US3871824A - Method of aseptically connecting a fitting to an aseptic storage tank - Google Patents

Method of aseptically connecting a fitting to an aseptic storage tank Download PDF

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Publication number
US3871824A
US3871824A US480842A US48084274A US3871824A US 3871824 A US3871824 A US 3871824A US 480842 A US480842 A US 480842A US 48084274 A US48084274 A US 48084274A US 3871824 A US3871824 A US 3871824A
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United States
Prior art keywords
tank
fitting
opening
sterilant
liquid
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Expired - Lifetime
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US480842A
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English (en)
Inventor
Steve A Rechtsteiner
Philip E Nelson
John R Heron
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Purdue Research Foundation
FR Mfg Corp
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Purdue Research Foundation
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Priority to US480842A priority Critical patent/US3871824A/en
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Priority to JP2031575A priority patent/JPS5523068B2/ja
Publication of US3871824A publication Critical patent/US3871824A/en
Application granted granted Critical
Priority to ZA00752756A priority patent/ZA752756B/xx
Priority to AU80665/75A priority patent/AU498653B2/en
Priority to IT7549497A priority patent/IT1035656B/it
Priority to FR7516655A priority patent/FR2275156A1/fr
Priority to CA228,009A priority patent/CA1029536A/en
Priority to ES438703A priority patent/ES438703A1/es
Priority to BR4963/75D priority patent/BR7503859A/pt
Assigned to FMI ACQUISITION ORP. A DE CORP reassignment FMI ACQUISITION ORP. A DE CORP ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: FRANRICA MFG., INC.
Assigned to FR MFG. CORPORATION reassignment FR MFG. CORPORATION CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: FMI ACQUISITION CORP.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances

Definitions

  • ABSTRACT A method of connecting an aseptic fitting to an opening in the top of an aseptic bulk storage tank, whereby asepsis of the tank interior is maintained.
  • the method includes the step of filling the tank interior with liquid chemical sterilant sufficiently to overflow sterilant from the tank into a liquid-retaining enclosure which surrounds the opening in the tank top. This is effective to both sterilize the interior of the tank, and provide a liquid sterilant bath in contact with the openings.
  • the method further includes immersing-the fitting in the sterilant bath to sterilize it, and while immersed and in a sterile condition, connecting it to the tank opening,
  • the fitting includes an internal cavity
  • sterilization of the fitting prior to its immersion in the bath and connection to the tank can be done by capping the fitting to seal the cavity and autoclaving it.
  • the capped fitting which has been sterilized remote from the sterilant bath is then immersed in the sterilant bath and while immersed connected to the tank opening, to thereby establish communication between the cavity of the fitting and the tank interior while both the cavity and the interior are maintained in a sterile condition,
  • substitution of oxygen-containing air within the unused portion of the tank is accomplished by connecting a pressurized source of nitrogen to theinterior of the tank at or near its top, i.e., above the maximum bulk material level to which the tank is filled. Since it is not practical to provide an aseptic source of pressurized nitrogen, it is necessary to provide filtering means, typically incorporating a nitrogen-pervious micro-biological filtering element, between the nonaseptic nitrogen source and the aseptic storage tank.
  • the nitrogen-pervious filter element incorporated within the filter assembly has a predetermined filtering capacity which, once depleted through use, renders it no longer satisfactory as a filter element. It therefore becomes necessary to periodically replace the filter element.
  • Such replacement typically is accomplished when the tank is empty by disconnecting the filter assembly from the tank, replacing the spent filter element with a fresh one, and thereafter reconnecting the filter assembly with its new filter element to the tank.
  • the filter assembly must be sterilized when connected to the tank; otherwise it would constitute a potential source of contamination for bulk material subsequently stored in the tank.
  • manhole or opening when the tank is empty, access to the tank interior by maintenance personnel for routine cleaning, repair, and the like.
  • the manhole or opening must be sealed with a suitable manhole cover or the like after the tank interior has been accessedby maintenance personnel and the sealing of the mahole with the cover must be accomplished in amanner such that the man hole opening once sealed does not represent a source of contaminating micro-organisms and the like.
  • the fitting e.'g., the viewing window, rupture disc, manhole cover, filter assembly, or the like is connected as desired in alignment with the tank opening, thereby isolating the aseptic interior environment with the sterile fitting under conditions which maintain asepsis of the tank interior.
  • the tank interior is sterilized and the tank opening to which the fitting is to be connected bathed in chemical sterilant by filling the tank with liquid chemical sterilant sufficiently to overflow the sterilant into the enclosure surrounding the opening.
  • the sterilant bath in the enclosure surrounding the opening to which the fitting is now connected is drained as is the sterilant located within the tank interior. This leaves the sterile tank with its interconnected sterile fitting ready for storage of bulk material such as food and the like.
  • sterilization of the fitting and interconnection thereof toan opening in the tank while maintaining the aseptic condition of the tank interior is accomplished by sterilizing the fitting remote from the sterilant-flooded enclosure bathing the tank opening and, while in sterilecondi tion, capping a port in the sterilized fitting which communicates with the cavity thereof.
  • the capped and sterilized fitting is then immersed in the sterilant bath present in the flooded enclosure surrounding the tank opening to which the fitting is to be connected, and while so immersed the cap removed and the uncapped fitting connected to the tank opening.
  • the sterile interior ofa fitting such as a filter assembly, establishes communication with the sterile tank interior without destroying asepsis of either the filter or the tank.
  • the cavitycontaining fitting such as a filter assembly
  • the cavity-containing fitting is sterilized remote from the flooded enclosure surrounding the tank opening to which the filter is to be connected by autoclaving the filter assembly which, before the autoclaving operation, is capped to seal the cavity.
  • the cavity-containing fitting instead of being sterilized remote from the sterilant-flooded enclosure surrounding the opening in the tank to which the fitting is to be connected, could be sterilized by immersing it in the sterilant-flooded enclosure in an uncapped condition such that the fitting, including its cavity, is sterilized as a consequence of the immersion in the sterilant bath of the flooded enclosure, whereafter the sterile fitting, while still immersed, is connected to the opening in the tank.
  • FIG. 1 is a front elevational view, partially exploded, of an aseptic storage tank, showing the associated fittings which, after sterilization, are connected to suitable openings in the aseptic tank in accordance with the method of this invention whereby asepsis of both the fittings and the tank interior are maintained;
  • FIG. 2 is a plan view of a portion of the top of the tank showing the fittings connected thereof, taken gen erally along line 22 of FIG. 1;
  • FIG. 3 is a cross-sectional view taken along line 3-3 of FIG. 2;
  • FIG. 3A is a cross-sectional view of the capped end of the filter assembly.
  • FIG. 4 is a cross-sectional view taken along line 44 of FIG. 2;
  • Aseptic bulk storage tanks of the type to which the fitting sterilization and interconnection method of this invention relates typically include, among other things, a large storage tank 10, e.g., 20,000 or more gallon capacity, in which previously sterilized bulk material, such as crushed tomatoes, fruit or the like, is adapted to be stored under aseptic conditions.
  • the storage tank has a cylindrical midsection 11 closed at the bottom'with a conical, or funnel-shaped, section 12 and at the top with a domed section 13, the latter section being provided with a selectively removable cover 14 which seals a manhole or access opening 15.
  • the access opening or manhole 15 in combination with the selectively removable manhole cover 14 permits maintenance personnel to enter the interior 16 of the tank for maintenance, cleaning, repair and like purposes.
  • the funnel-shaped bottom section 12 facilitates removal of stored material from the tank interior 16 by gravity action.
  • the tank 10 is also provided with an inlet/outlet pipe 17 at the lowermost portion, or apex, of the funnelshaped section 12. Bulk material passes through the inlet/outlet pipe 17 when the tank is being filled, being emptied, or a sample of stored material removed for testing.
  • an aseptic valve means 19 Interconnected between the tank inlet/outlet pipe 17 and a main bulk material conveying pipe 18 is an aseptic valve means 19.
  • the valve means 19 facilitates filling and emptying the tank 10 with bulk material, and in conjunction with other suitable aseptic plumbing connected thereto permits removal of samples of stored material from the tank for test purposes.
  • Aseptic valve suitable for use in this invention is disclosed in the copending application of Steve A. Rechtsteiner et al, entitled Aspetic Bulk Material Storage System And Improved Aseptic Valve Therefor, Ser. No. 467,460, filed May 6, 1974, the entire disclosure of which is incorporated herein by reference.
  • a filter assembly 23 connected at its upstream end 24 to a pressurized, unsterilized oxygen-free gas source 24A such as nitrogen.
  • a pressurized, unsterilized oxygen-free gas source 24A such as nitrogen.
  • the filter assembly 23 is connectable to the tank 10 foz communication with the interior 16 thereof via the opening 26 formed in the manhole cover 14 which is surrounded by a flange 27.
  • Located within a cavity 28 in the filter assembly 23 is a tubular gas-pe'rvious microbiological filter element 29 for filtering the unsterilized nitrogen gas input to .the filter assembly 23 at its upstream end 24.
  • the tubular filter element 29 defines an elongated chamber 30 which communicates solely with the downstream end 25 of the filter assembly 23.
  • a preferred nitrogen filter assembly 23 is disclosed and claimed in the copending application of Steve A. Rechtsteiner et al, entitled Aseptic Storage System For Bulk Materials And Improved Microbiological Filter Therefor, Ser. No. 466,672, filed May 3, 1974, the entire disclosure of which is incorporated herein by reference.
  • the aseptic storage tank 10 is also typically provided with at least one viewing window assembly 31.
  • the viewing window assembly 31 is mounted to the manhole cover 14 in alignment with an opening 32 provided therein. With the viewing window assembly 31 so mounted, the opening 32 is sealed, yet the contents of the tank are visable from the exterior.
  • two viewing window assemblies 31, 31' identical in structure and aligned with openings 32 and 32 in the manhole cover 14, are associated with tank 10.
  • the viewing panels 31 and 31 may be disposed'on opposite sides of the flanged opening 27 with respect to which the filter assembly 23 is aligned.
  • the aseptic storage system also typically includes a rupture disc assembly 34.
  • the rupture disc assembly 34 is connectable in use to the manhole cover 14 in alignment with an opening 35 provided in the manhole cover.
  • the rupture disc assembly 34 includes a rupturable disc which when the assembly 34 is mounted in alignment with the opening 35 in manhole cover 14 seals the opening 35.
  • the rupture disc is ruptured, venting the interior ofthe tank to atmosphere via a pipe 36 forming part of the rupture assembly.
  • Pipe 36 protects the disc 62 against accidental rupture should an object inadvertently be dropped on the disc. Pipe 36 also protects against dirt or other foreign material from reaching the disc 62.
  • a dual purpose enclosure 37 Surrounding the manhole 15 formed in the top of the domed tank section 13 is a dual purpose enclosure 37, preferably in the form of a hollow cylinder welded to the dome along its bottom circular edge 38.
  • the enclosure 37 defines a liquid-retaining enclosed volume 39 surrounding the manhole opening 15 in the tank and the openings 26, 32, 32' and 35 in the manhole cover.
  • the tubular enclosure 37 in addition to establishing a liquid-retaining volume 39 surrounding the access opening 15 in the tank dome l3 and the openings 26, 32, 32 and 35 in the manhole cover 14, also establishes, when capped with a suitable cover 40, an enclosed chamber which can during winter months be conveniently heated if the temperatures and conditions justify it.
  • the manhole or access opening 15 in the domed top section 13 of the tank is surrounded by a rim 41 having an upper annular surface or seat 42.
  • the seat 42 cooperates with the marginal bottom surface 43 of the manhole cover periphery 44.
  • a suitable annular gasket 45 is located between the cooperating annular confronting surfaces 42 and 43 of the rim 41 and cover periphery 44, respectively, to serve as a seal there-between when the manhole cover 14 is secured to the manhole-surrounding rim 41 with suitable means such as threaded fasteners 46.
  • Fasteners pass through oversized holes formed in the periphery 44 of the manhole cover 14 and threadedly engage suitable threaded blind holes formed in the manholedefining rim 41.
  • the manhole cover 14 which is preferably circular and sufficiently larger in diameter than the manhole to the threaded fasteners 46, is provided with openings 32, 32, 26 and 35 to which is fastened in alignment therewith viewing window assemblies 31 and 31, filter assembly 23, and rupture disc assembly 34, respectively. Openings 32, 32, 26 and 35 are surrounded by rims 50, 50, flange 27 and rim 51, respectively.
  • the rims 50, 50, 51 and the flange 27 are structurally integral with the manhole cover 14.
  • the viewing window assembly 31 includes an annular disc 53 having a central aperture 54 therein. Sand-' wiched between the annular disc 53 and the rim 50 is a transparent glass plate or viewing window 55. Annular gaskets 56 and 57 disposed between the apertured disc 53 and the rim 50 on opposite sides of the transparent window 55 seal the plate or window 55 relative to the manhole cover opening 32 when the window is secured in place over the opening, by tightening threaded fasteners 58. Fasteners 58 pass through suitably located holes in the annular disc 53 and threadedly engage threaded blind holes formed in the rim 50.
  • viewing window assembly 31' is identical in structure to viewing window 31, further description of viewing window 31' is considered unnecessary. Viewing window assembly 31 is shown in elevation in FIG. 3, whereas viewing window assembly 31 is shown in vertical cross-section in FIG. 3.
  • the rupture disc assembly 34 includes upper and lower annular discs 60 and 61 between which is sandwiched a rupturable disc or membrane 62. Positioned below the rupturable membrane 62 and extending inwardly from the lower annular disc 61 are a pair of fixed blades 64 and 65. Blades 64 and 65 rupture the membrane 62 which moves inwardly against the blades when the vacuum within the tank 10 exceeds that allowed by the structural design of the tank 10. Should the pressure within the tank 10 exceed atmospheric pressure by an amount at least equal to the structural design limits of the tank, the rupture disc 62 will rupture outwardly to relieve the superatmospheric pressure within the tank.
  • An aperture disc 67 to which the inner end of the pipe 36 is connected is bolted to the rim 51 by threaded fasteners 69 passing through holes in the disc 67 and threadedly engaging blind holes in the rim 51.
  • fasteners 69 secure the disc 67 and integral pipe 36 to the rim 51 surrounding the manhole cover opening 35 with the rupture disc 62 and associated upper and lower apertured discs 60 and 61 in alignment with the opening 35.
  • Gaskets 70 and 71 located adjacent the upper and lower discs 60 and 61 are provided to enhance sealing.
  • the downstream end 25 of the filter assembly 23 is in the form of an apertured disc 72 secured to the lower end-of a pipe section 73.
  • the pipe section 73 of the downstream end 25 of the filter assembly 23 is isolated from the upstream end 24 of the filter assembly by the filter element 29 located in the cavity 28 within the filter assembly.
  • the apertured disc 72 extending from the lower end of pipe 73 seats on the upper edge of flange 27 surrounding manhole cover opening 26, whereat it is maintained by a suitable circular clamp 75 which urges the periphery of the disc 72 into contact with the upper edge of the flange.
  • a suitable annular gasket 77 is positioned between the mating surfaces of the flange 27 and the disc 72 to enhance the seal therebetween.
  • the interior16 of the tank 10 and the various fittings and the sterilant overflows through the manhole 15 into the enclosed volume 39 established by the liquidretaining tubular enclosure 37 to establish a sterilant bath 78.
  • an overflow pipe 80 communicating with the enclosed volume 39 and a drain connected is bathed in sterilant thereby sterilizing the manhole and the associated seat 42 of manhole-surrounding rim 41.
  • the manhole cover 14 and gasket 45 are preferably totally immersed in the sterilant bath 78 located in enclosed volume 39, thereby sterilizing manhole cover 14 and its associated seat 42 and gasket 45.
  • the manhole and gasket are fastened to rim 41 surrounding the manhole 15 in alignment with the manhole by tightening threaded fasteners 46, which fasteners are also sterilized by reason of being immersed in the sterilant bath 78.
  • manhole openings 32, 32', 26 and 35 are bathed in sterilant, sterilizing these openings.
  • the viewing window assemblies 31 and 31, yet unsterilized, are also completely immersed in the liquid sterilant bath 78 thereby sterilizing these assemblies.
  • the assemblies 31 and 31' With the viewing window assemblies 31 and 31' sterilized, and while still immersed in the sterilant bath 78, the assemblies 31 and 31' are secured in position in alignment with their respective manhole cover openings 32 and 32' by tightening fasteners 58 and 58'.
  • openings 32 and 32' in manhole cover 14 are now sealed with respect to the environment by the sterilized assemblies 31 and 31'.
  • the rupture disc assembly 34 and in particular the elements 61, 62, 64, 65 and the gasket 71 which will communicate with the interior 16 of the tank 10, are immersed in the liquid sterilant bath 78, thereby sterilizing them. With the rupture disc assembly 34 so sterilized, and while still immersed in the liquid sterilant bath 78, the sterile assembly is secured to the manhole cover 14 in alignment with the opening 35 by tightening threaded fastener 69. The opening 35 in the manhole cover 14 is now sealed with respect to the environment by the sterilized rupture disc assembly 34.
  • the filter assembly 23 in a preferred form of the invention, is provided with a cap 85 secured to downstream end of disc 25 by a suitable circular clamp 75 to seal the pipe 73 which communicates with the interior cavity 30 of the filter element 29 located within filter assembly 23.
  • the capped downstream end of the filter assembly 23 is immersed in the sterilant bath 78. While the capped downstream end 25 of the filter assembly is so immersed, a circular clamp 75, which secures thecap to disc 72, is loosened and the cap 85 removed exposing the sterile filter cavity 30 of the filter assembly 23 to the interior of the tank 10 via manhole cover opening 26. With the uncapped downstream end 25 of the filter assembly still immersed in liquid sterilant bath 78, the disc 72 at the downstream end of the filter assembly is secured to the upper edge of the flange 27 with the gasket 77 sandwiched therebetween by means of the circular clamp 75.
  • the sterile interior cavity 30 of filter element 29 of assembly 23 now communicates with the sterile interior 16 of the tank 10. Stated differently, the interior 16 of the tank 10, and in particular the flanged opening 26 in the manhole cover 14, is isolated from the environment by means of the microbiological filter element 29, the interior 30 of which has been sterilized and remains sterilized throughout the process of interconnecting the filter assembly 23 to the manhole cover 14.
  • the unsterilized filter assembly 23 could be immersed in the liquid sterilant bath 78 and the filter assembly, including cavity 30 of filter element 29, sterilized thereby. Assuming sterilization was accomplished in bath 78, and while still immersed in the bath 78, the uncapped and now sterile filter assembly 23 could then have its downstream end 25 secured to the flanged opening 26 with clamp 75, in the manner previously described, 'to isolate manhole cover opening 26 from the environment via the sterilized filter element 29.
  • the liquid sterilant in the tank 10 is drained via the inlet/outlet port 17, valve 19 and main conduit 18, and nitrogen added via filter 23 to the tank volume previously occupied by the sterilant. Substitution of the drained sterilant by nitrogen prevents placement of the tank interior under a vacuum condition.
  • liquid sterilant bath 78 in the enclosed volume 39 defined by the tubular enclosure 37 is drained via a drain pipe 90 which communicates with the bottom of the enclosed volume 39 and connects to the overflow pipe 80 at end 81 via a suitable flow valve 91 connected between the pipe 90 and the downstream end 81 of the overflow pipe 80.
  • the aseptic tank with its associated manhole cover and assemblies 31, 31', 23 and 34 secured thereto is now ready to be filled with sterilized bulk material via the main conduit 18, valve 19, and inlet/outlet pipe 17.
  • the nitrogen in the tank which has been input thereto from a suitable source 24A connected to upstream filter end 24, via the filter assembly 23, is displaced by thhe incoming food by reverse nitrogen flow back through the filter assembly.
  • a preferred liquid chemical sterilant useful in the process of this invention is disclosed in US. Pat. No. 3,714,956, Philip E. Nelson, issued Feb. 6, 1973. Of course, other liquid chemical sterilants can also be used.
  • the tank interior and fitting sterilization and interconnecting process of this invention can be used to sterilize and aseptically mount fittings of other types to a tank whose interior thereof it is desired to maintain under aseptic conditions for subsequent storage of sterilized bulk material.
  • a method of aseptically connecting a fitting to an opening in a bulk storage tank, which opening is surrounded by a liquid-retaining enclosure, whereby the fitting communicates with the tank interior comprising the steps of:
  • filling step and tank interior sterilizing step includes the step of filling the tank interior with liquid chemical sterilant sufficiently to overflow sterilant from the tank into the enclosure.
  • step of sealing and sterilizing the cavity of the fitting includes the step of sealing a port in the fitting which connects to the cavity to thereby seal the cavity and sterilizing the cavity remote from the sterilant bath, and wherein the unsealing and connecting step includes, while the fitting is immersed in the sterilant bath, the step of uncapping the port and connecting-the uncapped port to the tank opening.
  • step of sterilizing the fitting cavity includes autoclaving the fitting.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Storage Of Fruits Or Vegetables (AREA)
  • Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
US480842A 1974-06-19 1974-06-19 Method of aseptically connecting a fitting to an aseptic storage tank Expired - Lifetime US3871824A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US480842A US3871824A (en) 1974-06-19 1974-06-19 Method of aseptically connecting a fitting to an aseptic storage tank
JP2031575A JPS5523068B2 (oth) 1974-06-19 1975-02-18
ZA00752756A ZA752756B (en) 1974-06-19 1975-04-29 Method of aseptically connecting a fitting to an aseptic storage tank
AU80665/75A AU498653B2 (en) 1974-06-19 1975-04-30 Aseptically connecting a fitting toa tank
IT7549497A IT1035656B (it) 1974-06-19 1975-05-07 Procedimento per collegare in modo asettico elementi accesori sudi un serbatoio di immagazzinamento asettico
FR7516655A FR2275156A1 (fr) 1974-06-19 1975-05-28 Procede de raccordement aseptique d'un accessoire a un reservoir de stockage aseptique
CA228,009A CA1029536A (en) 1974-06-19 1975-05-29 Method of aseptically connecting a fitting to an a septic storage tank
BR4963/75D BR7503859A (pt) 1974-06-19 1975-06-19 Processo de ligar assepticamente uma adaptacao a uma abertura num tanque de armazenagem em granel
ES438703A ES438703A1 (es) 1974-06-19 1975-06-19 Procedimiento para conectar asepticamente un accesorio a unaabertura de un deposito de almacenamiento a granel.

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Application Number Priority Date Filing Date Title
US480842A US3871824A (en) 1974-06-19 1974-06-19 Method of aseptically connecting a fitting to an aseptic storage tank

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US3871824A true US3871824A (en) 1975-03-18

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US480842A Expired - Lifetime US3871824A (en) 1974-06-19 1974-06-19 Method of aseptically connecting a fitting to an aseptic storage tank

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US (1) US3871824A (oth)
JP (1) JPS5523068B2 (oth)
AU (1) AU498653B2 (oth)
BR (1) BR7503859A (oth)
CA (1) CA1029536A (oth)
ES (1) ES438703A1 (oth)
FR (1) FR2275156A1 (oth)
IT (1) IT1035656B (oth)
ZA (1) ZA752756B (oth)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347877A (en) * 1980-04-21 1982-09-07 Jakob Hoiss Apparatus for aseptically discharging flowable substances
EP0448122A3 (en) * 1990-03-23 1993-01-20 Stephan Biermaier Plant for the disinfection of door handles, especially door handles of apparatus for cleaning and desinfection
WO1999023016A1 (en) 1997-10-31 1999-05-14 Enerfab, Inc. Methods of aseptically transporting bulk quantities of sterile products
WO1999061074A1 (en) * 1998-05-28 1999-12-02 Peeples Industries, Inc. Slurry treatment and shipping method
WO2003073873A1 (en) * 2002-03-04 2003-09-12 Tetra Laval Holdings & Finance Sa A method and an apparatus for aseptically supplying additives to a tank
US7101507B1 (en) 1998-05-28 2006-09-05 Adler Paul E Slurry treatment and shipping method
US20130146092A1 (en) * 2010-06-15 2013-06-13 Conagra Foods Food Ingredients Company, Inc. Transport scheduling for low microbial bulk products
DE202012104683U1 (de) * 2012-12-03 2014-03-05 Wild Dairy Ingredients Gmbh Schutzvorrichtung für einen innenliegenden Filter
WO2016204614A1 (en) 2015-06-19 2016-12-22 Milkways Holding B.V. Method to transport liquid milk
WO2023239234A1 (en) 2022-06-07 2023-12-14 Milkways Holding B.V. Methods for treatment of milk and cream
WO2025105954A1 (en) 2023-11-13 2025-05-22 Milkways Holding B.V. Methods for treatment and storage of whey products

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US265609A (en) * 1882-10-10 johnston
US3050791A (en) * 1958-03-31 1962-08-28 Univ Notre Dame Du Lac Sealed door for a compartment having a controlled environment
US3105335A (en) * 1960-12-30 1963-10-01 Fmc Corp Apparatus for aseptic canning of food products
US3376689A (en) * 1962-04-04 1968-04-09 Continental Can Co Packaging apparatus and method of utilizing the same
US3501213A (en) * 1967-05-19 1970-03-17 Snyder Mfg Co Inc Isolator assembly and method of entering same
US3536370A (en) * 1966-12-16 1970-10-27 Nat Res Dev Controlled environment apparatus
US3714956A (en) * 1972-05-18 1973-02-06 Purdue Research Foundation Aseptic storage and valving system

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US265609A (en) * 1882-10-10 johnston
US3050791A (en) * 1958-03-31 1962-08-28 Univ Notre Dame Du Lac Sealed door for a compartment having a controlled environment
US3105335A (en) * 1960-12-30 1963-10-01 Fmc Corp Apparatus for aseptic canning of food products
US3376689A (en) * 1962-04-04 1968-04-09 Continental Can Co Packaging apparatus and method of utilizing the same
US3536370A (en) * 1966-12-16 1970-10-27 Nat Res Dev Controlled environment apparatus
US3501213A (en) * 1967-05-19 1970-03-17 Snyder Mfg Co Inc Isolator assembly and method of entering same
US3714956A (en) * 1972-05-18 1973-02-06 Purdue Research Foundation Aseptic storage and valving system

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347877A (en) * 1980-04-21 1982-09-07 Jakob Hoiss Apparatus for aseptically discharging flowable substances
EP0448122A3 (en) * 1990-03-23 1993-01-20 Stephan Biermaier Plant for the disinfection of door handles, especially door handles of apparatus for cleaning and desinfection
US5314668A (en) * 1990-03-23 1994-05-24 Stephan Biermaier Method of automatically disinfecting door handles of disinfecting units
US6277328B1 (en) 1997-10-31 2001-08-21 Enerfab, Inc. Methods of aseptically transporting bulk quantities of sterile products
WO1999023016A1 (en) 1997-10-31 1999-05-14 Enerfab, Inc. Methods of aseptically transporting bulk quantities of sterile products
US6030580A (en) * 1997-10-31 2000-02-29 Enerfab, Inc. Method of aseptically transporting bulk quantities of sterile products
US7101507B1 (en) 1998-05-28 2006-09-05 Adler Paul E Slurry treatment and shipping method
WO1999061074A1 (en) * 1998-05-28 1999-12-02 Peeples Industries, Inc. Slurry treatment and shipping method
WO2003073873A1 (en) * 2002-03-04 2003-09-12 Tetra Laval Holdings & Finance Sa A method and an apparatus for aseptically supplying additives to a tank
US20130146092A1 (en) * 2010-06-15 2013-06-13 Conagra Foods Food Ingredients Company, Inc. Transport scheduling for low microbial bulk products
US10213811B2 (en) * 2010-06-15 2019-02-26 Ardent Mills, Llc Transport scheduling for low microbial bulk products
US20190134678A1 (en) * 2010-06-15 2019-05-09 Ardent Mills, Llc Transport scheduling for low microbial bulk products
US11027314B2 (en) * 2010-06-15 2021-06-08 Ardent Mills, Llc Transport scheduling for low microbial bulk products
DE202012104683U1 (de) * 2012-12-03 2014-03-05 Wild Dairy Ingredients Gmbh Schutzvorrichtung für einen innenliegenden Filter
WO2016204614A1 (en) 2015-06-19 2016-12-22 Milkways Holding B.V. Method to transport liquid milk
WO2023239234A1 (en) 2022-06-07 2023-12-14 Milkways Holding B.V. Methods for treatment of milk and cream
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IT1035656B (it) 1979-10-20
ES438703A1 (es) 1977-02-16
AU498653B2 (en) 1979-03-22
AU8066575A (en) 1976-11-04
JPS5523068B2 (oth) 1980-06-20
JPS50160448A (oth) 1975-12-25
FR2275156B1 (oth) 1981-08-07
ZA752756B (en) 1976-04-28
FR2275156A1 (fr) 1976-01-16
CA1029536A (en) 1978-04-18
BR7503859A (pt) 1976-07-06

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