US3803811A - Molecule separator - Google Patents

Molecule separator Download PDF

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Publication number
US3803811A
US3803811A US00303878A US30387872A US3803811A US 3803811 A US3803811 A US 3803811A US 00303878 A US00303878 A US 00303878A US 30387872 A US30387872 A US 30387872A US 3803811 A US3803811 A US 3803811A
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US
United States
Prior art keywords
tube
separator
molecules
nozzle
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00303878A
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English (en)
Inventor
E Ryhage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
LKB Produkter AB
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Filing date
Publication date
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
    • B01D53/24—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols by centrifugal force
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D59/00—Separation of different isotopes of the same chemical element
    • B01D59/10—Separation by diffusion
    • B01D59/18—Separation by diffusion by separation jets
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
    • H05H3/02—Molecular or atomic beam generation

Definitions

  • the present invention relates to a molecule separator working according to the jet principle and-comprising at least one separator step consisting of an evacuation chamber connected to a pump, to which chamber mol ecules in gas phase are supplied through a jet nozzle, an output nozzle being arranged coaxialto the jet nozzle in order that molecules ,with great molecular mass are passing to a greater extent through the output nozzle than are molecules with less molecular mass.
  • a combination instrument comprising a gas chromatograph, the output of whichis connected to the ion source of a mass spectrometer and the purpose of which is the analysis of organic chemical substances
  • the mass spectrometer is normally operated under essentially lower pressure than the gas chromatograph. Consequently a pressure reduction must be accomplished between these components, which for example is achieved by means of a molecule separator, working accordingto the jet principle and connected between the output of the gas chromatograph and the ion source of the mass spectrometer.
  • a molecule separator working accordingto the jet principle and connected between the output of the gas chromatograph and the ion source of the mass spectrometer.
  • a pressure reduction is achieved by forcing the gas flow from the gas chromatograph, consisting of sample and carrier gas with high velocity, to pass through an input nozzle to a chamber with reduced pressure, an' output nozzle being arranged coaxial to the input nozzle. In that way the pressure is being reduced at the same time as an enrichment of sample in relation to the carrier gas is achieved.
  • the separation then usually is carried out in at least two stages.
  • the pressure is reduced from atmospheric. pressure to 0,l-0,3 mm Hg.
  • the pressure is lowered to about 0,001 mm Hg.
  • About 99 percent of the carrier gas is separated totally, while at least 50-75% of the sample remains, depending on the nature of the sample.
  • Another method which is particularly applied at the use of capillary columns, is that the action of the first separator is completely eliminated in that way that a tube, usually of silver, is attached between the jet nozzle and the'output nozzle, in that way that the gas flow is conducted directly to the second separator stage.
  • This method however involves a heavy encroachment into the apparatus and is only suitable for definitive reconstruction of the apparatus for a capillary column.
  • the purpose of the present invention is to provide a device by means of which the distance between the nozzles of the molecule separator can be varied and by means of which the nozzles also can be completely pushed together.
  • the purpose of the present ivention is also to provide a device by means of which the distance between the nozzles of the molecule separatorcan be varied during separation, controlled from outside the combination instrument.
  • the optimal nozzle distance varies according to the magnitude of the supplied gas flow as well as according to its composition.
  • the possibility of adjusting the nozzle distance according to the output-measurement signal during separation highly improves the possibility to achieve an optimal nozzle distance.
  • Another purpose of the present invention is to make possible to maintain in the ion source of the mass spectrometer a suitable pressure independent of the flow in the gas chromatograph.
  • Another advantage of the present invention is that the costs of manufacture could be lowered, because the possibilities of accurate readjustment of the nozzle distance' in the completed combination instrument disminishes the demands on the accuracy of manufacture regarding the nozzle distance in the molecule separator.
  • FIG. 1 and FIG. 2 are showing two embodiments of I nozzle of the separator stage is denoted by 5.
  • 6 denotes a flange which is screwed onto the separator stage 1 by means of screws
  • FIG. 7 and 8 denotes two metal membranes, joined by soldering to the tube 3, and being part of the system of sealings between that gas, the molecules of which are subject to separation, and the surrounding atmosphere.
  • the remaining elements of this sealing system are a ring 9 and silver sealings 10 and 11.
  • the axial displacement of the tube 3 is achieved by means of an eccentric 12 by turning of an axle 13.
  • the eccentric l2 acts on a casing 14, which is mechanically connected to the tube 3 by a screw 15.
  • the device according to the invention works in the following way:
  • the axle 13 When it is desired to change the distance between the nozzles of the separator stage, the axle 13 is turned. Then the eccentric 12 will bring the casing 14 to move in axial direction. Thereby the casing 14 take the tube 3 with it, provided that the screw 15 is tightened.
  • the tube 3 is carried by the metal membranes 7 and 8, which ones allow a sufficient axial clearance of the tube 3.
  • the sealing between that gas phase, the molecules of which is subject to separation and which is flowing through the supply line 4 and further through the tube 3, and the surrounding atmosphere, is accomplished in that way that the ring 9 is pressed towards the separator stage 1 by the flange 6, in that way that the sharp edges of the ring 9 are pressing onto the metal membranes 7 and 8 which then are tightening towards the silver seals 10 and 11.
  • FIG. 2 differs from the embodiment described above mainly in the sealing device.
  • l6 denotes a partly slotted casing, clasping the tube 3.
  • l7 denotes a teflon sealing, 18 a silver sealmg.
  • the displacement device according to this embodiment works in similar manner as that one described above.
  • the eccentric 12 makes the casing 16 to move in axial direction.
  • the casing 16 then takes the tube 3 with it, due to the friction coupling present between the casing and the tube.
  • the sealing between that gas phase, the molecules of which is subject to separation, and the surrounding atmosphere is accomplished by the teflon sealing l7 and the silver sealing 18.
  • a device with an axially displaceable output nozzle fulfills the same purpose and should be part of the invention.
  • a separator according to the jet principle could be made in one or several stages, and is generally made in two stages. One or more stages then can be provided with the device according to the invention.
  • control means which is displacing the axially displaceable tube
  • Control means designed in other ways, are also conceivable within the scope of the invention.
  • the control means could consist of a axially displaceable rod, the movement of which is transferred to axial movement of the nozzle. This rod can be parallel to the direction of the tube 3 or form an angle, for instance to this direction.
  • the design of the sealings should not be restricted to what is described herein.
  • Molecule separator working according to the jet principle, comprising at least one separator stage comprising an evacuation chamber, connected to a pump, to which evacuation chamber molecules in gas phase are supplied via a jet nozzle, an output nozzle being arranged coaxially to said jet nozzle in order that molecules with great molecular mass will pass through said output nozzle to a greater extent than will molecules of small molecular mass, said molecule separator further comprising an axially displaceable tube, that end of which, turned towards said evacuation chamber, forms one of said nozzles of the separator, and further a control means, which is performing the displacement in axial direction of said tube, and sealings between that gas phase, the molecules of which are subject to separation, and the atmosphere at the outer end of the control means, in order that the distance between the jet nozzle and the output nozzle can be varied from outside said separator during separation.
  • control means comprises an axle, perpendicular to said axially displaceable tube, said axle giving, when turned, the axial displacement of said tube by means of an eccentric.

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
US00303878A 1971-11-10 1972-11-06 Molecule separator Expired - Lifetime US3803811A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE14362/71A SE357830B (ja) 1971-11-10 1971-11-10

Publications (1)

Publication Number Publication Date
US3803811A true US3803811A (en) 1974-04-16

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ID=20298967

Family Applications (1)

Application Number Title Priority Date Filing Date
US00303878A Expired - Lifetime US3803811A (en) 1971-11-10 1972-11-06 Molecule separator

Country Status (6)

Country Link
US (1) US3803811A (ja)
JP (1) JPS4859892A (ja)
DE (1) DE2254621A1 (ja)
FR (1) FR2159433B1 (ja)
GB (1) GB1393000A (ja)
SE (1) SE357830B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957470A (en) * 1973-10-18 1976-05-18 Ernest Fredrick Dawes Molecule separators
EP1865533A2 (en) 2006-06-08 2007-12-12 Microsaic systems limited Microengineerd vacuum interface for an ionization system

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5620496B2 (ja) * 1973-02-12 1981-05-14
JPS5418233Y2 (ja) * 1973-03-30 1979-07-10
JPS5063489U (ja) * 1973-10-12 1975-06-09

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3678656A (en) * 1969-04-17 1972-07-25 Curt Brunnee Separating device for mixtures of gaseous or vaporous substances, especially for separating a carrier gas from a fraction to be analyzed in a combined gaschromatograph and mass-spectrometer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1579570A (ja) * 1968-05-14 1969-08-29

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3678656A (en) * 1969-04-17 1972-07-25 Curt Brunnee Separating device for mixtures of gaseous or vaporous substances, especially for separating a carrier gas from a fraction to be analyzed in a combined gaschromatograph and mass-spectrometer

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957470A (en) * 1973-10-18 1976-05-18 Ernest Fredrick Dawes Molecule separators
EP1865533A2 (en) 2006-06-08 2007-12-12 Microsaic systems limited Microengineerd vacuum interface for an ionization system
US20080001082A1 (en) * 2006-06-08 2008-01-03 Richard Syms Microengineered vacuum interface for an ionization system
US7786434B2 (en) 2006-06-08 2010-08-31 Microsaic Systems Limited Microengineered vacuum interface for an ionization system

Also Published As

Publication number Publication date
FR2159433B1 (ja) 1976-06-04
GB1393000A (en) 1975-05-07
JPS4859892A (ja) 1973-08-22
SE357830B (ja) 1973-07-09
FR2159433A1 (ja) 1973-06-22
DE2254621A1 (de) 1973-05-24

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