US3744975A - Rotor for multistation photometric analyzer - Google Patents

Rotor for multistation photometric analyzer Download PDF

Info

Publication number
US3744975A
US3744975A US00206468A US3744975DA US3744975A US 3744975 A US3744975 A US 3744975A US 00206468 A US00206468 A US 00206468A US 3744975D A US3744975D A US 3744975DA US 3744975 A US3744975 A US 3744975A
Authority
US
United States
Prior art keywords
rotor
disk
sample
cuvettes
sample analysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00206468A
Other languages
English (en)
Inventor
J Mailen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Atomic Energy Commission (AEC)
Original Assignee
US Atomic Energy Commission (AEC)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Atomic Energy Commission (AEC) filed Critical US Atomic Energy Commission (AEC)
Application granted granted Critical
Publication of US3744975A publication Critical patent/US3744975A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00326—Analysers with modular structure
    • G01N2035/00336—Analysers adapted for operation in microgravity, i.e. spaceflight
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/111666—Utilizing a centrifuge or compartmented rotor

Definitions

  • the rotor comprises a laminated disk-shaped member with a central opaque disk sandwiched between outer transparent disks.
  • the central disk is provided with a circular array of axially extending apertures which form sample analysis cuvettes when that disk is sandwiched between the outer transparent disks.
  • Central loading ports extend through each outer transparent disk in register with respective distribution chambers formed in the opposing end faces of the central disk. Passageways extend from each distribution chamber to each sample analysis cuvette for adding sample and reagent liquids to the sample analysis cuvettes. Means are provided for uniformly distributing sample and reagent liquids to the sample analysis cuvettes while the rotor is in operation.
  • the invention described herein relates generally to photometers and more particularly to an improved rotor for a multistation photometric analyzer which is capable of operation without gravitational assistance to effect transfer or retention of liquids. It was made in the course of, or under, a contract with the US. Atomic Energy Commission.
  • the supernatant may then be transferred centrifugally to respective cuvettes in a rotary cuvette system surrounding the disk.
  • a light source and detector are aligned with transparent windows in the cuvettes to determine chemical species concentrations by light absorbancy in the samples contained in the cuvettes.
  • Means are provided for receiving the output of the detector and individually indicating the phototransmittance of samples Within the cuvettes.
  • an improved rotor for a multi-station photometric analyzer which is capable of operation without gravitational assistance to elfect transfer or retention of liquids.
  • the rotor comprises a laminated disk-shaped member with a central opaque disk sandwiched between outer transparent disks.
  • the central disk is provided with a circular array of axially extending apertures which form sample analysis cuvettes when the disk is sandwiched between the outer transparent disks.
  • Central loading ports extend through each outer transparent disk in register with respective distribution chambers formed in the opposing end faces of the central disk. Passages extend from each distribution chamber to each sample analysis cuvette for adding sample and reactant liquids to the cuvettes. Means are provided for uniformly distributing sample and reagent liquids to the sample analysis cuvettes while the rotor is in operation.
  • FIG. 1 is a vertical sectional View schematically illustrating a photometric analyzer utilizing the subject rotor.
  • FIG. 2 is a top plan view of the photometric analyzer of FIG. 1.
  • FIG. 3 is a plan view of the sample loading side of the subject rotor.
  • FIG. 4 is an isometric view, sectioned and partially cut away, illustrating the sample loading side of the subject rotor.
  • FIG. 5 is a plan view of the reagent loading side of the subject rotor.
  • FIG. 6 is an isometric view, sectioned and partially cut away, illustrating the reagent loading side of the subject rotor.
  • FIGS. 1 and 2 a photometric analyzer of the rotary type incorporating a rotor 1 made in accordance with the invention is shown in a simplified schematic manner.
  • a motor driven rotor support housing 2 has a generally cylindrical body portion 3 terminating in a circular fiat plate portion 4.
  • An annular upstanding rim 5 integrally fixed to flat plate portion 4 provides lateral restraint to rotor 1.
  • Means (not shown), such as a key and magnet are used to prevent relative rotation between rotor 1 and platform 2 and to secure the rotor to the platform under weightless flight conditions while permitting relatively effortless manual removal of the rotor when desired.
  • a photometric light source 6 provides a light beam of constant intensity intersecting rotor 1 at a point corresponding to the radial positions of sample analysis cuvettes 7.
  • Apertures 8 are provided in flat plate portion 4 of housing 2 in axial register with the sample analysis cuvettes 7.
  • the light beam from light source 6, indicated by a broken line in FIG. 1, is aligned in such a manner so as to be transmitted through each aperture 8 and cuvette 7 as they pass through the beam.
  • Electronic photodetecting means 9 is disposed below rotor 1 and flat plate portion 4 of housing 2 where it is aligned to receive light transmitted through the sample analysis cuvettes during rotation.
  • Photodetecting means 9 comprise a photomultiplier tube and is designed to respond electrically with an output proportional to the intensity of the light transmitted through the cuvettes.
  • adjustable filter selector 11 Interposed between photodetecting means 9 and fiat plate portion 4 of housing 2 is an adjustable filter selector 11 containing a plurality of light filters 12 having different light transmission characteristics.
  • a spring loaded indexing mechanism 13 engages appropriately spaced depressions in adjustable filter selector 11 to secure any one of light filters 12 in axial alignment with light source 6 and photodetecting means 9.
  • a solenoid disk brake assembly 14 is provided for rapid braking of rotatable housing 2 by engaging the radially outermost portion of flat plate portion 4.
  • a pickup head rotor position indicator 15 generates pulses by means of photodiodes which are illuminated through holes 16 drilled through housing 2. The pulses are used by means of appropirate circuitry to provide rotor speed control and correlation of the light pulses transmitted through the sample analyses cuvettes to rotor position.
  • FIGS. 3 and 4 a plan and perspective view of the sample loading side of rotor 1 are shown, respectively.
  • the rotor is of laminated design with a central, preferably opaque, plastic disk 17 sandwiched between outer transparent plastic disks 18 and 19.
  • a circular array of axially extending apertures are provided through disk 17 to serve as sample analysis cuvettes 7.
  • disk 17 is provided with a series of generally radially oriented depressions extending from each cuvette 7 to a central sample distribution chamber 20.
  • Centrally located, tapered, sample. loading port 21 extends through disk 17 in register with sample distribution chamber 20.
  • sample distribution passageways 22, one for each sample analysis cuvette 7, intersect at the periphery of sample distribution chamber 20 to create a saw-tooth or serrated edge effect which provides a sub stantially equal distribution of sample liquid into passageways 22 when rotor 1 is rotating and sample liquid is injected through loading port 21.
  • Overflow channels 23 and overflow collection cavities 24 may be provided to limit the volume of liquid retained in each passageway 22 and further ensure equal distribution of sample liquid in those channels.
  • Passageways 22 are of capillary size to prevent loss of sample liquid during conditions of weightlessness and when the rotor is not spinning.
  • each passageway 25 Extending from a point near but spaced from the radial extremity of each passageway 22 is a connecting passageway 25 which terminates at a corresponding sample analyses cuvette.
  • Each passageway 25 is folded to extend radially inward from its point of intersection with a passageway 22 and then radially outward to a cuvette. The folded configuration prevents direct passage of sample fluid to cuvettes 7 after it has been distributed to passageways 22 as the acceleration induced pressure head of the sample liquid in each passageway 22 is balanced by the pressure head of fluid in the inwardly extending leg 26 of each corresponding passageway 25.
  • each passageway 25 intersects a corresponding passageway 22 at a point spaced from its radial extremity. This creates a trap where particulates in the sample liquid may be centrifugally compacted and retained so that only the purely liquid component of the sample is passed on to the sample analysis cuvettes.
  • FIGS. 5 and 6 a plan and perspective view of the reagent loading side of the rotor 1 are shown.
  • a reagent distribution chamber 27 communicates with cuvettes 7 through radially extending reagent distribution passageways 28 which are of capillary size to retain liquids in the cuvettes when the rotor is not spinning and under conditions of weightlessness.
  • Reagent distribution chamber 27 is provided with a saw-tooth or serrated edge effect by the intersection of passageways 28 in the same manner as is sample distribution chamber 20.
  • a reagent loading port 29 extends through disk 19 in register with reagent distribution chamber 27.
  • a single reagent may be injected through reagent loading port 29 into the spinning rotor in the form of a solution. Once in the sample analysis cuvettes, capillary action retains the reagent liquid even under conditions of weightlessness and non-rotation. Use of a single reagent would limit the system to the analysis of replicate aliquots for a single constituent, however.
  • different reagents are preloaded into the cuvettes and lyophilized. When a photometric analysis is to be made, the lyophilized reagents are solubilized by injecting water or bufler into the spinning rotor in the manner described above. Such operation permits multiple chemical analyses to be made on a single blood sample.
  • Sample liquid such as blood is next injected into the spinning rotor by any suitable means such as a hypodermic syringe inserted through sample loading port 21 so as to discharge into sample distribution chamber 20.
  • the sample flows radially outward through sample distribution passageways 22 until it reaches and fills the end of the passageways and overflows into overflow channels 23 and collection cavities 24.
  • Rotor rotation is continued at suflicient speed to separate red blood cells, in the case of a blood sample, and trap them in the outermost ends of passageways 22.
  • Air pressure is then applied through sample loading port 21 to force the plasma, remaining after the red blood cells have been centrifugally removed and trapped, through passageways 25 into the sample analysis cuvettes 7.
  • a liquid such as water or saline solution can be injected to displace the plasma. Once in the cuvettes, the plasma and reactants mix and are photometrically analyzed.
  • the entire rotor may be discarded and a new rotor inserted in the support housing formultiple tests on another sample.
  • sample and reagent material in the discarded rotor will remain in that rotor even under weightless conditions due to capillary action in passageways 22 and 28.
  • the loading ports can be permanently plugged to furnish additional gontainment or the rotor placed in a leak-tight plastic EXAMPLE Rotors have been made in accordance with the invention for use in whole blood analysis which can be operated without liquid spillage either under space flight conditions of weightlessness or terrestrially.
  • the rotors which are substantially as shown in the drawings and described below in reference to the drawings, were made from plastic disks having overall diameters within the range from 2.25 to 3.5 inches, each center disk 17 having a thickness of 0.2 inch and outer disks 18 and 19 a thickness of 0.125.
  • each rotor To form the reagent loading side of each rotor, the central disk 17 was machined on one side to form reagent distribution chamber 27 measuring a distance A of inch between the radially innermost points formed by intersecting passageways 28.
  • reagent distribution chamber 27 measuring a distance A of inch between the radially innermost points formed by intersecting passageways 28.
  • eight, equally spaced holes were drilled through each center disk 17 near its periphery on a common circle 1% inch in diameter. These holes determined the volume of the cuvettes (0.006 cubic inch or 0.1 cubic centimeter).
  • Capillary passageways to permit liquid transfer on the reagent loading side were provided by machining grooves having a depth and with B of inch into the center disk.
  • the transparent disks were cemented to the opaque disk to cover the open passageways and holes formed therein and form a closed system of sample and reagent distribution passageways and sample analysis cuvettes. Wax coatings were applied to the machined passageways and holes to prevent cement from flowing into those places.
  • Rotors having a 3% inch diameter and 17 cuvettes were fabricated in a manner similar to that described above in reference to the 2.25 inch diameter rotors.
  • the dimensions of the cuvettes, distribution chambers and rotor thickness were identical to those in the smaller rotor.
  • the lengths of the various passageways were extended to accommodate the larger radius of the 3 /2 inch rotor.
  • the rotor disk may have more or less cuvettes than the eight shown and may be fabricated of different materials using diiferent fabrication techniques such as pressure molding. It is intended rather that the invention be limited only by the scope of the appended claims.
  • An improved rotor for a photometric solution analyzer of the rotary cuvette type suitable for operation without gravitational assistance to efiect transfer or retention of liquids; the improved rotor comprising a generally disk-shaped member defining:
  • first and second inlet ports communicating, respectively, between said first and second distribution chambers and opposite axial end faces of said diskshaped member to enable said distribution chambers to be loaded with liquids during rotation of said rotor.
  • first distribution passageways each comprise a first generally radially outward extending passageway portion communicating with said first distribution chamber and a second capillary size connecting passageway portion communicating between said first portion and a corresponding sample analysis cuvette, said second portion intersecting said first portion at a point radially inward from the radially outermost extremity of said first portion, said second portion extending generally radially inward from its point of intersection with said first portion and then generally radially outward to said sample analysis cuvette.
  • each of said first distribution passageways intersects with adjacent first distribution passageways at an acute angle so as to form a serrated periphery about said first distribution chamber.
  • each of said second distribution passageways intersects with adjacent second distribution passageways at an acute angle so as to form a serrated periphery about said second distribution chamber.
  • sample analysis cuvettes comprise axial perforations through said central opaque disk.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Spectrometry And Color Measurement (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
US00206468A 1971-12-09 1971-12-09 Rotor for multistation photometric analyzer Expired - Lifetime US3744975A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20646871A 1971-12-09 1971-12-09

Publications (1)

Publication Number Publication Date
US3744975A true US3744975A (en) 1973-07-10

Family

ID=22766526

Family Applications (1)

Application Number Title Priority Date Filing Date
US00206468A Expired - Lifetime US3744975A (en) 1971-12-09 1971-12-09 Rotor for multistation photometric analyzer

Country Status (17)

Country Link
US (1) US3744975A (enrdf_load_stackoverflow)
JP (1) JPS5536937B2 (enrdf_load_stackoverflow)
AT (1) AT322880B (enrdf_load_stackoverflow)
BE (1) BE792465A (enrdf_load_stackoverflow)
BR (1) BR7208672D0 (enrdf_load_stackoverflow)
CA (1) CA966333A (enrdf_load_stackoverflow)
CH (1) CH549209A (enrdf_load_stackoverflow)
DE (1) DE2260292C2 (enrdf_load_stackoverflow)
DK (1) DK148520C (enrdf_load_stackoverflow)
ES (1) ES409317A1 (enrdf_load_stackoverflow)
FR (1) FR2164306A5 (enrdf_load_stackoverflow)
GB (1) GB1371465A (enrdf_load_stackoverflow)
IL (1) IL40915A (enrdf_load_stackoverflow)
IT (1) IT984613B (enrdf_load_stackoverflow)
NL (1) NL173890C (enrdf_load_stackoverflow)
NO (1) NO138303C (enrdf_load_stackoverflow)
SE (1) SE384086B (enrdf_load_stackoverflow)

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3795451A (en) * 1973-04-24 1974-03-05 Atomic Energy Commission Rotor for fast analyzer of rotary cuvette type
US3856470A (en) * 1973-01-10 1974-12-24 Baxter Laboratories Inc Rotor apparatus
US3864089A (en) * 1973-12-10 1975-02-04 Atomic Energy Commission Multiple-sample rotor assembly for blood fraction preparation
US3890101A (en) * 1974-02-15 1975-06-17 Us Energy Collection ring for use in multiple-sample blood fractionation centrifugal rotors
US3899296A (en) * 1974-07-17 1975-08-12 Us Energy Whole blood analysis rotor for a multistation dynamic photometer
US3901658A (en) * 1974-07-30 1975-08-26 Us Energy Whole blood analysis rotor assembly having removable cellular sedimentation bowl
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
US4013368A (en) * 1972-09-20 1977-03-22 Akro-Medic Engineering, Inc. Sample cartridge for use in apparatus for evaluation of biological fluid
US4225558A (en) * 1978-09-19 1980-09-30 Honeywell Inc. Fluid sample test apparatus and fluid sample cell for use therein
US4226531A (en) * 1977-08-29 1980-10-07 Instrumentation Laboratory Inc. Disposable multi-cuvette rotor
EP0039825A1 (de) * 1980-05-05 1981-11-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Küvetten-Rotor für Analysengerät und Verfahren zum Betrieb des Küvetten-Rotors
FR2503866A1 (fr) * 1981-04-14 1982-10-15 Guigan Jean Dispositif pour delivrer une dose determinee d'un echantillon de liquide dans une cellule et procede associe
FR2507325A1 (fr) * 1981-06-05 1982-12-10 Guigan Jean Procede et dispositif pour la mise en contact successive d'un echantillon liquide avec plusieurs reactifs
FR2578054A1 (fr) * 1985-02-28 1986-08-29 Inovelf Sa Procedes et dispositifs de preparation, conditionnement et utilisation de supports de reactifs
US4663296A (en) * 1980-05-05 1987-05-05 Hoffmann-La Roche Inc. Multicuvette rotor for analyzer
US4756883A (en) * 1986-09-16 1988-07-12 E. I. Du Pont De Nemours And Company Analysis device
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4762683A (en) * 1986-09-16 1988-08-09 E. I. Du Pont De Nemours And Company Analysis device
US4814144A (en) * 1980-11-25 1989-03-21 Boehringer Mannheim Gmbh Centrifugal analyzer rotor unit and insert elements
US4938927A (en) * 1982-01-08 1990-07-03 Environmental Diagnostics, Inc. Rotary fluid manipulator
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5141875A (en) * 1982-01-08 1992-08-25 Environmental Diagnostics, Inc. Rotary fluid manipulator
US5160702A (en) * 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US5300779A (en) * 1985-08-05 1994-04-05 Biotrack, Inc. Capillary flow device
EP0629850A3 (en) * 1989-05-30 1994-12-28 Martin Marietta Energy Systems Rotor and method for automatically processing liquids for laboratory and bioanalysis purposes.
EP0608006A3 (en) * 1990-06-04 1995-10-18 Abay Sa Analytical rotors and methods for analyzing biological fluids.
US5496520A (en) * 1982-01-08 1996-03-05 Kelton; Arden A. Rotary fluid manipulator
US5622871A (en) * 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US5631166A (en) * 1995-03-21 1997-05-20 Jewell; Charles R. Specimen disk for blood analyses
US6187598B1 (en) 1987-04-27 2001-02-13 Conopco Inc. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US6352862B1 (en) 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
WO2001087487A3 (en) * 2000-05-15 2002-04-18 Tecan Trading Ag Bidirectional flow centrifugal microfluidic devices
US20020135754A1 (en) * 1994-09-21 2002-09-26 The University Court Of The University Of Glasgow Apparatus and method for carrying out analysis of samples using radiation detector split beam radiation inspection
WO2002043866A3 (en) * 2000-12-01 2003-03-06 Burstein Technologies Inc Apparatus and methods for separating components of particulate suspension
US20050023765A1 (en) * 2002-01-31 2005-02-03 Coombs James Howard Bio-safety features for optical analysis disc and disc system including same
EP1009996A4 (en) * 1997-08-07 2005-03-30 Careside Inc CARTRIDGE OF ANALYSIS
US20050083781A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Methods and apparatus for mixing of liquids
US20050169804A1 (en) * 2004-02-04 2005-08-04 Hach Company User-configurable analytical rotor system
US20050170515A1 (en) * 2004-02-04 2005-08-04 Hach Company Analytical rotor system with an analytical signal path
US20050170514A1 (en) * 2004-02-04 2005-08-04 Hach Company Analytical rotor system for method of standard additions testing
US20050169805A1 (en) * 2004-02-04 2005-08-04 Hach Company Analytical rotor system with a sample chamber
US20050170513A1 (en) * 2004-02-04 2005-08-04 Hach Company Analytical rotor system for titration testing
US20070092407A1 (en) * 2005-10-26 2007-04-26 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
US20070092975A1 (en) * 2005-10-26 2007-04-26 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
WO2007050539A3 (en) * 2005-10-26 2007-08-30 Gen Electric Methods and systems for delivery of fluidic samples to sensor arrays
US20070278434A1 (en) * 2003-11-27 2007-12-06 Takao Tsuda Injector
US20080280373A1 (en) * 2007-05-07 2008-11-13 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US11565260B2 (en) 2020-03-20 2023-01-31 Orbis Diagnostics Limited Multi-chambered assay devices and associated methods, systems and apparatuses thereof for detection of analytes

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE399768B (sv) * 1975-09-29 1978-02-27 Lilja Jan E Kyvett for provtagning, blandning av, provet med ett reagensmedel och direkt utforande av, serskilt optisk, analys av det med reagensmedlet blandade provet
JPS5695354A (en) * 1979-12-28 1981-08-01 Akira Okumura Dispensing and discharging method of liquid component in centrifugal rotor
JPS5849968U (ja) * 1981-09-30 1983-04-04 アキレス株式会社 マツトレス基材
JPS58191399U (ja) * 1982-06-16 1983-12-19 三菱電機株式会社 送風用羽根車
JPH0567800B1 (enrdf_load_stackoverflow) * 1987-10-05 1993-09-27 Mitsubishi Electric Corp
WO2010005000A1 (ja) 2008-07-10 2010-01-14 三光純薬株式会社 臨床検査用ディスク、ディスクパックおよび臨床検査装置
CN112246452A (zh) * 2020-08-27 2021-01-22 中国科学院苏州生物医学工程技术研究所 一种离心机、自动化离心系统及其操作方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3547547A (en) * 1969-03-13 1970-12-15 Atomic Energy Commission Analytical photometer with means for measuring,holding and transferring discrete liquid volumes and method of use thereof
GB1340497A (en) * 1970-03-25 1973-12-12 Mse Holdings Ltd Centrifugal analyser

Cited By (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6228660B1 (en) 1908-04-27 2001-05-08 Conopco Inc. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US4013368A (en) * 1972-09-20 1977-03-22 Akro-Medic Engineering, Inc. Sample cartridge for use in apparatus for evaluation of biological fluid
US3856470A (en) * 1973-01-10 1974-12-24 Baxter Laboratories Inc Rotor apparatus
US3795451A (en) * 1973-04-24 1974-03-05 Atomic Energy Commission Rotor for fast analyzer of rotary cuvette type
US3864089A (en) * 1973-12-10 1975-02-04 Atomic Energy Commission Multiple-sample rotor assembly for blood fraction preparation
US3890101A (en) * 1974-02-15 1975-06-17 Us Energy Collection ring for use in multiple-sample blood fractionation centrifugal rotors
US3899296A (en) * 1974-07-17 1975-08-12 Us Energy Whole blood analysis rotor for a multistation dynamic photometer
US3901658A (en) * 1974-07-30 1975-08-26 Us Energy Whole blood analysis rotor assembly having removable cellular sedimentation bowl
US3982691A (en) * 1974-10-09 1976-09-28 Schlutz Charles A Centrifuge separation and washing device and method
US4226531A (en) * 1977-08-29 1980-10-07 Instrumentation Laboratory Inc. Disposable multi-cuvette rotor
US4225558A (en) * 1978-09-19 1980-09-30 Honeywell Inc. Fluid sample test apparatus and fluid sample cell for use therein
EP0039825A1 (de) * 1980-05-05 1981-11-18 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Küvetten-Rotor für Analysengerät und Verfahren zum Betrieb des Küvetten-Rotors
US4431606A (en) * 1980-05-05 1984-02-14 Hoffmann-La Roche Inc. Multicuvette rotor for analyzer
FR2484645A1 (fr) * 1980-05-05 1981-12-18 Hoffmann La Roche Rotor d'analyse destine notamment a un analyseur de chimie clinique et son utilisation
US4663296A (en) * 1980-05-05 1987-05-05 Hoffmann-La Roche Inc. Multicuvette rotor for analyzer
DK157156B (da) * 1980-05-05 1989-11-13 Hoffmann La Roche Kuvetterotor til analyseapparat og fremgangsmaade ved drift af rotoren
US4814144A (en) * 1980-11-25 1989-03-21 Boehringer Mannheim Gmbh Centrifugal analyzer rotor unit and insert elements
FR2503866A1 (fr) * 1981-04-14 1982-10-15 Guigan Jean Dispositif pour delivrer une dose determinee d'un echantillon de liquide dans une cellule et procede associe
EP0062907A1 (fr) * 1981-04-14 1982-10-20 Jean Guigan Dispositif pour délivrer une dose déterminée d'un échantillon de liquide dans une cellule et procédé associé
FR2507325A1 (fr) * 1981-06-05 1982-12-10 Guigan Jean Procede et dispositif pour la mise en contact successive d'un echantillon liquide avec plusieurs reactifs
US4938927A (en) * 1982-01-08 1990-07-03 Environmental Diagnostics, Inc. Rotary fluid manipulator
US5496520A (en) * 1982-01-08 1996-03-05 Kelton; Arden A. Rotary fluid manipulator
US5141875A (en) * 1982-01-08 1992-08-25 Environmental Diagnostics, Inc. Rotary fluid manipulator
FR2578054A1 (fr) * 1985-02-28 1986-08-29 Inovelf Sa Procedes et dispositifs de preparation, conditionnement et utilisation de supports de reactifs
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US5300779A (en) * 1985-08-05 1994-04-05 Biotrack, Inc. Capillary flow device
US4756884A (en) * 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4762683A (en) * 1986-09-16 1988-08-09 E. I. Du Pont De Nemours And Company Analysis device
US4756883A (en) * 1986-09-16 1988-07-12 E. I. Du Pont De Nemours And Company Analysis device
US7109042B2 (en) 1987-04-27 2006-09-19 Inverness Medical Switzerland Gmbh Assays
US6818455B2 (en) 1987-04-27 2004-11-16 Inverness Medical Switzerland Gmbh Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US5622871A (en) * 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US5656503A (en) * 1987-04-27 1997-08-12 Unilever Patent Holdings B.V. Test device for detecting analytes in biological samples
US6187598B1 (en) 1987-04-27 2001-02-13 Conopco Inc. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US5160702A (en) * 1989-01-17 1992-11-03 Molecular Devices Corporation Analyzer with improved rotor structure
US6352862B1 (en) 1989-02-17 2002-03-05 Unilever Patent Holdings B.V. Analytical test device for imuno assays and methods of using same
US7238537B2 (en) 1989-02-17 2007-07-03 Inverness Medical Switzerland Gmbh Assays
US7407813B2 (en) 1989-02-17 2008-08-05 Inverness Medical Switzerland Gmbh Assays
US7384796B2 (en) 1989-02-17 2008-06-10 Inverness Medical Switzerland Gmbh Assays
US20030219908A1 (en) * 1989-02-17 2003-11-27 Davis Paul James Assays
EP0629850A3 (en) * 1989-05-30 1994-12-28 Martin Marietta Energy Systems Rotor and method for automatically processing liquids for laboratory and bioanalysis purposes.
EP0608006A3 (en) * 1990-06-04 1995-10-18 Abay Sa Analytical rotors and methods for analyzing biological fluids.
US6992769B2 (en) 1994-09-21 2006-01-31 Nagaoka & Co., Ltd. Apparatus and method for carrying out analysis of samples using semi-reflective beam radiation inspection
US20020135754A1 (en) * 1994-09-21 2002-09-26 The University Court Of The University Of Glasgow Apparatus and method for carrying out analysis of samples using radiation detector split beam radiation inspection
US5631166A (en) * 1995-03-21 1997-05-20 Jewell; Charles R. Specimen disk for blood analyses
EP1009996A4 (en) * 1997-08-07 2005-03-30 Careside Inc CARTRIDGE OF ANALYSIS
US6527432B2 (en) 2000-05-15 2003-03-04 Tecan Trading Ag Bidirectional flow centrifugal microfluidic devices
WO2001087487A3 (en) * 2000-05-15 2002-04-18 Tecan Trading Ag Bidirectional flow centrifugal microfluidic devices
WO2002043866A3 (en) * 2000-12-01 2003-03-06 Burstein Technologies Inc Apparatus and methods for separating components of particulate suspension
US20050023765A1 (en) * 2002-01-31 2005-02-03 Coombs James Howard Bio-safety features for optical analysis disc and disc system including same
US7147362B2 (en) * 2003-10-15 2006-12-12 Agilent Technologies, Inc. Method of mixing by intermittent centrifugal force
US20050083781A1 (en) * 2003-10-15 2005-04-21 Caren Michael P. Methods and apparatus for mixing of liquids
US7406886B2 (en) * 2003-11-27 2008-08-05 Takao Tsuda Injector
US20070278434A1 (en) * 2003-11-27 2007-12-06 Takao Tsuda Injector
US20050169805A1 (en) * 2004-02-04 2005-08-04 Hach Company Analytical rotor system with a sample chamber
US20050170513A1 (en) * 2004-02-04 2005-08-04 Hach Company Analytical rotor system for titration testing
US20050170514A1 (en) * 2004-02-04 2005-08-04 Hach Company Analytical rotor system for method of standard additions testing
US20050170515A1 (en) * 2004-02-04 2005-08-04 Hach Company Analytical rotor system with an analytical signal path
US20050169804A1 (en) * 2004-02-04 2005-08-04 Hach Company User-configurable analytical rotor system
US20070092407A1 (en) * 2005-10-26 2007-04-26 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
US8105552B2 (en) 2005-10-26 2012-01-31 General Electric Company Optical sensor array system for parallel processing of chemical and biochemical information
US20070092975A1 (en) * 2005-10-26 2007-04-26 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
US8420025B2 (en) 2005-10-26 2013-04-16 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
US7723120B2 (en) 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
US20100178208A1 (en) * 2005-10-26 2010-07-15 General Electric Company Optical sensor array system for parallel processing of chemical and biochemical information
US8133741B2 (en) 2005-10-26 2012-03-13 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
WO2007050539A3 (en) * 2005-10-26 2007-08-30 Gen Electric Methods and systems for delivery of fluidic samples to sensor arrays
US20110217213A1 (en) * 2007-05-07 2011-09-08 General Electric Company METHOD AND APPARATUS FOR MEASURING pH OF LOW ALKALINITY SOLUTIONS
US8076153B2 (en) 2007-05-07 2011-12-13 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US20110091985A1 (en) * 2007-05-07 2011-04-21 General Electric Company METHOD AND APPARATUS FOR MEASURING pH OF LOW ALKALINITY SOLUTIONS
US7883898B2 (en) 2007-05-07 2011-02-08 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US8148166B2 (en) 2007-05-07 2012-04-03 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US20080280373A1 (en) * 2007-05-07 2008-11-13 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US11565260B2 (en) 2020-03-20 2023-01-31 Orbis Diagnostics Limited Multi-chambered assay devices and associated methods, systems and apparatuses thereof for detection of analytes

Also Published As

Publication number Publication date
CH549209A (de) 1974-05-15
NL7216233A (enrdf_load_stackoverflow) 1973-06-13
NO138303B (no) 1978-05-02
AT322880B (de) 1975-06-10
DK148520B (da) 1985-07-22
DE2260292A1 (de) 1973-06-14
DE2260292C2 (de) 1984-09-27
CA966333A (en) 1975-04-22
FR2164306A5 (enrdf_load_stackoverflow) 1973-07-27
NO138303C (no) 1978-08-09
SE384086B (sv) 1976-04-12
IT984613B (it) 1974-11-20
AU4911972A (en) 1974-05-23
IL40915A (en) 1975-03-13
IL40915A0 (en) 1973-01-30
DK148520C (da) 1986-03-03
ES409317A1 (es) 1975-12-16
BR7208672D0 (pt) 1973-08-30
GB1371465A (en) 1974-10-23
JPS5536937B2 (enrdf_load_stackoverflow) 1980-09-25
JPS4866481A (enrdf_load_stackoverflow) 1973-09-12
BE792465A (fr) 1973-03-30
NL173890B (nl) 1983-10-17
NL173890C (nl) 1984-03-16

Similar Documents

Publication Publication Date Title
US3744975A (en) Rotor for multistation photometric analyzer
US3899296A (en) Whole blood analysis rotor for a multistation dynamic photometer
US3795451A (en) Rotor for fast analyzer of rotary cuvette type
US3901658A (en) Whole blood analysis rotor assembly having removable cellular sedimentation bowl
US3864089A (en) Multiple-sample rotor assembly for blood fraction preparation
US3555284A (en) Multistation, single channel analytical photometer and method of use
US3586484A (en) Multistation analytical photometer and method of use
US5122284A (en) Apparatus and method for optically analyzing biological fluids
US5186844A (en) Apparatus and method for continuous centrifugal blood cell separation
CA2082827C (en) Analytical rotors and methods for analysis of biological fluids
US3873217A (en) Simplified rotor for fast analyzer of rotary cuvette type
US5591643A (en) Simplified inlet channels
US5160702A (en) Analyzer with improved rotor structure
US3813031A (en) Rotor having sample holding means
US4740472A (en) Method and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer
US5242606A (en) Sample metering port for analytical rotor having overflow chamber
US5061381A (en) Apparatus and method for separating cells from biological fluids
US6235531B1 (en) Modified siphons for improved metering precision
US4035156A (en) Filter type rotor for multistation photometer
US5304348A (en) Reagent container for analytical rotor
US3744974A (en) Loading disk for photometric analyzer of rotary cuvette type
JPH07111436B2 (ja) 液体処理用回転子及び方法
JP2007520693A (ja) 被検体物のマイクロ流体デバイスへの取り込みならびに収納の方法および装置
US3582218A (en) Multistation photometric analyzer
CA2346975C (en) Analytical rotors and methods for analysis of biological fluids