US3902489A - Couplings - Google Patents

Couplings Download PDF

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Publication number
US3902489A
US3902489A US372848A US37284873A US3902489A US 3902489 A US3902489 A US 3902489A US 372848 A US372848 A US 372848A US 37284873 A US37284873 A US 37284873A US 3902489 A US3902489 A US 3902489A
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United States
Prior art keywords
diaphragms
coupling
equipment
diaphragm
bellows
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US372848A
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English (en)
Inventor
Douglas Vaughan Carter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avon Medicals Ltd
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Avon Medicals Ltd
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Publication date
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Publication of US3902489A publication Critical patent/US3902489A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/10—Tube connectors; Tube couplings
    • A61M39/14—Tube connectors; Tube couplings for connecting tubes having sealed ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/221—Frangible or pierceable closures within tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00—Surgery
    • Y10S604/905—Aseptic connectors or couplings, e.g. frangible, piercable

Definitions

  • Sleeves surrounding the diaphragms are preferably also unified together by the same solvent.
  • couplings have to be made between elements such as bags and tubes to establish a fluid flow path of a particular character, without however exposing the interior of the coupling or the other elements or the fluid to harm, e.g. by infection by harmful microorganisms, or by other entrapped contamination such as chemical contaminants.
  • a particular area in which the problem presents great difficulties is that of blood transfusion and in particular in the handling and the fractionation of blood once it has been received from the donor.
  • the blood is treated by various methods most of which include centrifuging and freezing in an array of three or even more bags linked to each other by closable tubes.
  • a first separation is done in the first bag and one of the fractions is pressed from that bag into a second where a further operation is carried out and then a fraction from the second bag is returned either to the first or to a third bag and so on.
  • the coupling is assembled in a disinfectant bath because if microorganisms are trapped between the parts of the coupling and in particular between the diaphragms they may pass into the fluid stream or may even be driven into it by the needle when that pushes through the diaphragms.
  • a coupling for medical or research equipment for example blood transfusion processing apparatus, wherein elements coupled together are sealed off by penetratable diaphragms one diaphragm being associated with each part of the coupling, the two diaphragms being unified together face to face by a solvent for the material of the diaphragms, and an internal means within the coupling for penetrating through the diaphragms when unified together.
  • the coupling includes male and female sleeves surrounding the diaphragm and forming a push-fit together, and the solvent for the material of the diaphragms is also a solvent for the sleeve parts and is applied between them whereby the coupling parts are unified over substantially the whole of the interacting surfaces of the sleeves and the diaphragms.
  • equipment for the handling of fluid which consists of at least two bags connected together by at least one tube, a coupling between the tube and. at least one of the bags including diaphragms unified by a solvent for the material of the diaphragms, the diaphragms respectively forming a barrier to access to the tubes and to the at least one of the bags, and means inside the coupling for penetrating the diaphragms when sealed together to open up a fluid path from the at least one bag to the tube.
  • FIG. 1 illustrates schematically a prior art arrangement of bag set
  • FIG. 2 illustrates schematically a bag set embodying the present invention
  • FIG. 3 shows, a male element and FIG. 4 a female element of the coupling embodying the invention, both in a diametrical section,
  • FIG. 5 shows, in a larger scale the elements assem bled and with diaphragms unified together
  • FIG. 6 illustrates how a fluid path is opened through the unified diaphragms.
  • FIG. I of the drawing we show a prior art bag set consisting of bags a, b and c, which are interlinked respectively by tubes 1 .and 2 each having socket parts 3 on their ends fitting over plugs extending from the bags u, b, and c.
  • the sockets 3 may be glued onto the plugs.
  • Each of these tubes is open ended at each end as are also the plugs of the bags so that sterility of the whole assembly is achieved only by sterilisation of the component parts and their assembly together into a sealed set all under sterile conditions. It is obvious the set cannot be dis-assembled in any way while maintaining sterility, except destructively (the method usually used being sealing-off tubes 1 or 2 by heating them and then cutting them beyond the seal).
  • FIG. 2 we show elements of a bag set embodying the present invention.
  • An inlet 6 to the first bag a is shown wherein for example blood from a donor may be first introduced into the bag set.
  • This connection may be one according to the invention or may be a conventional one.
  • Each of the bags has a plug 7 which may be one element of a coupling according to the invention or may be a known type of plug with a tear-off seal to allow access to the final contents of the bag when they are to be used.
  • bags may be sent out from the factory as they are in sterile and sealed condition to the user. They may be all the same size as is shown here or may be of a range of sizes which rationally should include only two sizes and not more. Since the bags are totally sealed they cannot be sterilised by ordinary heat treatment since they contain air and may contain for example anticoagulants, and they are therefore sterilised by irradiation preferably by gamma rays. Also making up part of the bag set are tubes such as 8 which have at each end a male element 9 for the coupling embodying the invention.
  • any of the male elements 9 will fit any of the female elements 5 on any of the bags a to c and thus the user may assemble with the bags and with the tubes he is given a set of bags which is uniquely adapted to his own requirements.
  • Each of the male elements 9, which will be described in more detail later, contains a diaphragm sealing off the interior of the tube to the outside atmosphere and the tubes are sent out in internally sterile condition having been sterilised by irradiation again preferably by irradiation with gamma rays.
  • FIG. 4 also shows how the female socket elements need not necessarily be integral with bags but may form the end fitting of a tube. It is equally possible that the male elements 9 may be integral with the bags.
  • the female socket part 5 has a sleeve at 10 across which is formed a diaphragm 11.
  • the sleeve is integral with a fitting 12 for receiving the end of a tube 8' as shown in FIG. 4 or the sleeve 10 may be moulded integrally with a bag.
  • the male element 9 is sealed off by a diaphragm 13 at the axially outer end of a sleeve 14 of which the outer diameter is such that the sleeves l4 and 10 are a tight push-fit together.
  • a bellows construction 15 allows for relative axial movement of the sleeve 14 and another sleeve 16 of similar diameter at the other end of the bellows.
  • This sleeve 16 constitutes a fitting in which the end of a tube such as 8 is securely fixed.
  • annular collar 17 which is a base for a hollow needle 18 which extends axially from that base within the sleeve 16 to Within the sleeve 14 and presents a sharp point 19 towards the diaphragm 13.
  • the needle point 19 is clear of the diaphragm 13.
  • the needle 18 has a pair of ports 20 near its pointed end so there may be fluid communication from that pointed end through the hollow needle and the collar 17 into the tube 8.
  • all the parts mentioned including the needle are formed of plastics material although the needle may of course be of metal.
  • a preferred material for the plastics is a polyvinyl chloride material since this is cheap, readily workable and not difficult to sterilise.
  • a solvent particularly suitable for use with polyvinyl chloride is cyclohexanone since this has, incidentally, an appreciable sterilizing effect of its own.
  • both diaphragms With an ample coating of a solvent for the material of those diaphragms. Obviously from the commercial point of view it would be desirable to make both diaphragms of the same material so that the widest range of solvents is available but obviously the diaphragms could be of different materials, and then a common solvent or else a solvent mixture would have to be used. The diaphragms are then pressed together face to face and left until the joint has solidifed.
  • the material of the diaphragms should be the same as that of the sleeves l0 and 14 and then the same solvent may be also used between the touching surfaces of the sleeves and a unified joint may be formed overall to give mechanical strength to the seal.
  • the layer 21 in FIG. 4 between the diaphragms is a solid layer of material common to each diaphragm while layer 22 is made up of material common to the sleeves l0 and 14.
  • any micro-organisms on the formerly exposed outer surfaces of the diaphragms are locked into the solid joint formed between the diaphragms by the layer 21 and when the needle 18 is pushed through the diaphragms so as to establish a fluid path through the coupling there is a statistically negligible risk that any viable micro-organisms will be introduced into that flow path.
  • the needle may remain penetrating the diaphragms so that the ports 20 remain beyond the diaphragms and fluid issues from them beyond the diaphragms, or may be withdrawn again so that the hole that it has pierced through the diaphragms is used for the passage of fluid.
  • the assembly step of the coupling need not be done under sterile conditions, the only precaution necessary being that a complete and adequate coating of solvent material is applied to the faces of the diaphragms.
  • the internal penetrating elements may be attached to a bellows on as female socket element rather on a male, as shown here, or may be entirely loose within either element of the coupling (cf German Auslegeschrift No. 1300635).
  • Equipment for the handling of fluid which comprises at least two bags connected together by at least one tube, a coupling between the tube and at least one of the bags including diaphragms unified by a solvent for the material of the diaphragms, the diaphragms respectively forming a barrier to access to the tubes and to the at least one of the bags, and means inside the coupling for penetrating the diaphragms when sealed together to open up a fluid path from the at least one bag to the tube.
  • the coupling includes male and female sleeves surrounding the respective diaphragms and forming a push-fit together, the coupling parts being unified over substantially the whole of the irreracting surfaces of the sleeves and the diaphragm by a resolidified region of their respective materials.
  • the said coupling includes an axially compressible bellows intermediate at least one tube and the diaphragms and the said means inside the coupling includes a needle mounted within the bellows with one end presented towards the diaphragm and one anchored to the end of the bellows remote from the diaphragm, whereby axial compression of the bellows can drive the needle through the diaphragm.
  • a modular coupled equipment system comprising a plurality of items of medical or research equipment sealingly attached together in temporarily nonintercommunicating manner, and adapted to be made intercommunicating for use, comprising a plurality of coupled-together sets of individual coupling elements and respective items of equipment, each set comprising a coupling element and an item of equipment attached thereto, each coupling element comprising a housing, and a coupling passage extending through the housing and open at each end, the coupling element being attached to the item of equipment so that one open end of the coupling passage communicates with the item of equipment; a penetrable diaphragm disposed across the coupling passage and sealing off the passage from flow therethrough until penetrated; the housing of each coupling element at the other open end of the passage being shaped to sealingly interconnect with the coupling element of another set to which it is sealingly attached, the coupling passages of interconnected coupling elements being aligned to form an intercommunicating through passage extending to each item of equipment closed off by the diaphragm in the coupling
  • interconnected coupling components comprise interconnected male and female sleeves surrounding the respective diaphragms and forming a pushfit together, the coupling components being united over substantially the whole of the abutting surfaces of the sleeves and the diaphragms by interdiffusion of diaphragm material.
  • a modular coupled equipment system according to claim 8 wherein the plastic material is polyvinyl chloride.
  • a modular coupled equipment system according to claim 6 wherein the said internal means includes an axially compressible bellows, a needle mounted within the bellows with one end presented towards the diaphragm and one anchored to the end of the bellows remote from the diaphragm, whereby axial compression of the bellows can drive the needle through the diaphragm.
US372848A 1972-06-23 1973-06-22 Couplings Expired - Lifetime US3902489A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2952472A GB1428391A (en) 1972-06-23 1972-06-23 Couplings

Publications (1)

Publication Number Publication Date
US3902489A true US3902489A (en) 1975-09-02

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US (1) US3902489A (de)
DE (1) DE2331687C3 (de)
FR (1) FR2202252B1 (de)
GB (1) GB1428391A (de)

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3986508A (en) * 1973-08-22 1976-10-19 Abcor, Inc. Sterilizable, medical connector for blood processing
US4004586A (en) * 1975-03-12 1977-01-25 Baxter Travenol Laboratories, Inc. Method and apparatus for sealed, sterile connection
US4019512A (en) * 1975-12-04 1977-04-26 Tenczar Francis J Adhesively activated sterile connector
US4022205A (en) * 1973-11-05 1977-05-10 Tenczar Francis J Fluid connectors
US4030494A (en) * 1973-11-05 1977-06-21 Francis Tenczar Fluid connectors
US4058363A (en) * 1974-01-15 1977-11-15 Silbert Jerome A Method and apparatus for sterile handling of fluids
US4162566A (en) * 1977-12-12 1979-07-31 General Electric Company Method and coupling for severing and rejoining sealed tubing
US4219221A (en) * 1979-02-26 1980-08-26 General Electric Company Coupling for rejoining sealed tubing
US4306976A (en) * 1979-05-25 1981-12-22 Bieffe S.P.A. Method and device for ambulatory peritoneal dialysis
US4334551A (en) * 1979-04-30 1982-06-15 Becton Dickinson & Company Connector
US4351328A (en) * 1980-03-27 1982-09-28 Sontek Industries, Inc. Simultaneous respiration and endotracheal suctioning of a critically ill patient
US4368729A (en) * 1980-10-14 1983-01-18 Baxter Travenol Laboratories, Inc. Aseptic system for total parenteral nutrition and the like
US4386933A (en) * 1981-05-21 1983-06-07 Sanchez Enrique R Sterile adapter for use in blood transfers
US4392850A (en) * 1981-11-23 1983-07-12 Abbott Laboratories In-line transfer unit
US4392851A (en) * 1981-11-23 1983-07-12 Abbott Laboratories In-line transfer unit
WO1983002395A1 (en) * 1982-01-11 1983-07-21 Baxter Travenol Lab Continuous ambulatory peritoneal dialysis clamping system
US4552277A (en) * 1984-06-04 1985-11-12 Richardson Robert D Protective shield device for use with medicine vial and the like
USRE32056E (en) * 1977-10-19 1985-12-24 Baxter Travenol Laboratories, Inc. Method of forming a connection between two sealed conduits using radiant energy
US4576313A (en) * 1980-05-08 1986-03-18 Steiner Corporation Fluid refill pouch and dispenser
EP0096062B1 (de) * 1981-12-14 1986-06-04 Ncr Corporation Nicht-fluchtige halbleiterspeicheranordnung und verfahren zur herstellung
EP0217055A1 (de) * 1985-07-31 1987-04-08 Kawasumi Laboratories, Inc. Kupplung für Plasmapheresebeutel
US4869398A (en) * 1986-11-25 1989-09-26 Life Technologies, Inc. Liquid container delivery and storage system
US4919658A (en) * 1987-06-05 1990-04-24 Institute Municipal D'assistencia Sanitaria Connection for catheters, perfusion units and flasks of liquid to be perfused
US5117875A (en) * 1988-06-02 1992-06-02 Piero Marrucchi Method and device for manipulating and transferring products between confined volumes
US5176673A (en) * 1988-06-02 1993-01-05 Piero Marrucchi Method and device for manipulating and transferring products between confined volumes
US5176415A (en) * 1990-08-16 1993-01-05 Choksi Pradip V Taper fitting with protective skirt
US5304192A (en) * 1992-01-16 1994-04-19 Sherwood Medical Company Lancet with locking cover
US5393101A (en) * 1992-10-02 1995-02-28 Pall Corporation Connector assembly
US5575779A (en) * 1994-12-30 1996-11-19 Namic U.S.A. Corporation Liquid regulator and method of use
US5584825A (en) * 1994-12-01 1996-12-17 Isolyser Co., Inc. Closure delivery system
US5810398A (en) * 1992-10-02 1998-09-22 Pall Corporation Fluid delivery systems and methods and assemblies for making connections
US6394992B1 (en) * 1997-07-14 2002-05-28 Arom Pak International Ab Aseptic connection device
US6539248B1 (en) 1993-07-14 2003-03-25 Abbott Laboratories Dye management system including an administration set with an in line burette
US6655655B1 (en) 1997-05-09 2003-12-02 Pall Corporation Connector assemblies, fluid systems, and methods for making a connection
US20040034328A1 (en) * 2000-04-06 2004-02-19 Peter Unger Sterile coupling
US20050017503A1 (en) * 2003-07-23 2005-01-27 Garry Tsaur Connector with frangible seal
US20050154368A1 (en) * 2003-11-21 2005-07-14 Vasogen Ireland Limited Medical material handling systems
EP1415635A3 (de) * 1998-09-15 2005-07-27 Baxter International Inc. Gleitende Wiederherstellungsvorrichtung für einen Verdünnungsmittelbehälter
US20060111658A1 (en) * 1999-07-29 2006-05-25 Jean-Marie Mathias Sampling tube holder for blood sampling system
US7074216B2 (en) 1998-09-15 2006-07-11 Baxter International Inc. Sliding reconstitution device for a diluent container
US20080086087A1 (en) * 2004-04-16 2008-04-10 Spohn Michael A Fluid delivery system including a fluid path set with sterile check valve connector
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
US7611503B2 (en) 2004-04-16 2009-11-03 Medrad, Inc. Fluid delivery system, fluid path set, sterile connector and improved drip chamber and pressure isolation mechanism
US20100010413A1 (en) * 2008-07-09 2010-01-14 Loiterman David A Needle for Subcutaneous Port
US20110092828A1 (en) * 2004-04-16 2011-04-21 Spohn Michael A Fluid Delivery System, Fluid Path Set, and Pressure Isolation Mechanism with Hemodynamic Pressure Dampening Correction
US8454059B2 (en) 2010-09-13 2013-06-04 Pall Corporation Connector assemblies, fluid systems including connector assemblies, and procedures for making fluid connections
WO2013136889A1 (ja) * 2012-03-12 2013-09-19 テルモ株式会社 血液流路接続装置及び血液バッグシステム

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4195632A (en) * 1978-05-03 1980-04-01 Cutter Laboratories, Inc. Fluid flow valve
DE2853635A1 (de) * 1978-12-08 1980-06-19 Affeld Klaus Prof Dr Kupplung fuer keimfrei zu haltende leitungsverbinder
US4439188A (en) * 1980-09-15 1984-03-27 Baxter Travenol Laboratories, Inc. Tube connector
US4412834A (en) * 1981-06-05 1983-11-01 Baxter Travenol Laboratories Antimicrobial ultraviolet irradiation of connector for continuous ambulatory peritoneal dialysis
EP0165926B1 (de) * 1983-05-20 1990-10-24 Bengt Gustavsson Anordnung zur übertragung einer substanz
US4611643A (en) * 1983-11-21 1986-09-16 Baxter Travenol Laboratories, Inc. Interlocking fluid transfer device and resulting assembly
IT1175783B (it) * 1984-03-06 1987-07-15 Bieffe Spa Sistema e dispositivo per dialisi

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2847995A (en) * 1954-08-23 1958-08-19 Becton Dickinson Co Transfusion needle sheath
US2933333A (en) * 1955-09-26 1960-04-19 Crane Co Pipe coupling
US2954769A (en) * 1958-08-20 1960-10-04 American Cyanamid Co Aseptic liquid transfer apparatus
US3127892A (en) * 1960-07-13 1964-04-07 Baxter Laboratories Inc Blood handling apparatus
US3306563A (en) * 1964-07-31 1967-02-28 Soto Ricardo Hurtado Aseptic draining and support means for flexible bags
US3336924A (en) * 1964-02-20 1967-08-22 Sarnoff Two compartment syringe package
US3416528A (en) * 1959-08-17 1968-12-17 Cutter Lab Blood handling equipment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1091292B (de) * 1956-10-05 1960-10-20 Dr Med Habil Jakob Clemens Schutzeinrichtung fuer den Gebrauch von Kanuelen
DE1300635B (de) * 1964-09-07 1969-08-07 Dr Med Karl Friedrich Sterile Leitungsverbindung fuer den Durchfluss von Transfusions- oder Infusionsfluessigkeiten
FR2104036A5 (de) * 1971-08-06 1972-04-14 Christensen Borge

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2847995A (en) * 1954-08-23 1958-08-19 Becton Dickinson Co Transfusion needle sheath
US2933333A (en) * 1955-09-26 1960-04-19 Crane Co Pipe coupling
US2954769A (en) * 1958-08-20 1960-10-04 American Cyanamid Co Aseptic liquid transfer apparatus
US3416528A (en) * 1959-08-17 1968-12-17 Cutter Lab Blood handling equipment
US3127892A (en) * 1960-07-13 1964-04-07 Baxter Laboratories Inc Blood handling apparatus
US3336924A (en) * 1964-02-20 1967-08-22 Sarnoff Two compartment syringe package
US3306563A (en) * 1964-07-31 1967-02-28 Soto Ricardo Hurtado Aseptic draining and support means for flexible bags

Cited By (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3986508A (en) * 1973-08-22 1976-10-19 Abcor, Inc. Sterilizable, medical connector for blood processing
US4022205A (en) * 1973-11-05 1977-05-10 Tenczar Francis J Fluid connectors
US4030494A (en) * 1973-11-05 1977-06-21 Francis Tenczar Fluid connectors
US4058363A (en) * 1974-01-15 1977-11-15 Silbert Jerome A Method and apparatus for sterile handling of fluids
US4004586A (en) * 1975-03-12 1977-01-25 Baxter Travenol Laboratories, Inc. Method and apparatus for sealed, sterile connection
US4019512A (en) * 1975-12-04 1977-04-26 Tenczar Francis J Adhesively activated sterile connector
USRE32056E (en) * 1977-10-19 1985-12-24 Baxter Travenol Laboratories, Inc. Method of forming a connection between two sealed conduits using radiant energy
US4162566A (en) * 1977-12-12 1979-07-31 General Electric Company Method and coupling for severing and rejoining sealed tubing
US4219221A (en) * 1979-02-26 1980-08-26 General Electric Company Coupling for rejoining sealed tubing
US4334551A (en) * 1979-04-30 1982-06-15 Becton Dickinson & Company Connector
US4306976A (en) * 1979-05-25 1981-12-22 Bieffe S.P.A. Method and device for ambulatory peritoneal dialysis
US4351328A (en) * 1980-03-27 1982-09-28 Sontek Industries, Inc. Simultaneous respiration and endotracheal suctioning of a critically ill patient
US4576313A (en) * 1980-05-08 1986-03-18 Steiner Corporation Fluid refill pouch and dispenser
US4368729A (en) * 1980-10-14 1983-01-18 Baxter Travenol Laboratories, Inc. Aseptic system for total parenteral nutrition and the like
US4386933A (en) * 1981-05-21 1983-06-07 Sanchez Enrique R Sterile adapter for use in blood transfers
US4392850A (en) * 1981-11-23 1983-07-12 Abbott Laboratories In-line transfer unit
US4392851A (en) * 1981-11-23 1983-07-12 Abbott Laboratories In-line transfer unit
EP0096062B1 (de) * 1981-12-14 1986-06-04 Ncr Corporation Nicht-fluchtige halbleiterspeicheranordnung und verfahren zur herstellung
WO1983002395A1 (en) * 1982-01-11 1983-07-21 Baxter Travenol Lab Continuous ambulatory peritoneal dialysis clamping system
US4473369A (en) * 1982-01-11 1984-09-25 Baxter Travenol Laboratories, Inc. Continuous ambulatory peritoneal dialysis clamping system
US4552277A (en) * 1984-06-04 1985-11-12 Richardson Robert D Protective shield device for use with medicine vial and the like
EP0217055A1 (de) * 1985-07-31 1987-04-08 Kawasumi Laboratories, Inc. Kupplung für Plasmapheresebeutel
US4869398A (en) * 1986-11-25 1989-09-26 Life Technologies, Inc. Liquid container delivery and storage system
US4919658A (en) * 1987-06-05 1990-04-24 Institute Municipal D'assistencia Sanitaria Connection for catheters, perfusion units and flasks of liquid to be perfused
US5117875A (en) * 1988-06-02 1992-06-02 Piero Marrucchi Method and device for manipulating and transferring products between confined volumes
US5176673A (en) * 1988-06-02 1993-01-05 Piero Marrucchi Method and device for manipulating and transferring products between confined volumes
US5176415A (en) * 1990-08-16 1993-01-05 Choksi Pradip V Taper fitting with protective skirt
US5286067A (en) * 1990-08-16 1994-02-15 Pradip Choksi Taper fitting with protective skirt
US5304192A (en) * 1992-01-16 1994-04-19 Sherwood Medical Company Lancet with locking cover
US5868433A (en) * 1992-10-02 1999-02-09 Pall Corporation Connector assembly
US5393101A (en) * 1992-10-02 1995-02-28 Pall Corporation Connector assembly
US6536805B2 (en) 1992-10-02 2003-03-25 Pall Corporation Fluid delivery systems and methods and assemblies for making connections
US6341802B1 (en) 1992-10-02 2002-01-29 Pall Corporation Fluid delivery systems and methods and assemblies for making connections
US5810398A (en) * 1992-10-02 1998-09-22 Pall Corporation Fluid delivery systems and methods and assemblies for making connections
US5324302A (en) * 1992-10-13 1994-06-28 Sherwood Medical Company Lancet with locking cover
US6539248B1 (en) 1993-07-14 2003-03-25 Abbott Laboratories Dye management system including an administration set with an in line burette
US5672162A (en) * 1994-12-01 1997-09-30 Isolyser Co., Inc. Closure delivery system
US5584825A (en) * 1994-12-01 1996-12-17 Isolyser Co., Inc. Closure delivery system
US5575779A (en) * 1994-12-30 1996-11-19 Namic U.S.A. Corporation Liquid regulator and method of use
US6655655B1 (en) 1997-05-09 2003-12-02 Pall Corporation Connector assemblies, fluid systems, and methods for making a connection
US6394992B1 (en) * 1997-07-14 2002-05-28 Arom Pak International Ab Aseptic connection device
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
US7074216B2 (en) 1998-09-15 2006-07-11 Baxter International Inc. Sliding reconstitution device for a diluent container
EP1415635A3 (de) * 1998-09-15 2005-07-27 Baxter International Inc. Gleitende Wiederherstellungsvorrichtung für einen Verdünnungsmittelbehälter
US20060111658A1 (en) * 1999-07-29 2006-05-25 Jean-Marie Mathias Sampling tube holder for blood sampling system
US7097209B2 (en) * 2000-04-06 2006-08-29 Gambro Inc. Sterile coupling
US20040034328A1 (en) * 2000-04-06 2004-02-19 Peter Unger Sterile coupling
US20050017503A1 (en) * 2003-07-23 2005-01-27 Garry Tsaur Connector with frangible seal
US20050154368A1 (en) * 2003-11-21 2005-07-14 Vasogen Ireland Limited Medical material handling systems
US7611503B2 (en) 2004-04-16 2009-11-03 Medrad, Inc. Fluid delivery system, fluid path set, sterile connector and improved drip chamber and pressure isolation mechanism
US20110092828A1 (en) * 2004-04-16 2011-04-21 Spohn Michael A Fluid Delivery System, Fluid Path Set, and Pressure Isolation Mechanism with Hemodynamic Pressure Dampening Correction
US20080086087A1 (en) * 2004-04-16 2008-04-10 Spohn Michael A Fluid delivery system including a fluid path set with sterile check valve connector
US8540698B2 (en) 2004-04-16 2013-09-24 Medrad, Inc. Fluid delivery system including a fluid path set and a check valve connector
US8992489B2 (en) 2004-04-16 2015-03-31 Bayer Medical Care Inc. Fluid delivery system, fluid path set, and pressure isolation mechanism with hemodynamic pressure dampening correction
US9895527B2 (en) 2004-04-16 2018-02-20 Bayer Healthcare Llc Fluid delivery system, fluid path set, and pressure isolation mechanism with hemodynamic pressure dampening correction
US20100010413A1 (en) * 2008-07-09 2010-01-14 Loiterman David A Needle for Subcutaneous Port
US8454059B2 (en) 2010-09-13 2013-06-04 Pall Corporation Connector assemblies, fluid systems including connector assemblies, and procedures for making fluid connections
WO2013136889A1 (ja) * 2012-03-12 2013-09-19 テルモ株式会社 血液流路接続装置及び血液バッグシステム

Also Published As

Publication number Publication date
FR2202252A1 (de) 1974-05-03
DE2331687C3 (de) 1978-05-11
FR2202252B1 (de) 1978-12-08
DE2331687A1 (de) 1974-01-10
DE2331687B2 (de) 1977-08-25
GB1428391A (en) 1976-03-17

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