US3811842A - Temperature-controlled fluid manifold for a fluid manifold for a fluid system of an automated sample analyzer - Google Patents

Temperature-controlled fluid manifold for a fluid manifold for a fluid system of an automated sample analyzer Download PDF

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Publication number
US3811842A
US3811842A US00260551A US26055172A US3811842A US 3811842 A US3811842 A US 3811842A US 00260551 A US00260551 A US 00260551A US 26055172 A US26055172 A US 26055172A US 3811842 A US3811842 A US 3811842A
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United States
Prior art keywords
manifold
fluid
temperature
plate
controlled
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Expired - Lifetime
Application number
US00260551A
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English (en)
Inventor
H Diebler
S Gyori
Candless W Mc
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Bayer Corp
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Technicon Instruments Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Technicon Instruments Corp filed Critical Technicon Instruments Corp
Priority to US00260551A priority Critical patent/US3811842A/en
Priority to CA169,063A priority patent/CA972983A/en
Priority to GB1946673A priority patent/GB1412210A/en
Priority to NL7305678A priority patent/NL7305678A/xx
Priority to IT68322/73A priority patent/IT986302B/it
Priority to AU55609/73A priority patent/AU469719B2/en
Priority to JP6039973A priority patent/JPS5623102B2/ja
Priority to CH808773A priority patent/CH559362A5/xx
Priority to DE2328637A priority patent/DE2328637A1/de
Priority to BE131931A priority patent/BE800524A/xx
Priority to SE7307983A priority patent/SE401271B/xx
Priority to FR7320547A priority patent/FR2188829A5/fr
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Publication of US3811842A publication Critical patent/US3811842A/en
Assigned to TECHNICON INSTRUMENTS CORPORATION reassignment TECHNICON INSTRUMENTS CORPORATION MERGER (SEE DOCUMENT FOR DETAILS). Assignors: REVGROUP PANTRY MIRROR CORP.
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4331—Mixers with bended, curved, coiled, wounded mixing tubes or comprising elements for bending the flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90—Heating or cooling systems
    • B01F35/92—Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis

Definitions

  • ABSTRACT Temperature-controlled fluid manifold for a fluid system of an automated sample analyzer of the type for analyzing a series of liquid samples flowing seriatum to quantitative analysis for a constituent of interest.
  • the temperature-controlled manifold may be permanently combined with a wide variety of other components to meet the requirements of many different chemistries to provide many different temperature-controlled manifolds each suited for analysis of a different constituent of a sample such as 1 blood for example.
  • the temperature-controlled manifold may be permanently combined with a wide variety of other components to meet the requirements of many different chemistries to provide many different temperature-controlled manifolds each suited for analysis of a different constituent of a sample such as 1 blood for example.
  • the temperature-controlled manifold may be permanently combined with a wide variety of other components to meet the requirements of many different chemistries to provide many different temperature-controlled manifolds each suited for analysis of a different constituent of a sample such as 1 blood for example.
  • the temperature-controlled manifold may be permanently combined with a wide variety of other components to meet the requirements of many different chemistries to provide many different temperature-controlled manifolds each suited for analysis of a different constituent of a sample such as 1 blood for example.
  • the manifold may be significantlysmaller in size and less costly than conventional manifolds.
  • PATENTEDIAYZI m4 sum 2 w 2 om N TEMPERATURECONTROLLED FLUID MANIFOLD FOR A FLUID SYSTEM OF AN AUTOMATED SAMPLE ANALYZER BACKGROUND OF THE INVENTION 1.
  • This invention relates to a temperature-controlled fluid manifold for a fluid system of an automated sample analyzer of the type for analyzing a series of liquid samples flowing seriatum to quantitative analysis for a constituent of interest.
  • automated apparatus for performing multiple quantitative analyses on different portions of a single sample of a series of such samples, each analysis being for adifferent specific sample constituent.
  • automated analysis apparatus may include for analysis purposes a'series of different analytical manifolds for different tests, the flow from each one of which is to analysis by a colorimeter or a spectral flame photometer for analysis of different portions of a same sample.
  • other conventional photometric analysis devices or ion-selective electrodes may be used foranalysis purposes in similar automated sample analysis apparatus.
  • the aforementioned Skeggs U.S. Pat. No. 2,797,149 which discloses an automated analyzer which is essentially a one-channel or a one-manifold system, and in the system illustrated in FIG. 3 of the drawings there is a water bath, indicated at 64, to control the temperature of a treated sample portion flowing through the bath in a helical coil.
  • the water in the water bath 64. is heated by an immersion heater of the rod type, and the temperature of the water bath 64 is suitably regulated.
  • the water bath 64 is of considerable size and may be supported on a table surface. It is also relatively expensive.
  • Another similar water bath, indicated at 99 is shown in a different system described in that patent and illustrated in FIG. 4.
  • Aforementioned Skeggs US. Pat. No. 2,879,141 discloses in FIG. 8 of the drawings similar fluid baths for the temperature control of a treated sample portion flowing therethrough.
  • U.S. Pat. No. 3,241,432 discloses as in FIG. l of the drawings heating baths 141 and 142 associated with respective ones of a pair of different analytical manifolds to conduct different tests on different portions of a same sample which is one of a series of such samples.
  • the heating bath contains oil which is heated as by a heater for heating the oil in each instance and the treated sample portion is flowed through the respective bath in a helical passageway which is encapsulated by the oil.
  • the last-mentioned heating baths are relatively large and costly though they may be smaller and less costly than the heating baths described above with reference to the other aformentioned Skeggs patents.
  • One object of the invention is to provide an improved temperature-controlled fluid manifold for a fluid system of an automated sample analyzer of the type for analyzing a series of liquid samples flowing seriatum to quantitative analysis for a constituent of interest.
  • Anotherobject is to provide in such temperaturecontrolled manifold, basic elements of the manifold which may be permanently combined with a wide variety of other components to meet the requirements of many different chemistries to provide many different temperature-controlled manifolds each suited for analysis of a different constituent of the sample such as blood for example.
  • Still another object is to provide, in such a manifold, for treatment of the respective sample portion as by combination and mixing with any appropriate reagent or reagents under temperaturecontrolled conditions for subsequent analysis as in a colorimeter for example.
  • Another object is to provide a manifold having plural temperature-controlled fluid passage portions all under the control of a single temperature regulator, effecting better uniformity of temperature-control to the extent that thetemperature of one such fluid passage portion effectively tends to .be the sameas the temperature of the other such fluid passageway portions.
  • Still another object is to provide a manifold which may be significantly smaller in size and less costly than conventional manifolds, and which is very durable and less subject to breakage of parts than conventional manifolds.
  • a manifold such as characterized above, the basic elements of which comprise a thermally conductive plate or block heated by conduction from a temperature-controlled source of heat, which plate has an outer, exposed surface of substantial area, and an appropriate number of appropriately configured fluid passageway portions, such as helical mixing or helical time-delay coils, encapsulated in a solid material characterized by a heat storage capacity and which material is supported in a selected one of a plurality of available locations on the last-mentioned surface for thermal transfer by conduction to the material from the plate.
  • the manifold includes a cover effectively tending to stagnate the ambient atmosphere around such encapsulated fluid passageway portions.
  • FIG. 1 is a front elevational view of a temperaturecontrolled fluid manifold, with the cover removed, embodying the invention
  • FIG. 2 is a bottom view of the manifold of FIG. 1;
  • FIG. 3 is a sectional view taken along line 33 of FIG. 1.
  • the manifold is shown as comprising an oblong base preferably constructed of material having thermal insulating properties, which may be of a plastic material.
  • the base 10 has a longitudinal, horizontally extending opening therethrough.
  • the outer part of the base 10 is cut-away in part as at 12 to receive a heater block or plate 14 having an outer, exposed surface 16 of substantial area and which is substantially flush with the right-hand end portion of the base 10 as viewed in FIG. 1.
  • thermostatically controlled heater element 18 preferably in direct contact with the last-mentioned side of the plate 14 for the transfer to the latter of thermal energy from the heater element 18.
  • the heater element 18 is preferably of the electrical type, and is located within the aforementioned horizontally extending opening through the base 10.
  • the heater plate 14 is characterized, at least to some extent, in that the material from which it is formed has good thermal conductivity characteristics.
  • the material of the plate 14 is preferably a metal and may be formed of powered aluminum or stainless steel, for example.
  • the base In a vertical plane intermediate the plate 14 and the inner extremity of the base 10 the base may be provided with an upwardly directed shoulder 20 to act as a stop and an abutment for the manifold cover 22 to limit inward movement of the last-mentioned cover with reference to the base 10.
  • the rigid cover 22 snugly fits over the base 10 and if desired may be removed from the manifold on outward sliding movement of the cover 22.
  • the cover may be supported from the manifold in any suitable manner as by being hinged thereto (not shown) and any suitable stop may be employed to limit closing movement of the cover 22.
  • the cover is preferably transparent so that, when the cover is assembled with the manifold base, a user may view through the cover at least certain fluid stream portions in the use of the manifold, as will appear more fully-hereinafter.
  • one or more temperaturecontrolled fluid passageway portions are associated with the heater plate 14 outside the plate 14, two such temperature-controlled portions being illustrated by way of example and indicated at 24 and 26.
  • Each such temperature-controlled fluid passageway portion 24, 26 defines a fluid passageway therethrough which is encapsulated in a solid material having heat conductive and storage characteristics which material may be formed of a metal such as lead-or aluminum for example.
  • the passageway portion 24 is formed as a helix from end-to-end with an inlet at one end thereof extending through an encapsulation material and an outlet at the other end thereof, also extending through the encapsulation material as shown in FIG. 1.
  • the temperature-controlled fluid passageway portion 26 includes two helical portions in axial arrangement with reference to one another and with communication therebetween, that is between the outlet of the first helical portion and the inlet of the second helical portion.
  • the inlet of the firstmentioned helical portion of the fluid passageway portion 26 extends through the encapsulation material as shown in the last-mentioned view and the outlet of the second mentioned helical portion of the fluid passageway portions 26 extends through the encapsulation material as also shown in this view.
  • a temperature-controlled fluid passageway portion such as the portion 24 may be encapsulated by molding the prefonned glass helix of the portion 24 within the heat storage material. Of couse in such a molding operation access must be provided to the inlet and the outlet of the portion 24.
  • the encapsulated fluid passageway portions 24 and 26 are secured to the outer surface 16 of the heater plate 14 in any suitable manner as by cementing the units to the plate 14 in the desired location on the outer surface 16 of the heater plate.
  • the manner of securing the encapsulated temperaturecontrolled fluid portions 24 and 26 to the heater plate surface 16 is not deemed critical, but it should be understood that the units 24 and 26 must be in proximity to the surface 16 of the heater plate to receive thermal conduction therefrom.
  • the electrical heater element 18 is preferably located substantially centrally of the area occupied by the units 24, 26 in plane laterally inwardly of the plane of the heater plate 14, for substantially uniform heat distribution of both units 24, 26.
  • the number and configuration of the temperaturecontrolled fluid passageway portions will depend upon the particular chemical and other requirements of the particular intended use of the manifold.
  • the illustrated manifold is for the quantitative determination of SGPT in a blood sample. Accordingly the fluid connections to the manifold and any temperature-controlled fluid passageway portions must be suitable to the particular test.
  • a fitting 28 which may be of glass and constructed in accordance with the technique of fabrication illustrated and described in the co-pending US Pat. application of De Angelis et al., Ser. No. 246,966 filed on Apr. 24, 1972, now US. Pat. No. 3,770,405. This fitting 28 does not require detailed explanation here.
  • the fitting 28, which is suitably secured to the surface 16 of the heater plate, has a passageway formed therein in communication with flexible tubes 30, 32, 34 all of which are inlets into the internal passageway in the fitting 28.
  • the last-mentioned passageway has an outlet in communication with the inlet of glass tube 36.
  • the material of which these tubes are formed is not critical but for the sake of convenience they may be flexible and formed of a suitable inert material.
  • Tube 36 has an outlet coupled to the inlet of temperature-controlled unit 26. Downstream a short distance from the lastmentioned inlet, another inlet in temperaturecontrolled unit 26 is provided in communication with the outlet of tube 38 which may be formed of inert glass and which is for the purpose of introducing another fluid into the temperature-control unit 26.
  • Miscible fluids flowing into the temperature-control unit 26 through the tubes 36 and 38 are mixed within the first section of the double helix of the unit 26.
  • another miscible fluid Prior to the introduction of fluid from the last-mentioned section of the double helix to the second section of the double helix of unit 26, another miscible fluid is added to the temperature control unit 26 through a plastic tube 40 having an outlet coupled to a port in the section of the temperature-control unit 26 providing communicationbetweenthe two helical sections thereof, so that the combined-stream ispassed through the second or right-hand helical portion-of the unit 26'for mixing of the miscible fluid therein.
  • the fluid flowing into the inlet of tube 32 is immiscible with the liquid flowinginto the inlet of tube 30 and such immiscible fluid may be an inert gas which segments the stream flowing from the outlet of tube 30 in the aforementioned passage in fitting 28.
  • Another liquid immiscible with the liquid inletted from the tube 30 is inletted from the tube34 into the last-mentioned passage in the fitting 28 to combine with a stream in the fitting 28.
  • the segmented liquid stream outletted from the fitting 28 to the tube 36 is combined with the sample inletted into the stream through the outlet of tube 38.
  • the sample flowing into tube 38 is itself in segmented condition while flowing in the tube 38.
  • the inlets of the tubes 30, 32, 34, 38 and 40 are not shown but it is to be understood that they may be some distance away from the manifold and haveany type of suitable connection to the sources-of the respective fluids, for flow through the manifold induced in a conventional manner by a pressure differential.
  • the tubes 34 and 40 enter the manifold by passing through respective holes in the base beyond the right-hand extremity of the heater plate 14 as seen in FIG. 1.
  • the tubes 30, 32 and 38 may enter the-manifold through a common opening 42 (F IG. 2) inthe cover 22 which opening is sufficiently small to essentially create a stagnant ambient atmosphere within the cover 22 so that the temperature-controlled units 24 and 26 are not subject to drafts when the cover 22 is in place, and changes in the temperature of the ambient atmosphere within the cover 22 are effectively inhibited when room temperature changes.
  • F IG. 2 common opening 42
  • all temperaturercontrolled fluid passageway portions are under the common control of a single heat regulator, and there is a large degree of uniformity of the temperature of one temperature-controlled fluid passageway portion with the temperature of all the other such fluid passageway portions.
  • the temperature may be in the order of 37C.
  • temperature-controlled fluid passageway portions 24 and 26 illustrated and described herein are of the type wherein a sample is treated as by mixing or passing through an incubator
  • fluid temperaturecontrolled passageway portions of other types and within the purview of the invention may be utilized such as a non-illustrated temperature-controlled flow controller for a reagent fluid, associated in a similar manner with the heated plate 14, which flow controller may be secured to the face of the plate 14 obverse to that on which the temperature-controlled fluid passageway portions 24 and 26 are secured.
  • the manifold may be mounted in the attitude of F 1G. 1 on a panel of which a large number of other manifolds are also mounted in an analytical chemistry module of an automated fluid sample analyzer.
  • the flow from the exit of the temperature-controlled unit 26 is through glass tube 44 having an inlet end coupled to the fluid outlet end of the temperaturecontrolled unit 26 and having an outlet end coupled to an inlet conduit 46 in a flow cell 48.
  • the flow cell 48 may be of any conventional construction and is secured in a conventional manner to the heater plate 14 though it may be spaced outwardly from the surface 16 thereof.
  • the flow cell 48 has a fluid passageway portion 50 to one end of which the outlet of the inlet 46 is connected, which portion 50'is arranged longitudinally of an optical path.
  • the fluid outlet from the portion 50 is to the flow cell outlet 52. Beyond the inlet 46 and the outlet 52 and within the passage portion 50, there are provided transparent fluid seals, not shown, which lie in the optical path. 7
  • Optical fiber assemblies 54, 56 of elongated form and of conventional construction each have an end aligned and supported with reference to the respective ends of fluid passageway 50, lying within the optical path, and which ends of the assemblies 54 and 56 are disposed outwardly of the respective last-mentioned fluid seals of the passage 50.
  • the optical fiber assembly 54 enters the manifold through an opening (not shown) in the base 10 and passes with clearance through the heater plate 14.
  • the optical fiber assembly 56 exits from the manifold through the base 10 and is likewise'provided with clearance with the heater plate 14.
  • the stream in the passageway 50 of the flow cell 48 is analyzed colorimetrically at a location remote from themanifold, and the signal from the colorimeter (not shown) is suitably processed and may be displayed in typical, non-illustrated fashion.
  • the outlet 52 of the flow cell 48 is coupled to the inlet end of a glass tube 58 for the flow through the tube 58 of the stream exiting from flow cell 48.
  • the outlet end of the tube 58 is'coupled to the inlet end of temperature-controlled fluid passageway unit 24 and the stream flowing through the helix of the illustrated unit 24 under temperature-controlled conditions is incubated therein.
  • a glass tube 60 has an inlet end coupled to the fluid 64 and 66 are utilized in a colorimetric analysis of the fluid stream passing through the flow cell 62 in a similar manner. While the fluid outlet of the flow cell 62 is shown as coupled to the inlet end of a plastic waste tube 68 exiting from the manifold through a hole, not shown, in the base 10 (FIGS. 1 and 2) for simplicity of illustration of the invention, in practice the flow from the flow cell 62 is directed through another temperature-controlled unit (not shown) similar to the unit 24 and is subsequently passed to still another flow cell (not shown), and it is from the last-mentioned flow cell that the stream flows to waste through the manifold in the manner of the exit tube 68 passing through the base 10. It is to be understood that the non-illustrated additional temperature-controlled fluid passage and the nonillustrated flow cell which receives the stream therefrom are supported on the heater plate 14 in similar fashion and are similarly configured.
  • the illustrated manifold may be approximately 12% inches long and 2 /2 inches wide and may take the form of a cartridge suitably secured through the base 10 to a vertical panel of a multiple analyzer on which-panel a relatively large number of such cartridges for different chemistries or analyses may be mounted in close proximity to one another. It will be understood that the manifold of the invention may utilize other analysis means than those illustrated. For example, the analysis may be by potentiometric measurement.
  • a manifold for an automated fluid analyzer having at least one temperature-controlled fluid passageway portion
  • said fluid passageway portion is of generally duplex spiral configuration with a fluid admission port for the admixture of a fluid to the spiral passageway between the two parts thereof.
  • a manifold as defined in claim 1 further including a fluid analyzer supported from said support and in fluid flow communication with said passageway portion.
  • a manifold is defined in claim 2, wherein: the manifold has a plurality of fluid inlet and outlet conduits external thereto and extending within said cover.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
US00260551A 1972-06-07 1972-06-07 Temperature-controlled fluid manifold for a fluid manifold for a fluid system of an automated sample analyzer Expired - Lifetime US3811842A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US00260551A US3811842A (en) 1972-06-07 1972-06-07 Temperature-controlled fluid manifold for a fluid manifold for a fluid system of an automated sample analyzer
CA169,063A CA972983A (en) 1972-06-07 1973-04-18 Temperature-controlled fluid manifold for a fluid system of an automated sample analyzer
GB1946673A GB1412210A (en) 1972-06-07 1973-04-24 Temperature controlled fluid manifold for an automated fluid analyser
NL7305678A NL7305678A (ja) 1972-06-07 1973-04-24
IT68322/73A IT986302B (it) 1972-06-07 1973-05-09 Collettore per fluidi a temperatura controllata per analizzatore automa tizzato di fluidi
AU55609/73A AU469719B2 (en) 1972-06-07 1973-05-11 Temperature-controlled fluid manifold fora fluid system ofan automated sample analyzer
JP6039973A JPS5623102B2 (ja) 1972-06-07 1973-05-31
CH808773A CH559362A5 (ja) 1972-06-07 1973-06-05
DE2328637A DE2328637A1 (de) 1972-06-07 1973-06-05 Leitungsanordnung fuer ein automatisch arbeitendes fluidanalysiergeraet
BE131931A BE800524A (fr) 1972-06-07 1973-06-06 Dispositif de circulation a temperature controlee pour fluides d'un analyseur automatique d'echantillons
SE7307983A SE401271B (sv) 1972-06-07 1973-06-06 Ledningssystem for en automatisk analysapparat med atminstone en tempera
FR7320547A FR2188829A5 (ja) 1972-06-07 1973-06-08

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Application Number Priority Date Filing Date Title
US00260551A US3811842A (en) 1972-06-07 1972-06-07 Temperature-controlled fluid manifold for a fluid manifold for a fluid system of an automated sample analyzer

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US3811842A true US3811842A (en) 1974-05-21

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US00260551A Expired - Lifetime US3811842A (en) 1972-06-07 1972-06-07 Temperature-controlled fluid manifold for a fluid manifold for a fluid system of an automated sample analyzer

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US (1) US3811842A (ja)
JP (1) JPS5623102B2 (ja)
AU (1) AU469719B2 (ja)
BE (1) BE800524A (ja)
CA (1) CA972983A (ja)
CH (1) CH559362A5 (ja)
DE (1) DE2328637A1 (ja)
FR (1) FR2188829A5 (ja)
GB (1) GB1412210A (ja)
IT (1) IT986302B (ja)
NL (1) NL7305678A (ja)
SE (1) SE401271B (ja)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933437A (en) * 1972-09-06 1976-01-20 Winfried Ebing Apparatus for automatically purifying extracts of vegetable and animal specimens for the determination free from interference of traces of selected extract constituents
US4054416A (en) * 1976-08-11 1977-10-18 Secretary Of State For Social Services Apparatus for use in investigating specimens
US4086061A (en) * 1977-02-28 1978-04-25 Beckman Instruments, Inc. Temperature control system for chemical reaction cell
USRE29880E (en) * 1975-06-11 1979-01-16 The Secretary Of State For Social Services In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Apparatus for use in investigating specimens
USRE30730E (en) * 1975-06-11 1981-09-01 National Research Development Corporation Apparatus for use in investigating specimens
US4294799A (en) * 1980-04-24 1981-10-13 Beckman Instruments, Inc. Temperature regulating apparatus
US4361540A (en) * 1980-05-05 1982-11-30 Instrumentation Laboratory Inc. Analysis system
US4361539A (en) * 1980-05-05 1982-11-30 Instrumentation Laboratory Inc. Analysis system
US4443407A (en) * 1981-04-02 1984-04-17 Instrumentation Laboratory Inc. Analysis system
US4738825A (en) * 1985-02-27 1988-04-19 Fisher Scientific Company Cuvette handling
US4788150A (en) * 1985-02-27 1988-11-29 Fisher Scientific Company Liquid handling
US5508197A (en) * 1994-07-25 1996-04-16 The Regents, University Of California High-speed thermal cycling system and method of use
US5795784A (en) * 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
US5856194A (en) * 1996-09-19 1999-01-05 Abbott Laboratories Method for determination of item of interest in a sample
US8596340B1 (en) * 2010-10-13 2013-12-03 Horn-Barber Technologies, LLC Apparatus for heating liquid samples for analysis
WO2022136607A1 (en) * 2020-12-22 2022-06-30 Radiometer Medical Aps Helical mixer
WO2023086042A1 (en) * 2021-11-15 2023-05-19 Bursa Uludağ Üni̇versi̇tesi̇ Thermal management system of static mixer produced by conventional or additive manufacturing

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3207229A1 (de) * 1982-03-01 1983-12-22 Leybold-Heraeus GmbH, 5000 Köln Rohrsystem fuer physikalische experimente
JPS5964103U (ja) * 1982-10-20 1984-04-27 松下電器産業株式会社 血圧計用腕帯
JPS59183206U (ja) * 1983-05-21 1984-12-06 モリト株式会社 締付用バンド
CN110916945A (zh) * 2019-11-04 2020-03-27 厦门市妇幼保健院（厦门市计划生育服务中心） 一种智能控温婴儿保温箱

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933437A (en) * 1972-09-06 1976-01-20 Winfried Ebing Apparatus for automatically purifying extracts of vegetable and animal specimens for the determination free from interference of traces of selected extract constituents
USRE29880E (en) * 1975-06-11 1979-01-16 The Secretary Of State For Social Services In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland Apparatus for use in investigating specimens
USRE30730E (en) * 1975-06-11 1981-09-01 National Research Development Corporation Apparatus for use in investigating specimens
US4054416A (en) * 1976-08-11 1977-10-18 Secretary Of State For Social Services Apparatus for use in investigating specimens
US4086061A (en) * 1977-02-28 1978-04-25 Beckman Instruments, Inc. Temperature control system for chemical reaction cell
US4294799A (en) * 1980-04-24 1981-10-13 Beckman Instruments, Inc. Temperature regulating apparatus
US4361540A (en) * 1980-05-05 1982-11-30 Instrumentation Laboratory Inc. Analysis system
US4361539A (en) * 1980-05-05 1982-11-30 Instrumentation Laboratory Inc. Analysis system
US4443407A (en) * 1981-04-02 1984-04-17 Instrumentation Laboratory Inc. Analysis system
US4788150A (en) * 1985-02-27 1988-11-29 Fisher Scientific Company Liquid handling
US4738825A (en) * 1985-02-27 1988-04-19 Fisher Scientific Company Cuvette handling
US5508197A (en) * 1994-07-25 1996-04-16 The Regents, University Of California High-speed thermal cycling system and method of use
US5795784A (en) * 1996-09-19 1998-08-18 Abbott Laboratories Method of performing a process for determining an item of interest in a sample
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Also Published As

Publication number Publication date
GB1412210A (en) 1975-10-29
DE2328637B2 (ja) 1978-11-09
BE800524A (fr) 1973-12-06
FR2188829A5 (ja) 1974-01-18
DE2328637C3 (ja) 1979-07-19
AU5560973A (en) 1974-11-14
DE2328637A1 (de) 1974-01-24
NL7305678A (ja) 1973-12-11
CA972983A (en) 1975-08-19
AU469719B2 (en) 1976-02-19
IT986302B (it) 1975-01-30
SE401271B (sv) 1978-04-24
JPS4952695A (ja) 1974-05-22
CH559362A5 (ja) 1975-02-28
JPS5623102B2 (ja) 1981-05-29

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