US3737608A - Method and apparatus for sterilizing the interior of a vessel containing a fluid with some void space allowed therein - Google Patents

Method and apparatus for sterilizing the interior of a vessel containing a fluid with some void space allowed therein Download PDF

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Publication number
US3737608A
US3737608A US00148098A US3737608DA US3737608A US 3737608 A US3737608 A US 3737608A US 00148098 A US00148098 A US 00148098A US 3737608D A US3737608D A US 3737608DA US 3737608 A US3737608 A US 3737608A
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United States
Prior art keywords
holder
ampul
oven
interior
microwave oven
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Expired - Lifetime
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US00148098A
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English (en)
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T Nagao
T Toishi
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Toshiba Corp
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Tokyo Shibaura Electric Co Ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02—Sterilising, e.g. of complete packages
    • B65B55/04—Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/08—Sterilising wrappers or receptacles prior to, or during, packaging by irradiation

Definitions

  • ABSTRACT A method for thermally sterilizing the interior of a vessel containing a fluid with some void space allowed therein comprises moving the vessel so as to cause the fluid contained therein to flow over its entire inner walls and irradiating microwave energy to the vessel while it is moved.
  • Fluid materials are generally handled as contents of a vessel.
  • certain kinds of liquid medicine and beverage should be preserved in a vessel in a sterilized state free from harmful germs.
  • liquid medicine is received in an ampule in a manner to occupy half or one-third of its inner volume, with the remaining space filled with a gas compressed with a higher pressure than the atmospheric,
  • the portion mainly heated is only the medicine contained therein.
  • Those inner walls of the ampule which are not contacted by the medicine but exposed to the gas are notpractically heated. This is due to the fact that the ampule made of glass or plastics material does not absorb high frequency waves and causes heat to be unduly radiated due to its thin walls. Therefore, even when the medicine in the ampule is heated to a sufficiently high temperature to obstruct the growth of miscellaneous germs, residual germs settled on the inner walls do not perish. Moreover, if microwaves continue to be applied, the medicine will eventually boil, causing the ampule to be damaged due to the resulting excessive vapour pressure.
  • a method for sterilizing the interior of a vessel containing a fluid containing void space which comprises moving the vessel in such a manner as to cause the fluid contained therein to flow over its entire inner walls and applying microwave energy to the vessel while it is being moved.
  • an apparatus for sterilizing the interior of a vessel containing a fluid with some void space allowed therein which comprises a microwave power source; a microwave oven; a waveguide for conducting microwaves from the microwave generator to the microwave oven; and a support member provided in the microwave oven for moving the vessel so as to cause the fluid contained therein to flow over its entire inner walls.
  • FIG. 1 is a schematic sectional view of a microwave sterilizer according to an embodiment of this invention
  • FIG. 2A represents another embodiment of the invention
  • FIG. 28 illustrates the manner in which the Si rilizer of FIG. 2A is operated
  • FIG. 3A shows another embodiment of the invention
  • FIG. 38 indicates the manner in which the sterilizer of FIG. 3A is operated
  • FIG. 4A is a schematic illustration of still another embodiment of the invention.
  • FIG. 4B is a sectional view on line 4B,'4B of FIG. 4A;
  • FIG. 5 indicates a further embodiment of the invention.
  • FIG. 6 is a schematic perspective view of a still further embodiment of the invention.
  • FIG. 7A shows the condition of vessels when the vessel support of FIG. 6 is not rotated
  • FIG. 7B indicates the condition of vessels when the vessel support of FIG. 6 is rotated
  • FIG. 8 is a schematic perspective view of a still further embodiment of the invention.
  • FIG. 9 shows the construction of the vessel support of FIG. 8.
  • FIG. 1 there is formed a microwave irradiation window 4 at the top 3 of a metal microwave oven 2 mounted on a 1.
  • a microwave power source 6 for exam ple, a magnetron.
  • a vessle support member 7 permissibly made of metal and rockably supported at one end.
  • a drive rod 8 for rocking the support member 7 penetratesthe base 1 and the bottom 9 of the microwave oven 2 to abut at the inner end on the underside of the support member 7 near its free end and contact a cam 11 driven by a motor 10 at the other end.
  • a holder 12 of vessels for example, ampules which consist of a material minimizing'the loss of high frequency waves such as polytetrafluo'roethylene, polypropylene or silicone rubber.
  • ampules 13 with the pointed end directe'ddownward.
  • Reference numeral 14 represents a known stirrer fan for distributing microwaves in all directions within the oven 2, and 15 denotes a known choke'portion for preventing the outward leakage of microwaves.
  • the liquid medicine in the ampule l3 is distributed throughout its interior.
  • the microwave power source 6 is actuated, the whole of the ampule is fully heated by microwave energy.
  • oneminute microwave enerby of 2450 MHz and 2 Kw to one hundred glass ampules each of 5 cc containing 2 cc. water to which there were purposely added hay bacilli the ampules, as well as the content, were heated to C, presenting a full sterilizing efi'ect.
  • FIG. 2A shows another embodiment of this invention, wherein microwaves are irradiated on ampules while they are rolled in a microwave oven.
  • a belt conveyor 16 for carrying ampules thereon which are to be forwarded by the motor through the oven 2 in the direction of the arrow.
  • the belt conveyor is formed of the same material as described above which minimizes loss of high frequency waves.
  • a cover plate 17 made of the same material as the belt conveyor 16 and fixed in the oven by proper means (not shown) so as to allow ampules placed on the belt conveyor 16 to be rolled.
  • the belt conveyor 16 has pawls 18 formed on its upper surface as illustrated in FIG. 2B which engage ampules 13.
  • the ampules 13 whose top contacts the cover plate 17 are sent forward in the direction of the arrow a through the oven 2 while rolling counterclockwise in the direction of the arrows b, thus causing the liquid medicine in the ampule 13 to be distributed over its entire inner walls.
  • there are irradiated microwaves the interior of the ampule 13, as well as its content, are fully sterilized.
  • the reference numerals 21 and 22 in FIG. 2A are known lossy portions provided around the inlet 19 and outlet of the oven 2, which consist of a vessel made of, for example, polypropylene and filled with water or sand so as to prevent the outward leakage of microwaves.
  • FIG. 3A is a modification of FIG. 2A, which is designed to cause ampules 13 to roll by gravitational fall.
  • the oven 2 inclined chutes 25, 26 and 27.
  • ampules 13 When ampules 13 are placed on the first chute 25 at the upper inlet 19 of the oven 2, they roll down the first, second and third chutes 25, 26 and 27 in turn to be taken out of the lower outlet 20 of the oven 2.
  • the lower end portions of the chutes may be provided with shutter means 28 and 29 driven by proper device (not shown) so as to allow the ampules 13 to fall'one by one on to the succeeding chutes.
  • proper device not shown
  • the reference numeral 30 shows a cylindrical ampule guide penetrating the microwave oven 2.
  • This guide is made of the same material as in the preceding cases which minimizes loss of high frequency waves and has four guide grooves 31, 32, 33 and 34 formed lengthwise along the outer periphery as shown in FIG. 4B.
  • Ampules 13 are fitted into the guides 31, 32, 33 and 34 as illustrated in FIG. 4A.
  • the cylindrical ampule guide 30 is covered with sleeves 35 formed of the material which similarly reduces loss of high frequency waves.
  • the cylindrical ampule guide 30 is made to travel from the inlet 19 to the outlet 20 of the oven 2, and at the same time rotate clockwise as indicated in FIG. 4B. Therefore, the embodiment of FIG. 4A has the same full sterilizing effect as the preceding embodiments.
  • the reference numeral 36 is an ampule-holding chuck portion fitted to a shaft 37, one end of which extends into the oven 2.
  • This chuck portion 36 is formed of the same material as in the preceding embodiments which minimizes loss of high frequency waves.
  • a pulley 38 To the outer end of the shaft 37 is fitted a pulley 38 which is coupled with a motor (not shown) by a belt 39.
  • the reference numeral 40 denotes a rail disposed above the oven 2.
  • a shaft 41 To this rail 40 is rotatably fitted a shaft 41, to the upper end of which there is fixed a pulley 42, and to the lower end of which there is attached an ampule holder 43.
  • the rail 40 is made to travel in the direction of the arrow.
  • the ampule holder 43 is introduced into the oven 2 through the inlet 19. Under this condition, the ampule holder 43 is carried forward in the travelling direction of the rail 40.
  • FIG. 7A represents the condition of the ampules 13 when the ampule holder 43 does not rotate. At this time, the liquid medicine contained the ampule 13 remains at the bottom. Upon rotation of the ampule holder 43, the medicine is brought upward by the centrifugal force applied thereto as shown in FIG. 7B.
  • the alternate rotating and non-rotating operation of the ampule holder 43 in the oven 2 enables the ampule 13 to be fully sterilized.
  • Those parts of the ampule holder 43 which are brought into contact with ampules 13 are made of the same material as in the preceding embodiments which minimizes loss of high frequency waves.
  • FIG. 6 is provided with a lossy or choke portion (not shown) as in the preceding embodiments to prevent microwaves from leaking out of the openings of the oven 2.
  • the ampule holder is shaken by the action of a spring.
  • the holder 50 is mounted, as shown in FIG. 9, on metal supports 51 and 52 having leg portions 51A and 52A, the
  • the ampule holder 50 and supports 51 and 52 are penetrated by rods 56 and 57, the lower ends of which contact those portions of the belt 53 defined between the respective pairs of slits 54 and 55.
  • the ampule holder 50 is normally urged upward by springs 58 and 59 stretched between the metal supports 51 and 52 and the belt 53.
  • the belt 53 moves in the direction of the arrow of FIG. 8.
  • the ampule holder 50 When the ampule holder 50 is brought to a section A near the inlet 19 of the oven 2, it is forced downward by metal rails 60 and 61.
  • the ampule holder 50 leaves the rails 60 and 61 by further movement of the belt 53, it is vertically shaken at a section B, as shown by the arrows, by the action of the springs 58 and 59.
  • the ampule holder 50 further advances to a section C, it is gradually forced downward by downwardly bent rails 62 and 63 to stop its shaking.
  • the ampule holder 50 consists of the same material as .well serve to prevent discharges of microwave energy from the springs 58 and,59.
  • This invention is adapted to-sterilize the interior of 5 capped bottles or other vessels in addition to ampules.
  • the materials to be sterilized include not only liquid medicine, but also other fluid materials requiring sterilization such as milk, juice or other beverage.
  • An apparatus for sterilizing the interior of ampuls each having a neck portion and a body portion and containing a liquid medicine with some void space therein comprising:
  • a waveguide for conducting microwaves from said microwave power source to said microwave oven; an ampul holder for supporting ampuls with their neck portions directed downward;
  • An apparatus for sterilizing the interior of ampuls each having a neck portion and body portion and containing a liquid medicine with some void space therein comprising:
  • a waveguide for conducting microwaves from said microwave power source to said microwave oven; an ampul holder for supporting ampuls with their neck portions directed downward; conveyor means for moving said ampul holder hori zontally in said microwave oven;

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Constitution Of High-Frequency Heating (AREA)
  • Non-Alcoholic Beverages (AREA)
US00148098A 1970-05-30 1971-03-28 Method and apparatus for sterilizing the interior of a vessel containing a fluid with some void space allowed therein Expired - Lifetime US3737608A (en)

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JP45046017A JPS4919598B1 (de) 1970-05-30 1970-05-30

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US (1) US3737608A (de)
JP (1) JPS4919598B1 (de)
CA (1) CA934827A (de)
DE (1) DE2127112A1 (de)
FR (1) FR2093892A5 (de)
GB (1) GB1294829A (de)

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3885915A (en) * 1971-12-01 1975-05-27 Tanabe Seiyaku Co Method and apparatus for the sterilization of ampoules with pharmaceutical liquid therein
US3909598A (en) * 1973-07-20 1975-09-30 Cem Corp Automatic volatility computer
US3926556A (en) * 1973-05-30 1975-12-16 Raymond Marcel Gut Boucher Biocidal electromagnetic synergistic process
US3955286A (en) * 1973-10-12 1976-05-11 Rene Anrep Method of and installation for treating various objects by means of microwaves
US4062127A (en) * 1974-07-01 1977-12-13 Klockner-Humboldt-Deutz Aktiengesellschaft Method for the continuous drying of wet, granular and/or lumpy materials and device for carrying out the method
US4308445A (en) * 1980-01-14 1981-12-29 Whirlpool Corporation Controlled movable support for microwave oven
US4310738A (en) * 1980-02-08 1982-01-12 Michael Moretti Microwave fluid heating system
US4424188A (en) 1981-12-31 1984-01-03 International Paper Company Sterilization of packaging material
US4742202A (en) * 1983-06-20 1988-05-03 The United State Of America As Represented By The Secretary Of The Navy Microwave apparatus for heating contained liquid
USRE32861E (en) * 1973-07-20 1989-02-07 Cem Corporation Automatic volatility computer
US4820892A (en) * 1985-08-22 1989-04-11 Tetra Pak International Ab Heating arrangement for packing containers holding liquid contents
US4879444A (en) * 1983-07-08 1989-11-07 Isover Saint-Gobain Apparatus for the heat treatment of insulating materials using microwave energy and hot gas
US4971773A (en) * 1983-11-21 1990-11-20 Board Of Regents Of The University Of Oklahoma Apparatus for sterilizing contact lenses
US5061443A (en) * 1988-07-29 1991-10-29 Eisai Co., Ltd. Method and apparatus for microwave sterilization of ampules
US5115166A (en) * 1989-03-08 1992-05-19 Abtox, Inc. Plasma sterilizer and method
US5165325A (en) * 1991-04-17 1992-11-24 Mitsubishi Jukogyo Kabushiki Kaisha Continuous pressurizing apparatus for liquid
US5178829A (en) * 1989-03-08 1993-01-12 Abtox, Inc. Flash sterilization with plasma
US5184046A (en) * 1990-09-28 1993-02-02 Abtox, Inc. Circular waveguide plasma microwave sterilizer apparatus
US5186893A (en) * 1989-03-08 1993-02-16 Abtox, Inc. Plasma cycling sterilizing process
US5244629A (en) * 1990-08-31 1993-09-14 Caputo Ross A Plasma sterilizing process with pulsed antimicrobial agent pretreatment
US5288460A (en) * 1989-03-08 1994-02-22 Abtox, Inc. Plasma cycling sterilizing process
US5325020A (en) * 1990-09-28 1994-06-28 Abtox, Inc. Circular waveguide plasma microwave sterilizer apparatus
US5374811A (en) * 1992-05-06 1994-12-20 The United States Of America As Represented By The Secretary Of The Air Force Blood and tissue rewarming device
US5376332A (en) * 1991-02-06 1994-12-27 Abtox, Inc. Plasma sterilizing with downstream oxygen addition
US5413759A (en) * 1989-03-08 1995-05-09 Abtox, Inc. Plasma sterilizer and method
US5413760A (en) * 1989-03-08 1995-05-09 Abtox, Inc. Plasma sterilizer and method
US5472664A (en) * 1989-03-08 1995-12-05 Abtox, Inc. Plasma gas mixture for sterilizer and method
US5593649A (en) * 1989-03-08 1997-01-14 Abtox, Inc. Canister with plasma gas mixture for sterilizer
US5609819A (en) * 1994-07-12 1997-03-11 Eisai Co., Ltd. Method of sterilizing sealed vial and apparatus for sealing the vial
US5645796A (en) * 1990-08-31 1997-07-08 Abtox, Inc. Process for plasma sterilizing with pulsed antimicrobial agent treatment
US5650693A (en) * 1989-03-08 1997-07-22 Abtox, Inc. Plasma sterilizer apparatus using a non-flammable mixture of hydrogen and oxygen
WO2003016143A1 (de) * 2001-08-08 2003-02-27 Robert Bosch Gmbh Verfahren und vorrichtung zur sterilisation von behältnissen
WO2003077959A1 (de) * 2002-03-19 2003-09-25 Robert Bosch Gmbh Verfahren und vorrichtung zumindest zur sterilisation von behältnissen und/oder deren verschliesselementen
EP1560604A1 (de) * 2002-06-10 2005-08-10 Jose Gutman System und verfahren für ozonhaltige verpackung zur desinfektionsanwendung
US20090292271A1 (en) * 2008-05-21 2009-11-26 Monterey Devices, Inc. Methods and apparatus for buffering anesthetics
US20110005958A1 (en) * 2009-07-09 2011-01-13 Onpharma, Inc. METHODS AND SYSTEMS FOR ADJUSTING THE pH OF MEDICAL BUFFERING SOLUTIONS
WO2011006122A1 (en) * 2009-07-09 2011-01-13 Onpharma, Inc. Methods and devices for sterilizing and holding buffering solution cartridges
US20110165017A1 (en) * 2009-07-09 2011-07-07 Onpharma, Inc. Methods and devices for sterilizing and holding buffering solution cartridges
US20120199580A1 (en) * 2009-08-20 2012-08-09 Electrolux Home Products Corporation N.V. wave stirrer for a microwave oven
US20130071527A1 (en) * 2010-09-10 2013-03-21 Pepsico, Inc. In-Package Non-Ionizing Electromagnetic Radiation Sterilization
US11229095B2 (en) 2014-12-17 2022-01-18 Campbell Soup Company Electromagnetic wave food processing system and methods

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5236826A (en) * 1975-09-19 1977-03-22 Yoshirou Suzuki Simplified safety moving fitting
US4599216A (en) * 1983-11-21 1986-07-08 Board Of Regents For The University Of Oklahoma Apparatus for exposure to microwaves
US4671935A (en) * 1983-11-21 1987-06-09 The Board Of Regents For The University Of Oklahoma Method for sterilizing contact lenses
GB2162728A (en) * 1984-08-01 1986-02-05 Thorn Emi Domestic Appliances Cooking apparatus
US4720924A (en) * 1986-11-03 1988-01-26 R & J Engineering Corporation Microwave drying of pharmaceutical gelatin capsules
DE3710156A1 (de) * 1987-03-27 1988-10-06 Wolfgang Schinke Vorrichtung zur behandlung von infektionsmuell mit hilfe von mikrowellen
SE8801373D0 (sv) * 1988-04-14 1988-04-14 Akerlund & Rausing Ab Forfarande for sterilisering av forpackningsmaterial, forpackningsbehallare eller delar till sadana samt anordning for genomforande av forfarandet

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US599205A (en) * 1898-02-15 vause
US2058826A (en) * 1933-04-27 1936-10-27 W E Long Company Apparatus for sterilizing food products
US2095502A (en) * 1931-03-06 1937-10-12 Hobart Mfg Co Cleaning and sterilizing method and apparatus
US3481266A (en) * 1963-12-17 1969-12-02 Atlas Werke Ag Apparatus for the sterilizing of products
US3494722A (en) * 1967-06-28 1970-02-10 Gray Ind Inc Method and apparatus for sterilizing
US3674422A (en) * 1970-05-12 1972-07-04 Gray Ind Inc Microwave treating apparatus

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US599205A (en) * 1898-02-15 vause
US2095502A (en) * 1931-03-06 1937-10-12 Hobart Mfg Co Cleaning and sterilizing method and apparatus
US2058826A (en) * 1933-04-27 1936-10-27 W E Long Company Apparatus for sterilizing food products
US3481266A (en) * 1963-12-17 1969-12-02 Atlas Werke Ag Apparatus for the sterilizing of products
US3494722A (en) * 1967-06-28 1970-02-10 Gray Ind Inc Method and apparatus for sterilizing
US3674422A (en) * 1970-05-12 1972-07-04 Gray Ind Inc Microwave treating apparatus

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3885915A (en) * 1971-12-01 1975-05-27 Tanabe Seiyaku Co Method and apparatus for the sterilization of ampoules with pharmaceutical liquid therein
US3926556A (en) * 1973-05-30 1975-12-16 Raymond Marcel Gut Boucher Biocidal electromagnetic synergistic process
USRE32861E (en) * 1973-07-20 1989-02-07 Cem Corporation Automatic volatility computer
US3909598A (en) * 1973-07-20 1975-09-30 Cem Corp Automatic volatility computer
US3955286A (en) * 1973-10-12 1976-05-11 Rene Anrep Method of and installation for treating various objects by means of microwaves
US4062127A (en) * 1974-07-01 1977-12-13 Klockner-Humboldt-Deutz Aktiengesellschaft Method for the continuous drying of wet, granular and/or lumpy materials and device for carrying out the method
US4308445A (en) * 1980-01-14 1981-12-29 Whirlpool Corporation Controlled movable support for microwave oven
US4310738A (en) * 1980-02-08 1982-01-12 Michael Moretti Microwave fluid heating system
US4424188A (en) 1981-12-31 1984-01-03 International Paper Company Sterilization of packaging material
US4742202A (en) * 1983-06-20 1988-05-03 The United State Of America As Represented By The Secretary Of The Navy Microwave apparatus for heating contained liquid
US4879444A (en) * 1983-07-08 1989-11-07 Isover Saint-Gobain Apparatus for the heat treatment of insulating materials using microwave energy and hot gas
US4971773A (en) * 1983-11-21 1990-11-20 Board Of Regents Of The University Of Oklahoma Apparatus for sterilizing contact lenses
US4820892A (en) * 1985-08-22 1989-04-11 Tetra Pak International Ab Heating arrangement for packing containers holding liquid contents
US5061443A (en) * 1988-07-29 1991-10-29 Eisai Co., Ltd. Method and apparatus for microwave sterilization of ampules
US5413759A (en) * 1989-03-08 1995-05-09 Abtox, Inc. Plasma sterilizer and method
US5115166A (en) * 1989-03-08 1992-05-19 Abtox, Inc. Plasma sterilizer and method
US5178829A (en) * 1989-03-08 1993-01-12 Abtox, Inc. Flash sterilization with plasma
US5593649A (en) * 1989-03-08 1997-01-14 Abtox, Inc. Canister with plasma gas mixture for sterilizer
US5186893A (en) * 1989-03-08 1993-02-16 Abtox, Inc. Plasma cycling sterilizing process
US5472664A (en) * 1989-03-08 1995-12-05 Abtox, Inc. Plasma gas mixture for sterilizer and method
US5288460A (en) * 1989-03-08 1994-02-22 Abtox, Inc. Plasma cycling sterilizing process
US5413760A (en) * 1989-03-08 1995-05-09 Abtox, Inc. Plasma sterilizer and method
US5650693A (en) * 1989-03-08 1997-07-22 Abtox, Inc. Plasma sterilizer apparatus using a non-flammable mixture of hydrogen and oxygen
US6261518B1 (en) 1990-08-31 2001-07-17 Depuy Orthopaedics, Inc. Process and apparatus for plasma sterilizing with pulsed antimicrobial agent treatment
US5645796A (en) * 1990-08-31 1997-07-08 Abtox, Inc. Process for plasma sterilizing with pulsed antimicrobial agent treatment
US5413758A (en) * 1990-08-31 1995-05-09 Abtox, Inc. Apparatus for plasma sterilizing with pulsed antimicrobial agent treatment
US5244629A (en) * 1990-08-31 1993-09-14 Caputo Ross A Plasma sterilizing process with pulsed antimicrobial agent pretreatment
US5325020A (en) * 1990-09-28 1994-06-28 Abtox, Inc. Circular waveguide plasma microwave sterilizer apparatus
US5184046A (en) * 1990-09-28 1993-02-02 Abtox, Inc. Circular waveguide plasma microwave sterilizer apparatus
US5376332A (en) * 1991-02-06 1994-12-27 Abtox, Inc. Plasma sterilizing with downstream oxygen addition
US5165325A (en) * 1991-04-17 1992-11-24 Mitsubishi Jukogyo Kabushiki Kaisha Continuous pressurizing apparatus for liquid
US5374811A (en) * 1992-05-06 1994-12-20 The United States Of America As Represented By The Secretary Of The Air Force Blood and tissue rewarming device
US5609819A (en) * 1994-07-12 1997-03-11 Eisai Co., Ltd. Method of sterilizing sealed vial and apparatus for sealing the vial
WO2003016143A1 (de) * 2001-08-08 2003-02-27 Robert Bosch Gmbh Verfahren und vorrichtung zur sterilisation von behältnissen
WO2003077959A1 (de) * 2002-03-19 2003-09-25 Robert Bosch Gmbh Verfahren und vorrichtung zumindest zur sterilisation von behältnissen und/oder deren verschliesselementen
US20040131496A1 (en) * 2002-03-19 2004-07-08 Bernd Goetzelmann Method and device at least for the sterilization of containers and/or the closing elements thereof
EP1560604A1 (de) * 2002-06-10 2005-08-10 Jose Gutman System und verfahren für ozonhaltige verpackung zur desinfektionsanwendung
EP1560604A4 (de) * 2002-06-10 2006-12-27 Jose Gutman System und verfahren für ozonhaltige verpackung zur desinfektionsanwendung
US20090292271A1 (en) * 2008-05-21 2009-11-26 Monterey Devices, Inc. Methods and apparatus for buffering anesthetics
US8162917B2 (en) 2008-05-21 2012-04-24 Onpharma, Inc. Methods and apparatus for buffering anesthetics
US20110005958A1 (en) * 2009-07-09 2011-01-13 Onpharma, Inc. METHODS AND SYSTEMS FOR ADJUSTING THE pH OF MEDICAL BUFFERING SOLUTIONS
WO2011006122A1 (en) * 2009-07-09 2011-01-13 Onpharma, Inc. Methods and devices for sterilizing and holding buffering solution cartridges
US20110165017A1 (en) * 2009-07-09 2011-07-07 Onpharma, Inc. Methods and devices for sterilizing and holding buffering solution cartridges
US8585963B2 (en) 2009-07-09 2013-11-19 Onpharma, Inc. Methods and devices for sterilizing and holding buffering solution cartridges
US8900513B2 (en) 2009-07-09 2014-12-02 Onpharma, Inc. Methods and devices for sterilizing and holding buffering solution cartridges
US20120199580A1 (en) * 2009-08-20 2012-08-09 Electrolux Home Products Corporation N.V. wave stirrer for a microwave oven
US20130071527A1 (en) * 2010-09-10 2013-03-21 Pepsico, Inc. In-Package Non-Ionizing Electromagnetic Radiation Sterilization
US9120587B2 (en) * 2010-09-10 2015-09-01 Pepsico, Inc. In-package non-ionizing electromagnetic radiation sterilization
US11229095B2 (en) 2014-12-17 2022-01-18 Campbell Soup Company Electromagnetic wave food processing system and methods

Also Published As

Publication number Publication date
CA934827A (en) 1973-10-02
GB1294829A (de) 1972-11-01
FR2093892A5 (de) 1972-01-28
JPS4919598B1 (de) 1974-05-18
DE2127112A1 (de) 1971-12-16

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