US3925663A - Extended monopole spectrometers and filters - Google Patents

Extended monopole spectrometers and filters Download PDF

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Publication number
US3925663A
US3925663A US374369A US37436973A US3925663A US 3925663 A US3925663 A US 3925663A US 374369 A US374369 A US 374369A US 37436973 A US37436973 A US 37436973A US 3925663 A US3925663 A US 3925663A
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United States
Prior art keywords
cylindrical electrode
combination
electrode
circular cylindrical
monopole
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Expired - Lifetime
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US374369A
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English (en)
Inventor
John Barry Hiller
John Alan Richards
Richard Meredyth Huey
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Unisearch Ltd
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Unisearch Ltd
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/009—Spectrometers having multiple channels, parallel analysis

Definitions

  • FIG Lb US. Patent Dec. 9, 1975 Sheet 3 of3 3,925,663
  • the circular cylindrical electrode may' in certain forms of the invention be divided into 2, 3 or 4 segments or quadrants by an insulating structure which may or may not extend to the hollow square cylindrical electrode.
  • FIG. 1 is anend view of a conventional monopole spectrometer
  • FIG. 2 is an exploded isometric sketch of a fourfold monopole mass spectrometer incorporatinganalyzing electrodes according to theinvention
  • FIG. 3 is an end view of the basic form of analyzing electrodes according to the invention.
  • FIG. 4a is a similar view of a further form of the invention in which the circular cylindrical electrode is divided into four quadrants by an insulating structure which extends to and is vacuum sealed to the hollow square cylindrical electrode, a
  • FIG. 4b is a similar view of a further form of the invention similar to that of FIG. 4a in which the insulating structure does not extend to the square cylindrical electrode,
  • FIG. 5a is a similar view of a further formof the invention in which the circular cylindrical electrode is divided into two semi-circular segments by an insulating structure.
  • FIG. 5b is a similar view of a still further form of the invention in which the circular cylindrical electrode is divided into three segments by an insulating structure and,
  • FIGS. 6, 6a and 6b illustrate the manner in which spatial extensions and duplications of the structures shown in the figures referred to above may be arranged.
  • the monopole mass spectrometer originally proposed by von Zahn (U. VONZAHN, Monopole Spec- FIG. 2 more than is necessary for an understanding of the present invention.
  • a central circular section cylindrical electrode is indicated at 1 and this is supported in the center of a square cylindrical box electrode 2 the space between the electrodes being evacuated,
  • a'suitable means for ionizing and inject ing a gaseous sample into four channels of the fourfold monopole structure which are constituted by the spaces defined between the cylindrical rod electrode and the four corners of the box electrode 2.
  • the hyperbolic cylindrical electrode can be supplied with any other suitably periodic high frequency waveform.
  • FIG. 2 shows a fourfold monopole mass spectrometer in a purely diagrammatic form illustrating the use of an electrode configuration similar to that shown in FIG. 3 and described below.
  • the present invention is concerned purely with the configuration of the analyzing electrodes and as the structure and functioning of mass it is not proposed to describe the arrangement shown in time varying voltage generator for exciting the cylindrical rod electrode 1 is indicated at 4 and 5 indicates a vacuum sealed electrical feed-through through which connection is made to the electrode 1.
  • 6, 7, 8, and 9 represent the ion beams to be analyzed.
  • Four Faraday cup collectors 10, 11, 12 and 13 serve to detect the stable ion currents in each of the four monopole channels of the fourfold monopole structure which originate from the ionfbeams 6, 7, 8 and 9-.
  • the output from this latter is led by means of a vacuum sealed electrical feed-through 16 to a suitable current measuring instrument 14 such as an electrometer amplifier.
  • a suitable current measuring instrument 14 such as an electrometer amplifier.
  • the portion trodes of the monopole mass spectrometer can be extended with resulting improvements in performance and/or increases in versatility and flexibility, thereby leading to a new class of monopole device..lnherent in the evolution of this new class is the approximation of the hyperbolic cylindrical electrode by a circular cylindrical electrode of a suitable diameter. This approximation is common place for the quadrupole mass spectrometer. Having made this approximation the angle .electrode A of FIG. 1 can be extended into a hollow square cylinder as shown, for example in FIG. 3,
  • Another simplifying feature is the possibility of making the rod electrode hollow thereby allowing electrical connections to the ion source to be carried within it. This would permit all wiring to the device to be made via a rear mounted plate as is usual for present day quadrupole devices.
  • FIG. 4a and 4b Two elaborations of the above structure are shown in FIG. 4a and 4b in both of which the single rod electrode 22 is segmented into four quadrants separated by and mounted upon a cruciform electrically insulating arrangement 23 the extremities of which are vacuum sealed to the box electrode 24.
  • the insulating structure is shown extended so that the four monopole structures formed by the rod and box electrodes 22 and 24 may filter beams originating in four ion sources which in turn may be sampling either four separate inlets or one common inlet. Since the four quadrants of the rod electrode are electrically isolated, each monopole structure may be tuned to filter different masses by suitably adjusting either the magnitude of the periodic high frequency potentials (and DC. potentials should they be used) applied to the quadrants, which is to be preferred, or alternatively the frequencies of the periodic potentials.
  • Four separate sources of potential g1 (t) to g4 (t) are indicated in the drawing.
  • each quadrant may be excited by suitably differing waveforms from sources gl(t) g4(t) thereby allowing the device to analyze one common sample for four differing mass numbers.
  • FIGS. a and 5b are subject to the same comments as set out above and represent variations which may be found desirable in certain applications.
  • the broken lines at the outer extremities of the insulators 28 and 29 indicate that these may either be continued to the hollow box electrodes 30 and 31 respectively and vacuum sealed to them or not as desired.
  • a monopole mass spectrometer comprising:
  • an analyzing configuration consisting of a circular cylindrical electrode extending coaxially within a surrounding hollow-square cylindrical electrode;

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
US374369A 1972-06-28 1973-06-28 Extended monopole spectrometers and filters Expired - Lifetime US3925663A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPA949772 1972-06-28

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US3925663A true US3925663A (en) 1975-12-09

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US (1) US3925663A (cs)
JP (1) JPS49133086A (cs)
CA (1) CA976280A (cs)
DE (1) DE2332960A1 (cs)
GB (1) GB1404386A (cs)
NL (1) NL7309023A (cs)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033564A1 (en) * 2002-08-19 2004-02-19 Seong Balk Lin Method for increasing solubility of target protein using RNA-binding protein as fusion partner
US6794647B2 (en) 2003-02-25 2004-09-21 Beckman Coulter, Inc. Mass analyzer having improved mass filter and ion detection arrangement
US20050087684A1 (en) * 2003-10-23 2005-04-28 Farnsworth Vincent R. Time of flight mass analyzer having improved mass resolution and method of operating same
US20050098723A1 (en) * 2003-11-12 2005-05-12 Farnsworth Vincent R. Mass analyzer having improved ion selection unit
US20090001265A1 (en) * 2007-06-29 2009-01-01 Hitachi, Ltd Ion trap, mass spectrometer and ion mobility analyzer using the ion trap
US7550717B1 (en) 2006-11-30 2009-06-23 Thermo Finnigan Llc Quadrupole FAIMS apparatus
US20220367163A1 (en) * 2018-06-05 2022-11-17 The Rockefeller University Parallel multi-beam time-of-flight mass spectrometer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197633A (en) * 1962-12-04 1965-07-27 Siemens Ag Method and apparatus for separating ions of respectively different specific electric charges
US3280326A (en) * 1963-05-02 1966-10-18 Siemens Ag Mass filter with sheet electrodes on each side of the analyzer rod that intersect on the ion beam axis
US3473018A (en) * 1967-03-02 1969-10-14 Bell & Howell Co Mass analyzer using two spaced,tubular,and coaxial electrodes
US3501630A (en) * 1969-03-17 1970-03-17 Bell & Howell Co Mass filter with removable auxiliary electrode

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3197633A (en) * 1962-12-04 1965-07-27 Siemens Ag Method and apparatus for separating ions of respectively different specific electric charges
US3280326A (en) * 1963-05-02 1966-10-18 Siemens Ag Mass filter with sheet electrodes on each side of the analyzer rod that intersect on the ion beam axis
US3473018A (en) * 1967-03-02 1969-10-14 Bell & Howell Co Mass analyzer using two spaced,tubular,and coaxial electrodes
US3501630A (en) * 1969-03-17 1970-03-17 Bell & Howell Co Mass filter with removable auxiliary electrode

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033564A1 (en) * 2002-08-19 2004-02-19 Seong Balk Lin Method for increasing solubility of target protein using RNA-binding protein as fusion partner
US6794647B2 (en) 2003-02-25 2004-09-21 Beckman Coulter, Inc. Mass analyzer having improved mass filter and ion detection arrangement
US20050087684A1 (en) * 2003-10-23 2005-04-28 Farnsworth Vincent R. Time of flight mass analyzer having improved mass resolution and method of operating same
US20050285030A1 (en) * 2003-10-23 2005-12-29 Farnsworth Vincent R Time of flight mass analyzer having improved detector arrangement and method of operating same
US7186972B2 (en) 2003-10-23 2007-03-06 Beckman Coulter, Inc. Time of flight mass analyzer having improved mass resolution and method of operating same
US20050098723A1 (en) * 2003-11-12 2005-05-12 Farnsworth Vincent R. Mass analyzer having improved ion selection unit
US6995365B2 (en) * 2003-11-12 2006-02-07 Beckman Coulter, Inc. Mass analyzer having improved ion selection unit
US7550717B1 (en) 2006-11-30 2009-06-23 Thermo Finnigan Llc Quadrupole FAIMS apparatus
US20090001265A1 (en) * 2007-06-29 2009-01-01 Hitachi, Ltd Ion trap, mass spectrometer and ion mobility analyzer using the ion trap
CN101335177B (zh) * 2007-06-29 2010-06-09 株式会社日立制作所 质量分析计、离子迁移率分析计
US20220367163A1 (en) * 2018-06-05 2022-11-17 The Rockefeller University Parallel multi-beam time-of-flight mass spectrometer

Also Published As

Publication number Publication date
NL7309023A (cs) 1974-01-02
DE2332960A1 (de) 1974-01-17
JPS49133086A (cs) 1974-12-20
CA976280A (en) 1975-10-14
GB1404386A (en) 1975-08-28

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