US3902491A - Syringe usable as container for storage and preservation of injection fluid - Google Patents
Syringe usable as container for storage and preservation of injection fluid Download PDFInfo
- Publication number
- US3902491A US3902491A US462767A US46276774A US3902491A US 3902491 A US3902491 A US 3902491A US 462767 A US462767 A US 462767A US 46276774 A US46276774 A US 46276774A US 3902491 A US3902491 A US 3902491A
- Authority
- US
- United States
- Prior art keywords
- piston
- flange
- sealing member
- hollow
- outlet end
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31513—Piston constructions to improve sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
- A61M2005/3121—Means preventing contamination of the medicament compartment of a syringe via the proximal end of a syringe, i.e. syringe end opposite to needle cannula mounting end
Definitions
- a syringe which may be used for storage and preservation of injection fluid includes a hollow cylindrical body which has an outlet end and an inlet end.
- a rupturable member is provided at the outlet end.
- a flange is provided at the inlet end.
- a sealing member which is desirably a fluid-impermeable membrane, is fixed to the flange to seal the inlet end.
- a rod is provided on which a piston is connected. The piston is positionable, with respect to the cylindrical body, for entering its interior, rupturing the sealing member and moving toward its outlet end. As a result, the injection fluid stored and preserved within the hollow cylinder may be removed via the outlet end by the piston under the influence of the rod.
- This invention relates to a syringe which may be used as a container for storing and preserving fluids which are to be injected and, more particularly, to such a syringe which may contain its own injection fluid which is thus stored in sterile condition and ready to be used.
- the foregoing objects, as well as others which are to become clear from the text below, are achieved in accordance with the present invention by providing a syringe which may be used for storage and preservation of injection fluid.
- the syringe includes a hollow cylindrical body which has an outlet end and an inlet end.
- a rupturable member is provided at the outlet end.
- a flange or the like is provided at the inlet end.
- a sealing member which is desirably a fluid-impermeable mem.
- brane is fixed to the flange or the like to seal the inlet end.
- a rod is provided on which a piston is connected.
- the piston is positionable, with respect to the cylindrical body, for entering its interior, rupturing the sealing member and moving toward the outlet end. The move ment of the piston, under the influence of the rod, causes the injection fluid stored and preserved within the hollow cylinder to be removed via the outlet end.
- the syringe according to the invention desirably has at its outlet end a rupturable member in the form of a breakable sealed nipple.
- a first flange, on which there is a fixed, fluid-impermeable membrane, constituting the sealing member, is provided to store and to preserve the injection fluid contained in the syringe in a fluidtight fashion. The membrane is ruptured by the motion of the piston toward the outlet end of the syringe.
- the syringe includes a piston which is also made of plastic material, such as polypropylene, which is resistant to the injection fluid.
- the piston in this case, also includes a second sealing flange or the like integral with the piston and joined, by fusing or other techniques, to the first flange formed on the body of the syringe.
- the second flange has a rupturable region formed by a reduction of its thickness.
- the piston is hollow and its associated piston rod has a tip which conforms to the interior shape of the piston. At a distance equal to the depth of the piston, the tip carries an enlargement of its diameter equal to that of the piston. This enlargement termi nates at a steep angle directed toward the syringe body in order to facilitate the separation of the flange attached thereto.
- FIG. 1 is a side view of a syringe according to an illustrative embodiment of the present invention.
- FIG. 2 is an exploded, perspective view showing the syringe of FIG. 1, its membrane, piston, and piston rod being shown.
- FIG. 3 is an axial, sectional view through a syringe according to a first variant of the embodiment shown in FIGS. 1 and 2.
- FIG. 4 is an axial, sectional view through a syringe according to another variant of the embodiment shown in FIGS. 1 and 2.
- FIG. 5 is an axial, sectional view of a most preferred embodiment of a syringe according to the present invention.
- an illustrative embodiment of a syringe according to the present invention includes a hollow, cylindrical body 1, an outlet end of which is equipped with an attachment known per se.
- the attachment is defined by a sleeve 2 having interior threads intended to be used to attach the syringe to a needle, a valve, or a catheter, or some other accessory for utilization.
- a thin, rupturable member such as a tube, with a sealed, fluidtight tip (see 20 FIG. 5) intended to be cut off prior to connecting the attachment sleeve 2 to the accessory needle or the like.
- the tip is intended to be broken easily, for example, by parting, with or without a rupture, along a circumferentially extending line of weakness.
- the hollow, cylindrical body 1 of the syringe has a first flange 3 whose open face is finished to permit sealing with a sealing member 4 (membrane) or a lid by gluing, or fusing, or some other known technique.
- the purpose of the sealing member 4 is primarily to hold the liquid in the syringe and to prevent its coming in contact with materials which can adulterate it duringstoragei
- the entire assembly, that is the syringe and sealing member 4 is kept sterile in a fluid-tight enclosure during storage just as in the case of storage of empty syringes.
- FIG. 2 which is an exploded, pictorial view of the syringe of FIG. 1 showing its lid 4 half removed, the head of a piston 5 which includes a sealing, stiffener flange 6, a point 7 and a seat :8 for a piston rod 9 is further shown.
- the head of the piston 5, and possibly its associated rod 9 as well, are kept sterile outside of the syringe in a fluid-tight envelope, which can be the same one that contains the syringe proper.
- any syringe constructed according to the present invention is for the injection of contrast material during radiographic examinations.
- the syringes are used in combination with a suitable, automatic injection apparatus which mechanically controls the advance of the pistons as a function of the desired flow rate.
- the movement of these pistons is relatively powerful and precise, this fact being used to assure rupture of the sealing members.
- one end of the piston 5 is in the shape of a point 7.
- the piston 5 places the piston 5 on an end of the rod 9, which may be connected to an automatic injection apparatus, and one places the syringe which includes the body 1 together with its associated sealing member 4 in its holding cradle (not shown).
- the apparatus which acts upon the piston rod 9 pushes the piston 5 whose point 7 pierces the sealing member 4.
- the resulting pieces of the sealing member 4 are pushed between the interior wall of the hollow, cylindrical body 1 of the syringe and the piston 5.
- the sealing member 4 is sufficiently thin and the sealing flange 6 of the piston 5 is sufficiently elastic to make this passsage possible.
- the syringe includes a hollow, cylindrical body 1 which is equipped with a piston 5 after being filled and prior to having a sealing member (membrane) 11 attached.
- a sealing member (membrane) 10 is placed between the piston 5 and the fluid within the hollow, cylindrical body I.
- it has substantially the shape of a bell or the like, or of a cylinder having a closed cone at one end.
- FIG. 3 is an illustration of a section through the syringe partially showing the hollow, cylindrical body 1, the piston 5, a flange 3, and the rod 9.
- the piston 5 has same shape as the embodiment of FIGS. 1 and 2, and includes a point 7.
- the sealing member 10 is shaped as a cylinder having a closed-cone configuration on one end, the other end being open. The sealing member 10 almost completely surrounds the piston 5 and is pressed against it. Its free, open end, which forms a second flange, is fused or otherwise fixed to the first flange 3, as in the embodiment shown in FIGS. 1 and 2.
- the sealing member 11, which is planar, is superimposed over the sealing member 10 at the rear portion of the piston 5 in order to hold it in place.
- FIG. 3 The use of the syringe illustrated in FIG. 3 is even simpler than the one shown in FIGS. I and 2, because it is sufficient to merely place it in its holding cradle (not shown).
- the piston 5 ruptures the sealing member 10 near the line of its attachment to the flange 3 and not at its closed end.
- the thickness and/or the strength of the sealing member 10 is lower in the vicinity of the flange 3 than in the other parts of the same sealing member 10. This reduction of the thickness and/or the strength, which constitutes a rupture region for the sealing member 10, is obtained, for example, by the partial removal of portions of the material of the sealing member 10 during the operation of fusing or otherwise fixing the sealing member 10 on the flange 3. After rupture has occurred in the vicinity of its fusing line, the sealing member 10 is pushed along by the piston 5 during its entire travel within the hollow, cylindrical body I.
- a sealing member (membrane) 12 replaces the sealing member 10 (FIG. 4) and is a part of a piston 5, i.e., the elastic material of the piston 5, which should not come in contact with the fluid, is covered,with a plastic foil which constitutes the sealing member 12, the foil adhering to the piston 5.
- the plastic foil constituting the sealing member 12 extends radially outward from the rear portion of the piston 5 and forms a second flange 13 so that the sealing can be affixed to the first flange 3.
- the flange 13 separates from that part of the sealing member 12 adhering to the piston 5 because of displacement of the piston 5 by a piston rod 9.
- the plastic foil constituting the sealing member 12 is sufficiently thin and flexible so that it can produce an acceptable fluid tightness between the piston 5 and hollow, cylindrical body I of the syringe during the entire travel of the piston 5. Furthermore, the piston 5 and the sealing member 12 stick together and the sealing member 12 is fused to the edge of the flange 3 of the syringe; consequently, it is no longer necessary to provide a second sealing member, such as sealing member 11 (FIG. 3) in order to hold the piston 5 within the body 1.
- the most preferred embodiment of the invention includes a hollow, cylindrical body I of the syringe which terminates at its output end as a sleeve 2 including a fluid-tight tip 20 intended to be cut off or otherwise ruptured during use.
- the body I of the syringe is terminated by a first flange 3 by means of which the body I is held in position in an injection apparatus at one end face; the other, free, face having a plane, annular form lying perpendicular to the axis of the body 1, is equipped with a sealing member (membrane) which closes it in a fluid-tight manner; and also constitutes a piston 50 which is provided with a number of sealing, stiffener flanges 6 which contact the interior wall of the body 1.
- the piston 50 of the syringe is itself made of a relatively flexible plastic material which is resistant to the injection fluid contained permanently in the syringe body 1 prior to its utilization.
- a relatively flexible plastic material which is resistant to the injection fluid contained permanently in the syringe body 1 prior to its utilization.
- Such a choice of materials makes it possible to omit the sealing member 4, l0, and 12, (FIGS. 2 and 3, 4) and to manufacture a sealing assembly, comprising the piston 50 and a second sealing flange 51, out of one single piece of plastic, for example, polypropylene.
- the .piston 50 Prior to the use of the syringe,.the .piston 50 is held fixed in the interior of the syringe body 1, and thesec nd flange 51 is fused to thefree face of the first flange 3, in such a way as to insure the fluid-tightness and sterility of the fluid contained within the syringe body 1.
- the thickness of the secondflange 51, at the points where it is joined to the piston 50, is reduced in thickness by a groove 52in order to create a rupture region between the piston 50 and the flange 51 which permits easy separation when the piston 50 is pushed into the body 1 of the syringe under the action of an operating rod 9.
- the piston 50 is itself hollow and a tip 90 at the end of the operating rod 9 has the same shape as the interior of the piston 50.-ln effect, the piston 50 constitutes an assembly comprising a flexible piston and a sealing member where one part of the body of the piston 50 is formed in a shape complimentary to the tip 90, which is made of a rigid material.
- the tip 90 at a distance of its end corresponding to that between the interior bottom of the piston 50 and its junction with the second flange 51, carries an enlargement 91 whose outer diameter is approximately equal to the outer diameter of the piston 50.
- the enlargement 91 terminates in an edge with a sharp angle 92 facing the syringe body and forming a kind of circular blade intended to cut the junction 52 between the second flange 51 and the major portion of the piston 50.
- the piston 50 is hollow and flexible and essentially constitutes a sealing assembly and carries at least one or preferably the several sealing stiffener flanges 6 of classical annular form, such as are described previously and shown in FIG. 3, as well as an end reinfforcement 60 of considerable length and terminated at a sharp angle facing the outlet end of the syringe.
- the end reinforcement 60 is strongly pressed against the internal wall of the syringe body 1 and insures excellent sealing between the piston 50 and the body 1.
- Such syringes are really ready to use. They are especially adapted to use in automatic injection systems and apparatus, especially to those which, because of prolonged injection times, use a mechanism wherein several syringes are placed into operation successively and where an empty syringe must immediately be replaced by a full one.
- a syringe which may be used for storage and preservation of injection fluid comprising, in combination:
- a piston connected to said rod means and movably positioned within said hollow cylindrical body for rupturing said sealing member and moving toward said outlet end; and wherein said rod means is separable from said piston; and further including means for holding said piston separately from said rod means, within said hollow, cylindrical body;
- injection fluid stored and. preserved within the hollow cylinder may be removed via the outlet end by the piston under the influence of the rod means.
- sealing surface is a surface of a first flange facing axially away from said hollow, cylindrical body; said sealing member is in the form of a hollow member having a substantially conical closed first end, said sealing member surrounding a portion of said piston, being inserted between said piston and the interior wall of said body and having a second end in the form of a second flange located exteriorly of said body, said second flange being joined to said first flange.
- a syringe according to claim 2 further including a second sealing member covering the rear of said pis ton, said second sealing member being joined to said first flange via said second flange so as to hold said pis ton within said body.
- a syringe according to claim 2 wherein said sealing member is provided with a rupture region defined by a thickness reduction therein substantially adjacent said first flange.
- a syringe which may be used for storage and preservation of injection fluid comprising, in combination:
- sealing surface is a surface of a first flange facing axially away from said hollow, cylindrical body
- said sealing member is composed of a member which intimately, adhesively adheres to a portion of said piston, said portion being located within the .interior of said body, said sealing member having a free portion in form of a second flange, and said first flange being joined to said sec ond flange ina fluid-tight manner whereby injection fluid stored and preserved within the hollow cylinder may be removed via the outlet end by the piston under the influence of the rod means.
- a syringe which may be used for storage and preservation of injection fluid comprising, in combination:
- a piston connected to said rod means and movably positioned with respect to said hollow cylindrical body for entering its interior, rupturing said sealing member and moving toward said outlet end;
- sealing surface is a surface of a first flange facing axially away from said hollow, cylindrical body
- sealing member and said piston are one and the same member, this member being of a material suitable for prolonged contact with the stored fluid within said body and being provided with a second flange which is joined to said first flange to provide a sealed fluid-tight closure for said body;
- said second flange is provided, at its joint with that portion of said sealing member constituting said piston, with a region of reduced thickness constituting a rupture area whereby injection fluid stored and preserved within the hollow cylinder may be removed via the outlet end by the piston under the influence of the rod means.
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7315452A FR2227020B1 (fr) | 1973-04-27 | 1973-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3902491A true US3902491A (en) | 1975-09-02 |
Family
ID=9118614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US462767A Expired - Lifetime US3902491A (en) | 1973-04-27 | 1974-04-22 | Syringe usable as container for storage and preservation of injection fluid |
Country Status (6)
Country | Link |
---|---|
US (1) | US3902491A (fr) |
DE (1) | DE2419435A1 (fr) |
FR (1) | FR2227020B1 (fr) |
GB (1) | GB1471375A (fr) |
IT (1) | IT1010106B (fr) |
SE (1) | SE401611B (fr) |
Cited By (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4053051A (en) * | 1976-09-10 | 1977-10-11 | Mine Safety Appliances Company | Earplug package and method of making it |
US4252118A (en) * | 1976-04-23 | 1981-02-24 | Jacques Richard | Non-reusable drug prefilled syringe assembly and method of use |
JPS62194866A (ja) * | 1985-12-20 | 1987-08-27 | マリンクロッド・メディカル・インコーポレイテッド | 既充填無菌プラスチック注射器およびその製造方法 |
US5256154A (en) * | 1992-01-31 | 1993-10-26 | Sterling Winthrop, Inc. | Pre-filled plastic syringes and containers and method of terminal sterilization thereof |
US5873861A (en) * | 1996-11-12 | 1999-02-23 | Medrad, Inc. | Plunger systems |
US5944694A (en) * | 1996-11-12 | 1999-08-31 | Medrad, Inc. | Prefillable syringes and injectors for use therewith |
US5947935A (en) * | 1996-11-12 | 1999-09-07 | Medrad, Inc. | Syringes, syringe plungers and injector systems |
FR2802104A1 (fr) * | 1999-12-14 | 2001-06-15 | Biodome | Corps de seringue pre-remplie, seringue pre-remplie pourvue d'un tel corps, jeu de ces corps et procede de fabrication d'un tel corps |
US20020183714A1 (en) * | 1999-12-10 | 2002-12-05 | Aneas Antoine | Method for producing a device for connecting a receptacle and a container ,corresponding connecting device and ready -for- use assembly comprising a device of this type |
US20020193777A1 (en) * | 2000-10-17 | 2002-12-19 | Antoine Aneas | Device for connection between a vessel and a container and ready-to-use assembly comprising same |
US6537263B1 (en) | 1998-09-24 | 2003-03-25 | Biodome | Device for connecting a receptacle and a container and ready-for-use set comprising same |
EP1459775A1 (fr) * | 2001-12-28 | 2004-09-22 | Terumo Kabushiki Kaisha | Seringue |
US6984222B1 (en) * | 1996-11-12 | 2006-01-10 | Medrad, Inc. | Plunger systems |
US20060211995A1 (en) * | 2005-03-04 | 2006-09-21 | Lennart Myhrberg | Sterile syringe |
US20060287638A1 (en) * | 2002-02-20 | 2006-12-21 | Antoine Aneas | Device for connection between a receptacle and a container and ready-to use assembly comprising same |
DE102005054600A1 (de) * | 2005-11-14 | 2007-05-24 | Lts Lohmann Therapie-Systeme Ag | Zylinderkolbeneinheit mit einer nichtzylindrischen Kammer |
AU2006301180B2 (en) * | 2005-05-02 | 2011-09-15 | Elastomeric Systems S.L. | Syringe for administering multiple doses, comprising an injection needle with sterility protection |
CN102316918A (zh) * | 2009-02-17 | 2012-01-11 | 椭元医疗技术有限公司 | 药物容器和输送机构 |
US20120109076A1 (en) * | 2009-07-17 | 2012-05-03 | Daikyo Seiko, Ltd. | Piston for syringe having very small capacity, and plunger having the piston mounted thereto |
US20120179098A1 (en) * | 2009-08-13 | 2012-07-12 | Luis Enrique Poveda Estepa | Medicinal biosecurity auto disposable syringe |
EP2589399A1 (fr) * | 2011-11-02 | 2013-05-08 | Uhlmann Pac-Systeme GmbH & Co. KG | Seringue destinée à l'application de liquides |
US9382106B2 (en) | 2013-07-19 | 2016-07-05 | Norman Werbner Information Services, Inc. | Liquid handling system with reduced exposure to air |
US9482215B2 (en) | 2013-07-19 | 2016-11-01 | Norman Werbner Information Services, Inc. | Liquid extraction system with reduced exposure to air |
US9480797B1 (en) | 2015-10-28 | 2016-11-01 | Bayer Healthcare Llc | System and method for syringe plunger engagement with an injector |
US9694131B2 (en) | 2003-11-25 | 2017-07-04 | Bayer Healthcare Llc | Medical injector system |
US9744305B2 (en) | 2012-09-28 | 2017-08-29 | Bayer Healthcare Llc | Quick release plunger |
US9844622B2 (en) | 2000-07-10 | 2017-12-19 | Bayer Healthcare Llc | Syringes for medical injector systems |
US9855390B2 (en) | 2006-03-15 | 2018-01-02 | Bayer Healthcare Llc | Plunger covers and plungers for use in syringes |
USD847985S1 (en) | 2007-03-14 | 2019-05-07 | Bayer Healthcare Llc | Syringe plunger cover |
US10384841B2 (en) | 2017-06-29 | 2019-08-20 | Norman Werbner Information Services, Inc. | Liquid extraction, storage, and dispensing system and method of use |
US10806852B2 (en) | 2014-03-19 | 2020-10-20 | Bayer Healthcare Llc | System for syringe engagement to an injector |
USD942005S1 (en) | 2007-03-14 | 2022-01-25 | Bayer Healthcare Llc | Orange syringe plunger cover |
USD1002840S1 (en) | 2007-03-14 | 2023-10-24 | Bayer Healthcare Llc | Syringe plunger |
US11883636B2 (en) | 2018-02-27 | 2024-01-30 | Bayer Healthcare Llc | Syringe plunger engagement mechanism |
US11969582B2 (en) | 2017-01-06 | 2024-04-30 | Bayer Healthcare Llc | Syringe plunger with dynamic seal |
US11998718B2 (en) | 2020-06-18 | 2024-06-04 | Bayer Healthcare Llc | System and method for syringe plunger engagement with an injector |
USD1031029S1 (en) | 2003-11-25 | 2024-06-11 | Bayer Healthcare Llc | Syringe plunger |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19925621A1 (de) * | 1998-06-16 | 1999-12-23 | Buelent Yilmaz | Injektionsspritze |
IT1398101B1 (it) * | 2010-02-15 | 2013-02-07 | Cgm Spa | Gruppo pistone-cilindro con tenuta. |
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US2338102A (en) * | 1940-09-03 | 1944-01-04 | Fields Mack Robert | Ampoule |
US3058467A (en) * | 1958-10-27 | 1962-10-16 | Faure Jean-Marie | Hypodermic syringes |
US3684136A (en) * | 1971-02-22 | 1972-08-15 | Erwin H Baumann | Receptacle having a dividing wall |
US3713780A (en) * | 1971-02-01 | 1973-01-30 | Becton Dickinson Co | Apparatus for chemical testing |
US3731853A (en) * | 1969-08-01 | 1973-05-08 | G Beham | Multi-chamber receptacle |
US3754644A (en) * | 1971-07-26 | 1973-08-28 | Braun Melsungen Ag | Sterile package containing a syringe cylinder of a disposable injection syringe having a piston rod detachable from the piston |
-
1973
- 1973-04-27 FR FR7315452A patent/FR2227020B1/fr not_active Expired
-
1974
- 1974-04-22 US US462767A patent/US3902491A/en not_active Expired - Lifetime
- 1974-04-23 DE DE2419435A patent/DE2419435A1/de not_active Withdrawn
- 1974-04-25 GB GB1821474A patent/GB1471375A/en not_active Expired
- 1974-04-26 SE SE7405667A patent/SE401611B/xx unknown
- 1974-04-26 IT IT21922/74A patent/IT1010106B/it active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US2338102A (en) * | 1940-09-03 | 1944-01-04 | Fields Mack Robert | Ampoule |
US3058467A (en) * | 1958-10-27 | 1962-10-16 | Faure Jean-Marie | Hypodermic syringes |
US3731853A (en) * | 1969-08-01 | 1973-05-08 | G Beham | Multi-chamber receptacle |
US3713780A (en) * | 1971-02-01 | 1973-01-30 | Becton Dickinson Co | Apparatus for chemical testing |
US3684136A (en) * | 1971-02-22 | 1972-08-15 | Erwin H Baumann | Receptacle having a dividing wall |
US3754644A (en) * | 1971-07-26 | 1973-08-28 | Braun Melsungen Ag | Sterile package containing a syringe cylinder of a disposable injection syringe having a piston rod detachable from the piston |
Cited By (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4252118A (en) * | 1976-04-23 | 1981-02-24 | Jacques Richard | Non-reusable drug prefilled syringe assembly and method of use |
US4053051A (en) * | 1976-09-10 | 1977-10-11 | Mine Safety Appliances Company | Earplug package and method of making it |
JPS62194866A (ja) * | 1985-12-20 | 1987-08-27 | マリンクロッド・メディカル・インコーポレイテッド | 既充填無菌プラスチック注射器およびその製造方法 |
JPH0634827B2 (ja) * | 1985-12-20 | 1994-05-11 | マリンクロッド・メディカル・インコーポレイテッド | 既充填無菌プラスチック注射器およびその製造方法 |
US5256154A (en) * | 1992-01-31 | 1993-10-26 | Sterling Winthrop, Inc. | Pre-filled plastic syringes and containers and method of terminal sterilization thereof |
US5873861A (en) * | 1996-11-12 | 1999-02-23 | Medrad, Inc. | Plunger systems |
US5944694A (en) * | 1996-11-12 | 1999-08-31 | Medrad, Inc. | Prefillable syringes and injectors for use therewith |
US5947935A (en) * | 1996-11-12 | 1999-09-07 | Medrad, Inc. | Syringes, syringe plungers and injector systems |
US6017330A (en) * | 1996-11-12 | 2000-01-25 | Medrad, Inc. | Plunger systems |
US6984222B1 (en) * | 1996-11-12 | 2006-01-10 | Medrad, Inc. | Plunger systems |
US6322535B1 (en) | 1996-11-12 | 2001-11-27 | Medrad, Inc. | Prefillable syringes and injectors for use therewith |
US6537263B1 (en) | 1998-09-24 | 2003-03-25 | Biodome | Device for connecting a receptacle and a container and ready-for-use set comprising same |
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Also Published As
Publication number | Publication date |
---|---|
FR2227020A1 (fr) | 1974-11-22 |
SE401611B (sv) | 1978-05-22 |
DE2419435A1 (de) | 1974-11-14 |
GB1471375A (en) | 1977-04-27 |
IT1010106B (it) | 1977-01-10 |
FR2227020B1 (fr) | 1975-08-22 |
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