US3774602A - Ultrasonic nebulizer for inhalation therapy - Google Patents

Ultrasonic nebulizer for inhalation therapy Download PDF

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Publication number
US3774602A
US3774602A US00215035A US3774602DA US3774602A US 3774602 A US3774602 A US 3774602A US 00215035 A US00215035 A US 00215035A US 3774602D A US3774602D A US 3774602DA US 3774602 A US3774602 A US 3774602A
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Prior art keywords
shell
combination
cup
liquid
set forth
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Expired - Lifetime
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US00215035A
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English (en)
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F Edwards
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American Hospital Supply Corp
Baxter International Inc
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American Hospital Supply Corp
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Assigned to BAXTER TRAVENOL LABORATORIES, INC. A CORP. OF DE reassignment BAXTER TRAVENOL LABORATORIES, INC. A CORP. OF DE MERGER (SEE DOCUMENT FOR DETAILS). EFFECTIVE ON 11/25/1985 ILLINOIS Assignors: AMERICAN HOSPITAL SUPPLY CORPORATION INTO
Assigned to BAXTER INTERNATIONAL INC. reassignment BAXTER INTERNATIONAL INC. CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). EFFECTIVE ON 10/17/1988 Assignors: BAXTER TRAVENOL LABORATORIES, INC., A CORP. OF DE
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0085—Inhalators using ultrasonics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/909—Breathing apparatus with means for preventing patient cross-contamination

Definitions

  • ABSTRACT A disposable single shot ultrasonic nebulizer that includes a sealed thermoplastic shell encasing a measured unit dose of nebulizable liquid that occupies less than one half of the shells volume.
  • the single shot cartridge type nebulizer includes an integral outwardly protruding liquid collecting nebulizer cup that progressively thins to an ultrasonically transparent dome shaped bottom wall.
  • Ultrasonic nebulization has been used increasingly in the treatment of respiratory illnesses in patients.
  • the procedure involves using a machine to apply ultrasonic energy to a liquid surface to break it up into very minute liquid particles which are then inhaled by the patient for treatment of emphysema and other respiratory illnesses.
  • One advantage of ultrasonic nebulization is that the liquid is much easier to absorb by the lungs when the particles are extremely small.
  • ultrasonic nebulization used for inhalation therapy.
  • One type is the so-called continuous therapy.
  • a patient is connected to an ultrasonic nebulizer and maintained thereon for prolonged periods of time, often several hours or days.
  • the nebulizer equipment is continuously fed with replacement liquid as the patient consumes the nebulized liquid.
  • ultrasonic nebulization used with increasing frequency in recent years is a short term treatment by ultrasonic nebulization for inhalation therapy.
  • the short term treatments are often only a few minutes in duration and the physician intends to give only a small prescribed amount of liquid to the patient.
  • This type of therapy is sometimes called a single shot therapy and gives the patient a precise amount of liquid such as 5, l0, 15, 25 or 50 cc.
  • Its relation to continuous ultrasonic nebulization is somewhat similar to the relationshipbetween a quick hypodermic injection into the vein as opposed to a long continuous intravenous feeding.
  • My invention provides a sealed thermoplastic shell with a precise premeasured amount of nebulizable liquid encased by this shell.
  • This shell can be rotated, handled, stored, etc., in any orientation and still maintain the sterile integrity of the inside surface of the shell.
  • the thin thermoplastic shell which contains the sterile nebulizable liquid occupying less than one half of its internal volumne can be thought of as a single shot cartridge similar to modern cartridge type rifle shells. It is quickly inserted into an ultrasonic nebulizer machine, the patient nebulized with a precisely measured volume of liquid, and then the cartridge removed and discarded. This single shot one-time-use cartridge greatly reduces the chance of cross contamination between one patient and another in a hospital.
  • the structure of the single shot cartridge of a sealed thermoplastic shell includes an integral liquid collecting nebulizer cup with a wall that progressively thins towards integral ultrasonically transparent dome section. This dome protrudes from a bottom end of the thermoplastic shell for coupling with an ultrasonic energy source.
  • a frangible inlet-outlet system in the form of three outwardly protruding measuring cups that form a frangible opening system for the cartridge.
  • This frangible seal system maintains the sterile integrity of the cartridge and its nebulizable liquid contents.
  • the single shot nebulizer of this invention also includes a skirt member surrounding the thin walled nebulizer cup of the shell and this skirt has two external parallel flanges. With this configuration of the skirt, the ultrasonic nebulizer fits numerous styles and designs of ultrasonic energy nebulizer sources.
  • FIG. 1 is a sectional view of the nebulizer shell showing it with its integral collection cup extending from its bottom as it would be used with a nebulizer machine;
  • FIG. 2 is the single shot shell cartridge of FIG. 1 showing it inverted as it is shipped, stored and handled;
  • FIG. 3 is a fragmentary side elevational view showing the measuring pocket of the frangible inlet-outlet system
  • FIG. 4 is a top plan view of FIG. 3 showing the nebulizer cup
  • FIG. 5 is a bottom plan view of FIG. 3 showing the measuring cups after the frangible seals have been broken;
  • FIG. 6 is an enlarged fragmentary sectional view showing the frangible inlet-outlet structure of the measuring cups
  • FIG. 7 is an enlarged fragmentary sectional view showing the progressively thinning wall of the nebulizer cup and the structure of its integral fused connection to form an integral part of the nebulizer shell;
  • FIGS. 8 through 11 show the supporting skirt structure with its two parallel flanges and how it supports the single shot nebulizer shell on four different ultrasonic energy machines.
  • the single shot nebulizer of this invention has a semi-rigid thermoplastic shell that is comprised of'a generally cylindrical upper body member 1, and a lower body member 2 integrally fused together.
  • the integral connection between upper and lower body member is at an external stepped section of the upper body member that has a ledge 3 and a downwardly extending skirt 4. Telescopically received in this stepped section is an integral skirt member 5 of the lower body portion.
  • a shoulder portion 6 of the lower body member abuttingly engages outward flange 3.
  • the tight telescopic fit between upper and lower body portions is sealed by an integral fusion bond made by ultrasonic welding, spin welding, solvent welding, etc., to create an integral bacteria type fusion between the two portions.
  • the upper body portion includes two or more integral outwardly protruding measuring cups 7 and 8, with top surfaces 9 and 10 respectively that define openings 11 and 12 into interiors of the measuring cups. Fitting across surfaces 9 and 10 is a thermoplastic material integrally fusion bonded to these surfaces to create a sealed thermoplastic shell.
  • This thermoplastic surface 13 is a portion of a laminated metal and thermoplastic panel, shown generally as 14, that forms a manually peelable frangible seal at the surfaces 9 and 10.
  • the bottom body portion of the shell includes a tapered drain ring portion 15 that integrally connects between shoulder 6 and a nebulizing cup 16 of the lower body portion.
  • This drain ring 15 funnels liquid 17 as shown in FIG. 1 into nebulizer cup 16.
  • the configuration of the nebulizer cup 16 performs an important function of this single shot ultrasonic nebulizer.
  • the collection cup has a tubular side wall 18 that is relatively thick at its upper end where it connects with drain ring portion 15. This is for firm support of the collection cup 16. As the tubular wall 18 proceeds downwardly in FIG. 1 it becomes progressively thinner and terminates in very thin bottom dome section 19. This dome section is between 0.002 and 0.008 inch thick and provides an integral ultrasonically transparent dome section of the nebulizer container.
  • the single shot nebulizer cartridge of FIGS. 1 and 2 provides a bacteria tight sealed barrier shell for the measured unit dose of nebulizable liquid 17. As shown in both FIGS. 1, with the dome down, and FIG. 2, with the dome up, the liquid occupies substantially less than one half of the internal volume of the nebulizer container.
  • the singleshot cartridge can be rotated, stored or moved in any orientation and the encased liquid is protected outside from bacterial contamination.
  • the nebulizer container, liquid contents, and inner surface are sterile because they have previously been steam sterilized.
  • the single shot nebulizer of this invention is also capable of delivering a measured amount of liquid that is less than the liquid shown in FIGS. 1 and 2. This is done by the procedure shown in FIG. 3. Here the frangible joint at one of the measuring cups 7 has been broken away from panel 14. This allows measuring cup 7 to drain while the liquid is retained and measured by measuring cup 8. Upon inverting the FIG. 3 container,
  • the collection cup is shown as having a very curved generally semispherical bottom wall, other shapes of the collecting cup could be used.
  • measuring cups 7, 8 and 21 are shown in the bottom plan view of FIG. 5. It is noted that only measuring pocket 7 and 8 have holes 11 and 12. Measuring pocket 21 has a solid end wall 20. All three cup members have annular external ribs for gripping a hose coupling as in FIGS. 8 11.
  • the top wall can be punched with a series of small holes with wall portions between the holes deflecting incoming air so it does not materially interfere with the geyser in a center of the nebulizer chamber. This same deflecting or baffling effect can be accomplished by making a C-shaped cut in a top wall of the measuring cup and leaving a small tab that is bent down from the top wall to deflect the incoming air.
  • FIG. 5 shows these measuring pockets after the flangible thermoplastic bond has been broken between the panel member 14 and the surfaces 9, 10 and 20 of the measuring cup.
  • the three measuring cups provide a stable three legged stand for the single shot nebulizer container which stands on panel member 14 in FIG. 2. The container is shipped and stored in this position. Panel 14 can also serve as a label with printed identification indicia and instructions.
  • Panel 14 includes a center laminate panel 22 of a metal foil, such as aluminum, sandwiched between an outer thermoplastic material 23 and an inner thermoplastic material 24.
  • the inner material is a thermoplastic of a polypropylene or polypropylene derivative. It is important that this thermoplastic material be able to take steam sterilization temperatures at between 240 and 260 F. without breaking loose from the measuring cup 7.
  • Measuring cup 7 is preferably of a polypropylene or polypropylene derivative thermoplastic material. Its upper ledge surface 9 is integrally fused to the thermoplastic laminate layer 24 at area 25 shown in dotted line in FIG. 6.
  • the fused joint 25 formed by either ultrasonic welding or heat welding is so strong the containers are actually shipped, stored and handled with the panel 13 forming the bottom base of the nebulizer container as shown in FIG. 2.
  • the liquid is constantly against panel 14 but does not leak through integral fusion joint 25.
  • an overhanging tab on the panel 14 is firmly pulled to fracture the frangible fused thermoplastic joint between the panel 14 and measuring cup 7. If the top wall of the nebulizer container supporting the measuring cups tends to flex beyond the desired limit, a more upwardly crowne configuration of this top wall can be used.
  • the single shot container is steam sterilized. Because of the high percentage of air within the container steam sterilization is carried out in a particular way and with the structure of the nebulizer container.
  • the bottom portion of the shell includes a vent channel 26 preferably in a tortuous or zigzag shape to resist bacterial growth along itspath.
  • the vent passage 26 is integrally formed in skirt 5 of the lower portion of the thermoplastic shell and also extends across shoulder 6. Skirt 4 shown in section fits over and protects the vent passage 26.
  • the nebulizer unit with sterile liquid contents is constructed as follows.
  • the thermoplastic shell is oriented as shown in FIG. 2 and then the portion 1 of the shell is filled with a precise amount of liquid.
  • Portion 2 of the shell is then assembled as shown leaving tiny vent 26 open to the atmosphere and as shown in FIG. 7.
  • Pressure differentials between the interior and exterior of the thermoplastic shell are balanced through vent passage 26. This prevents the container which is filled mostly with air from collapsing or exploding during steam sterilization to break the thermoplastic shell.
  • the portion 2 of the shell at flange 3 is integrally and permanently fused to portion 1 of the shell at shoulder 6.
  • thermoplastic shell which encases the liquid can be rotated, oriented and handled in any position without endangering the sterile interior of the shell or the liquid therein.
  • a single shot nebulizer container is adapted to fit to many different types of ultrasonic energy sources.
  • a very important feature of the chamber includes the downwardly extending skirt sections 4 and 5, which have outwardly extending parallel peripheral flanges 30 and 31. The skirts with these flanges are spaced outwardly from the nebulizer collection cup 16 to create an annular recess between the cup and skirts. If desired, the skirts can be spaced closer together than shown to fit the particular structure of ultrasonic energy source machines.
  • the nebulizer container is connected to an ultrasonic energy source shown schematically with an ultrasonically vibrating crystal 32 that is in a housing 34.
  • a liquid coupling bath 35 connects the collecting cups thin ultrasonically transparent dome section with the ultrasonic energy source crystal 32.
  • the dome is supported above the crystal a prescribed distance by a supporting ring 36 that fits between flanges 30 and 31.
  • the frangible panel 14 has been broken away and hoses 37 and 38 have been connected to circulate air through the nebulizing chamber, which air picks up the ultrasonically nebulized mist within the chamber.
  • FIG. illustrates still another structure of ultrasonic energy source machine which is coupled to the nebulizer chamber.
  • This machine has a ring section 41 that extends into the annular space between collection cup 16 and skirts 4 and 5.
  • FIG. 11 another ultrasonic energy source is coupled to the single shot nebulizing chamber.
  • the upper flange 42 of the nebulizer shell has been extended a considerable distance beyond a lower flange 43. With this machine the flange 42 provides the support for the chamber.
  • thermoplastic shell cartridge can be formed of a polypropylene.
  • the thin wall upper portion 1 of the chamber is preferably vacuum-formed and then integrally fused to the frangible panel 14.
  • the bottom portion 2 is also preferably thermoformed of polypropylene material to provide the ultrasonically transparent dome of the collecting cup. It is noted that the collecting cup 16, its side wall 18, shoulder 6, skirt 2 and flange 5 are all formed of a single sheet of thermoplastic material. Thus there is no seam required betweem the ultrasonic dome portion 19 and side wall portion 18 of the collecting cup.
  • the polypropylene material and the progressively thinning structure of the collecting cup wall I have unexpectedly discovered that the collection cup can be nebulized until dry of liquid and the ultrasonic energy source does not burn a hole in the cup.
  • Previous nebulizers have been plagued and burned pinholes in their reusable ultrasonically transparent windows when they become dry. A burnt pinhole can cause the nebulizer chamber to become contaminated with the coupling liquid such as shown at 35 in FIG. 8.
  • a disposable, measured-dosage, hermetically closed, ultrasonic nebulizer cartridge unit for use in medical therapy comprising in combination:
  • thermoplastic shell a single semi-rigid, self-supporting thermoplastic shell
  • a measured unit dose of a nebulizable liquid in said shell occupying substantially less than one-half the shell internal volume;
  • said shell including an upper body member including inlet-outlet structure for connection with means for communicating the nebulized dose to a patient;
  • said upper body member having a wall connected to an outer margin of an inwardly directed, downwardly converging drain wall forming a drain ring of a substantial area terminating in a substantially reduced area inner margin of the drain wall, said shell including a liquid collection cup having a mouth connected to the inner margin of said drain wall and a side wall depending therefrom and terminating in a bottom wall for concentrating the entire volume of the nebulizable liquid thereat, the cross section of said collection cup being substantially reduced as compared with said upper body member for concentrating the liquid dose immediately over an ultrasonic energy source; and universal support means on said shell adjacent the lower margin of said upper body member for adapting the cartridge to a plurality of differently constructed ultrasonic energy source apparatuses.
  • said means hermetically sealing sid inlet-outlet structure comprises manually removable frangible seal means capable of withstanding sterilization temperatures of from 240 to 260F and forming visual indication means whereby fracture of the hermatic seal indicates contamination of the medical dose liquid and aprizes a user that the cartridge should not be administered to a patient.
  • inlet-outlet structure comprises tubular sleeve elements terminating in peripheral flanges to which said frangible seal means is secured, said seal means including a projecting tab portion projecting beyond the peripheral flange to faciliate manual rupture and removal of the seal means.
  • the shell has a plurality of measuring cup members, at least one of which is openable for draining liquid from the shell to leave a measured amount of liquid within said shell.
  • said shell includes at least three outwardly protruding measuring cup members having generally co-planar outer surfaces for combining to provide a tripod support for the thermoplastic shell.
  • thermoplastic shell includes an upper body portion and a lower portion including the collection cup which are integrally fused together.
  • thermoplastic shell is generally cylindrical and substantially larger in diameter than the collection cups side wall.
  • thermoplastic shell includes a skirt member which encircles said collecting cup at a space distance out- I wardly therefrom, said collecting cup having a dome area protruding below said skirt member.
  • thermoplastic shell universal support means includes a pair of parallel exterior circumferential flanges for supporting the shell on an ultrasonic energy source.
  • the universal support means includes at least one external annular flange integral with said upper body member adjacent said drain wall.
  • the universal support means includes an outer annular support surface adjacent the outer margin of the drain wall, said outer annular support surface being spaced outwardly from the drain walls inner margin so that the cartridge can be supported by structure surrounding an opening that is approximately the size of the outer margin of the collection cup, and can also be supported by structure surrounding an opening approximately the size of the inner margin of the drain wall.
  • thermoplastic shell has scalable vent means, said vent means being fused shut after sterilization of the shell and the liquid contents being maintained in a medically sterile condition by subjecting the cartridge to temperatures of 240 to 250F.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)
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US00215035A 1972-01-03 1972-01-03 Ultrasonic nebulizer for inhalation therapy Expired - Lifetime US3774602A (en)

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US21503572A 1972-01-03 1972-01-03

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JP (1) JPS4874089A (tr)
AU (1) AU460201B2 (tr)
BE (1) BE791692A (tr)
ES (1) ES409226A1 (tr)
FR (1) FR2166980A5 (tr)
GB (1) GB1377031A (tr)
IT (1) IT973972B (tr)
TR (1) TR17784A (tr)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903884A (en) * 1973-08-15 1975-09-09 Becton Dickinson Co Manifold nebulizer system
US3938519A (en) * 1974-02-26 1976-02-17 American Hospital Supply Corporation Medical liquid container with a toggle film leak tester and method of leak testing with same
US4159803A (en) * 1977-03-31 1979-07-03 MistO2 Gen Equipment Company Chamber for ultrasonic aerosol generation
US4953545A (en) * 1989-10-18 1990-09-04 Mccarty Jerry Disposable respiratory medication dispersion chamber
US4976259A (en) * 1986-12-22 1990-12-11 Mountain Medical Equipment, Inc. Ultrasonic nebulizer
US5139016A (en) * 1987-08-07 1992-08-18 Sorin Biomedica S.P.A. Process and device for aerosol generation for pulmonary ventilation scintigraphy
US6202643B1 (en) 1998-02-23 2001-03-20 Thayer Medical Corporation Collapsible, disposable MDI spacer and method
US20020098139A1 (en) * 2001-01-22 2002-07-25 Beverly Sparks Resposable sterilization and transport unit
US6679252B2 (en) 1998-02-23 2004-01-20 Thayer Medical Corporation Collapsible, disposable MDI spacer and method
US20040045546A1 (en) * 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
US6726186B2 (en) * 2000-08-16 2004-04-27 Sonia Gaaloul Apparatus for cleaning and refreshing fabrics with an improved ultrasonic nebulizer
US20080283050A1 (en) * 2007-05-15 2008-11-20 Joseph Dee Faram Pre-filled, small-volume nebulizer
US20150265786A1 (en) * 2013-01-09 2015-09-24 Omron Healthcare Co., Ltd. Drug solution tank and drug solution pack for ultrasonic inhaler
US9566397B2 (en) 2007-05-15 2017-02-14 Joseph Dee Faram Small-volume nebulizers and methods of use thereof
US20190054260A1 (en) * 2017-08-17 2019-02-21 Monzano Group LLC Nebulizer devices and methods
US10258758B1 (en) 2018-04-20 2019-04-16 Caddo Medical Technologies Llc Flow controlled valve for a small-volume nebulizer
US10342935B2 (en) 2017-11-21 2019-07-09 Caddo Medical Technologies Llc Internal nebulizer seal and method of use
US10905837B2 (en) 2015-04-02 2021-02-02 Hill-Rom Services Pte. Ltd. Respiratory therapy cycle control and feedback
US20210113784A1 (en) * 2017-03-20 2021-04-22 Vectura Delivery Devices Limited Container for cleaning the membrane of a nebulizer
US20210293424A1 (en) * 2016-12-21 2021-09-23 Gree Electric Appliances, Inc. Of Zhuhai Anti-Splash Structure and Humidification Apparatus
CN114404746A (zh) * 2022-02-28 2022-04-29 广州大学 一种轻便式雾化装置
CN114618057A (zh) * 2022-03-10 2022-06-14 广州大学 一种用于经肺给药的雾化装置
CN114642797A (zh) * 2022-03-22 2022-06-21 广州大学 一种吸入式经肺给药的雾化装置

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1315897C (en) * 1987-08-07 1993-04-06 John Waser Process for the generation of aerosols for the scintigraphic measurement of pulmonary ventilation, and a device relating to this
FR2699510B1 (fr) * 1992-12-23 1995-03-24 Dp Medical Dispositif de montage d'une cloison interne et d'un couvercle sur le bord périphérique d'une cuve, notamment pour nébuliseur.
IT1277832B1 (it) * 1995-03-02 1997-11-12 Giuseppina Magni Confezione per sostanze nebulizzabili

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US787874A (en) * 1904-03-02 1905-04-18 Carl Ritter Von Wessely Atomizing-inhaler.
DE664024C (de) * 1938-08-18 Hans Weber Inhalationsapparat
US3325976A (en) * 1966-04-26 1967-06-20 Beckman Instruments Inc Sample atomizer
US3380622A (en) * 1966-12-15 1968-04-30 Procter & Gamble Method and material for hermetically sealing containers
US3387607A (en) * 1964-02-10 1968-06-11 Vilbiss Co Apparatus for inhalation therapy
US3397810A (en) * 1966-03-28 1968-08-20 American Can Co Container with tape opening device
US3561444A (en) * 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3593712A (en) * 1968-07-01 1971-07-20 Chemetron Corp Ultrasonic nebulizer

Patent Citations (8)

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DE664024C (de) * 1938-08-18 Hans Weber Inhalationsapparat
US787874A (en) * 1904-03-02 1905-04-18 Carl Ritter Von Wessely Atomizing-inhaler.
US3387607A (en) * 1964-02-10 1968-06-11 Vilbiss Co Apparatus for inhalation therapy
US3397810A (en) * 1966-03-28 1968-08-20 American Can Co Container with tape opening device
US3325976A (en) * 1966-04-26 1967-06-20 Beckman Instruments Inc Sample atomizer
US3380622A (en) * 1966-12-15 1968-04-30 Procter & Gamble Method and material for hermetically sealing containers
US3561444A (en) * 1968-05-22 1971-02-09 Bio Logics Inc Ultrasonic drug nebulizer
US3593712A (en) * 1968-07-01 1971-07-20 Chemetron Corp Ultrasonic nebulizer

Cited By (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903884A (en) * 1973-08-15 1975-09-09 Becton Dickinson Co Manifold nebulizer system
US3938519A (en) * 1974-02-26 1976-02-17 American Hospital Supply Corporation Medical liquid container with a toggle film leak tester and method of leak testing with same
US4159803A (en) * 1977-03-31 1979-07-03 MistO2 Gen Equipment Company Chamber for ultrasonic aerosol generation
US4976259A (en) * 1986-12-22 1990-12-11 Mountain Medical Equipment, Inc. Ultrasonic nebulizer
US5139016A (en) * 1987-08-07 1992-08-18 Sorin Biomedica S.P.A. Process and device for aerosol generation for pulmonary ventilation scintigraphy
GB2224446B (en) * 1988-11-02 1992-09-16 Mountain Medical Equipment Inc Ultrasonic nebulizer
US4953545A (en) * 1989-10-18 1990-09-04 Mccarty Jerry Disposable respiratory medication dispersion chamber
US6202643B1 (en) 1998-02-23 2001-03-20 Thayer Medical Corporation Collapsible, disposable MDI spacer and method
US6679252B2 (en) 1998-02-23 2004-01-20 Thayer Medical Corporation Collapsible, disposable MDI spacer and method
US6726186B2 (en) * 2000-08-16 2004-04-27 Sonia Gaaloul Apparatus for cleaning and refreshing fabrics with an improved ultrasonic nebulizer
US20020098139A1 (en) * 2001-01-22 2002-07-25 Beverly Sparks Resposable sterilization and transport unit
US20040045546A1 (en) * 2002-09-05 2004-03-11 Peirce Management, Llc Pharmaceutical delivery system for oral inhalation through nebulization consisting of inert substrate impregnated with substance (S) to be solubilized or suspended prior to use
US9849254B2 (en) * 2007-05-15 2017-12-26 Caddo Medical Technologies Llc Pre-filled, small-volume nebulizer
US9566397B2 (en) 2007-05-15 2017-02-14 Joseph Dee Faram Small-volume nebulizers and methods of use thereof
US20080283050A1 (en) * 2007-05-15 2008-11-20 Joseph Dee Faram Pre-filled, small-volume nebulizer
US10149950B2 (en) 2007-05-15 2018-12-11 Caddo Medical Technologies Llc Pre-filled, small-volume nebulizer and method of manufacture
US9814847B2 (en) * 2013-01-09 2017-11-14 Omron Healthcare Co., Ltd. Drug solution tank and drug solution pack for ultrasonic inhaler
US20150265786A1 (en) * 2013-01-09 2015-09-24 Omron Healthcare Co., Ltd. Drug solution tank and drug solution pack for ultrasonic inhaler
US11992611B2 (en) 2015-04-02 2024-05-28 Hill-Rom Services Pte. Ltd. Respiratory therapy apparatus control
US10905837B2 (en) 2015-04-02 2021-02-02 Hill-Rom Services Pte. Ltd. Respiratory therapy cycle control and feedback
US10905836B2 (en) 2015-04-02 2021-02-02 Hill-Rom Services Pte. Ltd. Manifold for respiratory device
US12061013B2 (en) * 2016-12-21 2024-08-13 Gree Electric Appliances, Inc. Of Zhuhai Anti-splash structure and humidification apparatus
US20210293424A1 (en) * 2016-12-21 2021-09-23 Gree Electric Appliances, Inc. Of Zhuhai Anti-Splash Structure and Humidification Apparatus
US20210113784A1 (en) * 2017-03-20 2021-04-22 Vectura Delivery Devices Limited Container for cleaning the membrane of a nebulizer
US20190054260A1 (en) * 2017-08-17 2019-02-21 Monzano Group LLC Nebulizer devices and methods
US10576221B2 (en) 2017-11-21 2020-03-03 Caddo Medical Technologies Llc Internal nebulizer seal and method of use
US10342935B2 (en) 2017-11-21 2019-07-09 Caddo Medical Technologies Llc Internal nebulizer seal and method of use
US10258758B1 (en) 2018-04-20 2019-04-16 Caddo Medical Technologies Llc Flow controlled valve for a small-volume nebulizer
CN114404746A (zh) * 2022-02-28 2022-04-29 广州大学 一种轻便式雾化装置
CN114404746B (zh) * 2022-02-28 2023-11-07 广州大学 一种轻便式雾化装置
CN114618057A (zh) * 2022-03-10 2022-06-14 广州大学 一种用于经肺给药的雾化装置
CN114618057B (zh) * 2022-03-10 2023-09-26 广州大学 一种用于经肺给药的雾化装置
CN114642797A (zh) * 2022-03-22 2022-06-21 广州大学 一种吸入式经肺给药的雾化装置
CN114642797B (zh) * 2022-03-22 2023-09-26 广州大学 一种吸入式经肺给药的雾化装置

Also Published As

Publication number Publication date
JPS4874089A (tr) 1973-10-05
ES409226A1 (es) 1975-12-16
BE791692A (fr) 1973-03-16
IT973972B (it) 1974-06-10
TR17784A (tr) 1976-09-01
FR2166980A5 (tr) 1973-08-17
AU4893772A (en) 1974-05-16
GB1377031A (en) 1974-12-11
AU460201B2 (en) 1975-04-17

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