US3905395A - Mixing chamber - Google Patents

Mixing chamber Download PDF

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Publication number
US3905395A
US3905395A US426417A US42641773A US3905395A US 3905395 A US3905395 A US 3905395A US 426417 A US426417 A US 426417A US 42641773 A US42641773 A US 42641773A US 3905395 A US3905395 A US 3905395A
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US
United States
Prior art keywords
mixing
liquid
grid
mixed
chamber
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US426417A
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English (en)
Inventor
Klaus Peter Hupe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hewlett Packard GmbH Germany
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Hewlett Packard GmbH Germany
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Filing date
Publication date
Application filed by Hewlett Packard GmbH Germany filed Critical Hewlett Packard GmbH Germany
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers

Definitions

  • an apparatus for continuously diluting a medium having a high viscosity wherein the viscous medium and the far greater quantity of diluting liquid are continuously supplied under pressure .to a first common chamber via rectangular inlet means. After sequentially passing through two grid walls the diluting medium is caused to rotate. The turbulent liquid streams are then pressed through the grid walls in order to align the macro-molecules and to avoid interlacings among them.
  • US. Pat. No. 2,509,288 discloses a mixing apparatus, wherein the liquids to be mixed are fed through opposing nozzles into a ball-shaped chamber and the mixed liquid stream is delivered through an outlet pipe connected to the chamber.
  • US. Pat. No. 2,391,110 discloses a mixing chamber for liquids which includes a cascade of screens with circumferentially extending channels.
  • a mixing chamber designed according to the preferred embodiment of this invention mixes two separate streams of liquid under pressure.
  • the mixing chamber comprises two continuous, parallel, pressureresistant grid walls between which liquid mixing occurs, an inlet means for entry of each liquid stream to be mixed into the mixing chamber through the grid walls and an outlet means for exit of the mixed liquid stream from the mixing chamber.
  • the distance between the grid walls is in the mm-range and is at least five times less than the lateral extension of each grid wall.
  • the grid apertures of the grid walls is in the micron, 1.1., range and the flow resistance of the grid walls provides uniform distribution of each liquid flowing under pres sure over the cross-sectional areas of their respective grid walls.
  • the principal object of this invention therefore is to provide an improved apparatus of simple design for mixing two liquids substantially without delay and with increased efficiency, wherein each partial volume of the one liquid is mixed with the partial volume of the other liquid.
  • FIG. I is a cross-sectional view of the preferred embodiment of the invention.
  • solvent A and B are pumped in parallel relation via inlet means 1 and 2 into a mixing apparatus 3.
  • the mixed homogeneous solvent is exited via outlet cally 0.5 mm with a larger cross-section at the point of connection to the mixing apparatus.
  • liquid pumps which do not necessarily operate in timed relation, press liquids to be mixed, A and B, intermittently through metal screens 5 and 6 respectively, thus forming a plurality of intermeshing, thin separate jets of liquid. Additional mixing is provided by the turbulence resulting from the transverse forces acting among the jet streams between the internal screen faces. Thus, a homogeneous solvent liquid is obtained by intense mixing within a very confined space.
  • the screens consist of metal frets, separated by a distance not greater than one fifth of the fret diameter.
  • the said distance may be 0.5 to 3 mm and adjustable according to the volumes of the liquids to be mixed.
  • the aperture size of the screen mesh must be sufficiently fine and the distance between screens must be sufficiently small to create a flow resistance in the mixing chamber that will ensure the uniform distribution of the liquids to be mixed over the entire area of the chamber.
  • several such arrangements may be joined in cascade so that the mixed flow leaving one stage is divided into partial flows and fed to the next stage and achieve a still more thorough mixed of the liquids.
  • the mixing chamber has a minimum dead volume and a maximum active mixing area.
  • the liquids to be mixed are uniformly distributed over the grid walls so that a build-up of flow profile, as would be observed with convection flows, is avoided. Thus, a more homogeneous mixing operation is obtained.
  • Extremely narrow grid apertures provide uniform quantization or division of the oppositely directed liquid flows. Because of the small space between the grid walls, which limit the volume of the mixing chamber, the liquid particles of both streams, after passing through the grid walls, directly impact against each other and, without convection flow, are mixed with each other. This result is obtained without any additional equipment, such as additional mixing chambers, stirring or the like.
  • the preferred embodiment of this invention has been used for the gradient elution in a liquid chromatography system, wherein two solvents are pumped through it in a discontinuous fashion in order to become intensely mixed without substantial time delay during the mixing operation.
  • the amount of the one solvent may be increased and the amount of the other solvent decreased proportionately, thus keeping the total volume of both solvents constant, while the mixing operation takes place'within the small volumeofthe mixing chamber.
  • the amount of the one solvent having a high dissolving power, for example methyl alcohol is continuously varied
  • the quantity of the other solvent for example octane, may also be proportionately varied to correspond withthe variations in the quantity of the first solvent. 7
  • a time-programmed separation of the applied substances is obtainable in accordance with temperature programming. Dead volumes are minimized and thus undue time delays are avoided which would tend to distort the exact time-programming and preclude reproducible results.
  • An apparatus for mixing two separate streams of liquid flowing under pressure comprising:
  • a secondinlet means coupled to theexternal side of the other sc-reenfor entry'of a-second liquid to be mixed into-thechamber through said screen;

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Accessories For Mixers (AREA)
US426417A 1972-12-28 1973-12-19 Mixing chamber Expired - Lifetime US3905395A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2263769 1972-12-28

Publications (1)

Publication Number Publication Date
US3905395A true US3905395A (en) 1975-09-16

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ID=5865638

Family Applications (1)

Application Number Title Priority Date Filing Date
US426417A Expired - Lifetime US3905395A (en) 1972-12-28 1973-12-19 Mixing chamber

Country Status (5)

Country Link
US (1) US3905395A (enrdf_load_stackoverflow)
JP (1) JPS4992654A (enrdf_load_stackoverflow)
CH (1) CH568093A5 (enrdf_load_stackoverflow)
DE (1) DE2263769C2 (enrdf_load_stackoverflow)
GB (1) GB1420036A (enrdf_load_stackoverflow)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4475821A (en) * 1980-10-07 1984-10-09 Bruker-Analytische Messtechnik Gmbh Mixing chamber
US4506987A (en) * 1982-09-08 1985-03-26 The United States Of America As Represented By The United States Department Of Energy High pressure liquid chromatographic gradient mixer
US4647212A (en) * 1986-03-11 1987-03-03 Act Laboratories, Inc. Continuous, static mixing apparatus
US6048496A (en) * 1996-06-05 2000-04-11 Gi Sciences Incorporated Mixer for liquid chromatograph
US6406555B1 (en) * 1997-07-01 2002-06-18 Motorola Inc. Point of use dilution tool and method
US6540715B1 (en) 1997-12-22 2003-04-01 Bayer Aktiengesellschaft Method and device for in-situ formulation of a medicinal solution for parenteral application
US20050068845A1 (en) * 2003-09-29 2005-03-31 Tomoki Oohashi Mixer and liquid analyzer provided with same
US20050213425A1 (en) * 2004-02-13 2005-09-29 Wanjun Wang Micro-mixer/reactor based on arrays of spatially impinging micro-jets
US20170151537A1 (en) * 2014-06-20 2017-06-01 Vrije Universiteit Brussel Mixing of Fluids
US10295512B2 (en) 2015-12-08 2019-05-21 Dionex Corporation Multi-lumen mixing device for chromatography
US10335753B2 (en) 2004-07-13 2019-07-02 Waters Technologies Corporation Fluid mixer assembly

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2195265B (en) * 1986-09-17 1990-06-20 Philips Electronic Associated Liquid chromatograph apparatus
JP4585800B2 (ja) * 2003-09-29 2010-11-24 株式会社日立ハイテクノロジーズ 混合器及び液体分析装置
JP2007319815A (ja) * 2006-06-02 2007-12-13 Toray Eng Co Ltd 液体混合装置、および液体混合システム

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2391110A (en) * 1944-07-03 1945-12-18 Standard Oil Dev Co Mixing device
US2509288A (en) * 1947-01-02 1950-05-30 Internat Morfat Corp Emulsifying apparatus
US2815532A (en) * 1953-05-25 1957-12-10 American Viscose Corp Spinneret mixing element
US3064680A (en) * 1961-07-19 1962-11-20 Virginia Chemicals & Smelting Apparatus for introduction of fluid

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2391110A (en) * 1944-07-03 1945-12-18 Standard Oil Dev Co Mixing device
US2509288A (en) * 1947-01-02 1950-05-30 Internat Morfat Corp Emulsifying apparatus
US2815532A (en) * 1953-05-25 1957-12-10 American Viscose Corp Spinneret mixing element
US3064680A (en) * 1961-07-19 1962-11-20 Virginia Chemicals & Smelting Apparatus for introduction of fluid

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4475821A (en) * 1980-10-07 1984-10-09 Bruker-Analytische Messtechnik Gmbh Mixing chamber
US4506987A (en) * 1982-09-08 1985-03-26 The United States Of America As Represented By The United States Department Of Energy High pressure liquid chromatographic gradient mixer
US4647212A (en) * 1986-03-11 1987-03-03 Act Laboratories, Inc. Continuous, static mixing apparatus
US6048496A (en) * 1996-06-05 2000-04-11 Gi Sciences Incorporated Mixer for liquid chromatograph
US6406555B1 (en) * 1997-07-01 2002-06-18 Motorola Inc. Point of use dilution tool and method
US6540715B1 (en) 1997-12-22 2003-04-01 Bayer Aktiengesellschaft Method and device for in-situ formulation of a medicinal solution for parenteral application
US20050068845A1 (en) * 2003-09-29 2005-03-31 Tomoki Oohashi Mixer and liquid analyzer provided with same
US7147364B2 (en) * 2003-09-29 2006-12-12 Hitachi High-Technologies Corporation Mixer and liquid analyzer provided with same
US20050213425A1 (en) * 2004-02-13 2005-09-29 Wanjun Wang Micro-mixer/reactor based on arrays of spatially impinging micro-jets
US10335753B2 (en) 2004-07-13 2019-07-02 Waters Technologies Corporation Fluid mixer assembly
US20170151537A1 (en) * 2014-06-20 2017-06-01 Vrije Universiteit Brussel Mixing of Fluids
US10807054B2 (en) * 2014-06-20 2020-10-20 Vrue Universiteit Brussel Mixing of fluids
US10295512B2 (en) 2015-12-08 2019-05-21 Dionex Corporation Multi-lumen mixing device for chromatography

Also Published As

Publication number Publication date
CH568093A5 (enrdf_load_stackoverflow) 1975-10-31
DE2263769B1 (de) 1974-02-28
DE2263769C2 (de) 1974-10-03
JPS4992654A (enrdf_load_stackoverflow) 1974-09-04
GB1420036A (en) 1976-01-07

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