US3886265A - Mouth cleansing preparation - Google Patents
Mouth cleansing preparation Download PDFInfo
- Publication number
- US3886265A US3886265A US375615A US37561573A US3886265A US 3886265 A US3886265 A US 3886265A US 375615 A US375615 A US 375615A US 37561573 A US37561573 A US 37561573A US 3886265 A US3886265 A US 3886265A
- Authority
- US
- United States
- Prior art keywords
- acid
- amount
- ene
- peroxide
- oxidizing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 238000002360 preparation method Methods 0.000 title abstract description 26
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 32
- -1 ene-diol compound Chemical class 0.000 claims abstract description 17
- 206010006326 Breath odour Diseases 0.000 claims abstract description 16
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 14
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 14
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 14
- 150000002978 peroxides Chemical class 0.000 claims abstract description 13
- 239000007800 oxidant agent Substances 0.000 claims abstract description 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229910052783 alkali metal Inorganic materials 0.000 claims abstract description 5
- 229940078916 carbamide peroxide Drugs 0.000 claims abstract description 5
- 150000003839 salts Chemical class 0.000 claims abstract description 5
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims abstract description 5
- CIWBSHSKHKDKBQ-DUZGATOHSA-N D-isoascorbic acid Chemical compound OC[C@@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-DUZGATOHSA-N 0.000 claims abstract description 4
- 235000010350 erythorbic acid Nutrition 0.000 claims abstract description 4
- 229940026239 isoascorbic acid Drugs 0.000 claims abstract description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 9
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical group [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 229940045872 sodium percarbonate Drugs 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 4
- 150000001340 alkali metals Chemical class 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 235000002639 sodium chloride Nutrition 0.000 claims 1
- CRTGSPPMTACQBL-UHFFFAOYSA-N 2,3-dihydroxycyclopent-2-en-1-one Chemical compound OC1=C(O)C(=O)CC1 CRTGSPPMTACQBL-UHFFFAOYSA-N 0.000 abstract description 7
- 125000004432 carbon atom Chemical group C* 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- BZCOSCNPHJNQBP-UPHRSURJSA-N (z)-2,3-dihydroxybut-2-enedioic acid Chemical compound OC(=O)C(\O)=C(\O)C(O)=O BZCOSCNPHJNQBP-UPHRSURJSA-N 0.000 abstract description 3
- BZCOSCNPHJNQBP-OWOJBTEDSA-N dihydroxyfumaric acid Chemical compound OC(=O)C(\O)=C(/O)C(O)=O BZCOSCNPHJNQBP-OWOJBTEDSA-N 0.000 abstract description 3
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 12
- 239000003826 tablet Substances 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 235000002906 tartaric acid Nutrition 0.000 description 5
- 239000011975 tartaric acid Substances 0.000 description 5
- 239000003054 catalyst Substances 0.000 description 4
- 235000013355 food flavoring agent Nutrition 0.000 description 4
- 239000002324 mouth wash Substances 0.000 description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 239000000594 mannitol Substances 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 229940041616 menthol Drugs 0.000 description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- WQOXQRCZOLPYPM-UHFFFAOYSA-N Dimethyl disulfide Natural products CSSC WQOXQRCZOLPYPM-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 244000005706 microflora Species 0.000 description 2
- 229940051866 mouthwash Drugs 0.000 description 2
- 230000001603 reducing effect Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 1
- 235000014749 Mentha crispa Nutrition 0.000 description 1
- 244000246386 Mentha pulegium Species 0.000 description 1
- 235000016257 Mentha pulegium Nutrition 0.000 description 1
- 244000078639 Mentha spicata Species 0.000 description 1
- 235000004357 Mentha x piperita Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229940085398 ascorbic acid 50 mg Drugs 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 1
- 239000007910 chewable tablet Substances 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 235000001050 hortel pimenta Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- ABSTRACT The use of at least one ene-diol compound having at most 6 carbon atoms and selected from the group consisting of ascorbic acid, isoascorbic acid, dihydroxymaleic acid, dihydroxyfumaric acid, and reductic acid, or salts or derivatives thereof, and an oxidizing agent in the form of a water soluble peroxide selected from the group consisting of alkali metal percarbonate, alkaline earth peroxide, carbamide peroxide, and hydrogen peroxide in the manufacture of preparations effective against bad breath, preferably in the form of peroral dosage units.
- the present invention relates to the use of an oxidizing agent together with at least one ene-diol compound having at most 6 carbon atoms, in the manufacture of preparations which are effective against bad breath.
- the object of the present invention is to eliminate feror ex ore, bad breath, without influencing the natural micro flora of the mouth.
- Tooth breath is a great social handicap to many people and therefore there is a demand for preparations which can eliminate'it. Although frequent tooth brushing is carried out it has been shown that bad breath persists.
- mouth-washes intended to be used against bad breath are known. However, such mouth-washes do not reduce the amount of eg methyl mercaptan but only mask it.
- ascorbic acid and sodium percarbonate are used.
- ene-diol compounds besides ascorbic acid, isoascorbic acid, dihydroxymaleic acid, dihydrox yfumaric acid, or reductic acid (2,3-dihydroxy 2- cyclopenten-l-one), may be used, or salt thereof, such as the sodium, potassium or calcium salt, or derivatives thereof such as the esters of fatty acids having 2-l8 carbon atoms, such as the acetate, palmitate or stearate.
- a peroxide besides sodium percarbonate, other alkali percarbonates, alkaline earth peroxides, carbamide peroxide (carbamide crystallized with H instead of H 0), and hydrogen peroxide may be used.
- inert filling agents and lubricants known per se are used.
- Such filling agents are e.g. mannitol, sodium bicarbonate, tartaric acid and starch.
- magnesium stearate As lubricants, magnesium stearate, and paraffin may be used.
- Binding agents used in the granulation of the com pounds prior to the manufacture of e.g. tablets and the like are e.g. polyvinylpyrrolidone and gelatin.
- flavoring agents may be added. Suitable flavors are spearmint, peppermint, menthol, spiced fruits, orange, lemon, lime, etc.
- pellets or granules is chewed, whereby a reaction between the two active components, the ene-diol compound and the oxidizing agent is obtained and a destruction of the bad smelling compounds takes place.
- the amount of active oxygen produced per occasion of administration is at least 1 mg, preferably 3 mg, and the amount of the ene-diol compound is at least 10 mg.
- the administration takes place 3 to 4 times per day.
- the preparation may also be manufactured as soaking tablets, lozenges, chewing gum or in aerosol or spray form.
- Tablets may be chewed, or dissolved in water to produce a mouth wash.
- the amount of ene-diol compound should not exceed 200 mg per occasion of administration and the amount of peroxide should thus not exceed mg as active oxygen.
- EXAMPLE 1 The tablets were prepared by granulating the mannito] and the sodium percarbonate with a solution of gelatin in water.
- the sodium bicarbonate was granulated with a 50% solution of polyvinylpyrrolidone in ethanol.
- the ascorbic acid and tartaric acid were granulated with a solution of polyethylene glycol in ethanol.
- the different granulates were passed through an oscillating granulator where the granulates are mixed with flavoring agents. Finally, tablets were pressed in a common tablet punching machine.
- EXAMPLE 2 Effervescing granules were prepared and packed in dosage units, whereby each dose contained Ascorbic acid l0 mg Sodium percarbonate corresponding to active oxygen 1 mg Sodium bicarbonate 4 mg Tartaric acid 5 mg Polyvinyl pyrrolrdone 0.02 mg Flavoring agents q.s. Coloring agents q.s. Mannitol 0.03 g
- the granules were prepared in accordance with the tablets above, excluding the tableting step.
- EXAMPLE 3 Effervescing tablets were prepared containing Ascorbic acid 50 mg Sodium percarbonate corresponding to active oxygen 5 mg Tartaric acid 5 mg The preparation contained ethanol "Standard Deviation -Continued Table 2 Sodium bicarbonate 25 mg Starch 10 g Polyvinyl pyrrolidone 2.5 mg Compound m the breath MeSH n-PrOH MeSSMe Flavoring agents q. pfepurmmn Coloring agents q.s.
- a composition effective in combattmg bad breath consisting essentially of an ene-diol compound selected
- the tablets were prepared in accordance with the from the group consisting of ascorbic acid and isotablets of Example 1. ascorbic acid, said compound being present in an The reducing effect of the above preparations on bad amount of at least 10 and oxldlzmg agent m the breath has been studied in vitro. Morning saliva from form of a w Solubl?
- peroxlde Selected from i a number of tested persons was incubated at for group consisting of alkali metal percarbonates, alkaline 5 to 12 hours until great amounts of methyl mercaptan f Peroxldes f carbalmde Peroxlder wherein sflld had been formed, whereupon the saliva was divided OXd1Z mg agent Present an amount corresp ondmg into samples each containing 3 ml in 20 ml injection to acme Oxygen m an amolfm of at least 1 each flasks, which were deep-frozen in a Dewer-vessel using Case Per peroridosage coricg The different Compared preparations were 2.
- composition according to claim 1 wherein the then added in the amounts stated by opening the capcne'dlol P H ascorbic acid sule of the deep-frozen flasks, introducing the preparacomposltlon aFCOrdmg P claim 1 the tion, rapidly removing the air by sweeping with nitro ene'dlol compound ascorbl? f f f" an gen gas and closing the flasks again.
- the amount at least 10 mg and the oxidizing agent is sodium flasks were thawed and after 20 minutes at 36C a samperFarbonate Present m an amount corresponfimg to ple was taken and analyzed on a gas chromatograph.
- Example 1 A method of inhibiting bad breath by administerabove In Example 1; C, a preparation according to the in Oran at 1 st 10 m f l d invention containing in addition 0.2% of a heavy metal g per y ea ah chelo h h catalyst in the form of copper sulphate calculated on Selecteh the group cohslshhg of hscorblc acid the ene diol compound and D a known mouthwash ascorbic acid, and salts or derivatives thereof, together containing menthol as masking agent are given.
- h Oxlchzmg agent In the form Water soluble?
- Table 2 a comparison between a control sample A, and peroxlde selected from group cohslshhg of alkah the preparations B and C and in addition, E, a liquid meial percaibohates alkhhhe earth.
- perhxldes carbantibacterial iodine composition having oxidizing prophhhde perohlde ahdhydrogeh heroxlde m an amount erties is given.
- the results are given in mm peak height corresphhdmg to achve Oxygen m an hmohht of at least of the g chromatograms 1 mg., in each case*per*perkorai dtlsage unit.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE08597/72A SE369036B (enrdf_load_stackoverflow) | 1972-06-30 | 1972-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3886265A true US3886265A (en) | 1975-05-27 |
Family
ID=20274522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US375615A Expired - Lifetime US3886265A (en) | 1972-06-30 | 1973-07-02 | Mouth cleansing preparation |
Country Status (13)
Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972996A (en) * | 1975-06-09 | 1976-08-03 | Warner-Lambert Company | Deodorant compositions containing trans-1,4-diphenyl-2-butene-1,4-dione |
| US4213961A (en) * | 1978-03-23 | 1980-07-22 | Beecham, Inc. | Oral compositions |
| US4229430A (en) * | 1978-08-21 | 1980-10-21 | Fahim Mostafa S | Oral composition for improving oral health |
| WO1981000205A1 (en) * | 1979-07-13 | 1981-02-05 | A Barr | A cosmetic breath freshener and palate coolant composition and method of use |
| US4256731A (en) * | 1978-03-23 | 1981-03-17 | Beecham, Inc. | Oral Compositions |
| US4457909A (en) * | 1982-09-27 | 1984-07-03 | Tames Theobaldo | Oral rinse formulation and method of treating mouth and throat irritations therewith |
| US4515771A (en) * | 1983-04-11 | 1985-05-07 | Fine Daniel H | Composition and method for the preventative treatment of dental disease and apparatus for dispensing said composition |
| US4590067A (en) * | 1984-10-18 | 1986-05-20 | Peritain, Ltd. | Treatment for periodontal disease |
| US4647453A (en) * | 1984-10-18 | 1987-03-03 | Peritain, Ltd. | Treatment for tissue degenerative inflammatory disease |
| US4839156A (en) * | 1987-04-17 | 1989-06-13 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel |
| US4849213A (en) * | 1983-03-01 | 1989-07-18 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery therof |
| US4876082A (en) * | 1987-07-06 | 1989-10-24 | Roch Romeo | Tooth-paste with brushing time indicator |
| US4891211A (en) * | 1988-06-29 | 1990-01-02 | Church & Dwight Co., Inc. | Stable hydrogen peroxide-releasing dentifice |
| US4983379A (en) * | 1983-03-01 | 1991-01-08 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
| US5223264A (en) * | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
| US5298237A (en) * | 1992-01-24 | 1994-03-29 | The Trustees Of Columbia University In The City Of New York | Gel composition for reduction of gingival inflammation and retardation of dental plaque |
| US5464608A (en) * | 1992-10-26 | 1995-11-07 | Regents Of The University Of Minnesota | Composition for the cleaning of teeth and the prophylaxis of caries |
| US5824291A (en) * | 1997-06-30 | 1998-10-20 | Media Group | Chewing gum containing a teeth whitening agent |
| US5908614A (en) * | 1995-08-15 | 1999-06-01 | Montgomery; Robert Eric | Peroxidase-activating oral compositions |
| US6217914B1 (en) | 1999-03-19 | 2001-04-17 | Bioderm, Inc. | Ascorbic acid composition and method for treatment of aging or damaged skin |
| US20020037314A1 (en) * | 1999-03-19 | 2002-03-28 | Meisner Lorraine Faxon | Compositions and methods |
| WO2002047637A1 (de) * | 2000-12-15 | 2002-06-20 | Haarmann & Reimer Gmbh | Verwendung von antioxidantien für mittel zur bekämpfung von mundgeruch |
| US6645472B1 (en) * | 2002-09-13 | 2003-11-11 | Michael R. Anderson | Oral hygiene powder composition and method |
| US6696043B2 (en) * | 2000-09-20 | 2004-02-24 | Scientific Pharmaceuticals, Inc. | Teeth whitening composition in the form of a chewing gum |
| US20080008666A1 (en) * | 2004-03-12 | 2008-01-10 | Michael Phillips | Breath Test for Oral Malodor |
| US20080179985A1 (en) * | 2007-01-30 | 2008-07-31 | Mitsubishi Electric Corporation | Rotating electrical machine |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2320083A1 (fr) * | 1975-08-07 | 1977-03-04 | Sigma Tau Ind Farmaceuti | Nouveau produit a base de gomme a macher, convenant a l'administration de substances medicamenteuses |
| US4812308A (en) * | 1987-02-20 | 1989-03-14 | Church & Dwight Co., Inc. | Hydrogen peroxide-releasing tooth powder |
| GB8909793D0 (en) * | 1989-04-28 | 1989-06-14 | Beecham Group Plc | Pharmaceutical formulation |
| ATE145551T1 (de) * | 1989-10-02 | 1996-12-15 | Cima Labs Inc | Brausedosisform sowie verfahren zu deren verabreichung |
| GB2290234B (en) * | 1994-06-07 | 1998-06-10 | Janina International | Oral care products |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065139A (en) * | 1953-11-12 | 1962-11-20 | Astra Ab | Anti-infectant topical preparations |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE367319B (enrdf_load_stackoverflow) * | 1970-07-13 | 1974-05-27 | Astra Laekemedel Ab |
-
1972
- 1972-06-30 SE SE08597/72A patent/SE369036B/xx unknown
-
1973
- 1973-06-12 ZA ZA733996A patent/ZA733996B/xx unknown
- 1973-06-19 BE BE132419A patent/BE801102A/xx unknown
- 1973-06-22 DE DE2331681A patent/DE2331681A1/de active Pending
- 1973-06-25 AU AU57271/73A patent/AU5727173A/en not_active Expired
- 1973-06-26 CA CA174,951A patent/CA1000204A/en not_active Expired
- 1973-06-26 IT IT51046/73A patent/IT986224B/it active
- 1973-06-27 GB GB3046273A patent/GB1429234A/en not_active Expired
- 1973-06-28 DK DK357173AA patent/DK135703B/da unknown
- 1973-06-29 NL NL7309085A patent/NL7309085A/xx unknown
- 1973-06-29 FR FR7324041A patent/FR2190408B1/fr not_active Expired
- 1973-06-30 JP JP48073339A patent/JPS4930544A/ja active Pending
- 1973-07-02 US US375615A patent/US3886265A/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3065139A (en) * | 1953-11-12 | 1962-11-20 | Astra Ab | Anti-infectant topical preparations |
Cited By (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3972996A (en) * | 1975-06-09 | 1976-08-03 | Warner-Lambert Company | Deodorant compositions containing trans-1,4-diphenyl-2-butene-1,4-dione |
| US4213961A (en) * | 1978-03-23 | 1980-07-22 | Beecham, Inc. | Oral compositions |
| US4256731A (en) * | 1978-03-23 | 1981-03-17 | Beecham, Inc. | Oral Compositions |
| US4229430A (en) * | 1978-08-21 | 1980-10-21 | Fahim Mostafa S | Oral composition for improving oral health |
| WO1981000205A1 (en) * | 1979-07-13 | 1981-02-05 | A Barr | A cosmetic breath freshener and palate coolant composition and method of use |
| US4292028A (en) * | 1979-07-13 | 1981-09-29 | Arthur Barr | Cosmetic breath freshener and palate coolant composition and method of use |
| US4457909A (en) * | 1982-09-27 | 1984-07-03 | Tames Theobaldo | Oral rinse formulation and method of treating mouth and throat irritations therewith |
| US4849213A (en) * | 1983-03-01 | 1989-07-18 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery therof |
| US4983379A (en) * | 1983-03-01 | 1991-01-08 | Schaeffer Hans A | Dental preparation, article and method for storage and delivery thereof |
| US4515771A (en) * | 1983-04-11 | 1985-05-07 | Fine Daniel H | Composition and method for the preventative treatment of dental disease and apparatus for dispensing said composition |
| US4590067A (en) * | 1984-10-18 | 1986-05-20 | Peritain, Ltd. | Treatment for periodontal disease |
| US4647453A (en) * | 1984-10-18 | 1987-03-03 | Peritain, Ltd. | Treatment for tissue degenerative inflammatory disease |
| US4839156A (en) * | 1987-04-17 | 1989-06-13 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel |
| US4876082A (en) * | 1987-07-06 | 1989-10-24 | Roch Romeo | Tooth-paste with brushing time indicator |
| US4891211A (en) * | 1988-06-29 | 1990-01-02 | Church & Dwight Co., Inc. | Stable hydrogen peroxide-releasing dentifice |
| US5223264A (en) * | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
| US5298237A (en) * | 1992-01-24 | 1994-03-29 | The Trustees Of Columbia University In The City Of New York | Gel composition for reduction of gingival inflammation and retardation of dental plaque |
| US5464608A (en) * | 1992-10-26 | 1995-11-07 | Regents Of The University Of Minnesota | Composition for the cleaning of teeth and the prophylaxis of caries |
| US5908614A (en) * | 1995-08-15 | 1999-06-01 | Montgomery; Robert Eric | Peroxidase-activating oral compositions |
| US20030211055A1 (en) * | 1995-08-15 | 2003-11-13 | Oraceutical Innovative Properties Llc | Peroxidase-activating oral compositions |
| US5824291A (en) * | 1997-06-30 | 1998-10-20 | Media Group | Chewing gum containing a teeth whitening agent |
| US6217914B1 (en) | 1999-03-19 | 2001-04-17 | Bioderm, Inc. | Ascorbic acid composition and method for treatment of aging or damaged skin |
| US20020037314A1 (en) * | 1999-03-19 | 2002-03-28 | Meisner Lorraine Faxon | Compositions and methods |
| US6444699B2 (en) | 1999-03-19 | 2002-09-03 | Bioderm, Inc. | Method for treatment of aging or damage skin |
| US20020031557A1 (en) * | 1999-03-19 | 2002-03-14 | Meisner Lorraine Faxon | Ascorbic acid composition and method for treatment of aging or damaged skin |
| US7816402B2 (en) | 1999-03-19 | 2010-10-19 | Bioderm, Inc. | Compositions and methods for the treatment of skin |
| US8003134B2 (en) | 1999-03-19 | 2011-08-23 | Bioderm, Inc. | Ascorbic acid composition and method for treatment of aging or damaged skin |
| US20080125395A1 (en) * | 1999-03-19 | 2008-05-29 | Lorraine Faxon Meisner | Compositions and methods for the treatment of skin |
| US7834055B2 (en) | 1999-03-19 | 2010-11-16 | Bioderm, Inc. | Compositions and methods for the treatment of skin |
| US6696043B2 (en) * | 2000-09-20 | 2004-02-24 | Scientific Pharmaceuticals, Inc. | Teeth whitening composition in the form of a chewing gum |
| WO2002047637A1 (de) * | 2000-12-15 | 2002-06-20 | Haarmann & Reimer Gmbh | Verwendung von antioxidantien für mittel zur bekämpfung von mundgeruch |
| US20040067204A1 (en) * | 2000-12-15 | 2004-04-08 | Florian Wolf | Use of antioxidants in means of treating halitosis |
| US6645472B1 (en) * | 2002-09-13 | 2003-11-11 | Michael R. Anderson | Oral hygiene powder composition and method |
| US20080008666A1 (en) * | 2004-03-12 | 2008-01-10 | Michael Phillips | Breath Test for Oral Malodor |
| US20080179985A1 (en) * | 2007-01-30 | 2008-07-31 | Mitsubishi Electric Corporation | Rotating electrical machine |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA733996B (en) | 1974-05-29 |
| BE801102A (fr) | 1973-10-15 |
| FR2190408A1 (enrdf_load_stackoverflow) | 1974-02-01 |
| JPS4930544A (enrdf_load_stackoverflow) | 1974-03-19 |
| NL7309085A (enrdf_load_stackoverflow) | 1974-01-02 |
| IT986224B (it) | 1975-01-20 |
| DK135703B (da) | 1977-06-13 |
| GB1429234A (en) | 1976-03-24 |
| CA1000204A (en) | 1976-11-23 |
| AU5727173A (en) | 1975-01-09 |
| DK135703C (enrdf_load_stackoverflow) | 1977-11-14 |
| SE369036B (enrdf_load_stackoverflow) | 1974-08-05 |
| FR2190408B1 (enrdf_load_stackoverflow) | 1977-09-16 |
| DE2331681A1 (de) | 1974-04-11 |
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