Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
  • A61L27/14—Macromolecular materials
  • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products

Definitions

• the present invention relates to artificial organs, parts or sections and the like of artificial organs that are adapted to be implanted into the human body, and a mehtod of producing such artificial organs or the like, in providing an immunizing protection whereby such organs are synthetized from a mixture of albumen and blood.
• the metabolism of the plasm cells and of the lymphocytes must be interfered with in a manner preventing the plasm cells and the lymphocytes from initiating the production of antibodies against the alien organ.
• This may be achieved either by administering medications or by eg covering with living cells the organs intended to be implanted. Both these expedients, however, are rather cumbersome and do not always lead to the desired success since the generation of antibodies may also be initiated after a relatively long time has lapsed since the transplantation of the organ has been performed.
• the technique of covering the organs to be transplanted with living cells is accompanied by problems of the stability of the cells at the artificial organs.
• the artificial organ comprises a tube made of a non-resorbing physiologically inert synthetic fiber tissue forming an outer layer of the artificial blood vessel, and a self-supporting tube made of an adhesive bonding material the reabsorption properties of which are modified by a partial chemical hardening operation and forming an inner layer whereby the inner surface of the adhesive bonding tube is treated with an anticoagulation agent.
• the support member of this prothesis therefore consists of a synthetic fiber tissue.
• tissue pad for implantation into a living organism and a method and an apparatus for producing the same.
• This tissue pad is characterized by a support or reinforcing member made of a coating of living tissue which is arranged adjacent to an inner surface of the reinforcing member and extends inwardly from this surface whereby the shape of the tissue pad corresponds to the configuration of a mold cavity in which the tissue pad has been cultivated.
• This prior art tissue pad therefore, does not consist of a mixture of albumen and blood.
• tissue includes an organic component that may be reabsorbed by the human body, and exhibits prior to implantation a very tight screen structure rendering the tissue virtually impermeable to blood, and the initial porosity of this screen structure is within a range from 0 to 500 and preferably has a value of 50 according to the scale of Wesolowski.
• the multi-component tissue includes, at least partly, evenly spaced compound yarns containing filaments of a non-absorbing synthetic substance having suitable strength, flexibility and elasticity. These fil aments are compatible with living tissue, will not alter in any substantial degree, may be wetted by blood, and may be sterilized.
• the composite yarns furthermore, include biologically absorbable filament strands of an animal material having a haemostatic effect sufficient to prevent bleeding-through in the early stages of the implantation whereby the synthetic filaments serve as a strong supporting skeleton for the porous flexible tubular structure.
• the proportion of filaments in the tissue that are made of animal material is selected in a manner so that upon biological absorption of the same the porosity of the tissue attains an ultimate value of at least 5,000, and is preferably in a range from 10,000 to 20,000 or in excess thereof, according to the scale of Wesolowski.
• This artificially implanted vessel likewise is not synthetized from albumen and blood.
• an artificial organ provides a strong immunizing protection if the artificial organ consists of a molded body or is covered with a coating either of which is produced, in accordance with the present invention, by preparing a mixture of artificial albumen or a protein and human blood of a blood group correspondingto the blood group of a person into the body of whom an artificial organ is to be implanted, plastifying the mixture, then molding the mixture into the shape of the desired artificial organs, subsequently hardening the molded organs and upon termination of the hardening step, drying the organs.
• a hardener such as a formaldehyde solution
• the basic components employed for producing artificial organs of this type according to the present invention may consist of albumcns or albumen-containing substances such as lactic albumen, mother's milk and the like as well as proteins.
• the blood for producing these artificial organs is human blood of a blood group corresponding to the blood group of the person into whose body the artificial organ is intended to be inserted.
• the method of the present invention allows to readily produce the most varied types of organs, parts and sections of organs suitable for implantation into the human body.
• organs may consist exclusively of the plastomer made of human blood of a blood group corresponding to the blood group of a person into whose body the artificial organ is intended to be implanted, and albumen.
• artificial organs made from any suitable material may be covered with a coating consisting of a plastomer made of human blood of a blood group corresonding to the blood group of a person into whose body the artificial organ is intended to be implanted, and albumen.
• the hardener may consist of a aqueous formaldehyde solution in a concentration of between 2 to 20 percent, or a catalyst suitable for hardening albumen or blood respectively.
• the hardening period of the molded body depends upon the thickness of the molded body and may extend over several weeks or months. Following this hardening step, the molded body is dried. The molded bodiesmay subsequently be machined or cut.
• Every organ intended for implantation into the human body may be produced according to the method of the present invention.
• Monitoring devices and the like which are implanted into the human body may likewise be covered with a coating produced in accor- 4 dance with the present invention so that the implanted organ or device is provided with a strong immunizing protection.
• Prothcses or parts of protheses produced according to the method of the present invention will be pre-fabricatcd and put at the disposal of the chirurgist or surgeon for implantation into the human body.
• the artificial organs produced in accordance with the method of the present invention will thus be ready for use by a surgeon in a manner analogous to blood in blood plasm banks containing blood of the various blood groups.
• the artificial organs will be produced and stored in adaptation to the various blood groups.
• a method of producing artificial organs and parts, sections and the like of artificial organs adapted to be implanted into a human body, comprising plasticizing a mixture for making the artificial organ into a mass, forming the mass into the shape of the desired artificial organ, and hardening and drying the product resulting from the forming wherein the improvement comprises preparing a mixture of one of artificial albumen, and protein, and human blood of a blood group corresponding to the blood group of a person into the body of whom an artificial organ is to be implanted so.
• step of plasticizing a mixture comprises employing from 10 to percent of one of albumen and protein and from 80 to 10 percent of the human blood of a blood group corresponding to the blood group of a person into the body of whom the artificial organ is to be implanted.
• An artificial organ and parts, sections and the like of artificial organs adapted to be implanted into a human body comprising a hardened plastomer, said plastorner comprising H) to 80 percent of one of artificial albumen and protein and 80 to 10 percent human blood of a blood group corresponding to the blood group of the patient in which the artificial organ is to be implanted.

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• Health & Medical Sciences (AREA)
• Chemical & Material Sciences (AREA)
• Dermatology (AREA)
• Medicinal Chemistry (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Transplantation (AREA)
• Epidemiology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Animal Behavior & Ethology (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Prostheses (AREA)

Applications Claiming Priority (1)

Publications (1)

Family

ID=3567020

Family Applications (1)

Country Status (2)

Cited By (8)

Citations (3)

• 1973
  • 1973-05-29 AT AT467973A patent/AT336173B/de not_active IP Right Cessation
• 1974
  • 1974-05-29 US US474154A patent/US3918099A/en not_active Expired - Lifetime

Patent Citations (3)

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