US5237178A - Non-invasive near-infrared quantitative measurement instrument - Google Patents

Non-invasive near-infrared quantitative measurement instrument Download PDF

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Publication number
US5237178A
US5237178A US07/813,739 US81373991A US5237178A US 5237178 A US5237178 A US 5237178A US 81373991 A US81373991 A US 81373991A US 5237178 A US5237178 A US 5237178A
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United States
Prior art keywords
analysis instrument
set forth
infrared
insert
infrared analysis
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Expired - Lifetime
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US07/813,739
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English (en)
Inventor
Robert D. Rosenthal
John J. Mastrototaro
Joseph K. Frischmann
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Individual
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Individual
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Publication date
Priority claimed from US07/544,580 external-priority patent/US5086229A/en
Priority claimed from US07/565,302 external-priority patent/US5077476A/en
Application filed by Individual filed Critical Individual
Priority to US07/813,739 priority Critical patent/US5237178A/en
Priority to US07/980,272 priority patent/US5365066A/en
Priority to MX9207675A priority patent/MX9207675A/es
Priority to CA002127100A priority patent/CA2127100C/fr
Priority to AU34292/93A priority patent/AU3429293A/en
Priority to JP5511975A priority patent/JPH07506497A/ja
Priority to EP93902881A priority patent/EP0619880B1/fr
Priority to DE69218966T priority patent/DE69218966T2/de
Priority to PCT/US1992/011371 priority patent/WO1993013402A1/fr
Priority to US08/103,758 priority patent/US5362966A/en
Priority to US08/106,758 priority patent/US5436455A/en
Publication of US5237178A publication Critical patent/US5237178A/en
Application granted granted Critical
Priority to US08/195,654 priority patent/US5438201A/en
Priority to US08/243,756 priority patent/US5574283A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A61B5/02422—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation within occluders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02416—Detecting, measuring or recording pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A61B5/02427—Details of sensor
    • A61B5/02433—Details of sensor for infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A61B5/6826—Finger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6838—Clamps or clips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A61B2560/0228—Operational features of calibration, e.g. protocols for calibrating sensors using calibration standards
    • A61B2560/0233—Optical standards
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495—Calibrating or testing of in-vivo probes

Definitions

  • This invention relates to instruments for the noninvasive quantitative measurement of constituents in blood, such as blood glucose levels. Specifically, this invention relates to an improved analysis instrument utilizing a removable insert which facilitates positioning of an individual user's finger and improves the internal cleanliness of the instrument.
  • Information concerning the chemical composition of blood is widely used to assess the health characteristics of both people and animals. For example, analysis of the glucose content of blood provides an indication of the current status of metabolism. Blood analysis, by the detection of above or below normal levels of various substances, also provides a direct indication of the presence of certain types of diseases and dysfunctions.
  • a current type of blood glucose analytical instrumentation is available for the specific purpose of determining blood glucose levels in people with diabetes.
  • This technology uses a small blood sample from a finger poke which is placed on a chemically treated carrier and is inserted into a portable battery operated instrument. The instrument analyzes the blood sample and provides a blood glucose level reading in a short period of time.
  • a different class of blood glucose analytical instruments is the near-infrared quantitative analysis instrument which noninvasively measures blood glucose, such as the type described in U.S. Pat. No. 5,077,476 (Rosenthal).
  • the noninvasive blood glucose measurement instrument analyzes near-infrared energy following interactance with venous or arterial blood, or transmission through a blood-containing body part. The instrument measures a change in light absorption that occurs, in part, due to the glucose content of the blood stream.
  • Non-invasive measurement instruments of this type have broad applications for the diabetic community. For example, people with diabetes have wide changes in their blood glucose content during the day which often require multiple measurements per day for good disease control. The ability to make these near-infrared blood glucose level measurements noninvasively means that more measurements will likely be made per day than would be made using the more painful blood drawing approach.
  • An example of a non-invasive measurement instrument is disclosed in the '476 patent wherein an individual user places the most distal portion of his or her finger within a "jaws" type arrangement. Light is then impinged upon the surface of the finger and a detector is placed axial with the light beam on the opposite side of the finger to receive any light emerging therefrom. A microprocessor receives the signal from the detector and calculates the user's blood glucose level.
  • Another analysis instrument is disclosed in copending application Ser. No. 07/565,302 which comprises a chamber formed in the instrument housing into which a user inserts his or her finger. The user's finger must be correctly placed within the chamber so that proper exposure to the near-infrared energy and detection can occur.
  • this type of analysis instrument may measure the individual's skin temperature and use this measurement in calculating the blood analyte concentration. As a result, the individual's finger must properly be in contact with a skin temperature sensor to acquire the temperature measurement.
  • a possible limitation of the above-described instruments is that the instruments, optical systems can be damaged by the measurement of a person, especially children, having extremely dirty or wet fingers. Moreover, moisture and foreign matter can degrade optical transmission of the near-infrared energy thereby resulting in inaccurate blood glucose level measurements.
  • Another potential limitation associated with these instruments involves obtaining inaccurate blood glucose measurements resulting from a failure to properly and securely position a user's finger, which may vary widely in size, inside the instrument. This limitation is particularly applicable to taking measurements on a child's finger. Also, proper connection with a skin temperature sensor may not occur if an individual's finger is improperly positioned within the instrument's chamber.
  • the analysis instrument is constructed having a housing means for housing at least the introducing means and the detecting means and a chamber means for permitting the body part to be exposed to the near-infrared energy.
  • an insert means is utilized for receiving the subject's body part and accurately placing the body part within the chamber means of the analysis instrument. The insert means removably engages the housing means and is aligned with the analysis instrument's optical system.
  • the insert means is semi-permanently and removably mounted into the chamber means of the analysis instrument.
  • the individual user's body part is placed into the insert means which is already mounted inside the instrument's chamber. Utilizing the insert means according to the present invention will protect the instrument's cleanliness and assure proper positioning of body parts for different sized patients, i.e. child, average adult or large adult.
  • FIG. 1 illustrates a non-invasive glucose measurement instrument according to one embodiment of the present invention
  • FIG. 2 is a cross-sectional view of the insert means according to one embodiment of the present invention.
  • FIGS. 3A and 3B are each an end view of an insert means and illustrate the constant diameter and variable inner diameter of the insert means
  • FIG. 4 is an end view of the analysis instrument having an insert means positioned inside its chamber and illustrates the channel means for properly positioning the insert means therein;
  • FIG. 5 illustrates a noninvasive near-infrared glucose measurement instrument according to a second embodiment of the present invention.
  • FIG. 6 illustrates an insert means according to another embodiment of the present invention.
  • near-infrared light energy at bandwidths centering on one or more wavelengths of interest is transmitted through a blood containing portion of the body of a test subject.
  • the near-infrared energy emerges from the test subject, generally opposite from the near-infrared source, and is detected by a detector.
  • the amplified output is processed into an output signal indicating the amount of blood analyte, such as blood glucose level, in the subject's blood.
  • FIG. 1 illustrates a noninvasive near-infrared quantitative analysis instrument 1 which is designed to measure a blood analyte using near-infrared transmission through a test subject's body part, such as a finger.
  • the analytical instrument 1 contains an introducing means including at least one near-infrared energy source for introducing near-infrared energy into the test subject's finger.
  • the introducing means comprises up to six or more near-infrared point sources (near-infrared IRED's).
  • IREDs 5 and 6 are shown for illustrative purposes in FIG. 1.
  • the IREDs emit energy in the range of approximately 600 nanometers to approximately 1100 nanometers.
  • the analytical instrument also utilizes detector 8 for detecting near-infrared energy emerging from the test subject's body part.
  • Detector 8 is electrically connected to data processing means 10 which, according to its programming, processes the signal produced by the detector 8 into a signal indicative of the quantity of blood analyte present in the test subject's blood, which is displayed on display 3.
  • the analytical instrument 1 calculates the quantity of blood analyte present in the test subject's blood substantially as disclosed in U.S. Pat. No. 5,077,476, incorporated herein by reference.
  • Illustrative IREDs 5 and 6 are separated by light baffle 4 and are positioned so that the near-infrared energy is directed through window 14, which may be light scattering, and onto the test subject's skin.
  • Window 14 is an optional component and is provided as a preferred embodiment.
  • Optical filters, illustrated at 12 and 13, are positioned between each IRED and the window 14 for filtering the near-infrared light, thereby optimizing the band of near-infrared light striking the subject.
  • the IREDs 5 and 6, detector 8 and processing means 10 are contained in a housing means which, preferably, is a light-weight hand-held housing unit 11.
  • Housing means 11 further comprises a chamber means 18 for enabling the individual user's body part to be exposed to the near-infrared energy.
  • the IREDs 5 and 6 and the detector 8 are positioned about the chamber means 18 forming an optical axis.
  • the IREDs expose the subject's body part with near-infrared energy and detector 8 detects any energy emerging therefrom.
  • temperature sensor 7 is positioned about chamber means 18 such that it senses the user's skin temperature and produces a signal representative thereof. In one embodiment, temperature sensor 7 comes into actual contact with the user's skin.
  • the measured skin temperature signal is input into the processing unit 10 which may be used in the calculation of the individual's blood glucose level.
  • potential errors in blood analyte concentration measurements may be caused by improper positioning of an individual's body part or by foreign matter degrading optical transmission.
  • FIG. 2 illustrates an insert means 20 for properly positioning an individual's body part inside the analysis instrument 1.
  • insert means 20 receives the test subject's body part, e.g. a finger, which are both then inserted into the chamber means 18 of the analysis instrument 1.
  • the insert means 20 comprises means for securely holding the individual's finger in place which insures its proper positioning within the analysis instrument's optical axis.
  • the means for securely holding the individual's finger can be any suitable structure, such as foam rubber lining 22 or the like.
  • Insert means 20 also includes a finger stop 23 which additionally facilitates finger positioning.
  • insert means 20 includes a window means through which the near-infrared energy emitted from the IREDs 5 and 6 can impinge upon the test subject's finger and be detected by the detector 8.
  • the window means comprises first and second open portions in the insert means which are positioned to permit the near-infrared energy to be transmitted from the IREDs to the detector.
  • the window means comprises openings 24 made of a material transparent to near-infrared energy, such as polystyrene, as shown in FIG. 2.
  • the near-infrared openings can also be a ring-shaped structure formed around the insert means, or can be any other structure suitable for enabling the near-infrared energy to be transmitted therethrough.
  • the insert means is preferably formed of an opaque material, such as PVC, which will protect against interference caused by external light.
  • Insert means 20 further comprises a conduction means 25 for conducting the heat from the individual's finger to the temperature sensor 7. Upon proper insertion, the conduction means 25 and the temperature sensor 7 will be in physical contact which will permit acquisition and utilization of the temperature signal by the processor 10.
  • the conductor means 25 can be made of any suitable material such as brass.
  • the insert means enables the proper positioning of user's fingers which may vary widely in size. This is accomplished by constructing the insert means with a constant outer diameter and by providing an inner diameter dimensioned to accommodate fingers of varying sizes, as illustrated by FIGS. 3A and 3B. Furthermore, constructing the insert means with a constant outside diameter and a choice of inside diameters, depending on finger size, will allow significant cost savings in the design of the analytical instrument. Other types of near-infrared analytical instruments have attempted to accommodate different finger sizes by loading a finger retainer, including a portion of the system optics, against the user's finger. Providing an insert with a constant outside diameter, however, will eliminate the need for movable optics.
  • light shielding means for blocking out unwanted impinging sunlight, or any other type of optical radiation. If the near-infrared measurements are made in bright sunlight, the finger acts as a "fiber optic" equivalent and transmits light to the most distal portion where the glucose is attempted to be measured.
  • the light shielding means is provided which can be any suitable structure for preventing stray light from interfering with blood glucose level measurements.
  • FIG. 2 shows an optically opaque bellows arrangement 26 attached to the insert means 20 and covering the finger portion which is external to the instrument.
  • the light shielding means could be connected to the instrument housing as well.
  • the bellows arrangement 26 blocks out impinging sunlight or any other type of optical radiation which can improve measurement accuracy.
  • the insert means 20 Properly using the insert means 20 with the analytical instrument 1 according to a first embodiment of the present invention will be described hereinafter.
  • the individual user slides his or her body part to be measured, e.g. finger, into the insert means 20.
  • the individual's finger will be securely positioned within the insert means by lining 22 and finger stop 23.
  • the insert is aligned and entered into the chamber means 18.
  • alignment rails 27 are provided on the insert means to insure that it is properly inserted within the chamber 18.
  • the insert means 20 enables the individual's finger to be securely fit and properly aligned within the analytical instrument. Blood analyte concentration measurements can then be performed as described above.
  • the insert means 20 is initially installed into chamber 18 of the analytical instrument 1 before receiving the user's finger, as illustrated in FIG. 5.
  • the individual user's finger is placed into the insert means which is already in the instrument.
  • This construction is advantageous in that the insert means is semi-permanently, removably, engaged by the instrument and is not a "loose piece" which can be lost. Also, the optical path for empty chamber measurement and for the finger measurement is consistent; both contain the insert.
  • the analytical instrument is provided with a protection means for preventing the insert means from being used if it has been damaged or is otherwise unable to permit accurate blood glucose measurements.
  • the insert means 20 is provided with a safety device which informs the user to replace the insert after a predetermined number of days or uses.
  • the insert means shown in FIG. 5 is provided with a safety device 28 including means for completing an electrical circuit which enables the instrument to make blood glucose measurements.
  • the means for completing the electrical circuit can be any suitable means known in the art.
  • safety device 28 comprises a filament which forms part of a circuit between a voltage source and processor 10. Voltage is applied to the filament while the instrument is taking blood glucose measurements. After the filament is expended, the time for which is selected to coincide with the desired useful life of the insert means, the instrument will be inactivated and will no longer perform measurements.
  • the processor 10 can perform the inactivation in any suitable way.
  • the signal from the filament can be to one input of an AND gate while the other AND gate input is from the instrument ON/OFF signal. After, the instrument becomes inactivated the individual user will then have to replace the insert means before additional blood glucose measurements can be taken.
  • the protection means uses the analytical instrument's optical system to determine when the insert means must be replaced.
  • the optical system makes an initial measurement when the insert is first placed into the chamber 18 which is then stored in the instrument's memory. This initial measurement is made with an empty insert, i.e. no finger would be in place at that time. Over a period of time, empty insert measurements are made and the values obtained are compared with the initial Log 1/T values. If significant changes from the initial value are detected, such as a Log 1/T value of approximately 0.1, then the analytical instrument will not perform any further measurements until the insert means has been instrument user will change the insert means to insure its cleanliness and, thus, enable more accurate flood glucose measurements.
  • the insert means is used to provide an optical standard to test the instrument performance.
  • the purpose of the optical standard is to satisfy the requirement that a measurement be made on an artificial substance to establish that the instrument is working properly.
  • insert means 20 is provided with a first optical filter 30 and a second optical filter 31, each located at 90 to the near-infrared transparent windows 24.
  • Filters 30 and 31 can be made of any suitable material, such as plastic, ceramic or formed by vapor deposition on glass.
  • the filters are arranged so that a pair of them can provide reading at two separate points in the spectrum.
  • the optical standardization is performed by rotating the insert means such that optical filters 30 and 31 are in the instrument's optical axis and performing a first measurement reading.
  • a second measurement is then taken after rotating the insert means 180 degrees.
  • the two measurement points are slightly different because the light enters the filters in opposite ways, thus enabling the standard readings to be made. Finger measurements can be made by returning the insert to the original position.
  • the insert means is constructed having the alignment rails only on a distal portion thereof.
  • the housing means comprises channel means for receiving the alignment rails which extend only partially along the length of the chamber means. When the insert means is positioned to perform blood glucose measurements, the alignment rails and the channel means are engaged and prevent the insert means from being rotated.
  • the housing means comprises means for receiving the insert means an additional distance which frees the alignment rails from the channel means which permits the insert means to be rotated.
  • the means for receiving the insert means an additional distance can be any suitable structure, such as spring loading the back wall of the chamber means.

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US07/813,739 1989-01-19 1991-12-30 Non-invasive near-infrared quantitative measurement instrument Expired - Lifetime US5237178A (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
US07/813,739 US5237178A (en) 1990-06-27 1991-12-30 Non-invasive near-infrared quantitative measurement instrument
US07/980,272 US5365066A (en) 1989-01-19 1992-11-23 Low cost means for increasing measurement sensitivity in LED/IRED near-infrared instruments
CA002127100A CA2127100C (fr) 1991-12-30 1992-12-30 Appareil non invasif ameliore pour effectuer des mesures quantitatives dans l'infrarouge proche
DE69218966T DE69218966T2 (de) 1991-12-30 1992-12-30 Verbessertes nichtinvasives quantitatives messinstrument im nahen infrarot
PCT/US1992/011371 WO1993013402A1 (fr) 1991-12-30 1992-12-30 Instrument ameliore pour la mesure quantitative non invasive par infrarouge proche
AU34292/93A AU3429293A (en) 1991-12-30 1992-12-30 Improved non-invasive near-infrared quantitative measurement instrument
JP5511975A JPH07506497A (ja) 1991-12-30 1992-12-30 改良型非侵襲近赤外定量測定装置
EP93902881A EP0619880B1 (fr) 1991-12-30 1992-12-30 Instrument ameliore pour la mesure quantitative non invasive par infrarouge proche
MX9207675A MX9207675A (es) 1991-12-30 1992-12-30 Instrumento de medicion cuantitativa mejorado no invasivo cercano al infrarrojo.
US08/103,758 US5362966A (en) 1990-06-27 1993-08-10 Measurement of finger temperature in near-infrared quantitative measurement instrument
US08/106,758 US5436455A (en) 1990-06-27 1993-08-16 Non-invasive near-infrared quantitative measurement instrument
US08/195,654 US5438201A (en) 1990-06-27 1994-02-15 Method and apparatus for restraining finger motion in blood analyte optical measurement
US08/243,756 US5574283A (en) 1990-06-27 1994-05-17 Non-invasive near-infrared quantitative measurement instrument

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/544,580 US5086229A (en) 1989-01-19 1990-06-27 Non-invasive measurement of blood glucose
US07/565,302 US5077476A (en) 1990-06-27 1990-08-10 Instrument for non-invasive measurement of blood glucose
US07/813,739 US5237178A (en) 1990-06-27 1991-12-30 Non-invasive near-infrared quantitative measurement instrument

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US07/565,302 Continuation-In-Part US5077476A (en) 1989-01-19 1990-08-10 Instrument for non-invasive measurement of blood glucose

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US07/980,272 Continuation-In-Part US5365066A (en) 1989-01-19 1992-11-23 Low cost means for increasing measurement sensitivity in LED/IRED near-infrared instruments
US08/103,758 Continuation-In-Part US5362966A (en) 1990-06-27 1993-08-10 Measurement of finger temperature in near-infrared quantitative measurement instrument
US08/106,758 Continuation-In-Part US5436455A (en) 1990-06-27 1993-08-16 Non-invasive near-infrared quantitative measurement instrument

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US5237178A true US5237178A (en) 1993-08-17

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US07/813,739 Expired - Lifetime US5237178A (en) 1989-01-19 1991-12-30 Non-invasive near-infrared quantitative measurement instrument

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US (1) US5237178A (fr)
EP (1) EP0619880B1 (fr)
JP (1) JPH07506497A (fr)
AU (1) AU3429293A (fr)
CA (1) CA2127100C (fr)
DE (1) DE69218966T2 (fr)
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EP0619880B1 (fr) 1997-04-09
WO1993013402A1 (fr) 1993-07-08
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JPH07506497A (ja) 1995-07-20
AU3429293A (en) 1993-07-28
DE69218966D1 (de) 1997-05-15
CA2127100A1 (fr) 1993-07-08
EP0619880A1 (fr) 1994-10-19
CA2127100C (fr) 1998-09-22
DE69218966T2 (de) 1997-10-09
EP0619880A4 (fr) 1995-02-22

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