US4386080A - Anti-androgenic amide derivative - Google Patents
Anti-androgenic amide derivative Download PDFInfo
- Publication number
- US4386080A US4386080A US06/266,047 US26604781A US4386080A US 4386080 A US4386080 A US 4386080A US 26604781 A US26604781 A US 26604781A US 4386080 A US4386080 A US 4386080A
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- nitro
- chloro
- hydroxy
- hydrogen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
- C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
Definitions
- This invention relates to new amide derivatives and more particularly it relates to novel acylanilides which possess antiandrogenic properties.
- the acylanilide derivative of the invention possesses an asymmetric carbon atom, namely the carbon atom which bears the substituents R 4 and R 5 , and it can therefore exist in racemic and optically-active forms. It is to be understood that this invention encompasses the racemic form of the acylanilide derivative and any optically-active form which possesses antiandrogenic activity, it being a matter of common general knowledge how a racemic compound may be resolved into its optically-active forms and how any antiandrogenic activity present in any of these forms may be determined.
- a suitable value for R 1 , R 3 or a substituent in ring A when it is alkyl is, for example, methyl or ethyl.
- R 3 is preferably hydrogen.
- a suitable value for R 1 or a substituent in ring A when it is alkoxy is, for example, methoxy or ethoxy.
- a suitable value for R 1 , R 2 or a substituent in ring A when it is alkanoyl is, for example, formyl or acetyl.
- a suitable value for R 1 , R 2 or a substituent in ring A when it is alkylthio, alkylsulphinyl, alkylsulphonyl, perfluoroalkyl, perfluoroalkylthio, perfluoroalkylsulphinyl or perfluoroalkylsulphonyl is, for example, methylthio, ethylthio, methylsulphinyl, methylsulphonyl, trifluoromethyl, pentafluoroethyl, trifluoromethylthio, trifluoromethylsulphinyl or trifluoromethylsulphonyl.
- R 4 is, for example, methyl, ethyl, n-propyl, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl or trichloromethyl.
- R 4 is preferably methyl.
- a suitable value for R 5 when it is alkoxy is, for example, methoxy, ethoxy, propyloxy, n-butyloxy or decyloxy.
- a suitable value for R 5 when it is acyloxy is, for example, alkanoyl or aroyl each of up to 15 carbon atoms, for example acetoxy, propionyloxy, decanoyloxy, dodecanoyloxy or benzoyloxy.
- R 5 is preferably hydroxy.
- a suitable value for R 6 or a substituent in ring A when it is halogen is fluoro, chloro, bromo or iodo.
- R 6 is preferably hydrogen or chloro, especially hydrogen.
- a suitable value for a substituent in ring A when it is alkoxycarbonyl or N-alkylcarbamoyl is, for example, methoxycarbonyl, ethoxycarbonyl or N-methylcarbamoyl.
- R 1 and R 2 are as follows:
- Ring A preferably contains one or two substituents only, one of which is an electron-withdrawing substituent in the para-position thereof, for example a nitro, fluoro, chloro, trifluoromethyl, cyano, methoxycarbonyl, methylthio, methylsulphinyl or methylsulphonyl substituent; and the other of which is hydrogen or chloro in the meta-position.
- ring A preferably bears a single nitro substituent in the para-position.
- a preferred acylanilide of the invention has the formula stated above wherein R 1 and R 2 , which may be the same or different, each is cyano, nitro, trifluoromethyl or chloro, R 3 and R 6 are both hydrogen, R 4 is methyl, R 5 is hydroxy and the ring A bears one substituent in the para position which is a nitro, fluoro, trifluoromethyl, cyano, methoxycarbonyl, methylthio or methylsulphinyl substituent.
- Particularly active compounds are 3,4-dichloro-N-(2-hydroxy-2-p-nitrophenylpropionyl) aniline;
- acylanilides of the invention may be manufactured by any chemical process known to be suitable for the manufacture of chemically-analogous compounds.
- a preferred process for the manufacture of an acylanilide of the invention wherein R 3 is hydrogen and R 5 is other than hydroxy comprises the reaction of an amine of the formula: ##STR5## wherein R 1 , R 2 and R 6 have the meanings stated above, with an acid of the formula: ##STR6## wherein R 4 and A have the meanings stated above and wherein R 5 is hydrogen, alkoxy or acyloxy, or with a reactive derivative of said acid.
- a suitable reactive derivative of an acid is, for example, an acid anhydride, or an acyl halide, for example an acyl chloride, or a lower alkyl ester of said acid, for example the methyl or ethyl ester.
- the reaction is carried out in pyridine solution using an acyl chloride (prepared from the acid and thionyl chloride) as reactant.
- An acylanilide of the invention wherein R 3 and R 5 are joined together to form a carbonyl-oxy group that is, an oxazolidinedione may be prepared by the reaction of an isocyanate of the formula: ##STR7## wherein R 1 , R 2 and R 6 have the meanings stated above, with an ester of the formula: ##STR8## wherein R 4 and A have the meanings stated above and wherein R is alkyl of up to 6 carbon atoms, for example methyl or ethyl.
- This reaction is preferably carried out in an organic solvent, for example diethyl ether, at laboratory temperature.
- An acylanilide of the invention wherein R 5 is hydroxy may be prepared by the hydrolysis of the corresponding acylanilide wherein R 5 is acyloxy, and this is a particularly important method for preparing such compounds when the acylanilide wherein R 5 is acyloxy has been prepared by the preferred process of the invention.
- An acylanilide of the invention wherein R 5 is hydroxy and R 3 is hydrogen may be prepared by the hydrolysis of the corresponding oxazolidinedione, which may be prepared as described in the preceding paragraph.
- An acylanilide of the invention wherein R 3 is alkyl may be prepared by the alkylation of the corresponding acylanilide wherein R 3 is hydrogen.
- An acylanilide of the invention wherein R 5 is acyloxy may be prepared by the acylation of the corresponding acylanilide wherein R 5 is hydroxy.
- An oxazolidinedione of the invention wherein R 3 and R 5 are joined together to form a carbonyl-oxy group, may be prepared by the reaction of the corresponding acylanilide wherein R 3 is hydrogen and R 5 is hydroxy with phosgene (COCl 2 ).
- An acylanilide of the invention wherein R 4 is chloromethyl and R 5 is hydroxy may be prepared by the reaction of an epoxide of the formula ##STR9## wherein R 1 , R 2 , R 3 , R 6 and A have the meanings stated above, with hydrogen chloride. This reaction is preferably carried out in an organic solvent, for example chloroform, at laboratory temperature.
- the starting material for the last-mentioned reaction may be prepared by the reaction of an aniline of the formula ##STR10## wherein R 1 , R 2 , R 3 and R 6 have the meanings stated above, with an epoxide of the formula: ##STR11## wherein R and A have the meanings stated above.
- An acylanilide of the invention wherein one or more of R 1 , R 2 and a substituent in the benzene ring A is alkylsulphinyl, perfluoroalkylsulphinyl or phenylsulphinyl, or is alkylsulphonyl, perfluoroalkylsulphonyl or phenylsulphonyl, may be prepared by the oxidation of the corresponding acylanilide wherein one or more of R 1 , R 2 and a substituent in the benzene ring A is alkylthio, perfluoroalkylthio or phenylthio, respectively.
- the oxidising agent and conditions used will determine whether a sulphinyl or a sulphonyl compound is obtained. Thus, oxidation with sodium metaperiodate in methanol solution at or below laboratory temperature will generally convert a thio compound into the corresponding sulphinyl compound; and oxidation with hydrogen peroxide in acetic acid solution at or above laboratory temperature will generally convert a thio compound into the corresponding sulphonyl compound.
- An acylanilide of the invention wherein the benzene ring A bears a carboxy substituent may be prepared by the oxidation of the corresponding acylanilide wherein the benzene ring A bears a formyl substituent; and an acylanilide of the invention wherein the benzene ring A bears an alkoxycarbonyl substituent may be prepared by the esterification of the corresponding acylanilide wherein the benzene ring a bears a carboxy substituent.
- an acylanilide of the invention possesses antiandrogenic properties as demonstrated by its ability to decrease the weight of the seminal vesicles of a mature male rat when administered orally for 4 successive days.
- An acylanilide of the invention may therefore be used in the treatment of, for example, malignant or benign prostatic disease or of androgen-dependent disease conditions, such as acne, hirsutism or seborrhoea, in warm-blooded vertebrates including man. It may also be used to improve ovulation in a domestic animal.
- a preferred acylanilide of the invention is up to 25 times more active as an antiandrogen than the known, chemically-related antiandrogens flutamide and hydroxyflutamide. At a dose of an acylanilide of the invention which produces antiandrogenic activity in rats no symptoms of toxicity are apparent.
- the acylanilide of the invention may be administered to a warm-blooded animal in the form of a pharmaceutical of veterinary composition which comprises the acylanilide in association with a pharmaceutically-acceptable diluent or carrier.
- the composition may be in a form suitable for oral dosage, as a tablet, capsule, aqueous or oily solution or suspension or emulsion. It may alternatively be in the form of a sterile solution or suspension suitable for parenteral administration, or be in the form of an ointment or lotion for topical administration, or be in the form of a suppository.
- the composition may additionally contain one or more drugs selected from anti-oestrogens, for example tamoxifen; progestins, for example medroxyprogesterone acetate; inhibitors of gonadotrophin secretion, for example danazol; cytotoxic agents, for example cyclophosphamide; antibiotics, for example penicillin or oxytetracyclin; and anti-inflammatory agents, for example, especially for topical use, fluocinolone acetonide.
- anti-oestrogens for example tamoxifen
- progestins for example medroxyprogesterone acetate
- inhibitors of gonadotrophin secretion for example danazol
- cytotoxic agents for example cyclophosphamide
- antibiotics for example penicillin or oxytetracyclin
- anti-inflammatory agents for example, especially for topical use, fluocinolone acetonide.
- the acylanilide of the invention will normally be administered to a warm-blooded animal at a dose of between 0.1 mg. and 125 mg. per kg. bodyweight.
- the residue was partitioned between ethyl acetate and dilute aqueous hydrochloric acid, and the ethyl acetate solution was separated, washed successively with dilute aqueous hydrochloric acid, water, aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution, then dried over magnesium sulphate and evaporated to dryness under reduced pressure.
- the residue was crystallised from toluene and there was thus obtained 3,4-dichloro-N-(2-acetoxy-2-p-nitrophenylpropionyl)aniline, m.p. 135°-136° C.
- the 2-acetoxy-2-p-nitrophenylpropionic acid used as starting material was obtained as follows:
- Zinc iodide (0.05 g.) and trimethylsilyl cyanide (36 g.) were added to a stirred solution of p-nitroacetophenone (50 g.) in methylene dichloride (500 ml.) and the mixture was stirred at laboratory temperature for 48 hours and then evaporated to dryness under reduced pressure.
- Aqueous 3 N-hydrochloric acid (500 ml.) was added and the mixture was heated at 50° C. for 5 hours, cooled and poured into water. The mixture was extracted three times with ethyl acetate and the combined extracts were washed with water and then with saturated aqueous sodium chloride solution, dried over magnesium sulphate and evaporated to dryness under reduced pressure.
- Example 2 The process described in the first and second paragraphs of Example 1 was repeated except that the appropriate aniline and the appropropriate 2-acetoxy-2-phenylalkanoic acid were used as starting materials. There were thus obtained the compounds described in the following table:
- a Grignard reagent was prepared from a solution of 1-bromo-4-fluorobenzene (50 g.) in diethyl ether (100 ml.) and a stirred suspension of magnesium (6.8 g.) in diethyl ether (20 ml.), and was heated under reflux for 1 hour and then cooled to 0° C.
- a solution of pyruvic acid (10.8 g.) in diethyl ether (50 ml.) was added dropwise and the mixture was stirred at laboratory temperature for 17 hours, cooled to 0° C., acidified with dilute aqueous hydrochloric acid and extracted three times with diethyl ether.
- Process (b) described above was also used to prepare 2-p-diethoxymethylphenyl- and 2-p-(1,1-diethoxyethyl)phenyl-2-hydroxypropionic acid, which were hydrolysed to 2-p-formylphenyl- and 2-p-acetylphenyl-2-hydroxypropionic acid respectively by heating under reflux for 17 hours in dioxan solution with aqueous 2 N-sulphuric acid.
- 2-p-Cyanophenyl-2-hydroxypropionic acid was prepared by a similar process to process (b) except that the organolithium compound prepared from a solution of 4-bromobenzonitrile (2 g.) in tetrahydrofuran (100 ml.) and n-butyl-lithium (7.3 ml of a 1.5 molar solution in hexane) at -90° C. was added to a solution of ethyl pyruvate (1.2 ml.) in tetrahydrofuran (100 ml.) at -100° C., the reaction mixture was worked up in conventional manner, and the ethyl ester was hydrolysed to the acid by conventional means.
- alkanophenones used as starting materials in process (a) are known compounds apart from 4-methylthio- ⁇ , ⁇ -difluoroacetophenone which was prepared as follows:
- n-Butyl-lithium (3.25 ml. of a 1.6 molar solution) was added dropwise to a stirred solution of 1-bromo-4-methylthiobenzene (1.06 g.) in tetrahydrofuran (50 ml.) which was maintained at -78° C., and the mixture was stirred at that temperature for 1 hour and then added to a solution of difluoroacetic acid (0.25 g.) in tetrahydrofuran (30 ml.). The mixture was stirred at -78° C. for 2 hours, acetic acid (0.5 ml.) was added and the mixture was allowed to warm up to room temperature and was then poured into water.
- the organic layer was separated, washed successively with saturated aqueous sodium bicarbonate solution, water and saturated sodium chloride solution, dried over magnesium sulphate and evaporated to dryness under reduced pressure.
- the residue consisted of 4-methylthio- ⁇ , ⁇ -difluoroacetophenone and was used without further purification.
- Trifluoroacetic anhydride (25.8 ml.) was added to a cooled, stirred suspension of the above compound (35.25 g.) in a mixture of dioxane (400 ml.) and pyridine (28 ml.) at such a rate that the temperature of the mixture was maintained at 10°-12° C., and the mixture was then stirred at laboratory temperature for 15 hours and poured into ice-water (3 liters). The mixture was filtered and the solid residue was crystallised from ethanol. There was thus obtained 2-methylthio-4-nitrobenzonitrile, m.p. 180°-181° C.
- the above compound (30 g.) was added in portions during 50 minutes to a stirred mixture of water (800 ml.), ethanol (200 ml.), glacial acetic acid (60 ml.) and iron powder (150 g.) which was heated at 85°-90° C., and the mixture was stirred at this temperature for a further 3 hours and then basified to pH 9 with aqueous sodium hydroxide solution.
- the mixture was shaken with diethyl ether (200 ml.) and the whole mixture filtered through a filter-aid.
- the solid residue was washed with diethyl ether (400 ml) and the aqueous part of the filtrate was extracted five times with diethyl ether (100 ml. each time).
- the 2-methoxy-2-p-nitrophenylpropionic acid used as starting material was obtained as follows:
- the 2-p-nitrophenylpropionic acid used as starting material was obtained as follows:
- Diethyl malonate (11 g.) was added dropwise to a stirred mixture of sodium hydride (3 g. of a 50% dispersion in mineral oil from which the oil has been removed by washing with petroleum ether) and dimethylformamide (150 ml.) and the mixture was stirred at laboratory temperature for 1 hour.
- Aqueous 2 N-sodium hydroxide solution (1.12 ml.) was added to a solution of methyl 2,3-epoxy-2-p-nitrophenylpropionate (0.5 g.) in a mixture of ethanol (15 ml.), tetrahydrofuran (3 ml.) and water (3 ml.) and the mixture was stirred at laboratory temperature for 1 hour and then evaporated to dryness under reduced pressure. The residue was suspended in toluene (20 ml.), oxalyl chloride (0.25 ml.) was added and the mixture was stirred at laboratory temperature for 2 hours.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8016915 | 1980-05-22 | ||
GB8016915 | 1980-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
US4386080A true US4386080A (en) | 1983-05-31 |
Family
ID=10513596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/266,047 Expired - Fee Related US4386080A (en) | 1980-05-22 | 1981-05-21 | Anti-androgenic amide derivative |
Country Status (19)
Country | Link |
---|---|
US (1) | US4386080A (de) |
EP (1) | EP0040932B1 (de) |
JP (1) | JPS5711951A (de) |
AT (1) | ATE14115T1 (de) |
AU (1) | AU543459B2 (de) |
CA (1) | CA1161850A (de) |
DE (1) | DE3171196D1 (de) |
DK (1) | DK219981A (de) |
ES (2) | ES8300088A1 (de) |
FI (1) | FI811547L (de) |
GR (1) | GR75659B (de) |
HU (1) | HU185799B (de) |
IE (1) | IE51201B1 (de) |
IL (1) | IL62873A (de) |
NO (1) | NO811730L (de) |
NZ (1) | NZ197008A (de) |
PT (1) | PT73079B (de) |
YU (1) | YU130981A (de) |
ZA (1) | ZA813099B (de) |
Cited By (97)
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US4535092A (en) * | 1981-11-06 | 1985-08-13 | Imperial Chemical Industries Plc | Acylanilides having antiandrogenic activity |
US4636505A (en) * | 1982-07-23 | 1987-01-13 | Imperial Chemical Industries Plc | Amide derivatives |
US4666885A (en) * | 1985-02-08 | 1987-05-19 | Fernand Labrie | Combination therapy for treatment of female breast cancer |
US4685962A (en) * | 1983-12-26 | 1987-08-11 | Yashima Chemical Industrial Co., Ltd. | Phenylacetanilide derivatives |
US4760053A (en) * | 1984-08-02 | 1988-07-26 | Fernand Labrie | Combination therapy for selected sex steroid dependent cancers |
US4845119A (en) * | 1985-02-18 | 1989-07-04 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US4873329A (en) * | 1984-03-07 | 1989-10-10 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US4880839A (en) * | 1986-07-18 | 1989-11-14 | Imperial Chemical Industries Plc | Acyanilide derivatives |
US4895715A (en) * | 1988-04-14 | 1990-01-23 | Schering Corporation | Method of treating gynecomastia |
US4921941A (en) * | 1987-07-01 | 1990-05-01 | Schering Corporation | Orally active antiandrogens |
US5236953A (en) * | 1982-04-14 | 1993-08-17 | Imperial Chemical Industries Plc | Alkene, alkyne or cycloalkylene derivatives |
US5260292A (en) * | 1991-03-05 | 1993-11-09 | Marvin S. Towsend | Topical treatment of acne with aminopenicillins |
US5272163A (en) * | 1991-07-25 | 1993-12-21 | Imperial Chemical Industries Plc | Therapeutic amides |
US5362720A (en) * | 1991-06-28 | 1994-11-08 | Endorecherche, Inc. | Methods of treating or preventing breast or endometrial cancer with low dose non-masculinizing androgenic compounds |
US5364847A (en) * | 1989-03-10 | 1994-11-15 | Endorecherche | Inhibitors of sex steroid biosynthesis and methods for their production and use |
US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
US5494914A (en) * | 1992-05-21 | 1996-02-27 | Endorecherche | Inhibitors for testosterone 5α-reductase activity |
US5510386A (en) * | 1993-05-17 | 1996-04-23 | Zeneca Limited | Aminosulfonylphenyl compounds for treating urinary incontinence |
US5593981A (en) * | 1989-07-07 | 1997-01-14 | Endorecherche Inc. | Method and treatment of androgen-related diseases |
US5631249A (en) * | 1988-10-31 | 1997-05-20 | Endorecherche Inc. | Estrogen nucleus derivatives for use in the inhibition of sex steroid activity |
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US6019957A (en) * | 1997-06-04 | 2000-02-01 | The University Of Tennessee Research Corporation | Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging |
US6071957A (en) * | 1996-11-27 | 2000-06-06 | The University Of Tennessee Research Corporation | Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer |
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US6110906A (en) * | 1989-03-10 | 2000-08-29 | Endorecherche, Inc. | Androgen derivatives for use in the inhibition of sex steroid activity |
US6160011A (en) * | 1997-05-30 | 2000-12-12 | The University Of Tennessee Research Corporation | Non-steroidal agonist compounds and their use in male hormone therapy |
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US20040167103A1 (en) * | 2003-02-24 | 2004-08-26 | Dalton James T. | Haloacetamide and azide substituted compounds and methods of use thereof |
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US20040197928A1 (en) * | 2002-10-15 | 2004-10-07 | Dalton James T. | Method for detecting selective androgen receptor modulators |
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Also Published As
Publication number | Publication date |
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ES502441A0 (es) | 1982-10-01 |
PT73079B (en) | 1982-07-15 |
ATE14115T1 (de) | 1985-07-15 |
PT73079A (en) | 1981-06-01 |
FI811547L (fi) | 1981-11-23 |
CA1161850A (en) | 1984-02-07 |
IE811010L (en) | 1981-11-22 |
IL62873A (en) | 1985-05-31 |
ES512702A0 (es) | 1983-02-01 |
AU7029581A (en) | 1981-11-26 |
YU130981A (en) | 1983-10-31 |
AU543459B2 (en) | 1985-04-18 |
NO811730L (no) | 1981-11-23 |
NZ197008A (en) | 1984-10-19 |
ES8303285A1 (es) | 1983-02-01 |
HU185799B (en) | 1985-03-28 |
ES8300088A1 (es) | 1982-10-01 |
EP0040932B1 (de) | 1985-07-03 |
DE3171196D1 (en) | 1985-08-08 |
GR75659B (de) | 1984-08-02 |
DK219981A (da) | 1981-11-23 |
ZA813099B (en) | 1982-05-26 |
EP0040932A1 (de) | 1981-12-02 |
IE51201B1 (en) | 1986-10-29 |
JPS5711951A (en) | 1982-01-21 |
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