US4233973A - Apparatus for administering intravenous drugs - Google Patents
Apparatus for administering intravenous drugs Download PDFInfo
- Publication number
- US4233973A US4233973A US06/037,957 US3795779A US4233973A US 4233973 A US4233973 A US 4233973A US 3795779 A US3795779 A US 3795779A US 4233973 A US4233973 A US 4233973A
- Authority
- US
- United States
- Prior art keywords
- container
- needle
- drug
- venipuncture
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1407—Infusion of two or more substances
- A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
Definitions
- This invention relates to apparatus for administering intravenous drugs to a patient, in particular drugs supplied in powdery form.
- a drug initially supplied in powdery form where the individual particles are either loose or compacted into cake form, such as a cytotoxic agent for treating cancer
- a standard procedure is currently adopted. This procedure involves providing a sealed container holding the powdery drug and injecting into the bottle, by way of a standard syringe and hypodermic needle, a volume of intravenously-acceptable liquid in which the drug will dissolve. The container is then shaken until the drug is dissolved and a solution is formed.
- a volume of air equal to that of the previously injected liquid is then drawn into the syringe and is injected into the container to equalise the pressures in the syringe and the container, and the desired volume of liquid medicament is drawn into the syringe.
- Said syringe is then removed from the container and the drug is injected into the patient.
- Such a procedure has a number of disadvantages, the administrator of the drug being particularly prone to possible exposure to the drug.
- the needle of the syringe may accidentally be removed from the body of the syringe during charging of said syringe; the needle may be accidentally removed from the container during said charging; the supposedly fluid-tight rubber stopper on the container may develop a leak after removal therefrom of the needle.
- cytotoxic agents and other drugs are photosensitive in that any, or extended exposure to light causes degradation of the drugs, rendering them substantially less effective and some of them more toxic, e.g. dacarbazine.
- An object of the present invention is to provide a closed circuit apparatus for administering drugs initially provided in powdery form in a manner which substantially reduces or eliminates the possibility of exposure of the person administering the drug.
- the invention also provides an apparatus which is readily adaptable to the administration of photosensitive drugs without increasing the possibility of exposure of the person administering the drug, and which can ensure the sterility of the administered drug.
- Such apparatus provides a closed system for the drug to be administered whereby initial mixing of the powdery drug into solution and the subsequent injection of the dissolved drug into the patient are achieved without removing from the system any component of the apparatus containing or supplied with the drug, the preparation of the solution and the injection thereof being under the control of the pump means, conveniently a standard injection syringe.
- FIG. 1 illustrates apparatus according to the invention
- FIG. 2 illustrates a venipuncture member of apparatus according to the invention
- FIG. 3 illustrates a needle provided with a bacterial filtration arrangement for use with apparatus according to the invention.
- the illustrated apparatus comprises an intravenous infusion set including a container 2, either a bottle or a container of the collapsible-bag type, of intravenous liquid connected by means of a length of flexible plastics tubing 4 with a venipuncture member indicated generally at 6.
- a drip chamber 8 which may or may not contain a filter 10, a safety valve indicated generally at 12 for reasons to be detailed below, a flexible bubble member 14 associated with the valve 12 again for reasons to be detailed below, a pinch clip 16, a first injection site 18, a flow-control clamp 19 for the drip feed and a second injection site 20 in the form of a length of self-sealing latex rubber tubing.
- the apparatus further comprises a container 22 sealed by a rubber stopper 24 in which container is a volume of powdery drug, for example a cytotoxic drug, to be administered to a patient.
- a container 22 sealed by a rubber stopper 24 in which container is a volume of powdery drug, for example a cytotoxic drug, to be administered to a patient.
- a standard injection syringe 26 includes a cylindrical body member 28 and a piston 30, the outlet from the body member 28 having attached thereto a standard hypodermic needle 32.
- the needle 32 extends through the stopper 24 of the container to terminate within the upper regions of said container.
- a further longer hollow metal needle 34 also extends through the stopper 24 to terminate adjacent the bottom of the container 22, the upper end of said needle having attached thereto, by means of a connecting piece 36, one end of a further length of flexible plastics tubing 38.
- the other end of said tubing carries a still further hollow metal needle 40 which may be a standard hypodermic needle.
- the venipuncture member 6 includes a flexible cannula 48 having a bevelled one end 50, a side arm 52 communicating into the bore of the cannula extending from the other end of said cannula. Positioned adjacent said other end of the cannula 48 is a plug 54 of latex rubber forming an extension of said cannula, while a hollow metal needle 56 extends through said plug 54, through the bore of said cannula 48 to terminate in a one end 58 located just beyond the one end 50 of the cannula 48.
- the other end of the needle 56 carries a transparent chamber 60 releasably attachable to the plug 54 to form a continuation of the cannula 48, said chamber being provided with a porous end cover 62.
- the venipuncture member 6 is housed within a protective sheath 63.
- the sheath 63 When attaching the venipuncture member 6 to a patient, the sheath 63 is removed therefrom and the ends 50,58 of the cannula 48 and needle 56 respectively are pushed into a vein of the patient. Once the needle 56 is in the vein, blood flows through said needle to the transparent chamber 60 where it can be seen by the doctor or nurse. The needle 56 and attached chamber 60 are then bodily removed from the venipuncture member to leave the cannula only in the vein, and the drip feed from the infusion set, which has previously been evacuated, is started.
- the piston 30 With the needle 34 extending to the lower regions of the container 22, the piston 30 is withdrawn in the body member 28 to withdraw a predetermined volume of bacteria-free air from the container 22.
- the pressure in said container thus falls, and intravenous liquid from the container 2, whilst continuing to flow to the patient, also flows under gravity through the needle 40, the tubing 38, the connecting piece 36 and the needle 34 into said container to replace the removed air.
- the container 22 can then be shaken to dissolve the drug into a solution 64, the pressures in the container 22 and the syring 26 being equal.
- Some or all of the solution 64 is then administered to the patient by depressing the piston 30 in the body member 28 of the syringe 26 to return the previously withdrawn bacteria-free air into the container 22 and thereby force an equivalent volume of solution from the container through the needle 34, tubing 38 and needle 40 into the drip feed from the infusion set and thence to the venipuncture member 6 and into the patient.
- the valve 42 in the tubing 38 comprises a transparent inspection chamber 66 in which is housed a float member 68.
- the float member 68 is such as, with the chamber 66 filled with liquid, to float at a midway position in said chamber with a closure portion 70 of the member 68 permitting liquid flow through an outlet 72 from the chamber 66. If air flows from the container 22 through the needle 34, it collects in the upper regions of the chamber 66, and the level of liquid in the container falls. When said chamber is full of air, the float member falls into a lowermost position sealing off the outlet 72 from the chamber. Thus no air is allowed to flow past the valve 42 and into the vein of the patient.
- any air in the chamber 66 can be sucked back into the container 22 by means of the syringe 26. If the float member 68 should stick in its lowermost position, the bubble member 44, which always contains liquid, can be squeezed (after clipping the tube 38 with the pinch clip 46) to release said member 68.
- valve 12 and bubble member 14 can be used in a similar way to prevent the passage of air from the container 22 to the venipuncture member 6 and to release the float member of said valve should it stick in its lowermost position.
- the bacterial filtration arrangement shown in FIG. 3 may be used to ensure that all air entering the container 22 to force solution 64 to a patient is bacteria free. More particularly, the solution is made up as detailed above but by withdrawing the bacteria-free air from the container 22 in two or more stages by means of the syringe 26--i.e. the needle 32 is inserted through the stopper 24, a volume of air is withdrawn into the syringe and the syringe is removed from the container 22. This air is then discharged from the syringe, the needle 32 is reinserted through the stopper 24 and a further volume of bacteria-free air is withdrawn into said syringe.
- FIG. 3 illustrates a cylindrical housing 74 adjacent one end of which is a rubber plug 76 and the other end of which comprises an apertured plastics grid 78. Within the housing 74, adjacent the other end thereof, is a bacterial filter element 80.
- a standard hypodermic needle 32' projects through the plug 76 into the housing 74, the upper end of said needle carrying a standard female adaptor 82 to permit attachment of said needle to a standard injection syringe.
- a cap 84 closes the one end of the housing 74.
- any air drawn into the syringe 26 through said needle 32' will be free from bacteria, said bacteria being removed therefrom by the filter element 80.
- the syringe 26 and needle 32' are then withdrawn from the housing 74 and the bacteria-free air in the body member 28 of the syringe can be injected into the container 22 to effect the administration of a further volume of drug to the patient.
- the provision of the injection site 18 in the drip feed set enables drugs additional to that in the container 22 to be readily injected into the patient without excessively puncturing the site 20 which may result in leakage of the drug onto the arm of a patient.
- a drug to be administered to a patient as a solution 64 is photosensitive in nature, photodegradation of such a drug can readily be avoided by making opaque the components of the apparatus which contain or transport the solution, in particular the container 22 and all tubing associated therewith. Additionally, the infusion set can also be made opaque to prevent photodegradation of any of the photosensitive drug that may be drawn or pushed into it during use of the apparatus although a chamber of the safety valve can be kept transparent to enable entry of air into the set to be viewed.
- Apparatus according to the invention provides a closed-circuit system whereby a drug, for example a photosensitive cytotoxic drug, can, once the apparatus is set up, be administered to a patient under the control of pump means, for example a standard medical injection syringe, and without the necessity to remove from the system any component containing or supplied with the drug in question.
- pump means for example a standard medical injection syringe
- the pump means may be other than a medical injection syringe and may be other than manually operated, for example mechanically or electrically operated.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1915578 | 1978-05-12 | ||
GB19155/78 | 1978-05-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
US4233973A true US4233973A (en) | 1980-11-18 |
Family
ID=10124668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US06/037,957 Expired - Lifetime US4233973A (en) | 1978-05-12 | 1979-05-09 | Apparatus for administering intravenous drugs |
Country Status (3)
Country | Link |
---|---|
US (1) | US4233973A (de) |
EP (1) | EP0005606A1 (de) |
AU (1) | AU4690379A (de) |
Cited By (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0077604A1 (de) * | 1981-08-26 | 1983-04-27 | Eli Lilly And Company | Patrone zur Verwendung bei der Verabreichung eines Trocken-Medikamentes |
US4432756A (en) * | 1981-11-27 | 1984-02-21 | Alza Corporation | Parenteral controlled therapy |
US4439183A (en) * | 1981-10-09 | 1984-03-27 | Alza Corporation | Parenteral agent dispensing equipment |
US4479794A (en) * | 1981-11-27 | 1984-10-30 | Alza Corporation | System for intravenous therapy |
US4479793A (en) * | 1981-11-27 | 1984-10-30 | Alza Corporation | Parenteral administration using drug delivery device |
US4484909A (en) * | 1981-11-27 | 1984-11-27 | Alza Corporation | Parenteral therapy using solid drug |
US4493702A (en) * | 1981-11-27 | 1985-01-15 | Alza Corporation | Parenteral administration using osmotically motivated delivery system |
US4501582A (en) * | 1980-12-20 | 1985-02-26 | Volker Schulz | Perfusion kit |
US4511352A (en) * | 1984-05-14 | 1985-04-16 | Alza Corporation | Parenteral delivery system with in-line container |
US4511351A (en) * | 1984-05-14 | 1985-04-16 | Alza Corporation | Parenteral delivery system utilizing a hollow fiber cellular unit |
US4511353A (en) * | 1981-07-13 | 1985-04-16 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4515585A (en) * | 1982-05-24 | 1985-05-07 | Alza Corporation | System for parenteral administration of agent |
US4521211A (en) * | 1981-10-09 | 1985-06-04 | Alza Corporation | Parenteral agent dispensing equipment |
US4525162A (en) * | 1981-07-31 | 1985-06-25 | Alza Corporation | Parenteral controlled delivery |
US4540403A (en) * | 1984-07-02 | 1985-09-10 | Alza Corporation | Parenteral dispensing system with programmable drug administration |
US4548599A (en) * | 1981-11-27 | 1985-10-22 | Alza Corporation | Parenteral controlled therapy |
US4548598A (en) * | 1981-10-09 | 1985-10-22 | Alza Corporation | Parenteral agent dispensing equipment |
US4552556A (en) * | 1981-11-27 | 1985-11-12 | Alza Corporation | Parenteral controlled therapy |
US4573967A (en) * | 1983-12-06 | 1986-03-04 | Eli Lilly And Company | Vacuum vial infusion system |
US4579553A (en) * | 1981-11-27 | 1986-04-01 | Alza Corporation | Parenteral controlled therapy |
US4583981A (en) * | 1981-11-27 | 1986-04-22 | Alza Corporation | Parenteral controlled therapy, using a porous matrix with parenteral agent |
US4586922A (en) * | 1981-10-09 | 1986-05-06 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4596555A (en) * | 1984-05-14 | 1986-06-24 | Alza Corporation | Parenteral delivery system utilizing a hollow fiber cellular unit |
EP0212100A1 (de) * | 1985-06-25 | 1987-03-04 | Laboratorien Hausmann AG | Vorrichtung mit zwei miteinander zu vermischenden Lösungen |
US4664650A (en) * | 1982-05-24 | 1987-05-12 | Alza Corporation | Apparatus for parenteral infusion of fluid containing beneficial agent |
US4715850A (en) * | 1984-12-06 | 1987-12-29 | Controlled Release Technologies, Inc. | Therapeutic agent delivery system and method |
US4740201A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4740197A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent via polymer delivery |
US4740200A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4740103A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4740199A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4740198A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Method of administering intravenous drug using rate-controlled dosage form |
US4741734A (en) * | 1981-10-09 | 1988-05-03 | Alza Corporation | Releasing means for adding agent using releasing means to IV fluid |
US4741735A (en) * | 1981-10-09 | 1988-05-03 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4745907A (en) * | 1985-08-01 | 1988-05-24 | Nuclear Medicine, Inc. | System and method for delivering insoluble materials into a living body |
US4790820A (en) * | 1981-07-13 | 1988-12-13 | Alza Corporation | Parenteral agent dispensing equipment with drug releasing member |
US4822339A (en) * | 1984-12-06 | 1989-04-18 | Controlled Release Technologies, Inc. | Therapeutic agent delivery system and method |
US4857052A (en) * | 1981-07-13 | 1989-08-15 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4871360A (en) * | 1981-07-31 | 1989-10-03 | Alza Corporation | System for intravenous delivery of a beneficial drug at a regulated rates |
US4908019A (en) * | 1982-05-24 | 1990-03-13 | Alza Corporation | Apparatus comprising dual reservoirs for parenteral infusion of fluid containing beneficial agent |
WO1990012606A2 (en) * | 1989-04-10 | 1990-11-01 | Baxter International Inc. | iRE-SLIT INJECTION SITE AND TAPERED CANNULA |
US4973307A (en) * | 1981-07-13 | 1990-11-27 | Alza Corporation | Method for administering drugs to a patient |
US4985017A (en) * | 1981-07-13 | 1991-01-15 | Alza Corporation | Parenteral therapeutical system comprising drug cell |
US4994031A (en) * | 1981-07-13 | 1991-02-19 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US5069671A (en) * | 1981-07-13 | 1991-12-03 | Alza Corporation | Intravenous medication |
USRE34365E (en) * | 1981-07-13 | 1993-08-31 | Intravenous system for delivering a beneficial agent | |
US20020004639A1 (en) * | 2000-01-07 | 2002-01-10 | Willis John P. | Injection device |
US20020151842A1 (en) * | 2000-11-30 | 2002-10-17 | Gonnelli Robert R. | Injection systems |
US6641556B1 (en) * | 1999-07-06 | 2003-11-04 | Respiratory Support Products, Inc. | Intravenous fluid heating system |
WO2003069632A3 (en) * | 2002-02-11 | 2003-12-11 | Sigma Tau Ind Farmaceuti | Container for vial of radiopharmaceutical and set for its infusion in a patient or for its transfer elsewhere |
US20040249339A1 (en) * | 1998-12-18 | 2004-12-09 | Biovalve Technologies, Inc. | Injection devices |
EP1535641A1 (de) * | 2003-11-28 | 2005-06-01 | ARIES S.r.l. | Tropfkammer mit Entlüftungsmitteln |
US20050124936A1 (en) * | 2001-09-27 | 2005-06-09 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US20110004184A1 (en) * | 2007-10-01 | 2011-01-06 | Karl-Heinz Proksch | Device for introducing medicine into an infusion container |
US8047157B2 (en) * | 2004-06-24 | 2011-11-01 | Cook Medical Technologies Llc | Method and apparatus for coating interior surfaces of medical devices |
CN108601707A (zh) * | 2015-12-04 | 2018-09-28 | 康尔福盛303公司 | 用于自动药物配制器的小瓶压轮系统 |
IT201800005988A1 (it) * | 2018-06-04 | 2019-12-04 | Dispositivo di infusione per la somministrazione di farmaci fotosensibili | |
RU2804991C1 (ru) * | 2022-12-23 | 2023-10-09 | Общество с ограниченной ответственностью "БЕБИГ" | Устройство для интраартериального введения суспензий и растворов, допускающее контрастирование целевой артерии |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2107191B (en) * | 1981-07-31 | 1984-08-30 | Alza Corp | Parenteral delivery system |
US4915689A (en) * | 1984-06-13 | 1990-04-10 | Alza Corporation | Parenteral delivery system comprising a vial containing a beneficial agent |
US4997430A (en) * | 1989-09-06 | 1991-03-05 | Npbi Nederlands Produktielaboratorium Voor Bloedtransfusieapparatuur En Infusievloeistoffen B.V. | Method of and apparatus for administering medicament to a patient |
CN101232919A (zh) * | 2005-07-27 | 2008-07-30 | 马林克罗特公司 | 确定供应到放射性同位素发生器的洗提液量的系统和方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US966591A (en) * | 1910-05-12 | 1910-08-09 | Richard T Payne | Embalming instrument. |
US1517849A (en) * | 1922-06-08 | 1924-12-02 | Mclellan Daniel | Blood-transfusion apparatus |
DE715653C (de) * | 1934-11-21 | 1942-01-05 | Ncr Co | Nullendruckvorrichtung fuer Registrierkassen oder Buchungsmaschinen |
US3332421A (en) * | 1964-08-21 | 1967-07-25 | Upjohn Co | Combination syringe and vial mixing container |
US3397694A (en) * | 1965-07-06 | 1968-08-20 | C S M Corp | Combination syringe package, syringe and chamber |
US3650093A (en) * | 1970-01-08 | 1972-03-21 | Pall Corp | Sterile disposable medicament administration system |
US3844283A (en) * | 1973-08-15 | 1974-10-29 | Cutter Lab | Apparatus for aseptically dispensing a measured volume of liquid |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3125092A (en) * | 1964-03-17 | Infusion flask | ||
US3066671A (en) * | 1959-10-27 | 1962-12-04 | Milton J Cohen | Disposable additive container |
DE1914749A1 (de) * | 1968-03-26 | 1969-10-09 | Matburn Holdings Ltd | Transfusionsgeraet,insbesondere intravenoeser Katheter |
US3719213A (en) * | 1971-03-03 | 1973-03-06 | Barter Lab Inc | Method for adding medicaments to a sealed expandable parenteral fluid container |
CA1042299A (en) * | 1974-05-31 | 1978-11-14 | Baxter Travenol Laboratories | Injection site |
US3976068A (en) * | 1975-01-03 | 1976-08-24 | Origo, Inc. | Drug dispenser for use with intravenous feeding pump |
US4005710A (en) * | 1975-02-12 | 1977-02-01 | Abbott Laboratories | Parenteral apparatus with one-way valve |
IL50907A (en) * | 1976-10-20 | 1978-12-17 | Ims Ltd | Alimentation kit comprising a plurality of cylindrical rigid vials and a transfer device for sequential addition of liquid contents of each of said vials to a conventional container of intravenous solution |
-
1979
- 1979-05-04 EP EP79300773A patent/EP0005606A1/de not_active Withdrawn
- 1979-05-09 AU AU46903/79A patent/AU4690379A/en not_active Abandoned
- 1979-05-09 US US06/037,957 patent/US4233973A/en not_active Expired - Lifetime
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US966591A (en) * | 1910-05-12 | 1910-08-09 | Richard T Payne | Embalming instrument. |
US1517849A (en) * | 1922-06-08 | 1924-12-02 | Mclellan Daniel | Blood-transfusion apparatus |
DE715653C (de) * | 1934-11-21 | 1942-01-05 | Ncr Co | Nullendruckvorrichtung fuer Registrierkassen oder Buchungsmaschinen |
US3332421A (en) * | 1964-08-21 | 1967-07-25 | Upjohn Co | Combination syringe and vial mixing container |
US3397694A (en) * | 1965-07-06 | 1968-08-20 | C S M Corp | Combination syringe package, syringe and chamber |
US3650093A (en) * | 1970-01-08 | 1972-03-21 | Pall Corp | Sterile disposable medicament administration system |
US3844283A (en) * | 1973-08-15 | 1974-10-29 | Cutter Lab | Apparatus for aseptically dispensing a measured volume of liquid |
Cited By (80)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4501582A (en) * | 1980-12-20 | 1985-02-26 | Volker Schulz | Perfusion kit |
US4790820A (en) * | 1981-07-13 | 1988-12-13 | Alza Corporation | Parenteral agent dispensing equipment with drug releasing member |
US4857052A (en) * | 1981-07-13 | 1989-08-15 | Alza Corporation | Intravenous system for delivering a beneficial agent |
USRE34365E (en) * | 1981-07-13 | 1993-08-31 | Intravenous system for delivering a beneficial agent | |
US5069671A (en) * | 1981-07-13 | 1991-12-03 | Alza Corporation | Intravenous medication |
US4994031A (en) * | 1981-07-13 | 1991-02-19 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4511353A (en) * | 1981-07-13 | 1985-04-16 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4973307A (en) * | 1981-07-13 | 1990-11-27 | Alza Corporation | Method for administering drugs to a patient |
US4985017A (en) * | 1981-07-13 | 1991-01-15 | Alza Corporation | Parenteral therapeutical system comprising drug cell |
US4525162A (en) * | 1981-07-31 | 1985-06-25 | Alza Corporation | Parenteral controlled delivery |
US4871360A (en) * | 1981-07-31 | 1989-10-03 | Alza Corporation | System for intravenous delivery of a beneficial drug at a regulated rates |
EP0077604A1 (de) * | 1981-08-26 | 1983-04-27 | Eli Lilly And Company | Patrone zur Verwendung bei der Verabreichung eines Trocken-Medikamentes |
US4521211A (en) * | 1981-10-09 | 1985-06-04 | Alza Corporation | Parenteral agent dispensing equipment |
US4740200A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4740198A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Method of administering intravenous drug using rate-controlled dosage form |
US4548598A (en) * | 1981-10-09 | 1985-10-22 | Alza Corporation | Parenteral agent dispensing equipment |
US4740199A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4740103A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4586922A (en) * | 1981-10-09 | 1986-05-06 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4740197A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent via polymer delivery |
US4740201A (en) * | 1981-10-09 | 1988-04-26 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4741735A (en) * | 1981-10-09 | 1988-05-03 | Alza Corporation | Intravenous system for delivering a beneficial agent |
US4741734A (en) * | 1981-10-09 | 1988-05-03 | Alza Corporation | Releasing means for adding agent using releasing means to IV fluid |
US4439183A (en) * | 1981-10-09 | 1984-03-27 | Alza Corporation | Parenteral agent dispensing equipment |
US4552556A (en) * | 1981-11-27 | 1985-11-12 | Alza Corporation | Parenteral controlled therapy |
US4479794A (en) * | 1981-11-27 | 1984-10-30 | Alza Corporation | System for intravenous therapy |
US4493702A (en) * | 1981-11-27 | 1985-01-15 | Alza Corporation | Parenteral administration using osmotically motivated delivery system |
US4579553A (en) * | 1981-11-27 | 1986-04-01 | Alza Corporation | Parenteral controlled therapy |
US4583981A (en) * | 1981-11-27 | 1986-04-22 | Alza Corporation | Parenteral controlled therapy, using a porous matrix with parenteral agent |
US4432756A (en) * | 1981-11-27 | 1984-02-21 | Alza Corporation | Parenteral controlled therapy |
US4484909A (en) * | 1981-11-27 | 1984-11-27 | Alza Corporation | Parenteral therapy using solid drug |
US4479793A (en) * | 1981-11-27 | 1984-10-30 | Alza Corporation | Parenteral administration using drug delivery device |
US4548599A (en) * | 1981-11-27 | 1985-10-22 | Alza Corporation | Parenteral controlled therapy |
US4515585A (en) * | 1982-05-24 | 1985-05-07 | Alza Corporation | System for parenteral administration of agent |
US4664650A (en) * | 1982-05-24 | 1987-05-12 | Alza Corporation | Apparatus for parenteral infusion of fluid containing beneficial agent |
US4908019A (en) * | 1982-05-24 | 1990-03-13 | Alza Corporation | Apparatus comprising dual reservoirs for parenteral infusion of fluid containing beneficial agent |
US4573967A (en) * | 1983-12-06 | 1986-03-04 | Eli Lilly And Company | Vacuum vial infusion system |
US4596555A (en) * | 1984-05-14 | 1986-06-24 | Alza Corporation | Parenteral delivery system utilizing a hollow fiber cellular unit |
US4511351A (en) * | 1984-05-14 | 1985-04-16 | Alza Corporation | Parenteral delivery system utilizing a hollow fiber cellular unit |
US4511352A (en) * | 1984-05-14 | 1985-04-16 | Alza Corporation | Parenteral delivery system with in-line container |
US4540403A (en) * | 1984-07-02 | 1985-09-10 | Alza Corporation | Parenteral dispensing system with programmable drug administration |
US4715850A (en) * | 1984-12-06 | 1987-12-29 | Controlled Release Technologies, Inc. | Therapeutic agent delivery system and method |
US4822339A (en) * | 1984-12-06 | 1989-04-18 | Controlled Release Technologies, Inc. | Therapeutic agent delivery system and method |
EP0212100A1 (de) * | 1985-06-25 | 1987-03-04 | Laboratorien Hausmann AG | Vorrichtung mit zwei miteinander zu vermischenden Lösungen |
AU590780B2 (en) * | 1985-08-01 | 1989-11-16 | Theragenics Corporation | System and method for delivering insoluble material into a living body |
US4745907A (en) * | 1985-08-01 | 1988-05-24 | Nuclear Medicine, Inc. | System and method for delivering insoluble materials into a living body |
US5135489A (en) * | 1988-01-25 | 1992-08-04 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
WO1990012606A3 (en) * | 1989-04-10 | 1992-10-15 | Baxter Int | iRE-SLIT INJECTION SITE AND TAPERED CANNULA |
WO1990012606A2 (en) * | 1989-04-10 | 1990-11-01 | Baxter International Inc. | iRE-SLIT INJECTION SITE AND TAPERED CANNULA |
US20040249339A1 (en) * | 1998-12-18 | 2004-12-09 | Biovalve Technologies, Inc. | Injection devices |
US7740607B2 (en) | 1998-12-18 | 2010-06-22 | Valeritas, Inc. | Modular units for use in an injection device |
US6960184B2 (en) | 1998-12-18 | 2005-11-01 | Biovalve Technologies, Inc. | Injection devices |
US20050154350A1 (en) * | 1998-12-18 | 2005-07-14 | Biovalve Technologies, Inc. | Injection devices |
US6641556B1 (en) * | 1999-07-06 | 2003-11-04 | Respiratory Support Products, Inc. | Intravenous fluid heating system |
US20020004639A1 (en) * | 2000-01-07 | 2002-01-10 | Willis John P. | Injection device |
US7806867B2 (en) | 2000-01-07 | 2010-10-05 | Valeritas, Inc. | Injection device |
US20040220525A1 (en) * | 2000-01-07 | 2004-11-04 | Willis John P | Injection device |
US20030149397A9 (en) * | 2000-11-30 | 2003-08-07 | Gonnelli Robert R. | Injection systems |
US20110172634A1 (en) * | 2000-11-30 | 2011-07-14 | Valeritas, Inc. | Injection systems |
US8500681B2 (en) | 2000-11-30 | 2013-08-06 | Valeritas, Inc. | Injection systems |
US20020151842A1 (en) * | 2000-11-30 | 2002-10-17 | Gonnelli Robert R. | Injection systems |
US20020161329A1 (en) * | 2000-11-30 | 2002-10-31 | Gonnelli Robert R. | Injection systems |
US7150409B2 (en) | 2000-11-30 | 2006-12-19 | Biovalve Technologies, Inc. | Injection systems |
US20020156418A1 (en) * | 2000-11-30 | 2002-10-24 | Gonnelli Robert R. | Injection systems |
US8172805B2 (en) * | 2001-09-27 | 2012-05-08 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US20050124936A1 (en) * | 2001-09-27 | 2005-06-09 | Unomedical A/S | Injector device for placing a subcutaneous infusion set |
US20100280302A1 (en) * | 2002-02-11 | 2010-11-04 | Sigma-Tau Industrie Farmaceutiche S.P.A. | Container for vial of radiopharmaceutical and set for its infusion in a patient or for its transfer elsewhere |
US7842023B2 (en) | 2002-02-11 | 2010-11-30 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Container for vial of radiopharmaceutical and set for its infusion in a patient or for its transfer elsewhere |
WO2003069632A3 (en) * | 2002-02-11 | 2003-12-11 | Sigma Tau Ind Farmaceuti | Container for vial of radiopharmaceutical and set for its infusion in a patient or for its transfer elsewhere |
US8292869B2 (en) | 2002-02-11 | 2012-10-23 | Sigma-Tau Industrie Farmaceutiche Riunite Spa | Container for vial of radiopharmaceutical and set for its infusion in a patient or for its transfer elsewhere |
EP1535641A1 (de) * | 2003-11-28 | 2005-06-01 | ARIES S.r.l. | Tropfkammer mit Entlüftungsmitteln |
US8047157B2 (en) * | 2004-06-24 | 2011-11-01 | Cook Medical Technologies Llc | Method and apparatus for coating interior surfaces of medical devices |
US20110004184A1 (en) * | 2007-10-01 | 2011-01-06 | Karl-Heinz Proksch | Device for introducing medicine into an infusion container |
US8647320B2 (en) * | 2007-10-01 | 2014-02-11 | B. Braun Melsungen Ag | Device for introducing medicine into an infusion container |
CN108601707A (zh) * | 2015-12-04 | 2018-09-28 | 康尔福盛303公司 | 用于自动药物配制器的小瓶压轮系统 |
US10806673B2 (en) | 2015-12-04 | 2020-10-20 | Carefusion 303, Inc. | Vial puck system for automatic drug compounder |
US11246803B2 (en) | 2015-12-04 | 2022-02-15 | Carefusion 303, Inc. | Vial puck system for automatic drug compounder |
US11622913B2 (en) | 2015-12-04 | 2023-04-11 | Carefusion 303, Inc. | Vial puck system for automatic drug compounder |
IT201800005988A1 (it) * | 2018-06-04 | 2019-12-04 | Dispositivo di infusione per la somministrazione di farmaci fotosensibili | |
RU2804991C1 (ru) * | 2022-12-23 | 2023-10-09 | Общество с ограниченной ответственностью "БЕБИГ" | Устройство для интраартериального введения суспензий и растворов, допускающее контрастирование целевой артерии |
Also Published As
Publication number | Publication date |
---|---|
AU4690379A (en) | 1979-11-15 |
EP0005606A1 (de) | 1979-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4233973A (en) | Apparatus for administering intravenous drugs | |
US4828548A (en) | Safety catheter | |
US5032117A (en) | Tandem syringe | |
US4685902A (en) | Disposable reservoir cassette | |
US4790829A (en) | Reusable injection catheter | |
US5370636A (en) | Plug-type connector for producing and interrupting a liquid flow connection | |
CA1204731A (en) | System for mixing and delivering medical liquids to the charge of a hypodermic needle | |
US5127904A (en) | Improved needle-less parenteral fluid injector | |
US5480386A (en) | Pump assembly for medical use | |
US5203771A (en) | Arterial/venous fluid transfer system | |
US4865583A (en) | Combination blood sampling and intravenous infusion apparatus and method | |
US5169385A (en) | Safety I. V. drug introducer set | |
US4981464A (en) | Plug device for a transfusible fluid container | |
US4512768A (en) | Analgesic syringe | |
US20050027233A1 (en) | Devices for collecting blood and administering medical fluids | |
EP0185808B1 (de) | Automatische parenterale Infusionvorrichtung | |
JP2007509691A5 (de) | ||
JPH0240338B2 (de) | ||
US4772265A (en) | Safety catheter | |
US6364847B1 (en) | Blood sampling device | |
US5183472A (en) | Arrangement for transcutaneous filling or replenishment of liquid medications in an implantable medication dosing device | |
US20060058741A1 (en) | Infusion apparatus for infusion bags | |
US6083204A (en) | Method and apparatus for gravity-fed intravenous infusion | |
WO2009031144A1 (en) | Envelope containing sterile needle | |
US20130110045A1 (en) | Single use intravenous therapy administering device with needle safety covers |