US3785990A - Method of manufacturing a generator which produces radio-isotopes and has an improved elution efficiency,and generator obtained by this method - Google Patents
Method of manufacturing a generator which produces radio-isotopes and has an improved elution efficiency,and generator obtained by this method Download PDFInfo
- Publication number
- US3785990A US3785990A US00230502A US3785990DA US3785990A US 3785990 A US3785990 A US 3785990A US 00230502 A US00230502 A US 00230502A US 3785990D A US3785990D A US 3785990DA US 3785990 A US3785990 A US 3785990A
- Authority
- US
- United States
- Prior art keywords
- generator
- adsorbent
- oxidant
- isotope
- salt solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000010828 elution Methods 0.000 title abstract description 14
- 238000000034 method Methods 0.000 title description 12
- 238000004519 manufacturing process Methods 0.000 title description 7
- 239000007800 oxidant agent Substances 0.000 abstract description 31
- 239000003463 adsorbent Substances 0.000 abstract description 30
- 230000001590 oxidative effect Effects 0.000 abstract description 30
- 230000002285 radioactive effect Effects 0.000 abstract description 15
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical compound [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 abstract description 4
- 239000000758 substrate Substances 0.000 abstract description 3
- 239000012266 salt solution Substances 0.000 description 16
- KMUONIBRACKNSN-UHFFFAOYSA-N potassium dichromate Chemical compound [K+].[K+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O KMUONIBRACKNSN-UHFFFAOYSA-N 0.000 description 12
- 239000000243 solution Substances 0.000 description 10
- 230000005855 radiation Effects 0.000 description 8
- 238000005406 washing Methods 0.000 description 8
- 239000003480 eluent Substances 0.000 description 7
- 239000000126 substance Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 235000002639 sodium chloride Nutrition 0.000 description 4
- SOCTUWSJJQCPFX-UHFFFAOYSA-N dichromate(2-) Chemical compound [O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O SOCTUWSJJQCPFX-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- MEFBJEMVZONFCJ-UHFFFAOYSA-N molybdate Chemical class [O-][Mo]([O-])(=O)=O MEFBJEMVZONFCJ-UHFFFAOYSA-N 0.000 description 2
- 229910052750 molybdenum Inorganic materials 0.000 description 2
- 239000011733 molybdenum Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- -1 alkali metal chromates Chemical class 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 229960005076 sodium hypochlorite Drugs 0.000 description 1
- 229910052713 technetium Inorganic materials 0.000 description 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/0005—Isotope delivery systems
Definitions
- the invention relates to a method of manufacturing a generator which produces radioisotopes.
- Radionuclides having a half-life of a few hours to a few days are used in medicine for diagnostic purposes.
- radionuclides which are pure gamma radiators.
- the optimum gamma lines lie between 100 and 400 kev.
- This radio-active technetium isotope may be used for the above indicated purpose as such but it is also suitable to label other substances such, for example, as albumins.
- the radioisotope suitable for medical use is obtained inter alia from a generator, which frequently is referred to as a cow or milker.
- the radioisotope then is marketed in the form of the generator.
- the user may withdrawn the desired radioisotope from the generator respectively.
- Such instantaneous production is of great practical importance because of the rapid decay of a suitable radioisotope.
- An isotope generator is obtainable by filling a container provided with an inlet and an outlet with an adsorbent material to which a radioactive parent isotope is then applied. If desired, the generator may be provided with seals which permit sterile use of the generator (Netherlands patent application No. 6,607,699, PHN. 1670).
- a frequently used adsorbent is A1 0
- an adsorbent largely consisting of A1 0 is used in producing the aforementioned Tc generator.
- the radioactive parent isotope present on the adsorbent by its decay produces the daughter isotope, which is of interest for medical purpose, with the emission of radiation.
- radioactive molybdenum in the form of a molybdate is used as the parent isotope.
- the Tc produced from M0 by radioactive decay will mainly be in the form of the pertechnetate.
- a washing liquid or eluent is admitted at the top through the inlet.
- the eluent traverse the adsorbent and carries along the radioactive daughter isotope present.
- the eluent together with the radioactive daughter isotope dissolved in it leaves the generator at the bottom and is collected in a receiver which if desired may be rigidly secured to the generator proper.
- the parent isotope is hardly, or not at all, displaced over the adsorbent by the eluent.
- a suitable eluent is an isotonic salt solution such, for example, as a 0.9% common salt solution.
- the proposed step of improving the efiiciency has to be taken by the user of the generator himself.
- the said degeneration may be greatly reduced or even prevented if at least at the regions in the generator in which there is strong radiation the generator system it brought into an oxidizing condition.
- the invention relates to a method of manufacturing an isotope generator in which a container provided with an inlet and an outlet is filled with an adsorbent mainly consisting of A1 to which a radioactive parent isotope is applied, and the invention is characterized in that even before first use of the generator the adsorbent is brought to an oxidizing condition by the application of an oxidant.
- the oxidant to be used according to the invention preferably should have a strong aflinity to the A1 0 adsorbent, for it is important that when the generator manufactured by the method according to the invention is used the washing agent used should not remove the oxidant from the adsorbent, but on the contrary it forms part of the substance of the invention that the oxidant is fixed as securely as possible in the region of the radiation field, i.e. of the parent isotope.
- the application of the oxidant may be effected by a known method.
- a solution of the oxidant is used.
- the solvent may be removed from the adsorbent, for example by drawing off at a reduced pressure.
- water or an aqueous salt solution is used as the solvent it need not be removed from the adsorbent.
- the amount of oxidant to be applied depends on various factors. Some of these factors are the radioactivity level and the shape of the generator, the position of the parent isotope on the adsorbent, the concentration of the oxidant in the solution used and the nature of the oxidant.
- the treatment with the oxidant may be effected either before or after sterilization.
- the pH of the solution was 1 to 2.
- Do. 29..- 1 mg. K2CrzO7 in 1 ml. of salt solution Do. 30.... -do Do.
- Table II shows that the elution efficiency of the generators 25 to 30 which contain a comparatively small amount of oxidant is appreciably lower than that of the generators 1-24 which contain larger amounts of oxidant.
- the reference generator without oxidant gives a very poor yield.
- the table shows that at the twelfth elution the difierences in elution efliciency are substantially eliminated. This may readily be explained by considering that at the twelfth elution the radioactivity of the generators, which initially was 300 mCi, had fallen to an extent such that the limit value below which the influence of the radiation on the etficiency is absent or at least greatly reduced is passed.
- an isotope generator in which a container provided with an inlet and outlet is filled with an adsorbent consisting mainly of A1 0 to which adsorbent a radioactive parent isotope is applied, the improvement which comprises bringing the adsorbent to an oxidizing condition by applying to the adsorbent an oxidant which is strongly bound to the adsorbent prior to the first elution.
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7102716.A NL165321C (nl) | 1971-03-02 | 1971-03-02 | Werkwijze voor de vervaardiging van een radio-isotopen producerende generator. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3785990A true US3785990A (en) | 1974-01-15 |
Family
ID=19812592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US00230502A Expired - Lifetime US3785990A (en) | 1971-03-02 | 1972-02-29 | Method of manufacturing a generator which produces radio-isotopes and has an improved elution efficiency,and generator obtained by this method |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3785990A (xx) |
| JP (1) | JPS544039B1 (xx) |
| BE (1) | BE780010A (xx) |
| CA (1) | CA971749A (xx) |
| CH (1) | CH578235A5 (xx) |
| DE (1) | DE2207309C3 (xx) |
| FR (1) | FR2128373B1 (xx) |
| GB (1) | GB1353293A (xx) |
| IT (1) | IT947968B (xx) |
| NL (1) | NL165321C (xx) |
| SE (1) | SE387768B (xx) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3902849A (en) * | 1971-08-19 | 1975-09-02 | Medi Physics Inc | Radioisotope and radiopharmaceutical generators |
| US3970583A (en) * | 1973-02-20 | 1976-07-20 | U.S. Philips Corporation | Isotope generator provided with a carrier material which in addition to Al2 O3 contains fully or partly hydrated MnO2 |
| US4010109A (en) * | 1973-07-02 | 1977-03-01 | Kurt Sauerwein | Device for marking fluent materials |
| US4041317A (en) * | 1976-05-19 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Multiple pH alumina columns for molybdenum-99/technetium-99m generators |
| US4206358A (en) * | 1977-10-19 | 1980-06-03 | Australian Atomic Energy Commission | Technetium-99 generators |
| US4280053A (en) * | 1977-06-10 | 1981-07-21 | Australian Atomic Energy Commission | Technetium-99m generators |
| US4414145A (en) * | 1979-04-17 | 1983-11-08 | Byk-Millinkcrodt Cil B.V. | Preparation and use of a 195M-AU-containing liquid |
| US4643891A (en) * | 1979-04-17 | 1987-02-17 | Mallinckrodt Diagnostica (Holland) B.V. | Preparation and use of a 195m Au-containing liquid |
| US20030219366A1 (en) * | 2002-04-12 | 2003-11-27 | Horwitz E. Philip | Multicolumn selectivity inversion generator for production of ultrapure radionuclides |
| US20080226543A1 (en) * | 2005-03-24 | 2008-09-18 | Nigel John Osborn | Stripping Method |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2443030C2 (ru) * | 2010-02-03 | 2012-02-20 | Федеральное государственное унитарное предприятие "Ордена Трудового Красного Знамени научно-исследовательский физико-химический институт им. Л.Я. Карпова" (ФГУП "НИФХИ им. Л.Я. Карпова") | ГЕНЕРАТОР ТЕХНЕЦИЯ-99m С СУЛЬФО-КАРБОКСИЛИРОВАННЫМ КАТИОНООБМЕННЫМ ЗАЩИТНЫМ СЛОЕМ И СПОСОБ ЕГО ПОЛУЧЕНИЯ |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3382152A (en) * | 1964-09-28 | 1968-05-07 | Union Carbide Corp | Production of high purity radioactive isotopes |
| NL6607699A (xx) * | 1966-06-03 | 1967-12-04 | ||
| US3468808A (en) * | 1967-06-16 | 1969-09-23 | Union Carbide Corp | Production of high purity radioactive technetium-99m |
| US3664964A (en) * | 1968-07-03 | 1972-05-23 | Squibb & Sons Inc | Eluent for radioisotopes |
-
1971
- 1971-03-02 NL NL7102716.A patent/NL165321C/xx not_active IP Right Cessation
-
1972
- 1972-02-17 DE DE2207309A patent/DE2207309C3/de not_active Expired
- 1972-02-28 JP JP1975872A patent/JPS544039B1/ja active Pending
- 1972-02-28 IT IT21138/72A patent/IT947968B/it active
- 1972-02-28 CH CH279272A patent/CH578235A5/xx not_active IP Right Cessation
- 1972-02-28 CA CA135,683A patent/CA971749A/en not_active Expired
- 1972-02-28 SE SE7202432A patent/SE387768B/xx unknown
- 1972-02-28 GB GB900772A patent/GB1353293A/en not_active Expired
- 1972-02-28 FR FR7206671A patent/FR2128373B1/fr not_active Expired
- 1972-02-29 US US00230502A patent/US3785990A/en not_active Expired - Lifetime
- 1972-02-29 BE BE780010A patent/BE780010A/xx not_active IP Right Cessation
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3902849A (en) * | 1971-08-19 | 1975-09-02 | Medi Physics Inc | Radioisotope and radiopharmaceutical generators |
| US3970583A (en) * | 1973-02-20 | 1976-07-20 | U.S. Philips Corporation | Isotope generator provided with a carrier material which in addition to Al2 O3 contains fully or partly hydrated MnO2 |
| US4010109A (en) * | 1973-07-02 | 1977-03-01 | Kurt Sauerwein | Device for marking fluent materials |
| US4041317A (en) * | 1976-05-19 | 1977-08-09 | E. R. Squibb & Sons, Inc. | Multiple pH alumina columns for molybdenum-99/technetium-99m generators |
| US4280053A (en) * | 1977-06-10 | 1981-07-21 | Australian Atomic Energy Commission | Technetium-99m generators |
| US4206358A (en) * | 1977-10-19 | 1980-06-03 | Australian Atomic Energy Commission | Technetium-99 generators |
| US4414145A (en) * | 1979-04-17 | 1983-11-08 | Byk-Millinkcrodt Cil B.V. | Preparation and use of a 195M-AU-containing liquid |
| US4643891A (en) * | 1979-04-17 | 1987-02-17 | Mallinckrodt Diagnostica (Holland) B.V. | Preparation and use of a 195m Au-containing liquid |
| US20030219366A1 (en) * | 2002-04-12 | 2003-11-27 | Horwitz E. Philip | Multicolumn selectivity inversion generator for production of ultrapure radionuclides |
| US6998052B2 (en) | 2002-04-12 | 2006-02-14 | Pg Research Foundation | Multicolumn selectivity inversion generator for production of ultrapure radionuclides |
| US20080226543A1 (en) * | 2005-03-24 | 2008-09-18 | Nigel John Osborn | Stripping Method |
| US8053622B2 (en) | 2005-03-24 | 2011-11-08 | Ge Healthcare Limited | Stripping method |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2207309C3 (de) | 1981-07-30 |
| CA971749A (en) | 1975-07-29 |
| JPS544039B1 (xx) | 1979-03-01 |
| NL165321B (nl) | 1980-10-15 |
| DE2207309B2 (de) | 1980-11-20 |
| NL165321C (nl) | 1981-03-16 |
| DE2207309A1 (de) | 1972-09-07 |
| SE387768B (sv) | 1976-09-13 |
| FR2128373B1 (xx) | 1983-04-08 |
| GB1353293A (en) | 1974-05-15 |
| FR2128373A1 (xx) | 1972-10-20 |
| NL7102716A (xx) | 1972-09-05 |
| IT947968B (it) | 1973-05-30 |
| CH578235A5 (xx) | 1976-07-30 |
| BE780010A (fr) | 1972-08-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AS | Assignment |
Owner name: MAALLINCKRODT DIAGNOSTICA (HOLLAND) B.V., WESTERDU Free format text: CHANGE OF NAME;ASSIGNOR:BYK-MALLINCKRODT CIL B.V.;REEL/FRAME:004466/0151 Effective date: 19850728 |