US3837341A - Medicament inhalation device with audible indicating means - Google Patents

Medicament inhalation device with audible indicating means Download PDF

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Publication number
US3837341A
US3837341A US00390739A US39073973A US3837341A US 3837341 A US3837341 A US 3837341A US 00390739 A US00390739 A US 00390739A US 39073973 A US39073973 A US 39073973A US 3837341 A US3837341 A US 3837341A
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United States
Prior art keywords
propeller
housing
air
audible
medicament
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Expired - Lifetime
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US00390739A
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English (en)
Inventor
J Bell
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Fisons Ltd
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Fisons Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/087—Measuring breath flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033—Details of the piercing or cutting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/43—General characteristics of the apparatus making noise when used correctly

Definitions

  • devices for the inhalation of medicaments in finely divided form which comprise a hollow elongate housing having at both ends thereof an air passageway and having one end adapted for insertion into the mouth; and a propeller-like member rotatably mounted in the housing on a rigid shaft mounted in the housing and coaxial with the longitudinal axis of the housing, said propeller-like device having on the part thereof furthest from the end of the housing adapted for insertion into the mouth, mounting means adapted to receive a container, such as a gelatine or like capsule for the medicament to be inhaled and said propeller-like device being so mounted on said shaft that the passage of a stream of air through the device causes not only rotational movement of the propeller-like device, but also a vibrational movement of the propeller-like device.
  • the device may be provided with means for piercing the container in situ in the device.
  • a number of other devices are also known and used for the inhalation of powder and other medicaments, and a number of these devices also depend upon the inspirational power of the user to actuate them or to disperse the medicament into the air stream to be inhaled (see for example Belgium Pat. No. 781,102 in which there is described a device comprising a chamber in which a perforated capsule containing a powdered medicament can be freely tumbled by tangential jets of incoming air and the air into which the medicament is dispersed passes from the chamber to the inhalers mouth). Indeed in certain devices and using certain medicament formulations it is desirable that a given minimum air speed be achieved (or maximum air speed avoided) to produce a satisfactory operation of the device (e.g. dispersion of the medicament).
  • inhalation devices are often used by people who have reduced inspiratory power, e.g. those suffering from respiratory diseases, and children. Therefore when people having reduced inspiratory power use inhalation devices it is not always possible to determine whether the flow of air through the device has been sufficient to actuate the device satisfactorily. Thus some such users may be receiving variable or insufficient medication.
  • an inhalation device which is adapted to administer a medicament to the lungs and to be activated by the inspiration of the user, in combination with means adapted to indicate audibly when a desired air flow through the device is achieved.
  • the inhalation device may be any of those conventionally used, but is preferably a device which is designed to administer a powdered medicament, e.g. the device described in either of British Patent Specifications Nos. 1,122,284 or 1,182,779.
  • the means adapted to indicate audibly when the desired air flow through the device (indicating means) is achieved may be, for example a whistle (Robert C Chanaud, Scientific American, January 1970 pages 40 to 46), such as an aerodynamic whistle.
  • Aerodynamic whistles may be roughly classified into three groups (a) hydrodynamic whistles, (b) acoustic whistles and (c) reflected whistles. Many conventional whistles combine characteristics of more than one of these groups.
  • hydrodynamic whistles there may be mentioned aeolian tone generators (e.g. a thin cylinder placed in an air stream), and vortex whistles in which latter a swirling flow of air encounters the open end of a pipe.
  • Acoustic whistles include those generated by the impingement of a jet of air on an edge, a ring or a hole to produce respectively an edge tone, a ring tone or a hole tone.
  • Acoustic whistles comprise those in which a resonant or reflecting structure is involved, as in a flute or organ pipe.
  • an acoustic whistle similar to the type used by English policemen (simple flute type) or by American policement (comprising a solid object, e.g. a pea or the like, loosely trapped in a sounding chamber) may be used.
  • a reed whistle may also be used.
  • Other indicating means include a propeller like device in which the blades are designed to emit a noise on reaching a given speed; or may be a siren. Any of the above indicating means may be used in conjunction with an air by-pass, the air by-pass being of such a size that the indicating means will only commence to sound or will change the sound at the desired air-flow rate.
  • the indicating means may be such that the sound emitted changes at more than one rate of air flow through the device.
  • the indicating means may be adapted to indicate a minimum and a maximum desirable air flow, or a minimum and a desirable average air flow.
  • the change of sound should be such as to be easily noticed and may be, for example a change of volume, pitch, quality, frequency, tone etc. We prefer the change to be from not sounding to sounding, orvice versa.
  • the indicating means should be actuatable when the user inhales through the device, but not when the user exhales through the device.
  • the indicating means may be made integrally with the inhalation device, or may be made separately, the two parts being made in such a way that they may be fitted together, for example by a screw thread, a bayonet fit or a simple push fit.
  • the indicating means may be positioned downstream of the point at which medicament is dispersed into the air stream, but, in order to avoid contamination of the indicating means, it is preferably positioned upstream of this point, e.g. at the point of entry of the air stream into the device.
  • the device according to the invention is particularly useful when it incorporates an inhalation device as described in British Patent Specification No. 1,182,779 and is used to disperse a powder composition as described in British Patent Specification No. 1,242,211, i.e., a mixture of a solid finely divided medicament having a particle size in the range 0.01 to 10 microns and a solid pharmaceutically acceptable water soluble car- BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a longitudinal section through a device according to the invention, which incorporates a device according to British Patent Specification No. 1,182,779.
  • an inhalation degice comprises a housing of approximately circular cross-section comprising two engaging housing members 6 and 7, housing member 7 being adapted for insertion into the mouth and having passageways 8 therein to permit the passage of air.
  • shaft 2 mounted rigidly in and co-axially with housing member 7 is shaft 2 upon which is loosely and rotatebly mounted by means of bearing 17 propeller-like member 3 having blades 4.
  • Propeller-like member 3 has a cup shaped member adapted to receive and hold a capsule or container 5 of finely powdered medicament.
  • Shaft 2 engages in bearing 17 on propeller-like member 3.
  • the diameter at the inner end of bearing 17 is about 3.75 percent greater than the diameter of shaft 2 and the diameter at the outer end of bearing 17 is equal to the diameter of shaft 2 plus about 2.5 percent of the total length of the bearing, which is about 7 times the diameter of shaft 2.
  • Housing member 6 has in its end wall air passages 9 to permit the passage of air.
  • Housing 6 is firmly attached to body member 1, for example it may be glued thereto, and mouthpiece 7 is removably attached to body member 1 by means of co-operating screw threads 34 in body member 1 and mouthpiece 7.
  • Housing member 6 has a central projection 25 with a slot in which is mounted resilient piercing member 26.
  • Piercing member 26 is retained in the slot in projection 25 by means of retaining block 27 which is, in turn, held in position in the slot by means of pin 28.
  • the arms of resilient piercing member 26 are located in slots in the walls of body member 1 and in guideways formed by guide members (not shown) extending inwardly from the inner surface of body member 1.
  • tubular member 30 Slidably mounted on body member 1 is tubular member 30 having cam-like projections 31 extending inwardly through the slots in body member 1.
  • cam-like projections 31 engage with the arms of resilient piercing member 26 to force them inwards and thus to force piercing projections 32 into contact with the surface of capsule 5 and finally to pierce capsule 5, the depth of piercing being limited by stops 33.
  • the resilience of member 26 causes the arms to spring apart and to resume the position shown in FIG. 1.
  • a double orifice whistle 41 comprising a first orifice plate 35 having central orifice 36, a second orifice plate 37 having a central orifice 38, a primary sound chamber 39 and a secondary sound chamber 40.
  • the device is first loaded with capsule 5 by unscrewing mouthpiece 7 from body member 1 and placing capsule 5 in the cup-like depression in propeller-like device 3. Mouthpiece 7 is then screwed back into body member 1, and capsule 5 pierced by sliding member 30 downwards from the position shown in FIG. 1 and then back to the position shown in FIG. 1.
  • An inhalation device for administering and dispensing a medicament to the lungs comprising a movable means activated by the air inspiration of the user, in combination with a means for indicating the operation of the device comprising an audible means operated by said inspired air when a desired air flow through the device is achieved.
  • a device further comprising a hollow elongate housing having at both ends thereof an air passageway and having one end adapted for insertion into the mouth; and said movable means comprises a propeller-like member rotatably mounted in the housing on a rigid shaft mounted in the housing and coaxial with the longitudinal axis of the housing, said propeller-like device having on the part thereof furthest from the end of the housing adapted for insertion into the mouth, mounting means adapted to receive a container, such as a gelatine or like capsule for the medicament to be inhaled and said propeller-like device being so mounted on said shaft that the passage of a stream of air through the device causes not only rotational movement of the propeller-like device, but also a vibrational movement of the propeller-like device.
  • a container such as a gelatine or like capsule for the medicament to be inhaled
  • a device wherein said audible means is an acoustic whistle.
  • a device wherein said audible r neansis a siren.
  • said acoustic whistle is an edge-type tone generator.
  • a device wherein said acoustic whistle is a hole-type tone generator.
  • said audible means is a double orifice whistle.
  • said audible means includes means operable to produce a change from not sounding to sounding.
  • a device according to claim 1, wherein said audible means is operable when the user inhales through the device, but not when the user exhales through the device.
  • said audible means is a propeller-like device in which the blades are designed to emit a noise when reaching a given speed.
  • a device wherein said acoustic whistle is a ring-type tone generator.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Physiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Percussion Or Vibration Massage (AREA)
US00390739A 1972-08-23 1973-08-23 Medicament inhalation device with audible indicating means Expired - Lifetime US3837341A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3917372A GB1392945A (en) 1972-08-23 1972-08-23 Inhalation device

Publications (1)

Publication Number Publication Date
US3837341A true US3837341A (en) 1974-09-24

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US00390739A Expired - Lifetime US3837341A (en) 1972-08-23 1973-08-23 Medicament inhalation device with audible indicating means

Country Status (16)

Country Link
US (1) US3837341A (fr)
JP (1) JPS572342B2 (fr)
AR (1) AR202192A1 (fr)
BE (1) BE803805A (fr)
BR (1) BR7306474D0 (fr)
CH (1) CH576261A5 (fr)
DE (1) DE2341346C2 (fr)
ES (1) ES418117A1 (fr)
FI (1) FI59338C (fr)
FR (1) FR2196818B1 (fr)
GB (1) GB1392945A (fr)
IE (1) IE38181B1 (fr)
IL (1) IL42991A (fr)
IT (1) IT1006603B (fr)
NL (1) NL7311443A (fr)
ZA (1) ZA735562B (fr)

Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054134A (en) * 1975-09-15 1977-10-18 Kritzer Richard W Respirators
US4291688A (en) * 1979-01-11 1981-09-29 Schering Corp. Inhalation device
US4811731A (en) * 1985-07-30 1989-03-14 Glaxo Group Limited Devices for administering medicaments to patients
US4889114A (en) * 1983-12-17 1989-12-26 Boehringer Ingelheim Kg Powdered pharmaceutical inhaler
US5152284A (en) * 1989-02-23 1992-10-06 Phidea S.P.A. Disposable inhaler with pre-pierced capsule
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5239991A (en) * 1989-06-21 1993-08-31 Fisons Plc Disposable powder medicament inhalation device with peel-off cover
US5372128A (en) * 1993-04-14 1994-12-13 Habley Medical Technology Corporation Fluidizing powder inhaler
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5505196A (en) * 1993-11-30 1996-04-09 Bayer Aktiengesellschaft Device for inhalation
US5619985A (en) * 1994-08-08 1997-04-15 Unisia Jecs Corporation Inhaler type medicine administering device
US5724959A (en) * 1990-10-02 1998-03-10 Aea Technology Plc Powder inhaler with specific orifice and baffle arrangement
FR2763507A1 (fr) * 1997-05-23 1998-11-27 Glaxo Wellcome Lab Inhalateur
US6182655B1 (en) * 1995-12-07 2001-02-06 Jago Research Ag Inhaler for multiple dosed administration of a pharmacological dry powder
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
WO2001000263A3 (fr) * 1999-06-30 2001-05-31 Inhale Therapeutic Syst Systemes et procedes de projection par aerosols de formulations pharmaceutiques
US6341605B1 (en) * 1998-02-05 2002-01-29 Unisia Jecs Corporation Inhalant medicator
US20020168322A1 (en) * 1998-10-09 2002-11-14 Andrew Clark Flow resistance modulated aerosolized active agent delivery
US20030094173A1 (en) * 2001-11-14 2003-05-22 Inhale Therapeutic Systems, Inc. Aerosolization device with improved endpiece connection
US20030131847A1 (en) * 2002-01-16 2003-07-17 Fabrizio Niccolai Device usable in the treatment of affections of the airways
US6655379B2 (en) 1998-03-16 2003-12-02 Nektar Therapeutics Aerosolized active agent delivery
US20040000309A1 (en) * 2002-06-18 2004-01-01 William Alston Flow regulator for aerosol drug delivery and methods
US6732732B2 (en) 2001-04-16 2004-05-11 Advanced Inhalation Research, Inc. Inhalation device and method
US7032593B2 (en) 2000-08-14 2006-04-25 Advanced Inhalation Research, Inc. Inhalation device and method
US7131441B1 (en) 1995-12-07 2006-11-07 Skyepharma Ag Inhaler for multiple dosed administration of a pharmacological dry powder
US20090025721A1 (en) * 2007-06-12 2009-01-29 Alkermes, Inc. Powder inhaler devices
US20090095294A1 (en) * 2006-03-03 2009-04-16 Smyth Hugh C Dry powder inhaler with aeroelastic dispersion mechanism
US20090194105A1 (en) * 2006-04-13 2009-08-06 Jens Besseler Inhaler
US20120318261A1 (en) * 2011-06-17 2012-12-20 Nostrum Technology Llc Valved Holding Chamber With Whistle for the Administration of Inhalable Drugs
US20130068221A1 (en) * 2010-04-22 2013-03-21 Omar Mian Gas flow indicator
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
US20130276783A1 (en) * 2010-12-17 2013-10-24 Qingtang Chen Filtering powder medicament inhaler and application
US8869794B1 (en) * 2003-04-09 2014-10-28 Novartis Pharma Ag Aerosolization apparatus with capsule puncturing member
US20150314086A1 (en) * 2012-02-21 2015-11-05 Respira Therapeutics, Inc. Powder inhaler, system and methods
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
EP3138601A1 (fr) * 2015-09-04 2017-03-08 Victor Esteve Inhalateur de poudre sèche
WO2018115915A1 (fr) * 2016-12-20 2018-06-28 Emphasys Importadora Exportadora E Distribuidora Ltda. Inhalateur de poudre sèche
WO2018220021A1 (fr) * 2017-05-30 2018-12-06 Clement Clarke International Ltd Dispositif avec indicateur de débit
US10441733B2 (en) 2012-06-25 2019-10-15 Respira Therapeutics, Inc. Powder dispersion devices and methods
US10525216B2 (en) 2012-02-21 2020-01-07 Respira Therapeutics, Inc. Powder dispersion methods and devices
US11076774B2 (en) * 2016-02-15 2021-08-03 Clement Clarke International Ltd. Device with flow rate indicator
US20220305222A1 (en) * 2019-06-24 2022-09-29 De Motu Cordis Pty Ltd Automatic dispenser for respiratory delivery device and method
US20220379052A1 (en) * 2019-06-24 2022-12-01 De Motu Cordis Pty Ltd Automatic dispenser for respiratory delivery device
US11577033B2 (en) 2018-06-05 2023-02-14 Medline Industries, Lp Valved spacer for inhalation device

Families Citing this family (10)

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EP0013534A1 (fr) * 1979-01-11 1980-07-23 Technobiotic Ltd. Dispositif inhalateur
DE3040641A1 (de) * 1980-10-29 1982-05-27 C.H. Boehringer Sohn, 6507 Ingelheim Mundrohr fuer dosieraerosol-geraete
JPS5925035U (ja) * 1982-08-10 1984-02-16 鹿島建設株式会社 空調装置
FI863841A (fi) * 1986-09-23 1988-03-24 Etelae Haemeen Keuhkovammayhdi Stroemningsindikator foer respiratoranordningar.
GB9104201D0 (en) * 1991-02-28 1991-04-17 Kraemer Richard Medical device
GB2299512A (en) * 1995-04-06 1996-10-09 Ian James Sharp Inhaler
TW533865U (en) 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
JP3950738B2 (ja) * 2002-05-14 2007-08-01 株式会社 バイオアクティス 鼻腔用粉状薬剤施薬装置
GB201107103D0 (en) * 2011-04-27 2011-06-08 Clement Clarke Int Ltd Improvements in drug delivery inhaler devices
US9427534B2 (en) 2012-07-05 2016-08-30 Clement Clarke International Ltd. Drug delivery inhaler devices

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US3518992A (en) * 1966-09-17 1970-07-07 Fisons Pharmaceuticals Ltd Oral inhaler with spring biased,cam driven piercing device
US3635219A (en) * 1968-06-07 1972-01-18 Fisons Pharmaceuticals Ltd Inhalation device

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US2641254A (en) * 1948-10-18 1953-06-09 Frederick M Turnbull Applicator
GB1122284A (en) * 1965-03-19 1968-08-07 Fisons Pharmaceuticals Ltd Inhalation device

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US701613A (en) * 1901-06-19 1902-06-03 Johannes Hermann Raecke Mouthpiece for cigars or cigarettes.
US3518992A (en) * 1966-09-17 1970-07-07 Fisons Pharmaceuticals Ltd Oral inhaler with spring biased,cam driven piercing device
US3635219A (en) * 1968-06-07 1972-01-18 Fisons Pharmaceuticals Ltd Inhalation device

Cited By (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054134A (en) * 1975-09-15 1977-10-18 Kritzer Richard W Respirators
US4291688A (en) * 1979-01-11 1981-09-29 Schering Corp. Inhalation device
US4889114A (en) * 1983-12-17 1989-12-26 Boehringer Ingelheim Kg Powdered pharmaceutical inhaler
US4811731A (en) * 1985-07-30 1989-03-14 Glaxo Group Limited Devices for administering medicaments to patients
US5152284A (en) * 1989-02-23 1992-10-06 Phidea S.P.A. Disposable inhaler with pre-pierced capsule
US5239991A (en) * 1989-06-21 1993-08-31 Fisons Plc Disposable powder medicament inhalation device with peel-off cover
US5724959A (en) * 1990-10-02 1998-03-10 Aea Technology Plc Powder inhaler with specific orifice and baffle arrangement
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5372128A (en) * 1993-04-14 1994-12-13 Habley Medical Technology Corporation Fluidizing powder inhaler
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5505196A (en) * 1993-11-30 1996-04-09 Bayer Aktiengesellschaft Device for inhalation
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US5619985A (en) * 1994-08-08 1997-04-15 Unisia Jecs Corporation Inhaler type medicine administering device
US7131441B1 (en) 1995-12-07 2006-11-07 Skyepharma Ag Inhaler for multiple dosed administration of a pharmacological dry powder
US6182655B1 (en) * 1995-12-07 2001-02-06 Jago Research Ag Inhaler for multiple dosed administration of a pharmacological dry powder
USD469527S1 (en) 1995-12-07 2003-01-28 Jago Research Ag Pharmacological inhaler
FR2763507A1 (fr) * 1997-05-23 1998-11-27 Glaxo Wellcome Lab Inhalateur
US6341605B1 (en) * 1998-02-05 2002-01-29 Unisia Jecs Corporation Inhalant medicator
US6655379B2 (en) 1998-03-16 2003-12-02 Nektar Therapeutics Aerosolized active agent delivery
US20050090798A1 (en) * 1998-03-16 2005-04-28 Andrew Clark Aerosolized active agent delivery
US20020168322A1 (en) * 1998-10-09 2002-11-14 Andrew Clark Flow resistance modulated aerosolized active agent delivery
US8408200B2 (en) 1998-10-09 2013-04-02 Novartis Ag Flow resistance modulated aerosolized active agent delivery
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
WO2001000263A3 (fr) * 1999-06-30 2001-05-31 Inhale Therapeutic Syst Systemes et procedes de projection par aerosols de formulations pharmaceutiques
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
AP1611A (en) * 1999-06-30 2006-05-17 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations.
US7032593B2 (en) 2000-08-14 2006-04-25 Advanced Inhalation Research, Inc. Inhalation device and method
US20060283448A1 (en) * 2001-04-16 2006-12-21 Advanced Inhalation Research, Inc. Inhalation device and method
US20040216738A1 (en) * 2001-04-16 2004-11-04 Advanced Inhalation Research, Inc. Inhalation device and method
US20040154619A1 (en) * 2001-04-16 2004-08-12 Advanced Inhalation Research, Inc. Inhalation device and method
US6732732B2 (en) 2001-04-16 2004-05-11 Advanced Inhalation Research, Inc. Inhalation device and method
US7146978B2 (en) 2001-04-16 2006-12-12 Advanced Inhalation Research, Inc. Inhalation device and method
US7278425B2 (en) 2001-04-16 2007-10-09 Alkermes, Inc. Inhalation device and method
US20040154618A1 (en) * 2001-04-16 2004-08-12 Advanced Inhalation Research, Inc. Inhalation device and method
US20030094173A1 (en) * 2001-11-14 2003-05-22 Inhale Therapeutic Systems, Inc. Aerosolization device with improved endpiece connection
US6705313B2 (en) * 2002-01-16 2004-03-16 Ph&T S.P.A. Device usable in the treatment of affections of the airways
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Also Published As

Publication number Publication date
NL7311443A (fr) 1974-02-26
IL42991A0 (en) 1973-11-28
FR2196818A1 (fr) 1974-03-22
IL42991A (en) 1976-05-31
IT1006603B (it) 1976-10-20
JPS49124893A (fr) 1974-11-29
BE803805A (fr) 1974-02-20
DE2341346C2 (de) 1982-04-29
AR202192A1 (es) 1975-05-23
JPS572342B2 (fr) 1982-01-16
FI59338B (fi) 1981-04-30
IE38181L (en) 1974-02-23
ES418117A1 (es) 1976-02-16
BR7306474D0 (pt) 1974-08-29
DE2341346A1 (de) 1974-03-14
GB1392945A (en) 1975-05-07
AU5956673A (en) 1975-02-27
FI59338C (fi) 1981-08-10
FR2196818B1 (fr) 1977-08-12
IE38181B1 (en) 1978-01-18
ZA735562B (en) 1974-11-27
CH576261A5 (fr) 1976-06-15

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