifetime US5383850A (en) 1992-06-05 1993-06-03 Inhaler

Country Status (10)

Country Link
US (1) US5383850A (fi)
EP (1) EP0572969B1 (fi)
JP (1) JP3510647B2 (fi)
AT (1) ATE142515T1 (fi)
DE (1) DE59303719D1 (fi)
DK (1) DK0572969T3 (fi)
ES (1) ES2092727T3 (fi)
FI (1) FI110064B (fi)
GR (1) GR3021212T3 (fi)
NO (1) NO304876B1 (fi)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5634900A (en) * 1993-05-12 1997-06-03 Teijin Limited Multi-dose powdered medicine administering device and method thereof
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
US6056169A (en) * 1995-09-04 2000-05-02 Valois S.A. Inhaler apparatus for dispensing accurate and reproducible doses of powder
EP1056496A1 (en) * 1998-02-12 2000-12-06 IEP Pharmaceutical Devices, Inc. Metered dose inhaler pump
US20030034033A1 (en) * 2000-06-30 2003-02-20 Medihale Ltd. System and method for aerosol delivery of a drug
US20050005933A1 (en) * 2001-06-20 2005-01-13 Kari Seppala Powder inhaler
EP1504781A1 (en) * 2003-08-07 2005-02-09 OLIVA, Roberto An inhalator for powder mixtures
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
WO2009082343A1 (en) * 2007-12-20 2009-07-02 Astrazeneca Ab Dispenser and method for entraining powder in an airflow 537
US9211383B2 (en) 2009-07-01 2015-12-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
EP4382154A1 (en) * 2022-12-05 2024-06-12 Uimei Srls Device for administering a predefined quantity of a compound to a patient

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111973848B (zh) * 2020-07-13 2022-09-02 四川省人民医院 一种吸入剂装置

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2590832A (en) * 1949-03-29 1952-03-25 Frederick M Turnbull Inhaler with closure
WO1990007351A1 (en) * 1989-01-06 1990-07-12 Hans Gernot Schenk An oral inhaler
WO1991006333A1 (en) * 1989-11-01 1991-05-16 Novo Nordisk A/S Manually operated dispenser for dispensing a predetermined amount of powdered substance
US5048514A (en) * 1989-07-07 1991-09-17 Somova S.P.A. Inhaler for medicaments contained in capsules
EP0451745A1 (en) * 1990-04-12 1991-10-16 CHIESI FARMACEUTICI S.p.A. Device for the administration of powdered medicinal substances
US5094403A (en) * 1989-04-08 1992-03-10 Sandoz Ltd. Shotcrete gun
WO1992004068A1 (de) * 1990-08-30 1992-03-19 Boehringer Ingelheim Kg Treibgasfreies inhalationsgerät mit fremdluftstrom
WO1992004928A2 (en) * 1990-09-26 1992-04-02 Pharbita B.V. Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
US5243970A (en) * 1991-04-15 1993-09-14 Schering Corporation Dosing device for administering metered amounts of powdered medicaments to patients
US5301666A (en) * 1991-12-14 1994-04-12 Asta Medica Aktiengesellschaft Powder inhaler

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2590832A (en) * 1949-03-29 1952-03-25 Frederick M Turnbull Inhaler with closure
WO1990007351A1 (en) * 1989-01-06 1990-07-12 Hans Gernot Schenk An oral inhaler
US5094403A (en) * 1989-04-08 1992-03-10 Sandoz Ltd. Shotcrete gun
US5048514A (en) * 1989-07-07 1991-09-17 Somova S.P.A. Inhaler for medicaments contained in capsules
WO1991006333A1 (en) * 1989-11-01 1991-05-16 Novo Nordisk A/S Manually operated dispenser for dispensing a predetermined amount of powdered substance
US5201308A (en) * 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
EP0451745A1 (en) * 1990-04-12 1991-10-16 CHIESI FARMACEUTICI S.p.A. Device for the administration of powdered medicinal substances
WO1992004068A1 (de) * 1990-08-30 1992-03-19 Boehringer Ingelheim Kg Treibgasfreies inhalationsgerät mit fremdluftstrom
WO1992004928A2 (en) * 1990-09-26 1992-04-02 Pharbita B.V. Inhaler devices provided with a reservoir for several doses of medium for inhaling, transporting device, whirl chamber
US5243970A (en) * 1991-04-15 1993-09-14 Schering Corporation Dosing device for administering metered amounts of powdered medicaments to patients
US5301666A (en) * 1991-12-14 1994-04-12 Asta Medica Aktiengesellschaft Powder inhaler

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5634900A (en) * 1993-05-12 1997-06-03 Teijin Limited Multi-dose powdered medicine administering device and method thereof
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5957124A (en) * 1994-09-27 1999-09-28 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US6056169A (en) * 1995-09-04 2000-05-02 Valois S.A. Inhaler apparatus for dispensing accurate and reproducible doses of powder
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5875776A (en) * 1996-04-09 1999-03-02 Vivorx Pharmaceuticals, Inc. Dry powder inhaler
EP1056496A1 (en) * 1998-02-12 2000-12-06 IEP Pharmaceutical Devices, Inc. Metered dose inhaler pump
EP1056496A4 (en) * 1998-02-12 2001-07-11 Iep Pharmaceutical Devices Inc PUMP FOR A DOSING INHALATION DEVICE
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US20030034033A1 (en) * 2000-06-30 2003-02-20 Medihale Ltd. System and method for aerosol delivery of a drug
US6691704B2 (en) * 2000-06-30 2004-02-17 Medihale Ltd. System and method for aerosol delivery of a drug
US20050005933A1 (en) * 2001-06-20 2005-01-13 Kari Seppala Powder inhaler
US8550070B2 (en) * 2001-06-20 2013-10-08 Orion Corporation Powder inhaler
EP1504781A1 (en) * 2003-08-07 2005-02-09 OLIVA, Roberto An inhalator for powder mixtures
WO2009082343A1 (en) * 2007-12-20 2009-07-02 Astrazeneca Ab Dispenser and method for entraining powder in an airflow 537
WO2009082341A1 (en) * 2007-12-20 2009-07-02 Astrazeneca Ab Device and method for deaggregating powder 854
US20110083667A1 (en) * 2007-12-20 2011-04-14 Astrazeneca Ab Dispenser and method for entraining powder in an airflow 537
US20110226243A1 (en) * 2007-12-20 2011-09-22 Orest Lastow Device and method for deaggregating powder 854
US8151793B2 (en) 2007-12-20 2012-04-10 Astrazeneca Ab Device and method for deaggregating powder
AU2008341217B2 (en) * 2007-12-20 2012-04-12 Astrazeneca Ab Dispenser and method for entraining powder in an airflow 537
US8479729B2 (en) 2007-12-20 2013-07-09 Astrazeneca Ab Device and method for deaggregating powder
US20110036348A1 (en) * 2007-12-20 2011-02-17 Orest Lastow Device and method for deaggregating powder
US8578933B2 (en) 2007-12-20 2013-11-12 Astrazeneca Ab Entraining powder in an airflow
CN101939040B (zh) * 2007-12-20 2014-11-05 阿斯利康(瑞典)有限公司 解聚集粉末的装置和方法
US9283337B2 (en) 2007-12-20 2016-03-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
US9211383B2 (en) 2009-07-01 2015-12-15 Astrazeneca Ab Dispenser and method for entraining powder in an airflow
EP4382154A1 (en) * 2022-12-05 2024-06-12 Uimei Srls Device for administering a predefined quantity of a compound to a patient
WO2024121663A1 (en) * 2022-12-05 2024-06-13 Uimei Srls Device for administering a predefined quantity of a compound to a patient

Also Published As

Publication number Publication date
JP3510647B2 (ja) 2004-03-29
FI932544A (fi) 1993-12-06
FI110064B (fi) 2002-11-29
JPH0639038A (ja) 1994-02-15
ES2092727T3 (es) 1996-12-01
NO932050L (no) 1993-12-06
EP0572969B1 (de) 1996-09-11
GR3021212T3 (en) 1996-12-31
ATE142515T1 (de) 1996-09-15
NO304876B1 (no) 1999-03-01
NO932050D0 (no) 1993-06-04
EP0572969A1 (de) 1993-12-08
FI932544A0 (fi) 1993-06-03
DK0572969T3 (fi) 1997-02-24
DE59303719D1 (de) 1996-10-17

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